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Items: 37


Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer.

Tiwari R, Manzar N, Bhatia V, Yadav A, Nengroo MA, Datta D, Carskadon S, Gupta N, Sigouros M, Khani F, Poutanen M, Zoubeidi A, Beltran H, Palanisamy N, Ateeq B.

Nat Commun. 2020 Jan 20;11(1):384. doi: 10.1038/s41467-019-14184-0.


Next-generation sequencing implicates oncogenic roles for p53 and JAK/STAT signaling in microcystic adnexal carcinomas.

Chan MP, Plouffe KR, Liu CJ, Palanisamy N, Carskadon S, Zhao L, Nazarian RM, Durham AB, Johnson TM, Andea AA, Patel RM, Lowe L, Fullen DR, Brown NA, Tomlins SA, Udager AM, Harms PW.

Mod Pathol. 2019 Dec 19. doi: 10.1038/s41379-019-0424-4. [Epub ahead of print]


Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole-mount radical prostatectomy tissue.

Lu Z, Williamson SR, Carskadon S, Arachchige PD, Dhamdhere G, Schultz DS, Stricker H, Peabody JO, Jeong W, Chitale DA, Bismar TA, Rogers CG, Menon M, Gupta NS, Palanisamy N.

Prostate. 2020 Jan;80(1):38-50. doi: 10.1002/pros.23914. Epub 2019 Oct 4.


CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation.

Rasool RU, Natesan R, Deng Q, Aras S, Lal P, Sander Effron S, Mitchell-Velasquez E, Posimo JM, Carskadon S, Baca SC, Pomerantz MM, Siddiqui J, Schwartz LE, Lee DJ, Palanisamy N, Narla G, Den RB, Freedman ML, Brady DC, Asangani IA.

Cancer Discov. 2019 Nov;9(11):1538-1555. doi: 10.1158/2159-8290.CD-19-0189. Epub 2019 Aug 29.


Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer.

Chakravarthi BV, Dedigama-Arachchige P, Carskadon S, Sundaram SK, Li J, Wu KH, Chandrashekar DS, Peabody JO, Stricker H, Hwang C, Chitale DA, Williamson SR, Gupta NS, Navone NM, Rogers C, Menon M, Varambally S, Palanisamy N.

Neoplasia. 2019 Oct;21(10):989-1002. doi: 10.1016/j.neo.2019.07.010. Epub 2019 Aug 22.


A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion.

Friedman BJ, Hernandez S, Fidai C, Jiang A, Shwayder TA, Carskadon S, Andea AA, Harms PW, Chitale D, Palanisamy N.

J Cutan Pathol. 2020 Jan;47(1):70-75. doi: 10.1111/cup.13566. Epub 2019 Sep 11.


Prostate cancer with comedonecrosis is frequently, but not exclusively, intraductal carcinoma: a need for reappraisal of grading criteria.

Madan R, Deebajah M, Alanee S, Gupta NS, Carskadon S, Palanisamy N, Williamson SR.

Histopathology. 2019 Jun;74(7):1081-1087. doi: 10.1111/his.13833. Epub 2019 Apr 29.


Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer.

Bhatia V, Yadav A, Tiwari R, Nigam S, Goel S, Carskadon S, Gupta N, Goel A, Palanisamy N, Ateeq B.

Clin Cancer Res. 2019 May 1;25(9):2755-2768. doi: 10.1158/1078-0432.CCR-18-3230. Epub 2018 Dec 26.


Neurofilament is superior to cytokeratin 20 in supporting cutaneous origin for neuroendocrine carcinoma.

Stanoszek LM, Chan MP, Palanisamy N, Carskadon S, Siddiqui J, Patel RM, Harms KL, Lowe L, Fullen DR, Harms PW.

Histopathology. 2019 Feb;74(3):504-513. doi: 10.1111/his.13758. Epub 2018 Dec 5.


Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.

Chakravarthi BVSK, Chandrashekar DS, Hodigere Balasubramanya SA, Robinson AD, Carskadon S, Rao U, Gordetsky J, Manne U, Netto GJ, Sudarshan S, Palanisamy N, Varambally S.

Prostate. 2018 Dec;78(16):1311-1320. doi: 10.1002/pros.23704. Epub 2018 Jul 26.


Enrichment and mutation detection of circulating tumor cells from blood samples.

Kou R, Zhao J, Gogoi P, Carskadon S, Chow W, Hwang C, Palanisamy N, Leung C, Wang Y.

Oncol Rep. 2018 Jun;39(6):2537-2544. doi: 10.3892/or.2018.6342. Epub 2018 Mar 30.


Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements.

Jebastin JAS, Smith SC, Perry KD, Gupta NS, Alanee S, Carskadon S, Chitale DA, Palanisamy N, Williamson SR.

