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Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Lakhal-Littleton S, Crosby A, Frise MC, Mohammad G, Carr CA, Loick PAM, Robbins PA.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13122-13130. doi: 10.1073/pnas.1822010116. Epub 2019 May 31.


Metabolic flux analyses to assess the differentiation of adult cardiac progenitors after fatty acid supplementation.

Malandraki-Miller S, Lopez CA, Alonaizan R, Purnama U, Perbellini F, Pakzad K, Carr CA.

Stem Cell Res. 2019 Jul;38:101458. doi: 10.1016/j.scr.2019.101458. Epub 2019 May 8.


Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.

Hu S, Offenbacher AR, Thompson EM, Gee CL, Wilcoxen J, Carr CAM, Prigozhin DM, Yang V, Alber T, Britt RD, Fraser JS, Klinman JP.

J Am Chem Soc. 2019 Jan 30;141(4):1555-1567. doi: 10.1021/jacs.8b10992. Epub 2019 Jan 15.


Improved cellular uptake of perfluorocarbon nanoparticles for in vivo murine cardiac 19F MRS/MRI and temporal tracking of progenitor cells.

Constantinides C, McNeill E, Carnicer R, Al Haj Zen A, Sainz-Urruela R, Shaw A, Patel J, Swider E, Alonaizan R, Potamiti L, Hadjisavvas A, Padilla-Parra S, Kyriacou K, Srinivas M, Carr CA.

Nanomedicine. 2019 Jun;18:391-401. doi: 10.1016/j.nano.2018.10.014. Epub 2018 Nov 16.


Changing Metabolism in Differentiating Cardiac Progenitor Cells-Can Stem Cells Become Metabolically Flexible Cardiomyocytes?

Malandraki-Miller S, Lopez CA, Al-Siddiqi H, Carr CA.

Front Cardiovasc Med. 2018 Sep 19;5:119. doi: 10.3389/fcvm.2018.00119. eCollection 2018. Review.


The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction.

Vieira JM, Norman S, Villa Del Campo C, Cahill TJ, Barnette DN, Gunadasa-Rohling M, Johnson LA, Greaves DR, Carr CA, Jackson DG, Riley PR.

J Clin Invest. 2018 Aug 1;128(8):3402-3412. doi: 10.1172/JCI97192. Epub 2018 Jul 9.


In Vivo Tracking and 1H/19F Magnetic Resonance Imaging of Biodegradable Polyhydroxyalkanoate/Polycaprolactone Blend Scaffolds Seeded with Labeled Cardiac Stem Cells.

Constantinides C, Basnett P, Lukasiewicz B, Carnicer R, Swider E, Majid QA, Srinivas M, Carr CA, Roy I.

ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25056-25068. doi: 10.1021/acsami.8b06096. Epub 2018 Jul 18.


Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017.

Carr CA, Dodd MS, Heather LC.

Heart. 2018 Aug;104(16):1383-1384. doi: 10.1136/heartjnl-2018-313271. Epub 2018 Jun 20. No abstract available.


Noninvasive Immunometabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic Resonance.

Lewis AJM, Miller JJ, Lau AZ, Curtis MK, Rider OJ, Choudhury RP, Neubauer S, Cunningham CH, Carr CA, Tyler DJ.

Circ Res. 2018 Apr 13;122(8):1084-1093. doi: 10.1161/CIRCRESAHA.117.312535. Epub 2018 Feb 12.


iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.

Barnette DN, Cahill TJ, Gunadasa-Rohling M, Carr CA, Freeman M, Riley PR.

JCI Insight. 2018 Feb 8;3(3). pii: 98268. doi: 10.1172/jci.insight.98268. eCollection 2018 Feb 8.


Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T.

Constantinides C, Maguire M, McNeill E, Carnicer R, Swider E, Srinivas M, Carr CA, Schneider JE.

PLoS One. 2018 Jan 11;13(1):e0190558. doi: 10.1371/journal.pone.0190558. eCollection 2018.


Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.

Miller JJ, Lau AZ, Nielsen PM, McMullen-Klein G, Lewis AJ, Jespersen NR, Ball V, Gallagher FA, Carr CA, Laustsen C, Bøtker HE, Tyler DJ, Schroeder MA.

JACC Cardiovasc Imaging. 2018 Nov;11(11):1594-1606. doi: 10.1016/j.jcmg.2017.09.020. Epub 2017 Dec 13.


Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.

Offenbacher AR, Hu S, Poss EM, Carr CAM, Scouras AD, Prigozhin DM, Iavarone AT, Palla A, Alber T, Fraser JS, Klinman JP.

ACS Cent Sci. 2017 Jun 28;3(6):570-579. doi: 10.1021/acscentsci.7b00142. Epub 2017 Jun 9.


Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.

Mansor LS, Sousa Fialho MDL, Yea G, Coumans WA, West JA, Kerr M, Carr CA, Luiken JJFP, Glatz JFC, Evans RD, Griffin JL, Tyler DJ, Clarke K, Heather LC.

Cardiovasc Res. 2017 Jun 1;113(7):737-748. doi: 10.1093/cvr/cvx045.


13C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling.

Horitani M, Offenbacher AR, Carr CA, Yu T, Hoeke V, Cutsail GE 3rd, Hammes-Schiffer S, Klinman JP, Hoffman BM.

J Am Chem Soc. 2017 Feb 8;139(5):1984-1997. doi: 10.1021/jacs.6b11856. Epub 2017 Jan 25.


Temporal accumulation and localization of isoflurane in the C57BL/6 mouse and assessment of its potential contamination in 19 F MRI with perfluoro-crown-ether-labeled cardiac progenitor cells at 9.4 Tesla.

Constantinides C, Maguire ML, Stork L, Swider E, Srinivas M, Carr CA, Schneider JE.

J Magn Reson Imaging. 2017 Jun;45(6):1659-1667. doi: 10.1002/jmri.25564. Epub 2016 Dec 19.


Ambiguity in the Presentation of Decellularized Tissue Composition: The Need for Standardized Approaches.

Bruyneel AAN, Carr CA.

Artif Organs. 2017 Aug;41(8):778-784. doi: 10.1111/aor.12838. Epub 2016 Dec 7.


On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K.

FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21.


Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.

Mansor LS, Mehta K, Aksentijevic D, Carr CA, Lund T, Cole MA, Le Page L, Sousa Fialho Mda L, Shattock MJ, Aasum E, Clarke K, Tyler DJ, Heather LC.

J Physiol. 2016 Jan 15;594(2):307-20. doi: 10.1113/JP271242. Epub 2015 Dec 20.


Chronic High-Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria.

Perbellini F, Gomes RS, Vieira S, Buchanan D, Malandraki-Miller S, Bruyneel AA, Sousa Fialho Mda L, Ball V, Clarke K, Faggian G, Carr CA.

Stem Cells Transl Med. 2015 Dec;4(12):1403-14. doi: 10.5966/sctm.2015-0024. Epub 2015 Oct 30.


Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy.

Betts CA, Saleh AF, Carr CA, Muses S, Wells KE, Hammond SM, Godfrey C, McClorey G, Woffindale C, Clarke K, Wells DJ, Gait MJ, Wood MJ.

Sci Rep. 2015 Jun 26;5:11632. doi: 10.1038/srep11632.


Uterine cells-an immunoprivileged cell source for therapy-but are they for everyone?

Perbellini F, Carr CA.

J Mol Cell Cardiol. 2015 Aug;85:127-30. doi: 10.1016/j.yjmcc.2015.05.017. Epub 2015 May 28. No abstract available.


Cardiac lymphatics are heterogeneous in origin and respond to injury.

Klotz L, Norman S, Vieira JM, Masters M, Rohling M, Dubé KN, Bollini S, Matsuzaki F, Carr CA, Riley PR.

