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Items: 1 to 50 of 92

1.

Functions of Nuclear Polyphosphoinositides.

Olazabal-Morán M, González-García A, Carrera AC.

Handb Exp Pharmacol. 2019 Jun 15. doi: 10.1007/164_2019_219. [Epub ahead of print]

PMID:
31201558
2.

The Opposing Roles of PIK3R1/p85α and PIK3R2/p85β in Cancer.

Vallejo-Díaz J, Chagoyen M, Olazabal-Morán M, González-García A, Carrera AC.

Trends Cancer. 2019 Apr;5(4):233-244. doi: 10.1016/j.trecan.2019.02.009. Epub 2019 Mar 16. Review.

PMID:
30961830
3.

The cell biology behind the oncogenic PIP3 lipids.

Carrera AC, Anderson R.

J Cell Sci. 2019 Jan 2;132(1). pii: jcs228395. doi: 10.1242/jcs.228395. Review.

4.

Persistent regulatory T-cell response 2 years after 3 years of grass tablet SLIT: Links to reduced eosinophil counts, sIgE levels, and clinical benefit.

Varona R, Ramos T, Escribese MM, Jimeno L, Galán A, Würtzen PA, Vega F, Marín A, Martín S, Carrera AC, Blanco C, Barber D.

Allergy. 2019 Feb;74(2):349-360. doi: 10.1111/all.13553. Epub 2018 Oct 11.

5.

E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing.

Millán-Uclés Á, Zuluaga S, Marqués M, Vallejo-Díaz J, Sanz L, Cariaga-Martínez AE, Real FX, Carrera AC.

Oncotarget. 2016 Dec 20;7(51):84054-84071. doi: 10.18632/oncotarget.13414.

6.

Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma.

Vallejo-Díaz J, Olazabal-Morán M, Cariaga-Martínez AE, Pajares MJ, Flores JM, Pio R, Montuenga LM, Carrera AC.

Oncotarget. 2016 Dec 20;7(51):85063-85078. doi: 10.18632/oncotarget.13195.

7.

Phosphoinositide 3-kinase beta protects nuclear envelope integrity by controlling RCC1 localization and Ran activity.

Redondo-Muñoz J, Pérez-García V, Rodríguez MJ, Valpuesta JM, Carrera AC.

Mol Cell Biol. 2015 Jan;35(1):249-63. doi: 10.1128/MCB.01184-14. Epub 2014 Oct 27.

8.

Phosphoinositide 3-kinase p85beta regulates invadopodium formation.

Cariaga-Martínez AE, Cortés I, García E, Pérez-García V, Pajares MJ, Idoate MA, Redondo-Muñóz J, Antón IM, Carrera AC.

Biol Open. 2014 Sep 12;3(10):924-36. doi: 10.1242/bio.20148185.

9.

Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity.

Pérez-García V, Redondo-Muñoz J, Kumar A, Carrera AC.

Mol Cell Biol. 2014 Sep 15;34(18):3359-73. doi: 10.1128/MCB.00167-14. Epub 2014 Jun 23.

10.

Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.

Suárez-Fueyo A, Rojas JM, Cariaga AE, García E, Steiner BH, Barber DF, Puri KD, Carrera AC.

J Immunol. 2014 Jul 15;193(2):544-54. doi: 10.4049/jimmunol.1400350. Epub 2014 Jun 16.

11.

Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation.

Suárez-Fueyo A, Ramos T, Galán A, Jimeno L, Wurtzen PA, Marin A, de Frutos C, Blanco C, Carrera AC, Barber D, Varona R.

J Allergy Clin Immunol. 2014 Jan;133(1):130-8.e1-2. doi: 10.1016/j.jaci.2013.09.043. Epub 2013 Nov 28.

PMID:
24290282
12.

PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels.

Zotes TM, Spada R, Mulens V, Pérez-Yagüe S, Sorzano CO, Okkenhaug K, Carrera AC, Barber DF.

PLoS One. 2013 Aug 29;8(8):e72960. doi: 10.1371/journal.pone.0072960. eCollection 2013.

13.

PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.

Zotes TM, Arias CF, Fuster JJ, Spada R, Pérez-Yagüe S, Hirsch E, Wymann M, Carrera AC, Andrés V, Barber DF.

PLoS One. 2013 Aug 22;8(8):e72674. doi: 10.1371/journal.pone.0072674. eCollection 2013.

14.

CXCL12-mediated murine neural progenitor cell movement requires PI3Kβ activation.

Holgado BL, Martínez-Muñoz L, Sánchez-Alcañiz JA, Lucas P, Pérez-García V, Pérez G, Rodríguez-Frade JM, Nieto M, Marín O, Carrasco YR, Carrera AC, Alvarez-Dolado M, Mellado M.

Mol Neurobiol. 2013 Aug;48(1):217-31. doi: 10.1007/s12035-013-8451-5. Epub 2013 Apr 19.

PMID:
23606281
15.

Phosphoinositide 3-kinase beta controls replication factor C assembly and function.