Histopathology. 2018 Aug;73(2):321-326. doi: 10.1111/his.13526. Epub 2018 May 30.


Increased expression of EZH2 in Merkel cell carcinoma is associated with disease progression and poorer prognosis.

Harms KL, Chubb H, Zhao L, Fullen DR, Bichakjian CK, Johnson TM, Carskadon S, Palanisamy N, Harms PW.

Hum Pathol. 2017 Sep;67:78-84. doi: 10.1016/j.humpath.2017.07.009. Epub 2017 Jul 21.


Age and Gender Associations of Virus Positivity in Merkel Cell Carcinoma Characterized Using a Novel RNA In Situ Hybridization Assay.

Wang L, Harms PW, Palanisamy N, Carskadon S, Cao X, Siddiqui J, Patel RM, Zelenka-Wang S, Durham AB, Fullen DR, Harms KL, Su F, Shukla S, Mehra R, Chinnaiyan AM.

Clin Cancer Res. 2017 Sep 15;23(18):5622-5630. doi: 10.1158/1078-0432.CCR-17-0299. Epub 2017 Jun 12.


Renal Cell Carcinoma With Chromosome 6p Amplification Including the TFEB Gene: A Novel Mechanism of Tumor Pathogenesis?

Williamson SR, Grignon DJ, Cheng L, Favazza L, Gondim DD, Carskadon S, Gupta NS, Chitale DA, Kalyana-Sundaram S, Palanisamy N.

Am J Surg Pathol. 2017 Mar;41(3):287-298. doi: 10.1097/PAS.0000000000000776.


Loss of p16 expression and copy number changes of CDKN2A in a spectrum of spitzoid melanocytic lesions.

Harms PW, Hocker TL, Zhao L, Chan MP, Andea AA, Wang M, Harms KL, Wang ML, Carskadon S, Palanisamy N, Fullen DR.

Hum Pathol. 2016 Dec;58:152-160. doi: 10.1016/j.humpath.2016.07.029. Epub 2016 Aug 26.


MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.

Chakravarthi BV, Goswami MT, Pathi SS, Robinson AD, Cieślik M, Chandrashekar DS, Agarwal S, Siddiqui J, Daignault S, Carskadon SL, Jing X, Chinnaiyan AM, Kunju LP, Palanisamy N, Varambally S.

Oncogene. 2016 Dec 8;35(49):6330-6340. doi: 10.1038/onc.2016.164. Epub 2016 Jun 6.


Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin.

East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, Harms PW.

Am J Dermatopathol. 2016 Oct;38(10):744-50. doi: 10.1097/DAD.0000000000000541.


Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing.

Tillman BN, Yanik M, Birkeland AC, Liu CJ, Hovelson DH, Cani AK, Palanisamy N, Carskadon S, Carey TE, Bradford CR, Tomlins SA, McHugh JB, Spector ME, Brenner JCh.

Head Neck. 2016 Apr;38 Suppl 1:E1646-52. doi: 10.1002/hed.24292. Epub 2016 Feb 5.


Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.

Goswami MT, Chen G, Chakravarthi BV, Pathi SS, Anand SK, Carskadon SL, Giordano TJ, Chinnaiyan AM, Thomas DG, Palanisamy N, Beer DG, Varambally S.

Oncotarget. 2015 Sep 15;6(27):23445-61.


Extensive survey of STAT6 expression in a large series of mesenchymal tumors.

Demicco EG, Harms PW, Patel RM, Smith SC, Ingram D, Torres K, Carskadon SL, Camelo-Piragua S, McHugh JB, Siddiqui J, Palanisamy N, Lucas DR, Lazar AJ, Wang WL.

Am J Clin Pathol. 2015 May;143(5):672-82. doi: 10.1309/AJCPN25NJTOUNPNF.


Molecular profiling of ETS and non-ETS aberrations in prostate cancer patients from northern India.

Ateeq B, Kunju LP, Carskadon SL, Pandey SK, Singh G, Pradeep I, Tandon V, Singhai A, Goel A, Amit S, Agarwal A, Dinda AK, Seth A, Tsodikov A, Chinnaiyan AM, Palanisamy N.

Prostate. 2015 Jul 1;75(10):1051-62. doi: 10.1002/pros.22989. Epub 2015 Mar 23.


Cutaneous basal cell carcinosarcomas: evidence of clonality and recurrent chromosomal losses.

Harms PW, Fullen DR, Patel RM, Chang D, Shalin SC, Ma L, Wood B, Beer TW, Siddiqui J, Carskadon S, Wang M, Palanisamy N, Fisher GJ, Andea A.

Hum Pathol. 2015 May;46(5):690-7. doi: 10.1016/j.humpath.2015.01.006. Epub 2015 Jan 14.


