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Items: 42

1.

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.

Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N.

Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6.

2.

Stereodivergent approach in the protected glycal synthesis of L-vancosamine, L-saccharosamine, L-daunosamine and L-ristosamine involving a ring-closing metathesis step.

Nocquet PA, Macé A, Legros F, Lebreton J, Dujardin G, Collet S, Martel A, Carboni B, Carreaux F.

Beilstein J Org Chem. 2018 Nov 29;14:2949-2955. doi: 10.3762/bjoc.14.274. eCollection 2018.

3.

1,3-Dioxa-[3,3]-sigmatropic Oxo-Rearrangement of Substituted Allylic Carbamates: Scope and Mechanistic Studies.

Agirre M, Henrion S, Rivilla I, Miranda JI, Cossío FP, Carboni B, Villalgordo JM, Carreaux F.

J Org Chem. 2018 Dec 21;83(24):14861-14881. doi: 10.1021/acs.joc.8b01320. Epub 2018 Dec 4.

4.

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Nguyen TL, Duchon A, Manousopoulou A, Loaëc N, Villiers B, Pani G, Karatas M, Mechling AE, Harsan LA, Limanton E, Bazureau JP, Carreaux F, Garbis SD, Meijer L, Herault Y.

Dis Model Mech. 2018 Sep 27;11(9). pii: dmm035634. doi: 10.1242/dmm.035634.

5.

Stereospecific C-Glycosylation by Mizoroki-Heck Reaction: A Powerful and Easy-to-Set-Up Synthetic Tool to Access α- and β-Aryl-C-Glycosides.

Mabit T, Siard A, Legros F, Guillarme S, Martel A, Lebreton J, Carreaux F, Dujardin G, Collet S.

Chemistry. 2018 Sep 20;24(53):14069-14074. doi: 10.1002/chem.201803674. Epub 2018 Aug 28.

PMID:
30035833
6.

Asymmetric synthesis of trans-4,5-disubstituted γ-butyrolactones involving a key allylboration step. First access to (-)-nicotlactone B and (-)-galbacin.

Henrion S, Macé A, Vallejos MM, Roisnel T, Carboni B, Villalgordo JM, Carreaux F.

Org Biomol Chem. 2018 Mar 7;16(10):1672-1678. doi: 10.1039/c8ob00101d.

PMID:
29446433
7.

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.

Loaëc N, Attanasio E, Villiers B, Durieu E, Tahtouh T, Cam M, Davis RA, Alencar A, Roué M, Bourguet-Kondracki ML, Proksch P, Limanton E, Guiheneuf S, Carreaux F, Bazureau JP, Klautau M, Meijer L.

Mar Drugs. 2017 Oct 17;15(10). pii: E316. doi: 10.3390/md15100316. Review.

8.

Total Synthesis of γ-Indomycinone and Kidamycinone by Means of Two Regioselective Diels-Alder Reactions.

Mabit T, Siard A, Pantin M, Zon D, Foulgoc L, Sissouma D, Guingant A, Mathé-Allainmat M, Lebreton J, Carreaux F, Dujardin G, Collet S.

J Org Chem. 2017 Jun 2;82(11):5710-5719. doi: 10.1021/acs.joc.7b00544. Epub 2017 May 23.

9.

Stereospecific Synthesis of α-Amino Allylsilane Derivatives through a [3,3]-Allyl Cyanate Rearrangement. Mild Formation of Functionalized Disiloxanes.

Henrion S, Carboni B, Cossío FP, Roisnel T, Villalgordo JM, Carreaux F.

J Org Chem. 2016 Jun 3;81(11):4633-44. doi: 10.1021/acs.joc.6b00505. Epub 2016 May 18.

PMID:
27163288
10.

[3,3]-Sigmatropic Rearrangement/Allylboration/Cyclization Sequence: Enantioenriched Seven-Membered-Ring Carbamates and Ring Contraction to Pyrrolidines.

Macé A, Touchet S, Andres P, Cossío F, Dorcet V, Carreaux F, Carboni B.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1025-9. doi: 10.1002/anie.201509824. Epub 2015 Dec 4.

PMID:
26636973
11.

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice.

