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Items: 1 to 50 of 192


The Antiresection Activity of the X Protein Encoded by Hepatitis Virus B.

Ren L, Zeng M, Tang Z, Li M, Wang X, Xu Y, Weng Y, Wang X, Wang H, Guo L, Zuo B, Wang X, Wang S, Lou J, Tang Y, Mu D, Zheng N, Wu X, Han J, Carr AM, Jeggo P, Liu C.

Hepatology. 2019 Jun;69(6):2546-2561. doi: 10.1002/hep.30571. Epub 2019 Apr 11.


An essential role for dNTP homeostasis following CDK-induced replication stress.

Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM, Humphrey TC.

J Cell Sci. 2019 Mar 25;132(6). pii: jcs226969. doi: 10.1242/jcs.226969.


Adolescents' Affective and Physiological Regulation Shape Negative Behavior During Challenging Equine Assisted Learning Activities.

Pendry P, Carr AM, Vandagriff JL.

Front Vet Sci. 2018 Dec 4;5:300. doi: 10.3389/fvets.2018.00300. eCollection 2018.


Preserving replication fork integrity and competence via the homologous recombination pathway.

Ait Saada A, Lambert SAE, Carr AM.

DNA Repair (Amst). 2018 Nov;71:135-147. doi: 10.1016/j.dnarep.2018.08.017. Epub 2018 Aug 25. Review.


Integrating DNA damage repair with the cell cycle.

Murray JM, Carr AM.

Curr Opin Cell Biol. 2018 Jun;52:120-125. doi: 10.1016/ Epub 2018 Mar 26. Review.


Analysis of Replicative Polymerase Usage by Ribonucleotide Incorporation.

Keszthelyi A, Miyabe I, Ptasińska K, Daigaku Y, Naiman K, Carr AM.

Methods Mol Biol. 2018;1672:239-259. doi: 10.1007/978-1-4939-7306-4_18.


Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

Pai CC, Kishkevich A, Deegan RS, Keszthelyi A, Folkes L, Kearsey SE, De León N, Soriano I, de Bruin RAM, Carr AM, Humphrey TC.

Cell Rep. 2017 Sep 12;20(11):2693-2705. doi: 10.1016/j.celrep.2017.08.058.


Characterisation of a stably integrated expression system for exogenous protein expression in DT40.

Skouteri M, Hochegger H, Carr AM.

Wellcome Open Res. 2017 Jun 8;2:40. doi: 10.12688/wellcomeopenres.11816.2. eCollection 2017.


PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast.

Daigaku Y, Etheridge TJ, Nakazawa Y, Nakayama M, Watson AT, Miyabe I, Ogi T, Osborne MA, Carr AM.

PLoS Genet. 2017 May 8;13(5):e1006789. doi: 10.1371/journal.pgen.1006789. eCollection 2017 May.


Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication.

Fleck O, Fahnøe U, Løvschal KV, Gasasira MU, Marinova IN, Kragelund BB, Carr AM, Hartsuiker E, Holmberg C, Nielsen O.

Genes (Basel). 2017 Apr 25;8(5). pii: E128. doi: 10.3390/genes8050128.


Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.

Kukalev A, Ng YM, Ju L, Saidi A, Lane S, Mondragon A, Dormann D, Walker SE, Grey W, Ho PW, Stephens DN, Carr AM, Lamsa K, Tse E, Yu VPCC.

Cereb Cortex. 2017 Jan 1;27(1):11-23. doi: 10.1093/cercor/bhw354.


Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?

Smith TC, Carr AM, Eyre-Walker AC.

PeerJ. 2016 Sep 20;4:e2391. doi: 10.7717/peerj.2391. eCollection 2016.


Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3676-85. doi: 10.1073/pnas.1525620113. Epub 2016 Jun 13.


Molecular Genetic Tools and Techniques in Fission Yeast.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 May 2;2016(5). doi: 10.1101/pdb.top087601.


Colony Polymerase Chain Reaction with Schizosaccharomyces pombe.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 May 2;2016(5). doi: 10.1101/pdb.prot090993.


Extraction of Chromosomal DNA from Schizosaccharomyces pombe.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 May 2;2016(5). doi: 10.1101/pdb.prot090985.


Identifying Products of Recombinase-Mediated Cassette Exchange (RMCE) in Schizosaccharomyces pombe.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 May 2;2016(5). doi: 10.1101/pdb.prot090944.


CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.

Zeng M, Ren L, Mizuno K, Nestoras K, Wang H, Tang Z, Guo L, Kong D, Hu Q, He Q, Du L, Carr AM, Liu C.

