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Items: 1 to 50 of 446

1.

Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner.

Su Z, Song J, Wang Z, Zhou L, Xia Y, Yu S, Sun Q, Liu SS, Zhao L, Li S, Wei L, Carson DA, Lu D.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7522-E7531. doi: 10.1073/pnas.1802422115. Epub 2018 Jul 23.

2.

Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist.

Hosoya T, Sato-Kaneko F, Ahmadi A, Yao S, Lao F, Kitaura K, Matsutani T, Carson DA, Hayashi T.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6836-E6844. doi: 10.1073/pnas.1803281115. Epub 2018 Jul 2.

PMID:
29967183
3.

Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants.

Shukla NM, Arimoto KI, Yao S, Fan JB, Zhang Y, Sato-Kaneko F, Lao FS, Hosoya T, Messer K, Pu M, Cottam HB, Carson DA, Hayashi T, Zhang DE, Corr M.

SLAS Discov. 2018 Oct;23(9):960-973. doi: 10.1177/2472555218774308. Epub 2018 May 11.

PMID:
29751735
4.

Chest CT scan findings in World Trade Center workers.

de la Hoz RE, Weber J, Xu D, Doucette JT, Liu X, Carson DA, Celedón JC.

Arch Environ Occup Health. 2018 Mar 15:1-8. doi: 10.1080/19338244.2018.1452712. [Epub ahead of print]

PMID:
29543564
5.

Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands.

Chan M, Kakitsubata Y, Hayashi T, Ahmadi A, Yao S, Shukla NM, Oyama SY, Baba A, Nguyen B, Corr M, Suda Y, Carson DA, Cottam HB, Wakao M.

J Med Chem. 2017 Nov 22;60(22):9142-9161. doi: 10.1021/acs.jmedchem.7b00797. Epub 2017 Nov 3.

6.

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE.

JCI Insight. 2017 Sep 21;2(18). pii: 93397. doi: 10.1172/jci.insight.93397. [Epub ahead of print]

7.

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice.

Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M.

J Virol. 2017 Sep 12;91(19). pii: e01050-17. doi: 10.1128/JVI.01050-17. Print 2017 Oct 1.

8.

Bacteriocins of Non-aureus Staphylococci Isolated from Bovine Milk.

Carson DA, Barkema HW, Naushad S, De Buck J.

Appl Environ Microbiol. 2017 Aug 17;83(17). pii: e01015-17. doi: 10.1128/AEM.01015-17. Print 2017 Sep 1.

9.

Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity.

Chan M, Ahmadi A, Yao S, Sato-Kaneko F, Messer K, Pu M, Nguyen B, Hayashi T, Corr M, Carson DA, Cottam HB, Shukla NM.

ACS Comb Sci. 2017 Aug 14;19(8):533-543. doi: 10.1021/acscombsci.7b00080. Epub 2017 Jul 13.

10.

Prevalence of non-aureus staphylococci species causing intramammary infections in Canadian dairy herds.

Condas LAZ, De Buck J, Nobrega DB, Carson DA, Naushad S, De Vliegher S, Zadoks RN, Middleton JR, Dufour S, Kastelic JP, Barkema HW.

J Dairy Sci. 2017 Jul;100(7):5592-5612. doi: 10.3168/jds.2016-12478. Epub 2017 May 17.

PMID:
28527793
11.

Distribution of non-aureus staphylococci species in udder quarters with low and high somatic cell count, and clinical mastitis.

Condas LAZ, De Buck J, Nobrega DB, Carson DA, Roy JP, Keefe GP, DeVries TJ, Middleton JR, Dufour S, Barkema HW.

J Dairy Sci. 2017 Jul;100(7):5613-5627. doi: 10.3168/jds.2016-12479. Epub 2017 Apr 27.

PMID:
28456402
12.

Comprehensive Phylogenetic Analysis of Bovine Non-aureus Staphylococci Species Based on Whole-Genome Sequencing.

Naushad S, Barkema HW, Luby C, Condas LA, Nobrega DB, Carson DA, De Buck J.

Front Microbiol. 2016 Dec 20;7:1990. doi: 10.3389/fmicb.2016.01990. eCollection 2016.

13.

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL.

Cell. 2016 Dec 1;167(6):1525-1539.e17. doi: 10.1016/j.cell.2016.11.005.

14.

Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells.

Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson DA, Lu D.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155. Epub 2016 Oct 31.

15.

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1.

Choi MY, Widhopf GF 2nd, Wu CC, Cui B, Lao F, Sadarangani A, Cavagnaro J, Prussak C, Carson DA, Jamieson C, Kipps TJ.

Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S167-9. doi: 10.1016/j.clml.2015.02.010. Review.

16.