Redondo-Muñoz J, Rodríguez MJ, Silió V, Pérez-García V, Valpuesta JM, Carrera AC.

Nucleic Acids Res. 2013 Jan;41(2):855-68. doi: 10.1093/nar/gks1095. Epub 2012 Nov 21.

16.

Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.

Silió V, Redondo-Muñoz J, Carrera AC.

Mol Biol Cell. 2012 Dec;23(23):4526-42. doi: 10.1091/mbc.E12-05-0371. Epub 2012 Oct 10.

17.

Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells.

Parrillas V, Martínez-Muñoz L, Holgado BL, Kumar A, Cascio G, Lucas P, Rodríguez-Frade JM, Malumbres M, Carrera AC, van Wely KH, Mellado M.

Cell Mol Life Sci. 2013 Feb;70(3):545-58. doi: 10.1007/s00018-012-1145-8. Epub 2012 Sep 23.

PMID:
23001011
18.

p85β increases phosphoinositide 3-kinase activity and accelerates tumor progression.

González-García A, Carrera AC.

Cell Cycle. 2012 Oct 1;11(19):3523-4. doi: 10.4161/cc.21961. Epub 2012 Aug 30. No abstract available.

19.

p85β phosphoinositide 3-kinase subunit regulates tumor progression.

Cortés I, Sánchez-Ruíz J, Zuluaga S, Calvanese V, Marqués M, Hernández C, Rivera T, Kremer L, González-García A, Carrera AC.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11318-23. doi: 10.1073/pnas.1118138109. Epub 2012 Jun 25.

20.

A promoter DNA demethylation landscape of human hematopoietic differentiation.

Calvanese V, Fernández AF, Urdinguio RG, Suárez-Alvarez B, Mangas C, Pérez-García V, Bueno C, Montes R, Ramos-Mejía V, Martínez-Camblor P, Ferrero C, Assenov Y, Bock C, Menendez P, Carrera AC, Lopez-Larrea C, Fraga MF.

Nucleic Acids Res. 2012 Jan;40(1):116-31. doi: 10.1093/nar/gkr685. Epub 2011 Sep 12.

21.

Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death.

Suárez-Fueyo A, Barber DF, Martínez-Ara J, Zea-Mendoza AC, Carrera AC.

J Immunol. 2011 Sep 1;187(5):2376-85. doi: 10.4049/jimmunol.1101602. Epub 2011 Aug 1.

22.

Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival.

Kumar A, Redondo-Muñoz J, Perez-García V, Cortes I, Chagoyen M, Carrera AC.

Mol Cell Biol. 2011 May;31(10):2122-33. doi: 10.1128/MCB.01313-10. Epub 2011 Mar 7.

23.

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.

Dubielecka PM, Machida K, Xiong X, Hossain S, Ogiue-Ikeda M, Carrera AC, Mayer BJ, Kotula L.

FEBS Lett. 2010 Aug 4;584(15):3279-86. doi: 10.1016/j.febslet.2010.06.029. Epub 2010 Jun 23.

24.

Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.

Kumar A, Fernandez-Capetillo O, Carrera AC.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7491-6. doi: 10.1073/pnas.0914242107. Epub 2010 Apr 5. Erratum in: Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11145. Fernadez-Capetillo, Oscar [corrected to Fernandez-Capetillo, Oscar].

25.

Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer.

González-García A, Sánchez-Ruiz J, Flores JM, Carrera AC.

Gastroenterology. 2010 Apr;138(4):1374-83. doi: 10.1053/j.gastro.2009.12.001. Epub 2009 Dec 11.

PMID:
20004201
26.

SADB kinases license centrosome replication.

Carrera AC, Alvarado-Kristensson M.

Cell Cycle. 2009 Dec 15;8(24):4005-6. Epub 2009 Dec 25. No abstract available.

PMID:
19949293
27.

PI3Kgamma activation by CXCL12 regulates tumor cell adhesion and invasion.

Monterrubio M, Mellado M, Carrera AC, Rodríguez-Frade JM.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):199-204. doi: 10.1016/j.bbrc.2009.07.153. Epub 2009 Aug 4.

PMID:
19660434
28.

SADB phosphorylation of gamma-tubulin regulates centrosome duplication.

Alvarado-Kristensson M, Rodríguez MJ, Silió V, Valpuesta JM, Carrera AC.

Nat Cell Biol. 2009 Sep;11(9):1081-92. doi: 10.1038/ncb1921. Epub 2009 Aug 2.

PMID:
19648910
29.

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.

Marqués M, Kumar A, Poveda AM, Zuluaga S, Hernández C, Jackson S, Pasero P, Carrera AC.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7525-30. doi: 10.1073/pnas.0812000106. Epub 2009 Apr 22.

30.

p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function.

Alcázar I, Cortés I, Zaballos A, Hernandez C, Fruman DA, Barber DF, Carrera AC.

Blood. 2009 Apr 2;113(14):3198-208. doi: 10.1182/blood-2008-04-152942. Epub 2009 Feb 3.

31.

Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase.

Marqués M, Kumar A, Cortés I, Gonzalez-García A, Hernández C, Moreno-Ortiz MC, Carrera AC.

