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Items: 1 to 50 of 97

1.

Short-term high glucose culture potentiates pancreatic beta cell function.

Rebelato E, Santos LR, Carpinelli AR, Rorsman P, Abdulkader F.

Sci Rep. 2018 Aug 30;8(1):13061. doi: 10.1038/s41598-018-31325-5.

2.

Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night.

Meneses-Santos D, Buonfiglio DDC, Peliciari-Garcia RA, Ramos-Lobo AM, Souza DDN, Carpinelli AR, Carvalho CRO, Sertie RAL, Andreotti S, Lima FB, Afeche SC, Fioretto ET, Cipolla-Neto J, Marçal AC.

Nat Sci Sleep. 2018 Jul 17;10:203-215. doi: 10.2147/NSS.S158602. eCollection 2018.

3.

Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia.

de Fatima Silva F, Ortiz-Silva M, Galia WBS, Cassolla P, da Silva FG, Graciano MFR, Carpinelli AR, de Souza HM.

Can J Physiol Pharmacol. 2018 May;96(5):498-505. doi: 10.1139/cjpp-2017-0171. Epub 2018 Jan 5.

PMID:
29304290
4.

Zinc Supplementation Improves Glucose Homeostasis in High Fat-Fed Mice by Enhancing Pancreatic β-Cell Function.

Cooper-Capetini V, de Vasconcelos DAA, Martins AR, Hirabara SM, Donato J Jr, Carpinelli AR, Abdulkader F.

Nutrients. 2017 Oct 20;9(10). pii: E1150. doi: 10.3390/nu9101150.

5.

Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats.

de Morais H, de Fatima Silva F, da Silva FG, Silva MO, Graciano MFR, Martins MIL, Carpinelli ÂR, Mazucco TL, Bazotte RB, de Souza HM.

Eur J Pharmacol. 2017 Jul 5;806:67-74. doi: 10.1016/j.ejphar.2017.03.010. Epub 2017 Apr 6.

PMID:
28390870
6.

Pioglitazone improves insulin sensitivity and reduces weight loss in Walker-256 tumor-bearing rats.

de Fatima Silva F, Ortiz-Silva M, de Souza Galia WB, Cassolla P, Graciano MF, Zaia CT, Zaia D, Carpinelli ÂR, da Silva FG, de Souza HM.

Life Sci. 2017 Feb 15;171:68-74. doi: 10.1016/j.lfs.2016.12.016. Epub 2016 Dec 26.

7.

Melatonin modifies basal and stimulated insulin secretion via NADPH oxidase.

Simões D, Riva P, Peliciari-Garcia RA, Cruzat VF, Graciano MF, Munhoz AC, Taneda M, Cipolla-Neto J, Carpinelli AR.

J Endocrinol. 2016 Dec;231(3):235-244.

PMID:
27803236
8.

L-Arginine supplementation improves insulin sensitivity and beta cell function in the offspring of diabetic rats through AKT and PDX-1 activation.

Carvalho DS, Diniz MM, Haidar AA, Cavanal MF, da Silva Alves E, Carpinelli AR, Gil FZ, Hirata AE.

Eur J Pharmacol. 2016 Nov 15;791:780-787. doi: 10.1016/j.ejphar.2016.10.001. Epub 2016 Oct 4.

PMID:
27717730
9.

NADPH oxidase-2 does not contribute to β-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice.

de Souza AH, Santos LRB, Roma LP, Bensellam M, Carpinelli AR, Jonas JC.

Mol Cell Endocrinol. 2017 Jan 5;439:354-362. doi: 10.1016/j.mce.2016.09.022. Epub 2016 Sep 22.

PMID:
27664519
10.

Control of Insulin Secretion by Production of Reactive Oxygen Species: Study Performed in Pancreatic Islets from Fed and 48-Hour Fasted Wistar Rats.

Munhoz AC, Riva P, Simões D, Curi R, Carpinelli AR.

PLoS One. 2016 Jun 30;11(6):e0158166. doi: 10.1371/journal.pone.0158166. eCollection 2016.

11.

Colonic Fermentation of Unavailable Carbohydrates from Unripe Banana and its Influence over Glycemic Control.

Dan MC, Cardenette GH, Sardá FA, Giuntini EB, Bello-Pérez LA, Carpinelli ÂR, Lajolo FM, Menezes EW.

Plant Foods Hum Nutr. 2015 Sep;70(3):297-303. doi: 10.1007/s11130-015-0493-6.

PMID:
26092708
12.

Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies.

Lucena CF, Roma LP, Graciano MF, Veras K, Simões D, Curi R, Carpinelli AR.