A window-of-opportunity biomarker study of etodolac in resectable breast cancer.

Schwab RB, Kato S, Crain B, Pu M, Messer K, Weidner N, Blair SL, Wallace AM, Carson DA, Parker BA.

Cancer Med. 2015 Oct;4(10):1583-8. doi: 10.1002/cam4.512. Epub 2015 Aug 15.

17.

Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides.

Shinchi H, Crain B, Yao S, Chan M, Zhang SS, Ahmadiiveli A, Suda Y, Hayashi T, Cottam HB, Carson DA.

Bioconjug Chem. 2015 Aug 19;26(8):1713-23. doi: 10.1021/acs.bioconjchem.5b00285. Epub 2015 Aug 5.

PMID:
26193334
18.

Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes.

Hayashi T, Yao S, Crain B, Promessi VJ, Shyu L, Sheng C, Kang M, Cottam HB, Carson DA, Corr M.

PLoS One. 2015 Jun 15;10(6):e0129867. doi: 10.1371/journal.pone.0129867. eCollection 2015.

19.

Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy.

Barrett CL, DeBoever C, Jepsen K, Saenz CC, Carson DA, Frazer KA.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3050-7. doi: 10.1073/pnas.1508057112. Epub 2015 May 26.

20.

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development.

Smith EN, Ghia EM, DeBoever CM, Rassenti LZ, Jepsen K, Yoon KA, Matsui H, Rozenzhak S, Alakus H, Shepard PJ, Dai Y, Khosroheidari M, Bina M, Gunderson KL, Messer K, Muthuswamy L, Hudson TJ, Harismendy O, Barrett CL, Jamieson CH, Carson DA, Kipps TJ, Frazer KA.

Blood Cancer J. 2015 Apr 10;5:e303. doi: 10.1038/bcj.2015.14.

21.

Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses.

Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA.

J Virol. 2015 Mar;89(6):3221-35. doi: 10.1128/JVI.03337-14. Epub 2015 Jan 7.

22.

Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.

Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF 2nd, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17266-71. doi: 10.1073/pnas.1419599111. Epub 2014 Nov 19.

23.

Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands.

Nour A, Hayashi T, Chan M, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Ahmadiiveli A, Messer K, Pu M, Corr M, Carson DA, Cottam HB.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):4931-8. doi: 10.1016/j.bmcl.2014.09.039. Epub 2014 Sep 22.

24.

Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments.

Smith EN, Jepsen K, Khosroheidari M, Rassenti LZ, D'Antonio M, Ghia EM, Carson DA, Jamieson CH, Kipps TJ, Frazer KA.

Genome Biol. 2014 Aug 7;15(8):420. doi: 10.1186/s13059-014-0420-4.

25.

Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation.

Hayashi T, Crain B, Yao S, Caneda CD, Cottam HB, Chan M, Corr M, Carson DA.

J Pharmacol Exp Ther. 2014 Aug;350(2):330-40. doi: 10.1124/jpet.114.214312. Epub 2014 Jun 3.

26.

The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells.

Fernandez A, Huggins IJ, Perna L, Brafman D, Lu D, Yao S, Gaasterland T, Carson DA, Willert K.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1409-14. doi: 10.1073/pnas.1323697111. Epub 2014 Jan 13.

27.

Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects.

Crain B, Yao S, Keophilaone V, Promessi V, Kang M, Barberis A, Maj R, Mura E, Passini N, Holldack J, Ochoa R, Cottam HB, Carson DA, Hayashi T.

Eur J Dermatol. 2013 Sep-Oct;23(5):618-28. doi: 10.1684/ejd.2013.2155.

28.

Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.

Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T.

J Innate Immun. 2014;6(3):315-24. doi: 10.1159/000355217. Epub 2013 Nov 1.

29.

Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.

Chan M, Hayashi T, Mathewson RD, Nour A, Hayashi Y, Yao S, Tawatao RI, Crain B, Tsigelny IF, Kouznetsova VL, Messer K, Pu M, Corr M, Carson DA, Cottam HB.

J Med Chem. 2013 Jun 13;56(11):4206-23. doi: 10.1021/jm301694x. Epub 2013 May 24.

30.

Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.

Barrett CL, Schwab RB, Jung H, Crain B, Goff DJ, Jamieson CH, Thistlethwaite PA, Harismendy O, Carson DA, Frazer KA.

PLoS One. 2013;8(3):e58714. doi: 10.1371/journal.pone.0058714. Epub 2013 Mar 20.

31.

Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

Hayashi T, Yao S, Crain B, Chan M, Tawatao RI, Gray C, Vuong L, Lao F, Cottam HB, Carson DA, Corr M.

PLoS One. 2012;7(9):e45860. doi: 10.1371/journal.pone.0045860. Epub 2012 Sep 28.

