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ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons.

Morita W, Snelling SJB, Wheway K, Watkins B, Appleton L, Carr AJ, Dakin SG.

Sci Rep. 2019 Dec 12;9(1):19005. doi: 10.1038/s41598-019-55387-1.


Reporting of key methodological issues in placebo-controlled trials of surgery needs improvement: a systematic review.

Cousins S, Blencowe NS, Tsang C, Lorenc A, Chalmers K, Carr AJ, Campbell MK, Cook JA, Beard DJ, Blazeby JM.

J Clin Epidemiol. 2019 Nov 28;119:109-116. doi: 10.1016/j.jclinepi.2019.11.016. [Epub ahead of print] Review.


Polydioxanone implants: A systematic review on safety and performance in patients.

Martins JA, Lach AA, Morris HL, Carr AJ, Mouthuy PA.

J Biomater Appl. 2020 Feb;34(7):902-916. doi: 10.1177/0885328219888841. Epub 2019 Nov 26. No abstract available.


Assessment on patient outcomes of primary hip replacement: an interrupted time series analysis from 'The National Joint Registry of England and Wales'.

Garriga C, Murphy J, Leal J, Arden NK, Price AJ, Prieto-Alhambra D, Carr AJ, Rangan A, Cooper C, Peat G, Fitzpatrick R, Barker KL, Judge A.

BMJ Open. 2019 Nov 21;9(11):e031599. doi: 10.1136/bmjopen-2019-031599.


Wrist pain: a systematic review of prevalence and risk factors- what is the role of occupation and activity?

Ferguson R, Riley ND, Wijendra A, Thurley N, Carr AJ, Bjf D.

BMC Musculoskelet Disord. 2019 Nov 14;20(1):542. doi: 10.1186/s12891-019-2902-8.


Sodium citrate ingestion protocol impacts induced alkalosis, gastrointestinal symptoms, and palatability.

Urwin CS, Snow RJ, Orellana L, Condo D, Wadley GD, Carr AJ.

Physiol Rep. 2019 Oct;7(19):e14216. doi: 10.14814/phy2.14216.


Injection therapy for base of thumb osteoarthritis: a systematic review and meta-analysis.

Riley N, Vella-Baldacchino M, Thurley N, Hopewell S, Carr AJ, Dean BJF.

BMJ Open. 2019 Sep 11;9(9):e027507. doi: 10.1136/bmjopen-2018-027507.


Long-term rates of knee arthroplasty in a cohort of 834 393 patients with a history of arthroscopic partial meniscectomy.

Abram SGF, Judge A, Beard DJ, Carr AJ, Price AJ.

Bone Joint J. 2019 Sep;101-B(9):1071-1080. doi: 10.1302/0301-620X.101B9.BJJ-2019-0335.R1.


Longitudinal study of use and cost of subacromial decompression surgery: the need for effective evaluation of surgical procedures to prevent overtreatment and wasted resources.

Jones T, Carr AJ, Beard D, Linton MJ, Rooshenas L, Donovan J, Hollingworth W.

BMJ Open. 2019 Aug 28;9(8):e030229. doi: 10.1136/bmjopen-2019-030229.


Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears.

Dakin SG, Colas RA, Wheway K, Watkins B, Appleton L, Rees J, Gwilym S, Little C, Dalli J, Carr AJ.

Am J Pathol. 2019 Nov;189(11):2258-2268. doi: 10.1016/j.ajpath.2019.07.011. Epub 2019 Aug 19.


Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy.

Khan MR, Smith RK, David F, Lam R, Hughes G, De Godoy R, Carr AJ, Goodship AE, Dudhia J.

J Orthop Res. 2020 Jan;38(1):128-138. doi: 10.1002/jor.24423. Epub 2019 Aug 16.


Antibiotic treatment and flares of rheumatoid arthritis: a self-controlled case series study analysis using CPRD GOLD.

Nagra NS, Robinson DE, Douglas I, Delmestri A, Dakin SG, Snelling SJB, Carr AJ, Prieto-Alhambra D.

Sci Rep. 2019 Jun 20;9(1):8941. doi: 10.1038/s41598-019-45435-1.


Registry stakeholders.

Lübbeke A, Carr AJ, Hoffmeyer P.

EFORT Open Rev. 2019 Jun 3;4(6):330-336. doi: 10.1302/2058-5241.4.180077. eCollection 2019 Jun. Review.


Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell-Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation.

