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Items: 42


Inhibition of T cell activation and function by the adaptor protein CIN85.

Kong MS, Hashimoto-Tane A, Kawashima Y, Sakuma M, Yokosuka T, Kometani K, Onishi R, Carpino N, Ohara O, Kurosaki T, Phua KK, Saito T.

Sci Signal. 2019 Feb 5;12(567). pii: eaav4373. doi: 10.1126/scisignal.aav4373.


Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins.

Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer TP, Carpino N, French JB.

ACS Infect Dis. 2019 Feb 8;5(2):250-259. doi: 10.1021/acsinfecdis.8b00238. Epub 2018 Dec 14.


Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans.

Frank D, Naseem S, Russo GL, Li C, Parashar K, Konopka JB, Carpino N.

MBio. 2018 Jul 17;9(4). pii: e00782-18. doi: 10.1128/mBio.00782-18.


Modulating Host Signaling Pathways to Promote Resistance to Infection by Candida albicans.

Carpino N, Naseem S, Frank DM, Konopka JB.

Front Cell Infect Microbiol. 2017 Nov 21;7:481. doi: 10.3389/fcimb.2017.00481. eCollection 2017. Review.


Suppressor of TCR signaling-2 (STS-2) suppresses arthritis development in mice.

Okabe N, Ohmura K, Katayama M, Akizuki S, Carpino N, Murakami K, Nakashima R, Hashimoto M, Imura Y, Yoshifuji H, Tanaka M, Mimori T.

Mod Rheumatol. 2018 Jul;28(4):626-636. doi: 10.1080/14397595.2017.1380249. Epub 2017 Oct 3.


Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2.

Zhou W, Yin Y, Weinheimer AS, Kaur N, Carpino N, French JB.

Biochemistry. 2017 Sep 5;56(35):4637-4645. doi: 10.1021/acs.biochem.7b00638. Epub 2017 Aug 21.


Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.

Parashar K, Kopping E, Frank D, Sampath V, Thanassi DG, Carpino N.

Infect Immun. 2017 Aug 18;85(9). pii: e00406-17. doi: 10.1128/IAI.00406-17. Print 2017 Sep.


TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk.

Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY.

J Biol Chem. 2017 Mar 10;292(10):4360. doi: 10.1074/jbc.A116.743732. No abstract available.


TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.

Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY.

J Biol Chem. 2016 Oct 21;291(43):22427-22441. Epub 2016 Sep 8. Erratum in: J Biol Chem. 2017 Mar 10;292(10 ):4360.


Negative regulation of TCR signaling by ubiquitination of Zap-70 Lys-217.

Ivanova E, Carpino N.

Mol Immunol. 2016 May;73:19-28. doi: 10.1016/j.molimm.2016.03.006. Epub 2016 Mar 28.


The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

Zhang J, Vakhrusheva O, Bandi SR, Demirel Ö, Kazi JU, Fernandes RG, Jakobi K, Eichler A, Rönnstrand L, Rieger MA, Carpino N, Serve H, Brandts CH.

Stem Cell Reports. 2015 Oct 13;5(4):633-46. doi: 10.1016/j.stemcr.2015.08.006. Epub 2015 Sep 10.


Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development.

Rella A, Mor V, Farnoud AM, Singh A, Shamseddine AA, Ivanova E, Carpino N, Montagna MT, Luberto C, Del Poeta M.

Front Microbiol. 2015 Aug 11;6:836. doi: 10.3389/fmicb.2015.00836. eCollection 2015.


Protection from systemic Candida albicans infection by inactivation of the Sts phosphatases.

Naseem S, Frank D, Konopka JB, Carpino N.

Infect Immun. 2015 Feb;83(2):637-45. doi: 10.1128/IAI.02789-14. Epub 2014 Nov 24.


Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo.

Newman TN, Liverani E, Ivanova E, Russo GL, Carpino N, Ganea D, Safadi F, Kunapuli SP, Tsygankov AY.

Immunol Cell Biol. 2014 Nov;92(10):837-50. doi: 10.1038/icb.2014.60. Epub 2014 Jul 22.


Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.

Cieniewicz B, Carpino N, Krug LT.

PLoS One. 2014 Feb 28;9(2):e90196. doi: 10.1371/journal.pone.0090196. eCollection 2014.


TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.

Back SH, Adapala NS, Barbe MF, Carpino NC, Tsygankov AY, Sanjay A.

Cell Mol Life Sci. 2013 Apr;70(7):1269-84. doi: 10.1007/s00018-012-1203-2. Epub 2012 Nov 13.


Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.

San Luis B, Sondgeroth B, Nassar N, Carpino N.