Nat Commun. 2016 Apr 21;7:11364. doi: 10.1038/ncomms11364.


Transformation of Schizosaccharomyces pombe: Protoplast Procedure.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 Apr 1;2016(4):pdb.prot090977. doi: 10.1101/pdb.prot090977.


Transformation of Schizosaccharomyces pombe: Lithium Acetate/ Dimethyl Sulfoxide Procedure.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 Apr 1;2016(4):pdb.prot090969. doi: 10.1101/pdb.prot090969.


Transformation of Schizosaccharomyces pombe: Electroporation Procedure.

Murray JM, Watson AT, Carr AM.

Cold Spring Harb Protoc. 2016 Apr 1;2016(4):pdb.prot090951. doi: 10.1101/pdb.prot090951.


DNA repair, genome stability and cancer: a historical perspective.

Jeggo PA, Pearl LH, Carr AM.

Nat Rev Cancer. 2016 Jan;16(1):35-42. doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15. Review.


Mapping ribonucleotides in genomic DNA and exploring replication dynamics by polymerase usage sequencing (Pu-seq).

Keszthelyi A, Daigaku Y, Ptasińska K, Miyabe I, Carr AM.

Nat Protoc. 2015 Nov;10(11):1786-801. doi: 10.1038/nprot.2015.116. Epub 2015 Oct 15.


Polymerase δ replicates both strands after homologous recombination-dependent fork restart.

Miyabe I, Mizuno K, Keszthelyi A, Daigaku Y, Skouteri M, Mohebi S, Kunkel TA, Murray JM, Carr AM.

Nat Struct Mol Biol. 2015 Nov;22(11):932-8. doi: 10.1038/nsmb.3100. Epub 2015 Oct 5.


Analyzing the Response to Dysfunction Replication Forks Using the RTS1 Barrier System in Fission Yeast.

Mohebi S, Lambert SA, Carr AM.

Methods Mol Biol. 2015;1300:239-59. doi: 10.1007/978-1-4939-2596-4_15.


Virtual-'light-sheet' single-molecule localisation microscopy enables quantitative optical sectioning for super-resolution imaging.

Palayret M, Armes H, Basu S, Watson AT, Herbert A, Lando D, Etheridge TJ, Endesfelder U, Heilemann M, Laue E, Carr AM, Klenerman D, Lee SF.

PLoS One. 2015 Apr 17;10(4):e0125438. doi: 10.1371/journal.pone.0125438. eCollection 2015.


Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements.

Mohebi S, Mizuno K, Watson A, Carr AM, Murray JM.

Nat Commun. 2015 Feb 27;6:6357. doi: 10.1038/ncomms7357.


A global profile of replicative polymerase usage.

Daigaku Y, Keszthelyi A, Müller CA, Miyabe I, Brooks T, Retkute R, Hubank M, Nieduszynski CA, Carr AM.

Nat Struct Mol Biol. 2015 Mar;22(3):192-198. doi: 10.1038/nsmb.2962. Epub 2015 Feb 9.


Corrigendum to "The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast" [DNA Repair 12 (December (12)) (2013) 1011-1023].

Fontebasso Y, Etheridge TJ, Oliver AW, Murray JM, Carr AM.

DNA Repair (Amst). 2014 Dec;24:150. doi: 10.1016/j.dnarep.2014.11.003. Epub 2014 Nov 20. No abstract available.


Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.

Gwon GH, Kim Y, Liu Y, Watson AT, Jo A, Etheridge TJ, Yuan F, Zhang Y, Kim Y, Carr AM, Cho Y.

Genes Dev. 2014 Oct 15;28(20):2276-90. doi: 10.1101/gad.248492.114.


Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy.

Etheridge TJ, Boulineau RL, Herbert A, Watson AT, Daigaku Y, Tucker J, George S, Jönsson P, Palayret M, Lando D, Laue E, Osborne MA, Klenerman D, Lee SF, Carr AM.

Nucleic Acids Res. 2014 Oct 29;42(19):e146. doi: 10.1093/nar/gku726. Epub 2014 Aug 8.


TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.

Wardlaw CP, Carr AM, Oliver AW.

DNA Repair (Amst). 2014 Oct;22:165-74. doi: 10.1016/j.dnarep.2014.06.004. Epub 2014 Jul 30. Review.


Improving adolescent social competence and behavior: a randomized trial of an 11-week equine facilitated learning prevention program.

Pendry P, Carr AM, Smith AN, Roeter SM.

