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Items: 1 to 50 of 67

1.

Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast.

Bi J, Carroll RT, James ML, Ouderkirk JL, Krendel M, Sirotkin V.

Dis Model Mech. 2015 Aug 1;8(8):891-902. doi: 10.1242/dmm.020214. Epub 2015 Jun 18.

2.

Novel thiazolidinedione mitoNEET ligand-1 acutely improves cardiac stem cell survival under oxidative stress.

Logan SJ, Yin L, Geldenhuys WJ, Enrick MK, Stevanov KM, Carroll RT, Ohanyan VA, Kolz CL, Chilian WM.

Basic Res Cardiol. 2015 Mar;110(2):19. doi: 10.1007/s00395-015-0471-z. Epub 2015 Mar 1.

3.

Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.

Suarez C, Carroll RT, Burke TA, Christensen JR, Bestul AJ, Sees JA, James ML, Sirotkin V, Kovar DR.

Dev Cell. 2015 Jan 12;32(1):43-53. doi: 10.1016/j.devcel.2014.10.027. Epub 2014 Dec 24.

4.

Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.

Bestul AJ, Christensen JR, Grzegorzewska AP, Burke TA, Sees JA, Carroll RT, Sirotkin V, Keenan RJ, Kovar DR.

Mol Biol Cell. 2015 Jan 15;26(2):283-93. doi: 10.1091/mbc.E13-05-0281. Epub 2014 Nov 12.

5.

mitoNEET as a novel drug target for mitochondrial dysfunction.

Geldenhuys WJ, Leeper TC, Carroll RT.

Drug Discov Today. 2014 Oct;19(10):1601-6. doi: 10.1016/j.drudis.2014.05.001. Epub 2014 May 9. Review.

PMID:
24814435
6.

A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.

Pedada KK, Zhou X, Jogiraju H, Carroll RT, Geldenhuys WJ, Lin L, Anderson DJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 15;945-946:141-6. doi: 10.1016/j.jchromb.2013.11.048. Epub 2013 Nov 28.

PMID:
24334225
7.

Curcumin and neurodegenerative diseases: a perspective.

Darvesh AS, Carroll RT, Bishayee A, Novotny NA, Geldenhuys WJ, Van der Schyf CJ.

Expert Opin Investig Drugs. 2012 Aug;21(8):1123-40. doi: 10.1517/13543784.2012.693479. Epub 2012 Jun 6. Review.

PMID:
22668065
8.

A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.

Geldenhuys WJ, Funk MO, Van der Schyf CJ, Carroll RT.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1380-3. doi: 10.1016/j.bmcl.2011.12.056. Epub 2011 Dec 16.

PMID:
22225638
9.

A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.

Geldenhuys WJ, Funk MO, Awale PS, Lin L, Carroll RT.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5498-501. doi: 10.1016/j.bmcl.2011.06.111. Epub 2011 Jul 2.

PMID:
21782425
10.

Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.

Carroll RT, Dluzen DE, Stinnett H, Awale PS, Funk MO, Geldenhuys WJ.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4798-803. doi: 10.1016/j.bmcl.2011.06.060. Epub 2011 Jun 21.

PMID:
21742494
11.

Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate.

Arif W, Xu S, Isailovic D, Geldenhuys WJ, Carroll RT, Funk MO.

Biochemistry. 2011 Jun 28;50(25):5806-11. doi: 10.1021/bi200546s. Epub 2011 Jun 2.

12.

The emergence of designed multiple ligands for neurodegenerative disorders.

Geldenhuys WJ, Youdim MB, Carroll RT, Van der Schyf CJ.

Prog Neurobiol. 2011 Sep 1;94(4):347-59. doi: 10.1016/j.pneurobio.2011.04.010. Epub 2011 Apr 22. Review.

PMID:
21536094
13.

In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery.

Darvesh AS, Carroll RT, Geldenhuys WJ, Gudelsky GA, Klein J, Meshul CK, Van der Schyf CJ.

Expert Opin Drug Discov. 2011 Feb;6(2):109-127.

14.

Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.

Mbimba T, Awale P, Bhatia D, Geldenhuys WJ, Darvesh AS, Carroll RT, Bishayee A.

Curr Pharm Biotechnol. 2012 Jan;13(1):229-34.

PMID:
21466437
15.

Natural products of dietary origin as lead compounds in virtual screening and drug design.

Geldenhuys WJ, Bishayee A, Darvesh AS, Carroll RT.

Curr Pharm Biotechnol. 2012 Jan;13(1):117-24. Review.

PMID:
21466431
16.

Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.