J Biol Chem. 2011 May 6;286(18):15943-54. doi: 10.1074/jbc.M110.177634. Epub 2011 Mar 10.


Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate.

Chen X, Ren L, Kim S, Carpino N, Daniel JL, Kunapuli SP, Tsygankov AY, Pei D.

J Biol Chem. 2010 Oct 8;285(41):31268-76. doi: 10.1074/jbc.M110.114181. Epub 2010 Jul 29.


A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.

Thomas DH, Getz TM, Newman TN, Dangelmaier CA, Carpino N, Kunapuli SP, Tsygankov AY, Daniel JL.

Blood. 2010 Oct 7;116(14):2570-8. doi: 10.1182/blood-2010-02-268136. Epub 2010 Jun 28.


The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate.

Jakoncic J, Sondgeroth B, Carpino N, Nassar N.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):643-7. doi: 10.1107/S1744309110014259. Epub 2010 May 25.


The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.

Carpino N, Chen Y, Nassar N, Oh HW.

Mol Immunol. 2009 Oct;46(16):3224-31. doi: 10.1016/j.molimm.2009.08.015. Epub 2009 Sep 5.


Structures of the phosphorylated and VO(3)-bound 2H-phosphatase domain of Sts-2.

Chen Y, Jakoncic J, Parker KA, Carpino N, Nassar N.

Biochemistry. 2009 Sep 1;48(34):8129-35. doi: 10.1021/bi9008648.


Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity.

Chen Y, Jakoncic J, Carpino N, Nassar N.

Biochemistry. 2009 Mar 3;48(8):1681-90. doi: 10.1021/bi802219n.


Structural and functional characterization of the c-terminal domain of the ecdysteroid phosphate phosphatase from bombyx mori reveals a new enzymatic activity.

Chen Y, Jakoncic J, Wang J, Zheng X, Carpino N, Nassar N.

Biochemistry. 2008 Nov 18;47(46):12135-45. doi: 10.1021/bi801318w. Epub 2008 Oct 21.


Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway.

Takahashi Y, Takahashi M, Carpino N, Jou ST, Chao JR, Tanaka S, Shigeyoshi Y, Parganas E, Ihle JN.

Mol Endocrinol. 2008 Jul;22(7):1673-81. doi: 10.1210/me.2008-0058. Epub 2008 May 1.


TULA proteins regulate activity of the protein tyrosine kinase Syk.

Agrawal R, Carpino N, Tsygankov A.

J Cell Biochem. 2008 Jun 1;104(3):953-64. doi: 10.1002/jcb.21678.


T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.

Collingwood TS, Smirnova EV, Bogush M, Carpino N, Annan RS, Tsygankov AY.

J Biol Chem. 2007 Oct 19;282(42):30920-8. Epub 2007 Aug 20.


A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling.

Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N.

Mol Cell. 2007 Aug 3;27(3):486-97.


Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1.

Kleinman H, Ford B, Keller J, Carpino N, Nassar N.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):218-20. Epub 2006 Feb 10.


Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.

Carpino N, Thierfelder WE, Chang MS, Saris C, Turner SJ, Ziegler SF, Ihle JN.

Mol Cell Biol. 2004 Mar;24(6):2584-92.


Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.

Carpino N, Turner S, Mekala D, Takahashi Y, Zang H, Geiger TL, Doherty P, Ihle JN.

Immunity. 2004 Jan;20(1):37-46.


SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation.

Takahashi Y, Carpino N, Cross JC, Torres M, Parganas E, Ihle JN.

EMBO J. 2003 Feb 3;22(3):372-84.


Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Carpino N, Wang D, Ihle JN.

Mol Cell Biol. 2002 Dec;22(24):8580-91.


Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein.

Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN.

Mol Cell Biol. 2002 Nov;22(21):7491-500.


The ornithine decarboxylase gene is essential for cell survival during early murine development.

Pendeville H, Carpino N, Marine JC, Takahashi Y, Muller M, Martial JA, Cleveland JL.

Mol Cell Biol. 2001 Oct;21(19):6549-58.


Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity.

Kashige N, Carpino N, Kobayashi R.

Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2093-8. Erratum in: Proc Natl Acad Sci U S A 2000 May 23;97(11):6236.


A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.

Wang D, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, Ihle JN.

EMBO J. 2000 Feb 1;19(3):392-9.


Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins.

Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD.

J Biol Chem. 1998 Feb 27;273(9):4827-30.


New understanding of the pathogenesis of CML: a prototype of early neoplasia.

Clarkson BD, Strife A, Wisniewski D, Lambek C, Carpino N.

Leukemia. 1997 Sep;11(9):1404-28. Review.


p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.

Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B.

Cell. 1997 Jan 24;88(2):197-204.

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