Mol Cell Biol. 2008 Apr;28(8):2803-14. doi: 10.1128/MCB.01786-07. Epub 2008 Feb 19.

32.

Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation.

Alcázar I, Marqués M, Kumar A, Hirsch E, Wymann M, Carrera AC, Barber DF.

J Exp Med. 2007 Nov 26;204(12):2977-87. Epub 2007 Nov 6.

33.

New functions for PI3K in the control of cell division.

Kumar A, Carrera AC.

Cell Cycle. 2007 Jul 15;6(14):1696-8. Epub 2007 May 25. Review.

PMID:
17598985
34.

A cascade involving p85, Cdc42 and septin 2 regulates cytokinesis.

Silió V, Marqués M, Cortés I, Zuluaga S, Carrera AC.

Biochem Soc Trans. 2007 Apr;35(Pt 2):222-4.

PMID:
17371243
35.

PTEN regulation, a novel function for the p85 subunit of phosphoinositide 3-kinase.

Barber DF, Alvarado-Kristensson M, González-García A, Pulido R, Carrera AC.

Sci STKE. 2006 Nov 21;2006(362):pe49.

PMID:
17119157
36.

A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis.

García Z, Silio V, Marqués M, Cortés I, Kumar A, Hernandez C, Checa AI, Serrano A, Carrera AC.

EMBO J. 2006 Oct 18;25(20):4740-51. Epub 2006 Oct 5.

37.

Phosphoinositide 3-kinase activation in late G1 is required for c-Myc stabilization and S phase entry.

Kumar A, Marqués M, Carrera AC.

Mol Cell Biol. 2006 Dec;26(23):9116-25. Epub 2006 Oct 2.

38.

Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells.

Otaegi G, Yusta-Boyo MJ, Vergaño-Vera E, Méndez-Gómez HR, Carrera AC, Abad JL, González M, de la Rosa EJ, Vicario-Abejón C, de Pablo F.

J Cell Sci. 2006 Jul 1;119(Pt 13):2739-48.

39.

Phosphoinositide 3-kinase controls early and late events in mammalian cell division.

García Z, Kumar A, Marqués M, Cortés I, Carrera AC.

EMBO J. 2006 Feb 22;25(4):655-61. Epub 2006 Jan 26. Review.

40.

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion.

Barber DF, Bartolomé A, Hernandez C, Flores JM, Fernandez-Arias C, Rodríguez-Borlado L, Hirsch E, Wymann M, Balomenos D, Carrera AC.

J Immunol. 2006 Jan 1;176(1):589-93.

41.

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.

Barber DF, Bartolomé A, Hernandez C, Flores JM, Redondo C, Fernandez-Arias C, Camps M, Rückle T, Schwarz MK, Rodríguez S, Martinez-A C, Balomenos D, Rommel C, Carrera AC.

Nat Med. 2005 Sep;11(9):933-5. Epub 2005 Aug 28.

42.

PTEN regulates motility but not directionality during leukocyte chemotaxis.

Lacalle RA, Gómez-Moutón C, Barber DF, Jiménez-Baranda S, Mira E, Martínez-A C, Carrera AC, Mañes S.

J Cell Sci. 2004 Dec 1;117(Pt 25):6207-15.

43.

TOR signaling in mammals.

Carrera AC.

J Cell Sci. 2004 Sep 15;117(Pt 20):4615-6. No abstract available.

44.

Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing.

Nombela-Arrieta C, Lacalle RA, Montoya MC, Kunisaki Y, Megías D, Marqués M, Carrera AC, Mañes S, Fukui Y, Martínez-A C, Stein JV.

Immunity. 2004 Sep;21(3):429-41.

45.

Phosphoinositide 3-kinase and Forkhead, a switch for cell division.

Martínez-Gac L, Alvarez B, García Z, Marqués M, Arrizabalaga M, Carrera AC.

Biochem Soc Trans. 2004 Apr;32(Pt 2):360-1. Review.

PMID:
15046609
46.

Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis.

Gómez-Moutón C, Lacalle RA, Mira E, Jiménez-Baranda S, Barber DF, Carrera AC, Martínez-A C, Mañes S.

J Cell Biol. 2004 Mar 1;164(5):759-68. Epub 2004 Feb 23.

47.
48.

A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation.

Sánchez S, Jiménez C, Carrera AC, Diaz-Nido J, Avila J, Wandosell F.

Neurochem Int. 2004 Mar;44(4):231-42.

PMID:
14602086
49.

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio.

Rodríguez-Borlado L, Barber DF, Hernández C, Rodríguez-Marcos MA, Sánchez A, Hirsch E, Wymann M, Martínez-A C, Carrera AC.

J Immunol. 2003 May 1;170(9):4475-82.

50.

Phosphoinositide 3-kinase activation regulates cell division time by coordinated control of cell mass and cell cycle progression rate.

Alvarez B, Garrido E, Garcia-Sanz JA, Carrera AC.

J Biol Chem. 2003 Jul 18;278(29):26466-73. Epub 2003 Apr 21.

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