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Items: 1 to 50 of 251

1.

Iridium-Catalyzed Enantioselective Allylic Substitution with Aqueous Solutions of Nucleophiles.

Sandmeier T, Goetzke FW, Krautwald S, Carreira EM.

J Am Chem Soc. 2019 Aug 7;141(31):12212-12218. doi: 10.1021/jacs.9b05830. Epub 2019 Jul 26.

PMID:
31318204
2.

Stereochemical Revision, Total Synthesis, and Solution State Conformation of the Complex Chlorosulfolipid Mytilipin B.

Sondermann P, Carreira EM.

J Am Chem Soc. 2019 Jul 3;141(26):10510-10519. doi: 10.1021/jacs.9b05013. Epub 2019 Jun 19.

PMID:
31244189
3.

Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands.

Rössler SL, Petrone DA, Carreira EM.

Acc Chem Res. 2019 Jun 19. doi: 10.1021/acs.accounts.9b00209. [Epub ahead of print]

PMID:
31243973
4.

Palladium-Catalyzed Regioselective C-H Iodination of Unactivated Alkenes.

Schreib BS, Carreira EM.

J Am Chem Soc. 2019 Jun 5;141(22):8758-8763. doi: 10.1021/jacs.9b03998. Epub 2019 May 22.

PMID:
31083939
5.

Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium-Catalyzed Asymmetric Allylic Alkylation.

Sempere Y, Alfke JL, Rössler SL, Carreira EM.

Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9537-9541. doi: 10.1002/anie.201903090. Epub 2019 May 30.

PMID:
31069899
6.

Organic Letters Global Enterprise.

Carreira EM.

Org Lett. 2019 May 3;21(9):2967. doi: 10.1021/acs.orglett.9b00974. Epub 2019 Apr 17. No abstract available.

PMID:
30993993
7.

Organic Letters 2.0: A New Beginning.

Carreira EM.

Org Lett. 2019 Jan 4;21(1):1-4. doi: 10.1021/acs.orglett.8b03964. No abstract available.

PMID:
30985151
8.

Twenty Years of Organic Letters: A Platinum Anniversary Collector's Edition.

Carreira EM.

Org Lett. 2019 Apr 5;21(7):1943. doi: 10.1021/acs.orglett.9b00656. Epub 2019 Apr 1. No abstract available.

PMID:
30931569
9.

Coordination-Induced Stereocontrol over Carbocations: Asymmetric Reductive Deoxygenation of Racemic Tertiary Alcohols.

Isomura M, Petrone DA, Carreira EM.

J Am Chem Soc. 2019 Mar 20;141(11):4738-4748. doi: 10.1021/jacs.9b00862. Epub 2019 Mar 7.

PMID:
30785741
10.

Total Synthesis of (-)-Merochlorin A.

Brandstätter M, Freis M, Huwyler N, Carreira EM.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2490-2494. doi: 10.1002/anie.201813090. Epub 2019 Jan 29.

PMID:
30575244
11.

Total Synthesis of (-)-Mitrephorone A.

Richter MJR, Schneider M, Brandstätter M, Krautwald S, Carreira EM.

J Am Chem Soc. 2018 Dec 5;140(48):16704-16710. doi: 10.1021/jacs.8b09685. Epub 2018 Nov 20.

PMID:
30412398
12.

Pyridyl Radical Cation for C-H Amination of Arenes.

Rössler SL, Jelier BJ, Tripet PF, Shemet A, Jeschke G, Togni A, Carreira EM.

Angew Chem Int Ed Engl. 2019 Jan 8;58(2):526-531. doi: 10.1002/anie.201810261. Epub 2018 Dec 12.

PMID:
30398683
13.

Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high.

Chicca A, Schafroth MA, Reynoso-Moreno I, Erni R, Petrucci V, Carreira EM, Gertsch J.

Sci Adv. 2018 Oct 24;4(10):eaat2166. doi: 10.1126/sciadv.aat2166. eCollection 2018 Oct.

14.

Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates.

Teiber JF, Xiao J, Kramer GL, Ogawa S, Ebner C, Wolleb H, Carreira EM, Shih DM, Haley RW.

Biochem Biophys Res Commun. 2018 Oct 20;505(1):87-92. doi: 10.1016/j.bbrc.2018.09.083. Epub 2018 Sep 18.

PMID:
30241945
15.

Total Synthesis of Epicolactone.

Kravina AG, Carreira EM.

Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13159-13162. doi: 10.1002/anie.201807709. Epub 2018 Sep 5.

PMID:
30073743
16.

Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues.

Wolleb H, Ogawa S, Schneider M, Shemet A, Muri J, Kopf M, Carreira EM.

Org Lett. 2018 May 18;20(10):3014-3016. doi: 10.1021/acs.orglett.8b01042. Epub 2018 May 8.

PMID:
29737177
17.

Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation.

Sempere Y, Carreira EM.

Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7654-7658. doi: 10.1002/anie.201803558. Epub 2018 May 23.

PMID:
29718576
18.

HATRIC-based identification of receptors for orphan ligands.

Sobotzki N, Schafroth MA, Rudnicka A, Koetemann A, Marty F, Goetze S, Yamauchi Y, Carreira EM, Wollscheid B.

Nat Commun. 2018 Apr 17;9(1):1519. doi: 10.1038/s41467-018-03936-z.

19.

Apoc Social: A Mobile Interactive and Social Learning Platform for Collaborative Solving of Advanced Problems in Organic Chemistry.

Sievertsen N, Carreira EM.

Chimia (Aarau). 2018 Feb 1;72(1):43-47. doi: 10.2533/chimia.2018.43.

PMID:
29490792
20.

Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations.

Petrone DA, Isomura M, Franzoni I, Rössler SL, Carreira EM.

J Am Chem Soc. 2018 Apr 4;140(13):4697-4704. doi: 10.1021/jacs.8b01416. Epub 2018 Mar 22.

PMID:
29488753
21.

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

Soethoudt M, Stolze SC, Westphal MV, van Stralen L, Martella A, van Rooden EJ, Guba W, Varga ZV, Deng H, van Kasteren SI, Grether U, IJzerman AP, Pacher P, Carreira EM, Overkleeft HS, Ioan-Facsinay A, Heitman LH, van der Stelt M.

J Am Chem Soc. 2018 May 16;140(19):6067-6075. doi: 10.1021/jacs.7b11281. Epub 2018 Feb 16.

22.

Total Synthesis of (+)-Sarcophytin.

Nannini LJ, Nemat SJ, Carreira EM.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):823-826. doi: 10.1002/anie.201711372. Epub 2017 Dec 13.

PMID:
29194883
23.

Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA.

J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12.

PMID:
29161035
24.

Stereochemistry and biological activity of chlorinated lipids: a study of danicalipin A and selected diastereomers.

Boshkow J, Fischer S, Bailey AM, Wolfrum S, Carreira EM.

Chem Sci. 2017 Oct 1;8(10):6904-6910. doi: 10.1039/c7sc03124f. Epub 2017 Aug 9.

25.

Total Synthesis and Stereochemical Assignment of (+)-Broussonetine H.

Rössler SL, Schreib BS, Ginterseder M, Hamilton JY, Carreira EM.

Org Lett. 2017 Oct 20;19(20):5533-5536. doi: 10.1021/acs.orglett.7b02620. Epub 2017 Oct 2.

PMID:
28968123
26.

Total Synthesis of (-)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution.

Shemet A, Carreira EM.

Org Lett. 2017 Oct 20;19(20):5529-5532. doi: 10.1021/acs.orglett.7b02619. Epub 2017 Oct 2.

PMID:
28968107
27.

Stereoselective Synthesis of Piperidines by Iridium-Catalyzed Cyclocondensation.

Sandmeier T, Krautwald S, Carreira EM.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11515-11519. doi: 10.1002/anie.201706374. Epub 2017 Aug 7.

PMID:
28731546
28.

Total Synthesis of (+)-Dendrowardol C.

Wolleb H, Carreira EM.

Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10890-10893. doi: 10.1002/anie.201705809. Epub 2017 Aug 3.

PMID:
28691326
29.

Enantio- and Diastereoselective Spiroketalization Catalyzed by Chiral Iridium Complex.

Hamilton JY, Rössler SL, Carreira EM.

J Am Chem Soc. 2017 Jun 21;139(24):8082-8085. doi: 10.1021/jacs.7b02856. Epub 2017 Jun 9.

PMID:
28598614
30.

Enantioselective Iridium-Catalyzed Allylic Cyclizations.

Schafroth MA, Rummelt SM, Sarlah D, Carreira EM.

Org Lett. 2017 Jun 16;19(12):3235-3238. doi: 10.1021/acs.orglett.7b01346. Epub 2017 Jun 2.

PMID:
28573860
31.

Cyclopropanation Strategies in Recent Total Syntheses.

Ebner C, Carreira EM.

Chem Rev. 2017 Sep 27;117(18):11651-11679. doi: 10.1021/acs.chemrev.6b00798. Epub 2017 May 3. Review.

PMID:
28467054
32.

Oxetanyl Amino Acids for Peptidomimetics.

Möller GP, Müller S, Wolfstädter BT, Wolfrum S, Schepmann D, Wünsch B, Carreira EM.

Org Lett. 2017 May 19;19(10):2510-2513. doi: 10.1021/acs.orglett.7b00745. Epub 2017 May 1.

PMID:
28459595
33.

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis.

Hönig M, Sondermann P, Turner NJ, Carreira EM.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):8942-8973. doi: 10.1002/anie.201612462. Epub 2017 Jun 26. Review.

PMID:
28407390
34.

Stereodivergence in Asymmetric Catalysis.

