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Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands.

Baba A, Wakao M, Shinchi H, Chan M, Hayashi T, Yao S, Cottam HB, Carson DA, Suda Y.

Bioorg Med Chem Lett. 2020 Feb 1;30(3):126840. doi: 10.1016/j.bmcl.2019.126840. Epub 2019 Dec 3.


Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly.

Battistella C, Callmann CE, Thompson MP, Yao S, Yeldandi AV, Hayashi T, Carson DA, Gianneschi NC.

Adv Healthc Mater. 2019 Dec;8(23):e1901105. doi: 10.1002/adhm.201901105. Epub 2019 Oct 30.


Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli.

Chan M, Lao FS, Chu PJ, Shpigelman J, Yao S, Nan J, Sato-Kaneko F, Li V, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM.

J Med Chem. 2019 Nov 14;62(21):9521-9540. doi: 10.1021/acs.jmedchem.9b00870. Epub 2019 Oct 25.


Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants.

Shinchi H, Yamaguchi T, Moroishi T, Yuki M, Wakao M, Cottam HB, Hayashi T, Carson DA, Suda Y.

Bioconjug Chem. 2019 Nov 20;30(11):2811-2821. doi: 10.1021/acs.bioconjchem.9b00560. Epub 2019 Oct 9.


Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model.

Narayanan JSS, Ray P, Hayashi T, Whisenant TC, Vicente D, Carson DA, Miller AM, Schoenberger SP, White RR.

Cancer Immunol Res. 2019 Oct;7(10):1714-1726. doi: 10.1158/2326-6066.CIR-19-0101. Epub 2019 Aug 13.


Conjugation of a Small-Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity.

Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Vallez CN, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC.

ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26637-26647. doi: 10.1021/acsami.9b08295. Epub 2019 Jul 22.


Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex.

Wang Z, Zhou L, Xiong Y, Yu S, Li H, Fan J, Li F, Su Z, Song J, Sun Q, Liu SS, Xia Y, Zhao L, Li S, Guo F, Huang P, Carson DA, Lu D.

Br J Pharmacol. 2019 Sep;176(17):3390-3406. doi: 10.1111/bph.14770. Epub 2019 Jul 24.


Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.

Zhang S, Zhang H, Ghia EM, Huang J, Wu L, Zhang J, Lam S, Lei Y, He J, Cui B, Widhopf GF 2nd, Yu J, Schwab R, Messer K, Jiang W, Parker BA, Carson DA, Kipps TJ.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1370-1377. doi: 10.1073/pnas.1816262116. Epub 2019 Jan 8.


Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators.

Shukla NM, Chan M, Hayashi T, Carson DA, Cottam HB.

ACS Med Chem Lett. 2018 Dec 3;9(12):1156-1159. doi: 10.1021/acsmedchemlett.8b00566. eCollection 2018 Dec 13.


Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy.

Sato-Kaneko F, Wang X, Yao S, Hosoya T, Lao FS, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Carson DA, Corr M, Hayashi T.

Biomed Res Int. 2018 Oct 10;2018:8091283. doi: 10.1155/2018/8091283. eCollection 2018.


Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner.

Su Z, Song J, Wang Z, Zhou L, Xia Y, Yu S, Sun Q, Liu SS, Zhao L, Li S, Wei L, Carson DA, Lu D.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7522-E7531. doi: 10.1073/pnas.1802422115. Epub 2018 Jul 23.


Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist.

Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6836-E6844. doi: 10.1073/pnas.1803281115. Epub 2018 Jul 2.


Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants.

Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M.

SLAS Discov. 2018 Oct;23(9):960-973. doi: 10.1177/2472555218774308. Epub 2018 May 11.


Chest CT scan findings in World Trade Center workers.

de la Hoz RE, Weber J, Xu D, Doucette JT, Liu X, Carson DA, Celedón JC.

Arch Environ Occup Health. 2019;74(5):263-270. doi: 10.1080/19338244.2018.1452712. Epub 2018 May 9. Erratum in: Arch Environ Occup Health. 2019 Sep 27;:1-2.


Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands.

Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M.

J Med Chem. 2017 Nov 22;60(22):9142-9161. doi: 10.1021/acs.jmedchem.7b00797. Epub 2017 Nov 3.


Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE.

JCI Insight. 2017 Sep 21;2(18). pii: 93397. doi: 10.1172/jci.insight.93397. eCollection 2017 Sep 21.


Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice.

Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M.

J Virol. 2017 Sep 12;91(19). pii: e01050-17. doi: 10.1128/JVI.01050-17. Print 2017 Oct 1.


Bacteriocins of Non-aureus Staphylococci Isolated from Bovine Milk.

Carson DA, Barkema HW, Naushad S, De Buck J.

Appl Environ Microbiol. 2017 Aug 17;83(17). pii: e01015-17. doi: 10.1128/AEM.01015-17. Print 2017 Sep 1.


Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity.

Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM.

ACS Comb Sci. 2017 Aug 14;19(8):533-543. doi: 10.1021/acscombsci.7b00080. Epub 2017 Jul 13.


Prevalence of non-aureus staphylococci species causing intramammary infections in Canadian dairy herds.

Condas LAZ, De Buck J, Nobrega DB, Carson DA, Naushad S, De Vliegher S, Zadoks RN, Middleton JR, Dufour S, Kastelic JP, Barkema HW.

J Dairy Sci. 2017 Jul;100(7):5592-5612. doi: 10.3168/jds.2016-12478. Epub 2017 May 17.


Distribution of non-aureus staphylococci species in udder quarters with low and high somatic cell count, and clinical mastitis.

Condas LAZ, De Buck J, Nobrega DB, Carson DA, Roy JP, Keefe GP, DeVries TJ, Middleton JR, Dufour S, Barkema HW.