J Prim Prev. 2014 Aug;35(4):281-93. doi: 10.1007/s10935-014-0350-7.


The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.

Tsang E, Miyabe I, Iraqui I, Zheng J, Lambert SA, Carr AM.

J Cell Sci. 2014 Jul 1;127(Pt 13):2983-94. doi: 10.1242/jcs.152678. Epub 2014 May 7.


Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.

Vejrup-Hansen R, Fleck O, Landvad K, Fahnøe U, Broendum SS, Schreurs AS, Kragelund BB, Carr AM, Holmberg C, Nielsen O.

J Cell Sci. 2014 Jun 1;127(Pt 11):2460-70. doi: 10.1242/jcs.139816. Epub 2014 Mar 20.


LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition.

Hart L, Rauch A, Carr AM, Vermeesch JR, O'Driscoll M.

Dis Model Mech. 2014 May;7(5):535-45. doi: 10.1242/dmm.014464. Epub 2014 Mar 13.


Optimisation of the Schizosaccharomyces pombe urg1 expression system.

Watson AT, Daigaku Y, Mohebi S, Etheridge TJ, Chahwan C, Murray JM, Carr AM.

PLoS One. 2013 Dec 20;8(12):e83800. doi: 10.1371/journal.pone.0083800. eCollection 2013.


A pediatric residency experience with surgical co-management.

Carr AM, Irigoyen M, Wimmer RS, Arbeter AM.

Hosp Pediatr. 2013 Apr;3(2):144-8.


The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y, Etheridge TJ, Oliver AW, Murray JM, Carr AM.

DNA Repair (Amst). 2013 Dec;12(12):1011-23. doi: 10.1016/j.dnarep.2013.10.003. Epub 2013 Nov 2. Erratum in: DNA Repair (Amst). 2014 Dec;24:150.


Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1).

Qu M, Rappas M, Wardlaw CP, Garcia V, Ren JY, Day M, Carr AM, Oliver AW, Du LL, Pearl LH.

Mol Cell. 2013 Sep 26;51(6):723-736. doi: 10.1016/j.molcel.2013.08.030.


Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.

Fleck O, Vejrup-Hansen R, Watson A, Carr AM, Nielsen O, Holmberg C.

J Cell Sci. 2013 Nov 1;126(Pt 21):4985-94. doi: 10.1242/jcs.132837. Epub 2013 Aug 28.


A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes.

Fadden AJ, Schalbetter S, Bowles M, Harris R, Lally J, Carr AM, McDonald NQ.

Nucleic Acids Res. 2013 Nov;41(21):9741-52. doi: 10.1093/nar/gkt760. Epub 2013 Aug 27.


An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.

Zhou ZW, Liu C, Li TL, Bruhn C, Krueger A, Min W, Wang ZQ, Carr AM.

PLoS Genet. 2013;9(8):e1003702. doi: 10.1371/journal.pgen.1003702. Epub 2013 Aug 8.


Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.

Dziadkowiec D, Kramarz K, Kanik K, Wisniewski P, Carr AM.

Nucleic Acids Res. 2013 Sep;41(17):8196-209. doi: 10.1093/nar/gkt564. Epub 2013 Jul 4.


Replication stress-induced genome instability: the dark side of replication maintenance by homologous recombination.

Carr AM, Lambert S.

J Mol Biol. 2013 Nov 29;425(23):4733-44. doi: 10.1016/j.jmb.2013.04.023. Epub 2013 Apr 30. Review.


Impediments to replication fork movement: stabilisation, reactivation and genome instability.

Lambert S, Carr AM.

Chromosoma. 2013 Mar;122(1-2):33-45. doi: 10.1007/s00412-013-0398-9. Epub 2013 Feb 28. Review.


Replication stress and genome rearrangements: lessons from yeast models.

Lambert S, Carr AM.

Curr Opin Genet Dev. 2013 Apr;23(2):132-9. doi: 10.1016/j.gde.2012.11.009. Epub 2012 Dec 22. Review.


Recombination-restarted replication makes inverted chromosome fusions at inverted repeats.

Mizuno K, Miyabe I, Schalbetter SA, Carr AM, Murray JM.

Nature. 2013 Jan 10;493(7431):246-9. doi: 10.1038/nature11676. Epub 2012 Nov 25.


A collaborative model for inpatient training in a small pediatric residency program.

Carr AM, Irigoyen M, Arbeter AM, Wimmer RS, McGregor RS, Reed CR, Schidlow DV.

J Grad Med Educ. 2011 Sep;3(3):383-6. doi: 10.4300/JGME-D-10-00216.1.

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