Pancreas. 2015 Mar;44(2):287-95. doi: 10.1097/MPA.0000000000000249.

PMID:
25426612
13.

DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet.

Veras K, Almeida FN, Nachbar RT, de Jesus DS, Camporez JP, Carpinelli AR, Goedecke JH, de Oliveira Carvalho CR.

FEBS Open Bio. 2014 Jan 18;4:141-6. doi: 10.1016/j.fob.2014.01.005. eCollection 2014.

14.

Long-term disruption of maternal glucose homeostasis induced by prenatal glucocorticoid treatment correlates with miR-29 upregulation.

Gomes PR, Graciano MF, Pantaleão LC, Rennó AL, Rodrigues SC, Velloso LA, Latorraca MQ, Carpinelli AR, Anhê GF, Bordin S.

Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E109-20. doi: 10.1152/ajpendo.00364.2013. Epub 2013 Nov 19.

15.

Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion.

Graciano MF, Valle MM, Curi R, Carpinelli AR.

Islets. 2013 Jul-Aug;5(4):139-48. doi: 10.4161/isl.25459. Epub 2013 Jun 28.

PMID:
23817296
16.

Oleic, linoleic and linolenic acids increase ros production by fibroblasts via NADPH oxidase activation.

Hatanaka E, Dermargos A, Hirata AE, Vinolo MA, Carpinelli AR, Newsholme P, Armelin HA, Curi R.

PLoS One. 2013 Apr 8;8(4):e58626. doi: 10.1371/journal.pone.0058626. Print 2013.

17.

Melatonin improves insulin sensitivity independently of weight loss in old obese rats.

Zanuto R, Siqueira-Filho MA, Caperuto LC, Bacurau RF, Hirata E, Peliciari-Garcia RA, do Amaral FG, Marçal AC, Ribeiro LM, Camporez JP, Carpinelli AR, Bordin S, Cipolla-Neto J, Carvalho CR.

J Pineal Res. 2013 Sep;55(2):156-65. doi: 10.1111/jpi.12056. Epub 2013 Apr 9.

PMID:
23565768
18.

Dual effect of advanced glycation end products in pancreatic islet apoptosis.

Costal F, Oliveira E, Raposo A, Machado-Lima A, Peixoto E, Roma L, Santos L, Lopes Faria JB, Carpinelli AR, Giannella-Neto D, Passarelli M, Correa-Giannella ML.

Diabetes Metab Res Rev. 2013 May;29(4):296-307. doi: 10.1002/dmrr.2390.

PMID:
23315923
19.

Fish oil supplementation for two generations increases insulin sensitivity in rats.

Hirabara SM, Folador A, Fiamoncini J, Lambertucci RH, Rodrigues CF Jr, Rocha MS, Aikawa J, Yamazaki RK, Martins AR, Rodrigues AC, Carpinelli AR, Pithon-Curi TC, Fernandes LC, Gorjão R, Curi R.

J Nutr Biochem. 2013 Jun;24(6):1136-45. doi: 10.1016/j.jnutbio.2012.08.014. Epub 2012 Dec 15.

PMID:
23246156
20.

Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets.

Marçal AC, Camporez JP, Lima-Salgado TM, Cintra DE, Akamine EH, Ribeiro LM, Almeida FN, Zanuto RP, Curi R, Boldrini SC, Liberti EA, Fiamoncini J, Hirabara SM, Deschamps FC, Carpinelli AR, Carvalho CR.

Br J Nutr. 2013 Jun 28;109(12):2154-65. doi: 10.1017/S0007114512004576. Epub 2012 Nov 27.

PMID:
23182275
21.

Maternal moderate physical training during pregnancy attenuates the effects of a low-protein diet on the impaired secretion of insulin in rats: potential role for compensation of insulin resistance and preventing gestational diabetes mellitus.

Leandro CG, Fidalgo M, Bento-Santos A, Falcão-Tebas F, Vasconcelos D, Manhães-de-Castro R, Carpinelli AR, Hirabara SM, Curi R.

J Biomed Biotechnol. 2012;2012:805418. doi: 10.1155/2012/805418. Epub 2012 Aug 13.

22.

Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration.

Marçal AC, Leonelli M, Fiamoncini J, Deschamps FC, Rodrigues MA, Curi R, Carpinelli AR, Britto LR, Carvalho CR.

Cell Biochem Funct. 2013 Jan;31(1):65-74. doi: 10.1002/cbf.2861. Epub 2012 Aug 23.

PMID:
22915345
23.

Expression of NADPH oxidase in human pancreatic islets.

Rebelato E, Mares-Guia TR, Graciano MF, Labriola L, Britto LR, Garay-Malpartida HM, Curi R, Sogayar MC, Carpinelli AR.