Geldenhuys WJ, Darvesh AS, Funk MO, Van der Schyf CJ, Carroll RT.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5295-8. doi: 10.1016/j.bmcl.2010.06.128. Epub 2010 Jul 1.

PMID:
20650633
17.

Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.

Bishayee A, Barnes KF, Bhatia D, Darvesh AS, Carroll RT.

Cancer Prev Res (Phila). 2010 Jun;3(6):753-63. doi: 10.1158/1940-6207.CAPR-09-0171. Epub 2010 May 25.

18.

Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.

Darvesh AS, Carroll RT, Bishayee A, Geldenhuys WJ, Van der Schyf CJ.

Expert Rev Neurother. 2010 May;10(5):729-45. doi: 10.1586/ern.10.42. Review.

PMID:
20420493
19.

Nitrogen use efficiencies of spring barley grown under varying nitrogen conditions in the field and growth chamber.

Beatty PH, Anbessa Y, Juskiw P, Carroll RT, Wang J, Good AG.

Ann Bot. 2010 Jun;105(7):1171-82. doi: 10.1093/aob/mcq025. Epub 2010 Mar 21.

20.

Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.

Carroll RT, Bhatia D, Geldenhuys W, Bhatia R, Miladore N, Bishayee A, Sutariya V.

J Drug Target. 2010 Nov;18(9):665-74. doi: 10.3109/10611861003639796.

PMID:
20158436
21.

Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.

Geldenhuys WJ, Funk MO, Barnes KF, Carroll RT.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):819-23. doi: 10.1016/j.bmcl.2009.12.088. Epub 2010 Jan 4.

PMID:
20064719
22.

Transcriptome analysis of nitrogen-efficient rice over-expressing alanine aminotransferase.

Beatty PH, Shrawat AK, Carroll RT, Zhu T, Good AG.

Plant Biotechnol J. 2009 Aug;7(6):562-76. doi: 10.1111/j.1467-7652.2009.00424.x. Epub 2009 Jun 8.

23.

Genetic engineering of improved nitrogen use efficiency in rice by the tissue-specific expression of alanine aminotransferase.

Shrawat AK, Carroll RT, DePauw M, Taylor GJ, Good AG.

Plant Biotechnol J. 2008 Sep;6(7):722-32. doi: 10.1111/j.1467-7652.2008.00351.x. Epub 2008 May 27.

24.

The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

Hu LY, Boxer PA, Kesten SR, Lei HJ, Wustrow DJ, Moreland DW, Zhang L, Ahn K, Ryder TR, Liu X, Rubin JR, Fahnoe K, Carroll RT, Dutta S, Fahnoe DC, Probert AW, Roof RL, Rafferty MF, Kostlan CR, Scholten JD, Hood M, Ren XD, Schielke GP, Su TZ, Taylor CP, Mistry A, McConnell P, Hasemann C, Ohren J.

Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. Epub 2005 Sep 6.

PMID:
16143519
25.

Three-dimensional structure of a purple lipoxygenase.

Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr.

J Am Chem Soc. 2001 Nov 7;123(44):10814-20.

PMID:
11686682
26.

LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels.

Althaus JS, Schmidt KR, Fountain ST, Tseng MT, Carroll RT, Galatsis P, Hall ED.

Free Radic Biol Med. 2000 Dec;29(11):1085-95.

PMID:
11121715
27.

Phagocytosis is regulated by nitric oxide in murine microglia.

Kopec KK, Carroll RT.

Nitric Oxide. 2000 Apr;4(2):103-11.

PMID:
10835290
28.

4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration.

Carroll RT, Galatsis P, Borosky S, Kopec KK, Kumar V, Althaus JS, Hall ED.

Chem Res Toxicol. 2000 Apr;13(4):294-300.

PMID:
10775330
29.
30.

Beta-amyloid levels predict cholinesterase activity in human cerebrospinal fluid.

Carroll RT, Lust MR, Emmerling MR.

Neuroreport. 1999 Jan 18;10(1):127-30.

PMID:
10094147
31.
32.

Cerebral lipid deposition in aged apolipoprotein-E-deficient mice.

Walker LC, Parker CA, Lipinski WJ, Callahan MJ, Carroll RT, Gandy SE, Smith JD, Jucker M, Bisgaier CL.

Am J Pathol. 1997 Nov;151(5):1371-7.

33.

Factors secreted by activated microglia and monocytes reduce amyloidogenesis in vascular smooth muscle cells.

Frackowiak J, Mazur-Kolecka B, Carroll RT, Chauhan A, Wisniewski HM.

Neuroreport. 1997 Jul 7;8(9-10):2259-63.

PMID:
9243622
34.