Eastlake K, Wang W, Jayaram H, Murray-Dunning C, Carr AJF, Ramsden CM, Vugler A, Gore K, Clemo N, Stewart M, Coffey P, Khaw PT, Limb GA.

Stem Cells Transl Med. 2019 Aug;8(8):775-784. doi: 10.1002/sctm.18-0263. Epub 2019 Apr 29.


Pyridine as an additive to improve the deposition of continuous electrospun filaments.

Lach AA, Morris HL, Martins JA, Stace ET, Carr AJ, Mouthuy PA.

PLoS One. 2019 Apr 25;14(4):e0214419. doi: 10.1371/journal.pone.0214419. eCollection 2019.


15-Epi-LXA4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture.

Dakin SG, Colas RA, Newton J, Gwilym S, Jones N, Reid HAB, Wood S, Appleton L, Wheway K, Watkins B, Dalli J, Carr AJ.

FASEB J. 2019 Jul;33(7):8043-8054. doi: 10.1096/fj.201900196R. Epub 2019 Mar 27.


Divergent roles of prostacyclin and PGE2 in human tendinopathy.

Bergqvist F, Carr AJ, Wheway K, Watkins B, Oppermann U, Jakobsson PJ, Dakin SG.

Arthritis Res Ther. 2019 Mar 13;21(1):74. doi: 10.1186/s13075-019-1855-5.


Arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of symptomatic femoroacetabular impingement: multicentre randomised controlled trial.

Palmer AJR, Ayyar Gupta V, Fernquest S, Rombach I, Dutton SJ, Mansour R, Wood S, Khanduja V, Pollard TCB, McCaskie AW, Barker KL, Andrade TJMD, Carr AJ, Beard DJ, Glyn-Jones S; FAIT Study Group.

BMJ. 2019 Feb 7;364:l185. doi: 10.1136/bmj.l185.


Tissue inflammation signatures point towards resolution in adhesive capsulitis.

Dakin SG, Rangan A, Martinez F, Brealey S, Northgraves M, Kottam L, Cooper C, Buckley CD, Carr AJ.

Rheumatology (Oxford). 2019 Jun 1;58(6):1109-1111. doi: 10.1093/rheumatology/kez007. No abstract available.


Cost-effectiveness analysis of a placebo-controlled randomized trial evaluating the effectiveness of arthroscopic subacromial decompression in patients with subacromial shoulder pain.

Rombach I, Merritt N, Shirkey BA, Rees JL, Cook JA, Cooper C, Carr AJ, Beard DJ, Gray AM.

Bone Joint J. 2019 Jan;101-B(1):55-62. doi: 10.1302/0301-620X.101B1.BJJ-2018-0555.R1.


Patch-augmented rotator cuff surgery (PARCS) study-protocol for a feasibility study.

Cook JA, Merritt N, Rees JL, Crocker JC, Hopewell S, Dritsaki M, Beard DJ, Rangan A, Cooper C, Kottam L, Farrar-Hockley D, Thomas M, Earle R, Carr AJ.

Pilot Feasibility Stud. 2018 Dec 21;4:188. doi: 10.1186/s40814-018-0380-7. eCollection 2018.


Sandwich layering in binary nanoparticle films and effect of size ratio on stratification behavior.

Liu W, Carr AJ, Yager KG, Routh AF, Bhatia SR.

J Colloid Interface Sci. 2019 Mar 7;538:209-217. doi: 10.1016/j.jcis.2018.11.084. Epub 2018 Nov 23.


Author Correction: Pathogenic stromal cells as therapeutic targets in joint inflammation.

Dakin SG, Coles M, Sherlock JP, Powrie F, Carr AJ, Buckley CD.

Nat Rev Rheumatol. 2019 Jan;15(1):61. doi: 10.1038/s41584-018-0134-1.


Pathogenic stromal cells as therapeutic targets in joint inflammation.

Dakin SG, Coles M, Sherlock JP, Powrie F, Carr AJ, Buckley CD.

Nat Rev Rheumatol. 2018 Dec;14(12):714-726. doi: 10.1038/s41584-018-0112-7. Review. Erratum in: Nat Rev Rheumatol. 2019 Jan;15(1):61.


The Reporting Items for Patent Landscapes statement.

Smith JA, Arshad Z, Trippe A, Collins GS, Brindley DA, Carr AJ.

Nat Biotechnol. 2018 Nov 9;36(11):1043-1047. doi: 10.1038/nbt.4291.