32.

Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia.

Wu RP, Li H, Rassenti LZ, Hayashi T, Wu CN, Kipps TJ, Messer K, Carson DA.

Leuk Lymphoma. 2013 Feb;54(2):400-2. doi: 10.3109/10428194.2012.709630. Epub 2012 Aug 13. No abstract available.

33.

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.

Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH.

PLoS One. 2012;7(6):e39725. doi: 10.1371/journal.pone.0039725. Epub 2012 Jun 29.

34.

Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand.

Hayashi T, Yao S, Crain B, Chan M, Cottam HB, Lao F, Carson DA, Corr M.

Mediators Inflamm. 2012;2012:262394. doi: 10.1155/2012/262394. Epub 2011 Nov 17.

35.

Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.

Norton JT, Hayashi T, Crain B, Cho JS, Miller LS, Corr M, Carson DA.

J Immunol. 2012 Apr 1;188(7):2977-80. doi: 10.4049/jimmunol.1100830. Epub 2012 Mar 2.

36.

Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.

Zinkernagel AS, Hruz P, Uchiyama S, von Köckritz-Blickwede M, Schuepbach RA, Hayashi T, Carson DA, Nizet V.

J Innate Immun. 2012;4(2):213-8. doi: 10.1159/000329550. Epub 2011 Aug 19.

37.

Inhibition of Wnt signaling and cancer stem cells.

Lu D, Carson DA.

Oncotarget. 2011 Aug;2(8):587. No abstract available.

38.

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.

Lu D, Choi MY, Yu J, Castro JE, Kipps TJ, Carson DA.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7. doi: 10.1073/pnas.1110431108. Epub 2011 Jul 25.

39.

Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.

Norton JT, Hayashi T, Crain B, Corr M, Carson DA.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11163-8. doi: 10.1073/pnas.1107899108. Epub 2011 Jun 20.

40.

Influencing the Wnt signaling pathway in multiple myeloma.

Kim Y, Reifenberger G, Lu D, Endo T, Carson DA, Gast SM, Meschenmoser K, Nowak M, Schmidt-Wolf IG.

Anticancer Res. 2011 Feb;31(2):725-30. Review.

PMID:
21378363
41.

Synthesis and characterization of PEGylated toll like receptor 7 ligands.

Chan M, Hayashi T, Mathewson RD, Yao S, Gray C, Tawatao RI, Kalenian K, Zhang Y, Hayashi Y, Lao FS, Cottam HB, Carson DA.

Bioconjug Chem. 2011 Mar 16;22(3):445-54. doi: 10.1021/bc1004813. Epub 2011 Feb 21.

42.

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2.

Hayashi T, Chan M, Norton JT, Wu CC, Yao S, Cottam HB, Tawatao RI, Corr M, Carson DA, Daniels GA.

Melanoma Res. 2011 Feb;21(1):66-75. doi: 10.1097/CMR.0b013e328340ce6c.

43.

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia.

Wu RP, Hayashi T, Cottam HB, Jin G, Yao S, Wu CC, Rosenbach MD, Corr M, Schwab RB, Carson DA.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7479-84. doi: 10.1073/pnas.1002890107. Epub 2010 Apr 5.

44.

Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer.

Hayashi T, Crain B, Corr M, Chan M, Cottam HB, Maj R, Barberis A, Leoni L, Carson DA.

Int J Urol. 2010 May;17(5):483-90. doi: 10.1111/j.1442-2042.2010.02503.x. Epub 2010 Mar 11.

45.

Repression of beta-catenin signaling by PPAR gamma ligands.

Lu D, Carson DA.

Eur J Pharmacol. 2010 Jun 25;636(1-3):198-202. doi: 10.1016/j.ejphar.2010.03.010. Epub 2010 Mar 19.

46.

Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.

Lu D, Liu JX, Endo T, Zhou H, Yao S, Willert K, Schmidt-Wolf IG, Kipps TJ, Carson DA.

PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.

47.

Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway.

Lu D, Carson DA.

BMC Pharmacol. 2009 Nov 30;9:13. doi: 10.1186/1471-2210-9-13.

48.

Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates.

Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA.

Bioconjug Chem. 2009 Jun;20(6):1194-200. doi: 10.1021/bc900054q.

49.

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.

Hayashi T, Gray CS, Chan M, Tawatao RI, Ronacher L, McGargill MA, Datta SK, Carson DA, Corr M.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2764-9. doi: 10.1073/pnas.0813037106. Epub 2009 Feb 2.

50.

Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival.

Jin G, Lu D, Yao S, Wu CC, Liu JX, Carson DA, Cottam HB.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):606-9. doi: 10.1016/j.bmcl.2008.12.067. Epub 2008 Dec 24.

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