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Items: 1 to 50 of 52

1.

Lack of anti-tumor activity with the β-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis.

Hasson RM, Briggs A, Rizvi H, Carothers AM, Davids JS, Bertagnolli MM, Cho NL.

Biochem Biophys Res Commun. 2014 Feb 14;444(3):283-9. doi: 10.1016/j.bbrc.2013.11.135. Epub 2014 Jan 31.

PMID:
24486542
2.

Estrogen receptor α or β loss in the colon of Min/+ mice promotes crypt expansion and impairs TGFβ and HNF3β signaling.

Hasson RM, Briggs A, Carothers AM, Davids JS, Wang J, Javid SH, Cho NL, Bertagnolli MM.

Carcinogenesis. 2014 Jan;35(1):96-102. doi: 10.1093/carcin/bgt323. Epub 2013 Oct 8.

3.

Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors.

Carothers AM, Rizvi H, Hasson RM, Heit YI, Davids JS, Bertagnolli MM, Cho NL.

Cancer Res. 2012 Jan 1;72(1):346-55. doi: 10.1158/0008-5472.CAN-11-2819. Epub 2011 Nov 17.

4.

Immunohistochemical and molecular analysis of tyrosine kinase activity in desmoid tumors.

Cho NL, Carothers AM, Rizvi H, Hasson RM, Redston M, Bertagnolli MM.

J Surg Res. 2012 Apr;173(2):320-6. doi: 10.1016/j.jss.2010.10.037. Epub 2010 Nov 26.

PMID:
21195420
5.

Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis.

Carothers AM, Davids JS, Damas BC, Bertagnolli MM.

Cancer Res. 2010 Jun 1;70(11):4433-42. doi: 10.1158/0008-5472.CAN-09-4289. Epub 2010 May 18.

6.

Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation.

Cho NL, Lin CI, Whang EE, Carothers AM, Moore FD Jr, Ruan DT.

Thyroid. 2010 Jun;20(6):615-22. doi: 10.1089/thy.2009.0415.

PMID:
20470206
7.

Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis.

Davids JS, Carothers AM, Damas BC, Bertagnolli MM.

Cancer Prev Res (Phila). 2010 Mar;3(3):348-58. doi: 10.1158/1940-6207.CAPR-09-0146. Epub 2010 Feb 23.

8.

Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer.

Lin CI, Whang EE, Donner DB, Jiang X, Price BD, Carothers AM, Delaine T, Leffler H, Nilsson UJ, Nose V, Moore FD Jr, Ruan DT.

Mol Cancer Res. 2009 Oct;7(10):1655-62. doi: 10.1158/1541-7786.MCR-09-0274. Epub 2009 Oct 13.

9.

Aberrant crypt foci in the adenoma prevention with celecoxib trial.

Cho NL, Redston M, Zauber AG, Carothers AM, Hornick J, Wilton A, Sontag S, Nishioka N, Giardiello FM, Saltzman JR, Gostout C, Eagle CJ, Hawk ET, Bertagnolli MM.

Cancer Prev Res (Phila). 2008 Jun;1(1):21-31. doi: 10.1158/1940-6207.CAPR-07-0011. Epub 2008 Apr 14.

10.

Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice.

Cho NL, Javid SH, Carothers AM, Redston M, Bertagnolli MM.

Cancer Res. 2007 Mar 1;67(5):2366-72.

11.

Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor.

Carothers AM, Moran AE, Cho NL, Redston M, Bertagnolli MM.

Cancer Res. 2006 Jun 15;66(12):6432-8.

12.

Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.

Carothers AM, Javid SH, Moran AE, Hunt DH, Redston M, Bertagnolli MM.

Exp Cell Res. 2006 Feb 15;312(4):387-400.

PMID:
16368433
13.

Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea.

Ju J, Hong J, Zhou JN, Pan Z, Bose M, Liao J, Yang GY, Liu YY, Hou Z, Lin Y, Ma J, Shih WJ, Carothers AM, Yang CS.

Cancer Res. 2005 Nov 15;65(22):10623-31.

14.

Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse.

Moran AE, Carothers AM, Weyant MJ, Redston M, Bertagnolli MM.

Cancer Res. 2005 Feb 1;65(3):1097-104.

15.

Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.

Javid SH, Moran AE, Carothers AM, Redston M, Bertagnolli MM.

Carcinogenesis. 2005 Mar;26(3):587-95. Epub 2004 Dec 3.

PMID:
15579483
16.

Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.

Moran AE, Hunt DH, Javid SH, Redston M, Carothers AM, Bertagnolli MM.

J Biol Chem. 2004 Oct 8;279(41):43261-72. Epub 2004 Aug 4.

17.

Adenomatous polyposis coli truncation alters cytoskeletal structure and microtubule stability in early intestinal tumorigenesis.

Hughes SA, Carothers AM, Hunt DH, Moran AE, Mueller JD, Bertagnolli MM.

J Gastrointest Surg. 2002 Nov-Dec;6(6):868-74; discussion 875.

PMID:
12504226
18.