The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.

Rooshenas L, Scott LJ, Blazeby JM, Rogers CA, Tilling KM, Husbands S, Conefrey C, Mills N, Stein RC, Metcalfe C, Carr AJ, Beard DJ, Davis T, Paramasivan S, Jepson M, Avery K, Elliott D, Wilson C, Donovan JL; By-Band-Sleeve study group; CSAW study group; HAND-1 study group; Optima prelim study group; Romio feasibility study group.

J Clin Epidemiol. 2019 Feb;106:108-120. doi: 10.1016/j.jclinepi.2018.10.004. Epub 2018 Oct 16.


Training to Compete at Altitude:Natural Altitude or Simulated Live High:Train Low?

Carr AJ, Garvican-Lewis LA, Vallance BS, Drake AP, Saunders PU, Humberstone CE, Gore CJ.

Int J Sports Physiol Perform. 2019 Apr 1;14(4):509-517. doi: 10.1123/ijspp.2018-0099. Epub 2019 Mar 4.


Labeling of Phosphatidylinositol Lipid Products in Cells through Metabolic Engineering by Using a Clickable myo-Inositol Probe.

Ricks TJ, Cassilly CD, Carr AJ, Alves DS, Alam S, Tscherch K, Yokley TW, Workman CE, Morrell-Falvey JL, Barrera FN, Reynolds TB, Best MD.

Chembiochem. 2019 Jan 18;20(2):172-180. doi: 10.1002/cbic.201800248. Epub 2018 Oct 17.


Can Shoulder Arthroscopy Work? (CSAW) trial - Authors' reply.

Beard DJ, Carr AJ, Cook JA.

Lancet. 2018 Jul 28;392(10144):281-282. doi: 10.1016/S0140-6736(18)30773-6. No abstract available.


Trends in the theory that inflammation plays a causal role in tendinopathy: a systematic review and quantitative analysis of published reviews.

Mosca MJ, Rashid MS, Snelling SJ, Kirtley S, Carr AJ, Dakin SG.

BMJ Open Sport Exerc Med. 2018 Jun 26;4(1):e000332. doi: 10.1136/bmjsem-2017-000332. eCollection 2018.


Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.

Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe'er D.

Cell. 2018 Aug 23;174(5):1293-1308.e36. doi: 10.1016/j.cell.2018.05.060. Epub 2018 Jun 28.


Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.

van Dijk D, Sharma R, Nainys J, Yim K, Kathail P, Carr AJ, Burdziak C, Moon KR, Chaffer CL, Pattabiraman D, Bierie B, Mazutis L, Wolf G, Krishnaswamy S, Pe'er D.

Cell. 2018 Jul 26;174(3):716-729.e27. doi: 10.1016/j.cell.2018.05.061. Epub 2018 Jun 28.


Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium.

Khan MR, Dudhia J, David FH, De Godoy R, Mehra V, Hughes G, Dakin SG, Carr AJ, Goodship AE, Smith RKW.

Stem Cell Res Ther. 2018 Jun 19;9(1):169. doi: 10.1186/s13287-018-0900-7.


The use of placebos in controlled trials of surgical interventions: a brief history.

Wartolowska KA, Beard DJ, Carr AJ.

J R Soc Med. 2018 May;111(5):177-182. doi: 10.1177/0141076818769833. Review. No abstract available.


A structural comparison of casein micelles in cow, goat and sheep milk using X-ray scattering.

Ingham B, Smialowska A, Kirby NM, Wang C, Carr AJ.

Soft Matter. 2018 May 2;14(17):3336-3343. doi: 10.1039/c8sm00458g.


Mapping existing hip and knee replacement registries in Europe.

Lübbeke A, Silman AJ, Barea C, Prieto-Alhambra D, Carr AJ.

Health Policy. 2018 May;122(5):548-557. doi: 10.1016/j.healthpol.2018.03.010. Epub 2018 Mar 17. Review.


Chronic Ketogenic Low Carbohydrate High Fat Diet Has Minimal Effects on Acid-Base Status in Elite Athletes.

Carr AJ, Sharma AP, Ross ML, Welvaert M, Slater GJ, Burke LM.

Nutrients. 2018 Feb 18;10(2). pii: E236. doi: 10.3390/nu10020236.


The Use of Electrospun Scaffolds in Musculoskeletal Tissue Engineering: A Focus on Tendon and the Rotator Cuff.