J Dairy Sci. 2017 Jul;100(7):5613-5627. doi: 10.3168/jds.2016-12479. Epub 2017 Apr 27.


Comprehensive Phylogenetic Analysis of Bovine Non-aureus Staphylococci Species Based on Whole-Genome Sequencing.

Naushad S, Barkema HW, Luby C, Condas LA, Nobrega DB, Carson DA, De Buck J.

Front Microbiol. 2016 Dec 20;7:1990. doi: 10.3389/fmicb.2016.01990. eCollection 2016.


The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL.

Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.


Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells.

Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson DA, Lu D.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155. Epub 2016 Oct 31.


Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1.

Choi MY, Widhopf GF 2nd, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ.

Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S167-9. doi: 10.1016/j.clml.2015.02.010. Review.


A window-of-opportunity biomarker study of etodolac in resectable breast cancer.

Schwab RB, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson DA, Parker BA.

Cancer Med. 2015 Oct;4(10):1583-8. doi: 10.1002/cam4.512. Epub 2015 Aug 15.


Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides.

Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA.

Bioconjug Chem. 2015 Aug 19;26(8):1713-23. doi: 10.1021/acs.bioconjchem.5b00285. Epub 2015 Aug 5.


Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes.

Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M.

PLoS One. 2015 Jun 15;10(6):e0129867. doi: 10.1371/journal.pone.0129867. eCollection 2015.


Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy.

Barrett CL, DeBoever C, Jepsen K, Saenz CC, Carson DA, Frazer KA.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3050-7. doi: 10.1073/pnas.1508057112. Epub 2015 May 26.


Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development.

Smith EN, Ghia EM, DeBoever CM, Rassenti LZ, Jepsen K, Yoon KA, Matsui H, Rozenzhak S, Alakus H, Shepard PJ, Dai Y, Khosroheidari M, Bina M, Gunderson KL, Messer K, Muthuswamy L, Hudson TJ, Harismendy O, Barrett CL, Jamieson CH, Carson DA, Kipps TJ, Frazer KA.

Blood Cancer J. 2015 Apr 10;5:e303. doi: 10.1038/bcj.2015.14.


Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses.

Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA.

J Virol. 2015 Mar;89(6):3221-35. doi: 10.1128/JVI.03337-14. Epub 2015 Jan 7.


Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.

Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF 2nd, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17266-71. doi: 10.1073/pnas.1419599111. Epub 2014 Nov 19.


Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands.

Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):4931-8. doi: 10.1016/j.bmcl.2014.09.039. Epub 2014 Sep 22.


Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments.

Smith EN, Jepsen K, Khosroheidari M, Rassenti LZ, D'Antonio M, Ghia EM, Carson DA, Jamieson CH, Kipps TJ, Frazer KA.

Genome Biol. 2014 Aug 7;15(8):420. doi: 10.1186/s13059-014-0420-4.


Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation.

Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA.

J Pharmacol Exp Ther. 2014 Aug;350(2):330-40. doi: 10.1124/jpet.114.214312. Epub 2014 Jun 3.


The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells.

Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson DA, Willert K.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1409-14. doi: 10.1073/pnas.1323697111. Epub 2014 Jan 13.


Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects.

Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson DA, Hayashi T.

Eur J Dermatol. 2013 Sep-Oct;23(5):618-28. doi: 10.1684/ejd.2013.2155.


Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.

Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T.

J Innate Immun. 2014;6(3):315-24. doi: 10.1159/000355217. Epub 2013 Nov 1.


Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.

Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB.

J Med Chem. 2013 Jun 13;56(11):4206-23. doi: 10.1021/jm301694x. Epub 2013 May 24.


Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.

Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA.

PLoS One. 2013;8(3):e58714. doi: 10.1371/journal.pone.0058714. Epub 2013 Mar 20.


Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M.

PLoS One. 2012;7(9):e45860. doi: 10.1371/journal.pone.0045860. Epub 2012 Sep 28.


Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia.

Wu RP, Li H, Rassenti LZ, Hayashi T, Wu CN, Kipps TJ, Messer K, Carson DA.

Leuk Lymphoma. 2013 Feb;54(2):400-2. doi: 10.3109/10428194.2012.709630. Epub 2012 Aug 13. No abstract available.


NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.

Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH.

PLoS One. 2012;7(6):e39725. doi: 10.1371/journal.pone.0039725. Epub 2012 Jun 29.


Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand.

Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M.

Mediators Inflamm. 2012;2012:262394. doi: 10.1155/2012/262394. Epub 2011 Nov 17.


Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.

Norton JT, Hayashi T, Crain B, Cho JS, Miller LS, Corr M, Carson DA.

J Immunol. 2012 Apr 1;188(7):2977-80. doi: 10.4049/jimmunol.1100830. Epub 2012 Mar 2.


Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.

Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V.

J Innate Immun. 2012;4(2):213-8. doi: 10.1159/000329550. Epub 2011 Aug 19.


Inhibition of Wnt signaling and cancer stem cells.

Lu D, Carson DA.

Oncotarget. 2011 Aug;2(8):587. No abstract available.


Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.

Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson DA.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7. doi: 10.1073/pnas.1110431108. Epub 2011 Jul 25.


Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.

Norton JT, Hayashi T, Crain B, Corr M, Carson DA.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11163-8. doi: 10.1073/pnas.1107899108. Epub 2011 Jun 20.


Influencing the Wnt signaling pathway in multiple myeloma.

Kim Y, Reifenberger G, Lu D, Endo T, Carson DA, Gast SM, Meschenmoser K, Nowak M, Schmidt-Wolf IG.

Anticancer Res. 2011 Feb;31(2):725-30. Review.


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