2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells.

Carothers AM, Hughes SA, Ortega D, Bertagnolli MM.

Cancer Lett. 2002 Dec 10;187(1-2):77-86.

PMID:
12359354
19.

Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice.

Carothers AM, Melstrom KA Jr, Mueller JD, Weyant MJ, Bertagnolli MM.

J Biol Chem. 2001 Oct 19;276(42):39094-102. Epub 2001 Aug 1.

20.

Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis.

Weyant MJ, Carothers AM, Mahmoud NN, Bradlow HL, Remotti H, Bilinski RT, Bertagnolli MM.

Cancer Res. 2001 Mar 15;61(6):2547-51.

21.

(+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse.

Weyant MJ, Carothers AM, Dannenberg AJ, Bertagnolli MM.

Cancer Res. 2001 Jan 1;61(1):118-25.

22.

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis.

Mahmoud NN, Carothers AM, Grunberger D, Bilinski RT, Churchill MR, Martucci C, Newmark HL, Bertagnolli MM.

Carcinogenesis. 2000 May;21(5):921-7.

PMID:
10783313
23.

Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways.

Weyant MJ, Carothers AM, Bertagnolli ME, Bertagnolli MM.

Clin Cancer Res. 2000 Mar;6(3):949-56.

24.

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.

Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ.

Cancer Res. 1999 May 15;59(10):2347-52.

25.
26.
27.

Hydroxylated aromatic inhibitors of HIV-1 integrase.

Burke TR Jr, Fesen MR, Mazumder A, Wang J, Carothers AM, Grunberger D, Driscoll J, Kohn K, Pommier Y.

J Med Chem. 1995 Oct 13;38(21):4171-8.

PMID:
7473544
28.

Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells.

Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, Barrett JC.

Cancer Res. 1995 Aug 15;55(16):3576-83.

29.
31.

A mutational hot spot induced by N-hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells.

Carothers AM, Urlaub G, Mucha J, Yuan W, Chasin LA, Grunberger D.

Carcinogenesis. 1993 Oct;14(10):2181-4.

PMID:
8222072
32.

Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells.

Carothers AM, Urlaub G, Grunberger D, Chasin LA.

Mol Cell Biol. 1993 Aug;13(8):5085-98.

33.

DNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene.

Carothers AM, Zhen W, Mucha J, Zhang YJ, Santella RM, Grunberger D, Bohr VA.

Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11925-9.

35.

Splicing mutations in the CHO DHFR gene preferentially induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene.

Carothers AM, Urlaub G, Mucha J, Harvey RG, Chasin LA, Grunberger D.

Proc Natl Acad Sci U S A. 1990 Jul;87(14):5464-8.

36.

RNA processing mutants at the dihydrofolate reductase locus in Chinese hamster ovary cells.

Chasin LA, Urlaub G, Mitchell P, Ciudad C, Barth J, Carothers AM, Steigerwalt R, Grunberger D.

Prog Clin Biol Res. 1990;340A:295-304. No abstract available.

PMID:
2388917
37.
38.

DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells.

Carothers AM, Steigerwalt RW, Urlaub G, Chasin LA, Grunberger D.

J Mol Biol. 1989 Aug 5;208(3):417-28.

PMID:
2477551
39.

Point mutation analysis in a mammalian gene: rapid preparation of total RNA, PCR amplification of cDNA, and Taq sequencing by a novel method.

Carothers AM, Urlaub G, Mucha J, Grunberger D, Chasin LA.

Biotechniques. 1989 May;7(5):494-6, 498-9.

PMID:
2483818
40.

Mapping and characterization of mutations induced by benzo[a]pyrene diol epoxide at dihydrofolate reductase locus in CHO cells.

Carothers AM, Urlaub G, Grunberger D, Chasin LA.

Somat Cell Mol Genet. 1988 Mar;14(2):169-83.

PMID:
2831629
41.

Repetitive cloning of mutant genes using locus-specific sticky ends.

Chasin LA, Carothers AM, Urlaub G.

Methods Enzymol. 1987;151:449-60. No abstract available.

PMID:
2828835
42.

Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells.

Carothers AM, Urlaub G, Steigerwalt RW, Chasin LA, Grunberger D.

Proc Natl Acad Sci U S A. 1986 Sep;83(17):6519-23.

43.

Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.

Mitchell PJ, Carothers AM, Han JH, Harding JD, Kas E, Venolia L, Chasin LA.

Mol Cell Biol. 1986 Feb;6(2):425-40.

44.
45.
46.

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells.

Urlaub G, Käs E, Carothers AM, Chasin LA.

Cell. 1983 Jun;33(2):405-12.

PMID:
6305508
47.

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells.

Carothers AM, Urlaub G, Ellis N, Chasin LA.

Nucleic Acids Res. 1983 Apr 11;11(7):1997-2012.

48.

Position effect on expression of dsd genes cloned onto multicopy plasmids.

Carothers AM, Heincz MC, McFall E.

J Bacteriol. 1980 Apr;142(1):185-90.

49.

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