Stace ET, Nagra NS, Tiberwel S, Khan W, Carr AJ.

Curr Stem Cell Res Ther. 2018;13(8):619-631. doi: 10.2174/1574888X13666180129105707. Review.


Stratification during evaporative assembly of multicomponent nanoparticle films.

Liu X, Liu W, Carr AJ, Santiago Vazquez D, Nykypanchuk D, Majewski PW, Routh AF, Bhatia SR.

J Colloid Interface Sci. 2018 Apr 1;515:70-77. doi: 10.1016/j.jcis.2018.01.005. Epub 2018 Jan 3.


Calcium-Responsive Liposomes via a Synthetic Lipid Switch.

Lou J, Carr AJ, Watson AJ, Mattern-Schain SI, Best MD.

Chemistry. 2018 Mar 7;24(14):3599-3607. doi: 10.1002/chem.201705810. Epub 2018 Feb 8.


United Kingdom Frozen Shoulder Trial (UK FROST), multi-centre, randomised, 12 month, parallel group, superiority study to compare the clinical and cost-effectiveness of Early Structured Physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a primary frozen shoulder: study protocol for a randomised controlled trial.

Brealey S, Armstrong AL, Brooksbank A, Carr AJ, Charalambous CP, Cooper C, Corbacho B, Dias J, Donnelly I, Goodchild L, Hewitt C, Keding A, Kottam L, Lamb SE, McDaid C, Northgraves M, Richardson G, Rodgers S, Shah S, Sharp E, Spencer S, Torgerson D, Toye F, Rangan A.

Trials. 2017 Dec 22;18(1):614. doi: 10.1186/s13063-017-2352-2.


Cytokines in tendon disease: A Systematic Review.

Morita W, Dakin SG, Snelling SJB, Carr AJ.

Bone Joint Res. 2017 Dec;6(12):656-664. doi: 10.1302/2046-3758.612.BJR-2017-0112.R1.


Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial.

Beard DJ, Rees JL, Cook JA, Rombach I, Cooper C, Merritt N, Shirkey BA, Donovan JL, Gwilym S, Savulescu J, Moser J, Gray A, Jepson M, Tracey I, Judge A, Wartolowska K, Carr AJ; CSAW Study Group.

Lancet. 2018 Jan 27;391(10118):329-338. doi: 10.1016/S0140-6736(17)32457-1. Epub 2017 Nov 20.


Incidence of shoulder dislocations in the UK, 1995-2015: a population-based cohort study.

Shah A, Judge A, Delmestri A, Edwards K, Arden NK, Prieto-Alhambra D, Holt TA, Pinedo-Villanueva RA, Hopewell S, Lamb SE, Rangan A, Carr AJ, Collins GS, Rees JL.

BMJ Open. 2017 Nov 14;7(11):e016112. doi: 10.1136/bmjopen-2017-016112.


Chronic inflammation is a feature of Achilles tendinopathy and rupture.

Dakin SG, Newton J, Martinez FO, Hedley R, Gwilym S, Jones N, Reid HAB, Wood S, Wells G, Appleton L, Wheway K, Watkins B, Carr AJ.

Br J Sports Med. 2018 Mar;52(6):359-367. doi: 10.1136/bjsports-2017-098161. Epub 2017 Nov 8.


The role of national registries in improving patient safety for hip and knee replacements.

Lübbeke A, Silman AJ, Prieto-Alhambra D, Adler AI, Barea C, Carr AJ.

BMC Musculoskelet Disord. 2017 Oct 16;18(1):414. doi: 10.1186/s12891-017-1773-0.


Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.

Dakin SG, Ly L, Colas RA, Oppermann U, Wheway K, Watkins B, Dalli J, Carr AJ.

Sci Rep. 2017 Sep 8;7(1):11009. doi: 10.1038/s41598-017-11188-y.


International variation in shoulder arthroplasty.

Lübbeke A, Rees JL, Barea C, Combescure C, Carr AJ, Silman AJ.

Acta Orthop. 2017 Dec;88(6):592-599. doi: 10.1080/17453674.2017.1368884. Epub 2017 Sep 7.


Increasing age and tear size reduce rotator cuff repair healing rate at 1 year.

Rashid MS, Cooper C, Cook J, Cooper D, Dakin SG, Snelling S, Carr AJ.

Acta Orthop. 2017 Dec;88(6):606-611. doi: 10.1080/17453674.2017.1370844. Epub 2017 Sep 7.

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