Nature. 2015 Jun 4;522(7554):62-7.


Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study.

Le Page LM, Rider OJ, Lewis AJ, Ball V, Clarke K, Johansson E, Carr CA, Heather LC, Tyler DJ.

Diabetes. 2015 Aug;64(8):2735-43. doi: 10.2337/db14-1560. Epub 2015 Mar 20.


Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice.

Betts CA, Saleh AF, Carr CA, Hammond SM, Coenen-Stass AM, Godfrey C, McClorey G, Varela MA, Roberts TC, Clarke K, Gait MJ, Wood MJ.

Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986.


Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.

Tan SC, Gomes RS, Yeoh KK, Perbellini F, Malandraki-Miller S, Ambrose L, Heather LC, Faggian G, Schofield CJ, Davies KE, Clarke K, Carr CA.

Cell Transplant. 2016;25(1):35-53. doi: 10.3727/096368915X687697. Epub 2015 Mar 6.


In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy.

Seymour AM, Giles L, Ball V, Miller JJ, Clarke K, Carr CA, Tyler DJ.

Cardiovasc Res. 2015 May 1;106(2):249-60. doi: 10.1093/cvr/cvv101. Epub 2015 Mar 5.


Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.

Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1812.


iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.

Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJ, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81. doi: 10.1073/pnas.1408111112. Epub 2015 Feb 17.


Varying degrees of ventricular unloading in the heterotopic rat heart transplant model demonstrated by magnetic resonance imaging.

Carr CA, Ball D, Tyler DJ, Bushell A, Sykes A, Clarke K, Evans RD.

Int J Biomed Sci. 2014 Dec;10(4):223-8.


Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Dodd MS, Atherton HJ, Carr CA, Stuckey DJ, West JA, Griffin JL, Radda GK, Clarke K, Heather LC, Tyler DJ.

Circ Cardiovasc Imaging. 2014 Nov;7(6):895-904. doi: 10.1161/CIRCIMAGING.114.001857. Epub 2014 Sep 8.


Testing VHF/GPS collar design and safety in the study of free-roaming horses.

Collins GH, Petersen SL, Carr CA, Pielstick L.

PLoS One. 2014 Sep 8;9(9):e103189. doi: 10.1371/journal.pone.0103189. eCollection 2014.


Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation.

Hu S, Sharma SC, Scouras AD, Soudackov AV, Carr CA, Hammes-Schiffer S, Alber T, Klinman JP.

J Am Chem Soc. 2014 Jun 11;136(23):8157-60. doi: 10.1021/ja502726s. Epub 2014 Jun 2.


Hydrogen tunneling in a prokaryotic lipoxygenase.

Carr CA, Klinman JP.

Biochemistry. 2014 Apr 15;53(14):2212-4. doi: 10.1021/bi500070q. Epub 2014 Apr 3.


Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation.

Ambrose LJ, Abd-Jamil AH, Gomes RS, Carter EE, Carr CA, Clarke K, Heather LC.

J Cardiovasc Pharmacol Ther. 2014 Nov;19(6):574-85. doi: 10.1177/1074248414524480. Epub 2014 Mar 7.


Megaesophagus in a line of transgenic rats: a model of achalasia.

Pang J, Borjeson TM, Muthupalani S, Ducore RM, Carr CA, Feng Y, Sullivan MP, Cristofaro V, Luo J, Lindstrom JM, Fox JG.

Vet Pathol. 2014 Nov;51(6):1187-200. doi: 10.1177/0300985813519136. Epub 2014 Jan 23.


Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction.

Hsiao LC, Perbellini F, Gomes RS, Tan JJ, Vieira S, Faggian G, Clarke K, Carr CA.

Stem Cells Dev. 2014 May 1;23(9):1027-36. doi: 10.1089/scd.2013.0388. Epub 2014 Jan 31.


Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin.