Life Sci. 2012 Sep 17;91(7-8):244-9. doi: 10.1016/j.lfs.2012.07.004. Epub 2012 Jul 17.

24.

Potential contribution of translational factors to triiodo-L-thyronine-induced insulin synthesis by pancreatic beta cells.

Goulart-Silva F, Teixeira Sda S, Luchessi AD, Dos Santos LR, Rebelato E, Carpinelli AR, Nunes MT.

Thyroid. 2012 Jun;22(6):637-42. doi: 10.1089/thy.2011.0252.

PMID:
22667453
25.

Cytotoxicity and cytoprotective effects of citrus flavonoids on insulin-secreting cells BRIN-BD11: beneficial synergic effects.

Felipe ET, Maestri JS, Kanunfre CC, Curi R, Newsholme P, Carpinelli AR, Oliveira-Emilio HR.

Nat Prod Res. 2013;27(10):925-8. doi: 10.1080/14786419.2012.671315. Epub 2012 Mar 26.

PMID:
22443082
26.

Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment.

de Oliveira AC, Andreotti S, Farias Tda S, Torres-Leal FL, de Proença AR, Campaña AB, de Souza AH, Sertié RA, Carpinelli AR, Cipolla-Neto J, Lima FB.

Endocrinology. 2012 May;153(5):2178-88. doi: 10.1210/en.2011-1675. Epub 2012 Feb 28.

PMID:
22374967
27.

Angiotensin II-induced JNK activation is mediated by NAD(P)H oxidase in isolated rat pancreatic islets.

Alves ES, Haidar AA, Quadros CD, Carvalho DS, Morgan D, Rocha MS, Curi R, Carpinelli AR, Hirata AE.

Regul Pept. 2012 Apr 10;175(1-3):1-6. doi: 10.1016/j.regpep.2012.01.003. Epub 2012 Jan 25.

28.

Control of the intracellular redox state by glucose participates in the insulin secretion mechanism.

Rebelato E, Abdulkader F, Curi R, Carpinelli AR.

PLoS One. 2011;6(8):e24507. doi: 10.1371/journal.pone.0024507. Epub 2011 Aug 31.

29.

Oleic acid modulates metabolic substrate channeling during glucose-stimulated insulin secretion via NAD(P)H oxidase.

Santos LR, Rebelato E, Graciano MF, Abdulkader F, Curi R, Carpinelli AR.

Endocrinology. 2011 Oct;152(10):3614-21. doi: 10.1210/en.2011-0127. Epub 2011 Aug 9.

PMID:
21828179
30.

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets.

Graciano MF, Valle MM, Kowluru A, Curi R, Carpinelli AR.

Islets. 2011 Sep-Oct;3(5):213-23. Epub 2011 Sep 1. Review.

PMID:
21750413
31.

Alterations of NADPH oxidase activity in rat pancreatic islets induced by a high-fat diet.

Valle MM, Graciano MF, Lopes de Oliveira ER, Camporez JP, Akamine EH, Carvalho CR, Curi R, Carpinelli AR.

Pancreas. 2011 Apr;40(3):390-5. doi: 10.1097/MPA.0b013e31820569d0.

PMID:
21206327
32.

NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets.

Graciano MF, Santos LR, Curi R, Carpinelli AR.

J Cell Physiol. 2011 Apr;226(4):1110-7. doi: 10.1002/jcp.22432.

PMID:
20857410
33.

Low doses of hydrogen peroxide impair glucose-stimulated insulin secretion via inhibition of glucose metabolism and intracellular calcium oscillations.

Rebelato E, Abdulkader F, Curi R, Carpinelli AR.

Metabolism. 2010 Mar;59(3):409-13. doi: 10.1016/j.metabol.2009.08.010. Epub 2009 Oct 2.

PMID:
19800636
34.

Short-term modulation of extracellular signal-regulated kinase 1/2 and stress-activated protein kinase/c-Jun NH2-terminal kinase in pancreatic islets by glucose and palmitate: possible involvement of ceramide.

Nogueira TC, Graciano MF, Anhê GF, Curi R, Bordin S, Carpinelli AR.

Pancreas. 2009 Jul;38(5):585-92. doi: 10.1097/MPA.0b013e31819fef03.

PMID:
19295452
35.

Palmitate activates insulin signaling pathway in pancreatic rat islets.

Graciano MF, Nogueira TC, Carvalho CR, Curi R, Carpinelli AR.

Pancreas. 2009 Jul;38(5):578-84. doi: 10.1097/MPA.0b013e31819e65d1.

PMID:
19287336
36.

Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells.