Krautwald S, Carreira EM.

J Am Chem Soc. 2017 Apr 26;139(16):5627-5639. doi: 10.1021/jacs.6b13340. Epub 2017 Apr 12.

PMID:
28384402
35.

Study of Intermediates in Iridium-(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution.

Rössler SL, Krautwald S, Carreira EM.

J Am Chem Soc. 2017 Mar 15;139(10):3603-3606. doi: 10.1021/jacs.6b12421. Epub 2017 Mar 7.

PMID:
28267330
36.

Aqueous Instability of δ-Fluorobutylpiperidines.

Vorberg R, Carreira EM, Müller K.

ChemMedChem. 2017 Mar 17;12(6):431-437. doi: 10.1002/cmdc.201700027. Epub 2017 Feb 16.

PMID:
28139081
37.

Enantioselective Addition of Alkynes to α,α-Dichlorinated Aldehydes.

Sempere Molina Y, Ruchti J, Carreira EM.

Org Lett. 2017 Feb 17;19(4):743-745. doi: 10.1021/acs.orglett.6b03692. Epub 2017 Jan 27.

PMID:
28127958
38.

Synthesis of Phytocannabinoids.

Schafroth MA, Carreira EM.

Prog Chem Org Nat Prod. 2017;103:37-59. doi: 10.1007/978-3-319-45541-9_2. Review.

PMID:
28120230
39.

Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA.

Vorberg R, Trapp N, Carreira EM, Müller K.

Chemistry. 2017 Mar 2;23(13):3126-3138. doi: 10.1002/chem.201605179. Epub 2017 Feb 1.

PMID:
27976829
40.

Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups.

Huchet QA, Schweizer WB, Kuhn B, Carreira EM, Müller K.

Chemistry. 2016 Nov 14;22(47):16920-16928. doi: 10.1002/chem.201602643. Epub 2016 Oct 12.

PMID:
27730683
41.

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.

Vorberg R, Trapp N, Zimmerli D, Wagner B, Fischer H, Kratochwil NA, Kansy M, Carreira EM, Müller K.

ChemMedChem. 2016 Oct 6;11(19):2216-2239. doi: 10.1002/cmdc.201600325. Epub 2016 Sep 15.

PMID:
27629993
42.

Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids.

Ruchti J, Carreira EM.

Org Lett. 2016 May 6;18(9):2174-6. doi: 10.1021/acs.orglett.6b00793. Epub 2016 Apr 18.

PMID:
27088306
43.

Bioisosteric Exchange of Csp3 -Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues.

Krautwald S, Nilewski C, Mori M, Shiomi K, Ōmura S, Carreira EM.

Angew Chem Int Ed Engl. 2016 Mar 14;55(12):4049-53. doi: 10.1002/anie.201511672. Epub 2016 Feb 17.

PMID:
26891236
44.

Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A.

Fischer S, Huwyler N, Wolfrum S, Carreira EM.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2555-8. doi: 10.1002/anie.201510608. Epub 2016 Jan 14.

PMID:
26840217
45.

Formation of α-SF5-Enolate Enables Preparation of 3-SF5-Quinolin-2-ones, 3-SF5-Quinolines, and 3-SF5-Pyridin-2-ones: Evaluation of their Physicochemical Properties.

Joliton A, Plancher JM, Carreira EM.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2113-7. doi: 10.1002/anie.201510380. Epub 2016 Jan 6.

PMID:
26732047
46.

A Unified Strategy to Plakortin Pentalenes: Total Syntheses of (±)-Gracilioethers E and F.

Ruider SA, Carreira EM.

Org Lett. 2016 Jan 15;18(2):220-3. doi: 10.1021/acs.orglett.5b03356. Epub 2015 Dec 21.

PMID:
26691775
47.

Biological Investigations of (+)-Danicalipin A Enabled Through Synthesis.

Bailey AM, Wolfrum S, Carreira EM.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):639-43. doi: 10.1002/anie.201509082. Epub 2015 Nov 27.

PMID:
26610732
48.

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.

Huchet QA, Kuhn B, Wagner B, Kratochwil NA, Fischer H, Kansy M, Zimmerli D, Carreira EM, Müller K.

J Med Chem. 2015 Nov 25;58(22):9041-60. doi: 10.1021/acs.jmedchem.5b01455. Epub 2015 Nov 17.

PMID:
26523333
49.

Synthesis and Biological Evaluation of Chlorinated Analogs of Leukotoxin Diol.

Nilewski C, Le Chapelain C, Wolfrum S, Carreira EM.

Org Lett. 2015 Nov 20;17(22):5602-5. doi: 10.1021/acs.orglett.5b02814. Epub 2015 Oct 30.

PMID:
26517019
50.

Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes.

Sandmeier T, Krautwald S, Zipfel HF, Carreira EM.

Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14363-7. doi: 10.1002/anie.201506933. Epub 2015 Oct 2.

PMID:
26427612

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