Mansor LS, Gonzalez ER, Cole MA, Tyler DJ, Beeson JH, Clarke K, Carr CA, Heather LC.

Cardiovasc Diabetol. 2013 Sep 24;12:136. doi: 10.1186/1475-2840-12-136.


Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.

Ball DR, Rowlands B, Dodd MS, Le Page L, Ball V, Carr CA, Clarke K, Tyler DJ.

Magn Reson Med. 2014 May;71(5):1663-9. doi: 10.1002/mrm.24849. Epub 2013 Jun 24.


Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate.

Ball DR, Cruickshank R, Carr CA, Stuckey DJ, Lee P, Clarke K, Tyler DJ.

NMR Biomed. 2013 Nov;26(11):1441-50. doi: 10.1002/nbm.2972. Epub 2013 Jun 14.


Magnetic resonance imaging for the study of ovarian follicles in the mouse.

Stephenson AP, Tyler DJ, Carr CA, Williams SA.

Theriogenology. 2012 Oct 1;78(6):1190-8. doi: 10.1016/j.theriogenology.2012.05.012. Epub 2012 Aug 13.


Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsies.

Chan HH, Meher Homji Z, Gomes RS, Sweeney D, Thomas GN, Tan JJ, Zhang H, Perbellini F, Stuckey DJ, Watt SM, Taggart D, Clarke K, Martin-Rendon E, Carr CA.

J Cardiovasc Transl Res. 2012 Oct;5(5):678-87. Epub 2012 Jul 3. Erratum in: J Cardiovasc Transl Res. 2012 Oct;5(5):688.


In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.

Stuckey DJ, Carr CA, Camelliti P, Tyler DJ, Davies KE, Clarke K.

PLoS One. 2012;7(1):e28569. doi: 10.1371/journal.pone.0028569. Epub 2012 Jan 3.


Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors.

Tan SC, Carr CA, Yeoh KK, Schofield CJ, Davies KE, Clarke K.

Mol Biol Rep. 2012 Apr;39(4):4857-67. doi: 10.1007/s11033-011-1281-5. Epub 2011 Nov 9.


Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study.

Carr CA, Stuckey DJ, Tan JJ, Tan SC, Gomes RS, Camelliti P, Messina E, Giacomello A, Ellison GM, Clarke K.

PLoS One. 2011;6(10):e25669. doi: 10.1371/journal.pone.0025669. Epub 2011 Oct 17.


First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart.

Stuckey DJ, Carr CA, Meader SJ, Tyler DJ, Cole MA, Clarke K.

J Cardiovasc Magn Reson. 2011 Aug 3;13:38. doi: 10.1186/1532-429X-13-38.


Ongoing dual-angle measurements for the correction of partial saturation in 31P MR spectroscopy.

Tyler DJ, Lopez O, Cole MA, Carr CA, Stuckey DJ, Lakatta E, Clarke K, Spencer RG.

Magn Reson Med. 2010 Oct;64(4):957-66. doi: 10.1002/mrm.22511.


Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction.

Stuckey DJ, Ishii H, Chen QZ, Boccaccini AR, Hansen U, Carr CA, Roether JA, Jawad H, Tyler DJ, Ali NN, Clarke K, Harding SE.

Tissue Eng Part A. 2010 Nov;16(11):3395-402. doi: 10.1089/ten.TEA.2010.0213. Epub 2010 Jul 20.


An ecological approach to addressing HIV/AIDS in the African American community.

Moore D, Carr CA, Williams C, Richlen W, Huber M, Wagner J.

J Evid Based Soc Work. 2010 Jan;7(1):144-61. doi: 10.1080/15433710903176047.


Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy.

Sato M, Carr CA, Stuckey DJ, Ishii H, Kanda GK, Terracciano CM, Siedlecka U, Tatton L, Watt SM, Martin-Rendon E, Clarke K, Harding SE.

Stem Cells Dev. 2010 Jul;19(7):1025-34. doi: 10.1089/scd.2009.0330.


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