Accumulation of Alzheimer amyloid-beta peptide in cultured myocytes is enhanced by serum and reduced by cerebrospinal fluid.

Mazur-Kolecka B, Frackowiak J, Carroll RT, Wisniewski HM.

J Neuropathol Exp Neurol. 1997 Mar;56(3):263-72.

PMID:
9056540
35.

The role of arachidonic acid in the secretion of the amyloid precursor protein (APP).

Emmerling MR, Dudley DT, Dyer RD, Carroll RT, Doyle PD, Davis RE.

Ann N Y Acad Sci. 1996 Jan 17;777:310-5.

PMID:
8624105
36.

High levels of amyloid-beta protein from S182 (Glu246) familial Alzheimer's cells.

Martins RN, Turner BA, Carroll RT, Sweeney D, Kim KS, Wisniewski HM, Blass JP, Gibson GE, Gandy S.

Neuroreport. 1995 Dec 29;7(1):217-20.

PMID:
8742455
37.

IL-1 beta converting enzyme (ICE) is not required for apoptosis induced by lymphokine deprivation in an IL-2-dependent T cell line.

Vasilakos JP, Ghayur T, Carroll RT, Giegel DA, Saunders JM, Quintal L, Keane KM, Shivers BD.

J Immunol. 1995 Oct 1;155(7):3433-42.

PMID:
7561038
38.

Purification of acetylcholinesterase by tacrine affinity chromatography.

Carroll RT, Grimm JL, Hepburn TW, Emmerling MR.

Protein Expr Purif. 1995 Aug;6(4):389-93.

PMID:
8527921
39.

An age-related correlation between levels of beta-amyloid precursor protein and beta-amyloid in human cerebrospinal fluid.

Carroll RT, Lust MR, Kim KS, Doyle PD, Emmerling MR.

Biochem Biophys Res Commun. 1995 May 16;210(2):345-9.

PMID:
7755609
40.

Secretion and accumulation of Alzheimer's beta-protein by cultured vascular smooth muscle cells from old and young dogs.

Frackowiak J, Mazur-Kolecka B, Wisniewski HM, Potempska A, Carroll RT, Emmerling MR, Kim KS.

Brain Res. 1995 Apr 3;676(1):225-30.

PMID:
7796174
41.

Cholinergic therapies for Alzheimer's disease. Palliative or disease altering?

Davis RE, Doyle PD, Carroll RT, Emmerling MR, Jaen J.

Arzneimittelforschung. 1995 Mar;45(3A):425-31. Review.

PMID:
7763338
42.

Interleukin-1 beta dissociates beta-amyloid precursor protein and beta-amyloid peptide secretion.

Vasilakos JP, Carroll RT, Emmerling MR, Doyle PD, Davis RE, Kim KS, Shivers BD.

FEBS Lett. 1994 Nov 14;354(3):289-92.

43.

Phospholipase A2 activation influences the processing and secretion of the amyloid precursor protein.

Emmerling MR, Moore CJ, Doyle PD, Carroll RT, Davis RE.

Biochem Biophys Res Commun. 1993 Nov 30;197(1):292-7.

PMID:
8250938
44.

Rapid purification of rabbit reticulocyte lipoxygenase for electron paramagnetic spectroscopy characterization of the non-heme iron.

Carroll RT, Muller J, Grimm J, Dunham WR, Sands RH, Funk MO Jr.

Lipids. 1993 Mar;28(3):241-4.

46.

Limited proteolysis and active-site labeling studies of soybean lipoxygenase.

Ramachandran S, Carroll RT, Dunham WR, Funk MO Jr.

Biochemistry. 1992 Aug 25;31(33):7700-6.

PMID:
1324720
47.

Identification of the trypsin-like activity in commercial preparations of eel acetylcholinesterase.

Carroll RT, Emmerling MR.

Biochem Biophys Res Commun. 1991 Dec 16;181(2):858-62.

PMID:
1755864
48.

Preparation and characterization of monoclonal antibodies against soybean seed lipoxygenase isoenzymes.

Wheelock MJ, Richards TJ, Carroll RT, Funk MO.

Arch Biochem Biophys. 1991 Aug 1;288(2):578-83.

PMID:
1910311
49.

The initial characterization of the iron environment in lipoxygenase by Mössbauer spectroscopy.

Dunham WR, Carroll RT, Thompson JF, Sands RH, Funk MO Jr.

Eur J Biochem. 1990 Jul 5;190(3):611-7.

50.

Crystallization and preliminary X-ray characterization of a soybean seed lipoxygenase.

Stallings WC, Kroa BA, Carroll RT, Metzger AL, Funk MO.

J Mol Biol. 1990 Feb 20;211(4):685-7.

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