Naert G, Ferré V, Meunier J, Keller E, Malmström S, Givalois L, Carreaux F, Bazureau JP, Maurice T.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82. doi: 10.1016/j.euroneuro.2015.03.018. Epub 2015 Apr 10.

PMID:
26381812
12.

Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions.

Brun E, Safer A, Carreaux F, Bourahla K, L'helgoua'ch JM, Bazureau JP, Villalgordo JM.

Molecules. 2015 Jun 23;20(6):11617-31. doi: 10.3390/molecules200611617.

13.

Cross-metathesis/isomerization/allylboration sequence for a diastereoselective synthesis of anti-homoallylic alcohols from allylbenzene derivatives and aldehydes.

Hemelaere R, Carreaux F, Carboni B.

Chemistry. 2014 Oct 27;20(44):14518-23. doi: 10.1002/chem.201403954. Epub 2014 Sep 11.

PMID:
25212967
14.

Boron-substituted 1,3-dienes and heterodienes as key elements in multicomponent processes.

Eberlin L, Tripoteau F, Carreaux F, Whiting A, Carboni B.

Beilstein J Org Chem. 2014 Jan 22;10:237-50. doi: 10.3762/bjoc.10.19. eCollection 2014. Review.

15.

New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Guiheneuf S, Paquin L, Carreaux F, Durieu E, Roisnel T, Meijer L, Bazureau JP.

Mol Divers. 2014 May;18(2):375-88. doi: 10.1007/s11030-014-9509-7. Epub 2014 Mar 2.

16.

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

Fant X, Durieu E, Chicanne G, Payrastre B, Sbrissa D, Shisheva A, Limanton E, Carreaux F, Bazureau JP, Meijer L.

Mol Pharmacol. 2014 Mar;85(3):441-50. doi: 10.1124/mol.113.090837. Epub 2013 Dec 23.

17.

Synthesis of alkenyl boronates from allyl-substituted aromatics using an olefin cross-metathesis protocol.

Hemelaere R, Carreaux F, Carboni B.

J Org Chem. 2013 Jul 5;78(13):6786-92. doi: 10.1021/jo400872x. Epub 2013 Jun 24.

PMID:
23772914
18.

[3,3]-Sigmatropic rearrangement of boronated allylcyanates: a new route to α-aminoboronate derivatives and trisubstituted tetrahydrofurans.

Touchet S, Macé A, Roisnel T, Carreaux F, Bouillon A, Carboni B.

Org Lett. 2013 Jun 7;15(11):2712-5. doi: 10.1021/ol401016x. Epub 2013 May 21.

PMID:
23692512
19.

Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.

Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP.

Eur J Med Chem. 2013 Apr;62:728-37. doi: 10.1016/j.ejmech.2013.01.035. Epub 2013 Feb 6.

PMID:
23454515
20.

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L.

J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8.

PMID:
22998443
21.

Iridium-Catalyzed Allylic Amination Route to α-Aminoboronates: Illustration of the Decisive Role of Boron Substituents.

Touchet S, Carreaux F, Molander GA, Carboni B, Bouillon A.

Adv Synth Catal. 2011 Dec;353(18):3391-3396.

22.

An efficient approach to dispacamide A and its derivatives.

Guihéneuf S, Paquin L, Carreaux F, Durieu E, Meijer L, Bazureau JP.

Org Biomol Chem. 2012 Feb 7;10(5):978-87. doi: 10.1039/c1ob06161e. Epub 2011 Dec 8.

PMID:
22159215
23.

Boron- and silicon-substituted [3]-1-heterodendralenes as versatile building blocks for the rapid construction of polycyclic architectures.

Tripoteau F, Verdelet T, Hercouet A, Carreaux F, Carboni B.

Chemistry. 2011 Dec 2;17(49):13670-5. doi: 10.1002/chem.201101624. Epub 2011 Nov 8. No abstract available.

PMID:
22069230
24.

A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives.

Bourahla K, Paquin L, Lozach O, Meijer L, Carreaux F, Bazureau JP.

Molecules. 2011 Aug 30;16(9):7377-90. doi: 10.3390/molecules16097377.

25.

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP.

J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26.

PMID:
21615147
26.

Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.

Touchet S, Carreaux F, Carboni B, Bouillon A, Boucher JL.