Clear cell melanoma: a cutaneous clear cell malignancy.

Pletneva MA, Andea A, Palanisamy N, Betz BL, Carskadon S, Wang M, Patel RM, Fullen DR, Harms PW.

Arch Pathol Lab Med. 2014 Oct;138(10):1328-36. doi: 10.5858/arpa.2014-0307-CC. Review.


Expression of the p40 isoform of p63 has high specificity for cutaneous sarcomatoid squamous cell carcinoma.

Ha Lan TT, Chen SJ, Arps DP, Fullen DR, Patel RM, Siddiqui J, Carskadon S, Palanisamy N, Harms PW.

J Cutan Pathol. 2014 Nov;41(11):831-8. doi: 10.1111/cup.12387. Epub 2014 Nov 3.


Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer.

Kunju LP, Carskadon S, Siddiqui J, Tomlins SA, Chinnaiyan AM, Palanisamy N.

Appl Immunohistochem Mol Morphol. 2014 Sep;22(8):e32-40. doi: 10.1097/PAI.0000000000000095.


The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression.

Chakravarthi BV, Pathi SS, Goswami MT, Cieślik M, Zheng H, Nallasivam S, Arekapudi SR, Jing X, Siddiqui J, Athanikar J, Carskadon SL, Lonigro RJ, Kunju LP, Chinnaiyan AM, Palanisamy N, Varambally S.

Oncotarget. 2014 Aug 30;5(16):6654-69.


Evaluation of tissue PCA3 expression in prostate cancer by RNA in situ hybridization--a correlative study with urine PCA3 and TMPRSS2-ERG.

Warrick JI, Tomlins SA, Carskadon SL, Young AM, Siddiqui J, Wei JT, Chinnaiyan AM, Kunju LP, Palanisamy N.

Mod Pathol. 2014 Apr;27(4):609-20. doi: 10.1038/modpathol.2013.169. Epub 2013 Sep 27.


Novel dual-color immunohistochemical methods for detecting ERG-PTEN and ERG-SPINK1 status in prostate carcinoma.

Bhalla R, Kunju LP, Tomlins SA, Christopherson K, Cortez C, Carskadon S, Siddiqui J, Park K, Mosquera JM, Pestano GA, Rubin MA, Chinnaiyan AM, Palanisamy N.

Mod Pathol. 2013 Jun;26(6):835-48. doi: 10.1038/modpathol.2012.234. Epub 2013 Jan 25.


Prognostic implications of parathyroid hormone-related protein in males and females with non--small-cell lung cancer.

Montgrain PR, Deftos LJ, Arenberg D, Tipps A, Quintana R, Carskadon S, Hastings RH.

Clin Lung Cancer. 2011 May;12(3):197-205. doi: 10.1016/j.cllc.2011.03.018. Epub 2011 Apr 24.


Macrophage migration inhibitory factor promotes tumor growth in the context of lung injury and repair.

Arenberg D, Luckhardt TR, Carskadon S, Zhao L, Amin MA, Koch AE.

Am J Respir Crit Care Med. 2010 Oct 15;182(8):1030-7. doi: 10.1164/rccm.201001-0120OC. Epub 2010 Jun 25.


Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer.

McClelland M, Zhao L, Carskadon S, Arenberg D.

Am J Pathol. 2009 Feb;174(2):638-46. doi: 10.2353/ajpath.2009.080463. Epub 2009 Jan 8.


Diversity of the angiogenic phenotype in non-small cell lung cancer.

McClelland MR, Carskadon SL, Zhao L, White ES, Beer DG, Orringer MB, Pickens A, Chang AC, Arenberg DA.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):343-50. Epub 2006 Nov 1.


The effect of tetrathiomolybdate on cytokine expression, angiogenesis, and tumor growth in squamous cell carcinoma of the head and neck.

Teknos TN, Islam M, Arenberg DA, Pan Q, Carskadon SL, Abarbanell AM, Marcus B, Paul S, Vandenberg CD, Carron M, Nor JE, Merajver SD.

Arch Otolaryngol Head Neck Surg. 2005 Mar;131(3):204-11.


Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10.

White ES, Thannickal VJ, Carskadon SL, Dickie EG, Livant DL, Markwart S, Toews GB, Arenberg DA.

Am J Respir Crit Care Med. 2003 Aug 15;168(4):436-42. Epub 2003 Jun 5.


Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis.

White ES, Flaherty KR, Carskadon S, Brant A, Iannettoni MD, Yee J, Orringer MB, Arenberg DA.

Clin Cancer Res. 2003 Feb;9(2):853-60.


Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles.

Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M.

Neuron. 1998 Jul;21(1):111-22.

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