Morgan D, Rebelato E, Abdulkader F, Graciano MF, Oliveira-Emilio HR, Hirata AE, Rocha MS, Bordin S, Curi R, Carpinelli AR.

Endocrinology. 2009 May;150(5):2197-201. doi: 10.1210/en.2008-1149. Epub 2009 Jan 15.

PMID:
19147679
37.

Angiotensin II induces superoxide generation via NAD(P)H oxidase activation in isolated rat pancreatic islets.

Hirata AE, Morgan D, Oliveira-Emilio HR, Rocha MS, Carvalho CR, Curi R, Carpinelli AR.

Regul Pept. 2009 Feb 25;153(1-3):1-6. doi: 10.1016/j.regpep.2008.11.004. Epub 2008 Nov 27.

PMID:
19081082
38.

Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion.

Nogueira TC, Anhê GF, Carvalho CR, Curi R, Bordin S, Carpinelli AR.

Pancreas. 2008 Oct;37(3):309-15. doi: 10.1097/mpa.0b013e318168dac3.

PMID:
18815554
39.

Activation of insulin and IGF-1 signaling pathways by melatonin through MT1 receptor in isolated rat pancreatic islets.

Picinato MC, Hirata AE, Cipolla-Neto J, Curi R, Carvalho CR, Anhê GF, Carpinelli AR.

J Pineal Res. 2008 Jan;44(1):88-94.

PMID:
18078453
40.

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R.

J Physiol. 2007 Aug 15;583(Pt 1):9-24. Epub 2007 Jun 21. Review.

41.

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line.

Morgan D, Oliveira-Emilio HR, Keane D, Hirata AE, Santos da Rocha M, Bordin S, Curi R, Newsholme P, Carpinelli AR.

Diabetologia. 2007 Feb;50(2):359-69. Epub 2006 Dec 7.

PMID:
17151863
42.

ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion.

Anhê GF, Torrão AS, Nogueira TC, Caperuto LC, Amaral ME, Medina MC, Azevedo-Martins AK, Carpinelli AR, Carvalho CR, Curi R, Boschero AC, Bordin S.

Mol Cell Endocrinol. 2006 Jun 7;251(1-2):33-41. Epub 2006 Apr 4.

PMID:
16597486
43.

New insights into fatty acid modulation of pancreatic beta-cell function.

Haber EP, Procópio J, Carvalho CR, Carpinelli AR, Newsholme P, Curi R.

Int Rev Cytol. 2006;248:1-41. Review.

PMID:
16487789
44.

Propionate inhibits glucose-induced insulin secretion in isolated rat pancreatic islets.

Ximenes HM, Hirata AE, Rocha MS, Curi R, Carpinelli AR.

Cell Biochem Funct. 2007 Mar-Apr;25(2):173-8.

PMID:
16444779
45.

Dehydroepiandrosterone increases beta-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats.

Medina MC, Souza LC, Caperuto LC, Anhê GF, Amanso AM, Teixeira VP, Bordin S, Carpinelli AR, Britto LR, Barbieri RL, Borella MI, Carvalho CR.

FEBS Lett. 2006 Jan 9;580(1):285-90. Epub 2005 Dec 19. Erratum in: FEBS Lett. 2006 Feb 20;580(5):1528.

46.

Perinatal salt restriction: a new pathway to programming insulin resistance and dyslipidemia in adult wistar rats.

Vidonho AF Jr, da Silva AA, Catanozi S, Rocha JC, Beutel A, Carillo BA, Furukawa LN, Campos RR, de Toledo Bergamaschi CM, Carpinelli AR, Quintão EC, Dolnikoff MS, Heimann JC.

Pediatr Res. 2004 Dec;56(6):842-8. Epub 2004 Oct 6.

PMID:
15470199
47.

Changes of fatty acid composition in incubated rat pancreatic islets.

Martins EF, Miyasaka CK, Newsholme P, Curi R, Carpinelli AR.

Diabetes Metab. 2004 Feb;30(1):21-7.

PMID:
15029094
48.

Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets.

Haber EP, Hirabara SM, Gomes AD, Curi R, Carpinelli AR, Carvalho CR.

FEBS Lett. 2003 Jun 5;544(1-3):185-8.

49.

Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase.

Oliveira HR, Verlengia R, Carvalho CR, Britto LR, Curi R, Carpinelli AR.

Diabetes. 2003 Jun;52(6):1457-63.

50.

Insulin secretion induced by palmitate--a process fully dependent on glucose concentration.

Carpinelli AR, Picinato MC, Stevanato E, Oliveira HR, Curi R.

Diabetes Metab. 2002 Dec;28(6 Pt 2):3S37-44; discussion 3S108-12.

PMID:
12688632

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