Chem Soc Rev. 2011 Jul;40(7):3895-914. doi: 10.1039/c0cs00154f. Epub 2011 Mar 22. Review.

PMID:
21431144
27.

Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.

Debdab M, Renault S, Lozach O, Meijer L, Paquin L, Carreaux F, Bazureau JP.

Eur J Med Chem. 2010 Feb;45(2):805-10. doi: 10.1016/j.ejmech.2009.10.009. Epub 2009 Oct 12.

PMID:
19879673
28.

Ruthenium-catalyzed synthesis of allylic alcohols: boronic acid as a hydroxide source.

Bouziane A, Hélou M, Carboni B, Carreaux F, Demerseman B, Bruneau C, Renaud JL.

Chemistry. 2008;14(18):5630-7. doi: 10.1002/chem.200702030.

PMID:
18421726
30.

Parallel solution-phase synthesis of 2-alkylthio-5-arylidene-3,5-dihydro-4H-imidazol-4-one by one-pot three-component domino reaction.

Renault S, Bertrand S, Carreaux F, Bazureau JP.

J Comb Chem. 2007 Nov-Dec;9(6):935-42. Epub 2007 Sep 7.

PMID:
17822301
31.

(E)-alpha-substituted gamma-alkoxyallylboronic esters as new reagents: synthesis and reactivity toward aldehydes.

Possémé F, Deligny M, Carreaux F, Carboni B.

J Org Chem. 2007 Feb 2;72(3):984-9.

PMID:
17253820
32.
33.

Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.

Busnel O, Carreaux F, Carboni B, Pethe S, Goff SV, Mansuy D, Boucher JL.

Bioorg Med Chem. 2005 Apr 1;13(7):2373-9.

PMID:
15755639
34.

A novel diastereoselective route to alpha-hydroxyalkyl dihydropyrans using a hetero Diels-Alder/allylboration sequence.

Deligny M, Carreaux F, Carboni B, Toupet L, Dujardin G.

Chem Commun (Camb). 2003 Dec 21;(24):3052. No abstract available.

PMID:
14725315
35.

A novel diastereoselective route to alpha-hydroxyalkyl dihydropyrans using an hetero Diels-Alder/allylboration sequence.

Deligny M, Carreaux F, Carboni B, Toupet L, Dujardin G.

Chem Commun (Camb). 2003 Dec 21;(24):276-7.

PMID:
14703853
36.
37.

[4+3] versus [4+2] mechanisms in the dimerization of 2-boryl-1,3-butadienes. A theoretical and experimental study.

Carreaux F, Possémé F, Carboni B, Arrieta A, Lecea B, Cossío FP.

J Org Chem. 2002 Dec 27;67(26):9153-61.

PMID:
12492315
38.

(Z)-1,4-diamino-2-butene as a vector of boron, fluorine, or iodine for cancer therapy and imaging: synthesis and biological evaluation.

Martin B, Possémé F, Le Barbier C, Carreaux F, Carboni B, Seiler N, Moulinoux JP, Delcros JG.

Bioorg Med Chem. 2002 Sep;10(9):2863-71.

PMID:
12110306
39.

N-Benzylpolyamines as vectors of boron and fluorine for cancer therapy and imaging: synthesis and biological evaluation.

Martin B, Possémé F, Le Barbier C, Carreaux F, Carboni B, Seiler N, Moulinoux JP, Delcros JG.

J Med Chem. 2001 Oct 25;44(22):3653-64.

PMID:
11606130
40.

Metal-catalyzed release of supported boronic acids for C-C bond formation.

Pourbaix C, Carreaux F, Carboni B.

Org Lett. 2001 Mar 22;3(6):803-5.

PMID:
11263886
41.

Homologation of boronic esters with (dialkoxymethyl)lithiums. Asymmetric synthesis of alpha-alkoxy boronic esters

Carmes L, Carreaux F, Carboni B.

J Org Chem. 2000 Aug 25;65(17):5403-8. No abstract available.

PMID:
10993372
42.

Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase.

Lebarbier C, Carreaux F, Carboni B, Boucher JL.

Bioorg Med Chem Lett. 1998 Sep 22;8(18):2573-6.

PMID:
9873583

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