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Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression.

Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG.

Gastroenterology. 2019 Apr 25. pii: S0016-5085(19)36715-0. doi: 10.1053/j.gastro.2019.04.022. [Epub ahead of print]


Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept.

Jacobsen JPR, Oh A, Bangle R, Roberts WL, Royer EL, Modesto N, Windermere SA, Yi Z, Vernon R, Cajina M, Urs NM, Snyder JC, Nicholls PJ, Sachs BD, Caron MG.

Neuropsychopharmacology. 2019 Apr 29. doi: 10.1038/s41386-019-0400-1. [Epub ahead of print]


A Brief History of the β-Arrestins.

Caron MG, Barak LS.

Methods Mol Biol. 2019;1957:3-8. doi: 10.1007/978-1-4939-9158-7_1.


Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists.

Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs N, McCorvy JD, Caron MG, Roth BL, Jin J.

J Med Chem. 2019 Apr 11;62(7):3753-3772. doi: 10.1021/acs.jmedchem.9b00351. Epub 2019 Mar 27.


hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.

Mackie DI, Al Mutairi F, Davis RB, Kechele DO, Nielsen NR, Snyder JC, Caron MG, Kliman HJ, Berg JS, Simms J, Poyner DR, Caron KM.

J Exp Med. 2018 Sep 3;215(9):2339-2353. doi: 10.1084/jem.20180528. Epub 2018 Aug 16.


Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.

Hultman R, Ulrich K, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K.

Cell. 2018 Mar 22;173(1):166-180.e14. doi: 10.1016/j.cell.2018.02.012.


The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.

Pack TF, Orlen MI, Ray C, Peterson SM, Caron MG.

J Biol Chem. 2018 Apr 20;293(16):6161-6171. doi: 10.1074/jbc.RA117.001300. Epub 2018 Feb 27.


Brain-region-specific Molecular Responses to Maternal Separation and Social Defeat Stress in Mice.

Sachs BD, Tran HL, Folse E, Caron MG.

Neuroscience. 2018 Mar 1;373:122-136. doi: 10.1016/j.neuroscience.2018.01.018. Epub 2018 Jan 16.


Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.

Beraldo FH, Ostapchenko VG, Xu JZ, Di Guglielmo GM, Fan J, Nicholls PJ, Caron MG, Prado VF, Prado MAM.

J Neurochem. 2018 Apr;145(1):68-79. doi: 10.1111/jnc.14281. Epub 2018 Jan 12.


Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.

Rose SJ, Pack TF, Peterson SM, Payne K, Borrelli E, Caron MG.

Neuropsychopharmacology. 2018 Apr;43(5):1164-1173. doi: 10.1038/npp.2017.254. Epub 2017 Oct 25.


Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.

Toth K, Slosky LM, Pack TF, Urs NM, Boone P, Mao L, Abraham D, Caron MG, Barak LS.

Synapse. 2018 Jan;72(1). doi: 10.1002/syn.22012. Epub 2017 Oct 7.


Design, synthesis and biological evaluation of GPR55 agonists.

Fakhouri L, Cook CD, Al-Huniti MH, Console-Bram LM, Hurst DP, Spano MBS, Nasrallah DJ, Caron MG, Barak LS, Reggio PH, Abood ME, Croatt MP.

Bioorg Med Chem. 2017 Aug 15;25(16):4355-4367. doi: 10.1016/j.bmc.2017.06.016. Epub 2017 Jun 13.


Hepatic β-arrestin 2 is essential for maintaining euglycemia.

Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J.

J Clin Invest. 2017 Aug 1;127(8):2941-2945. doi: 10.1172/JCI92913. Epub 2017 Jun 26.


Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.

Snyder JC, Rochelle LK, Ray C, Pack TF, Bock CB, Lubkov V, Lyerly HK, Waggoner AS, Barak LS, Caron MG.

J Biol Chem. 2017 Apr 28;292(17):7208-7222. doi: 10.1074/jbc.M116.756635. Epub 2017 Mar 8.


Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

Le Gonidec S, Chaves-Almagro C, Bai Y, Kang HJ, Smith A, Wanecq E, Huang XP, Prats H, Knibiehler B, Roth BL, Barak LS, Caron MG, Valet P, Audigier Y, Masri B.

FASEB J. 2017 Jun;31(6):2507-2519. doi: 10.1096/fj.201601074R. Epub 2017 Feb 27.


β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.

Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J.

Nat Commun. 2017 Feb 1;8:14295. doi: 10.1038/ncomms14295.


Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands.

Ray C, Soderblom EJ, Bai Y, Carroll FI, Caron MG, Barak LS.

ACS Chem Biol. 2017 Mar 17;12(3):702-714. doi: 10.1021/acschembio.6b01117. Epub 2017 Jan 24.


Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.

Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186. Epub 2016 Dec 1.


New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy.

Urs NM, Peterson SM, Caron MG.

Biol Psychiatry. 2017 Jan 1;81(1):78-85. doi: 10.1016/j.biopsych.2016.10.011. Epub 2016 Oct 19. Review.


Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.

Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG.

Trends Pharmacol Sci. 2016 Nov;37(11):933-944. doi: 10.1016/ Epub 2016 Sep 28. Review.


ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.

Barak LS, Bai Y, Peterson S, Evron T, Urs NM, Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Chung TD, Rodriguiz RM, Wetsel WC, Thomas JB, Hanson GR, Pinkerton AB, Caron MG.

ACS Chem Biol. 2016 Jul 15;11(7):1880-90. doi: 10.1021/acschembio.6b00291. Epub 2016 May 5.


Structural biology: Antidepressants at work.

Caron MG, Gether U.

Nature. 2016 Apr 21;532(7599):320-1. doi: 10.1038/nature17883. Epub 2016 Apr 6. No abstract available.


SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept.

Jacobsen JP, Rudder ML, Roberts W, Royer EL, Robinson TJ, Oh A, Spasojevic I, Sachs BD, Caron MG.

Neuropsychopharmacology. 2016 Aug;41(9):2324-34. doi: 10.1038/npp.2016.35. Epub 2016 Mar 2.


Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.

Meza-Aviña ME, Lingerfelt MA, Console-Bram LM, Gamage TF, Sharir H, Gettys KE, Hurst DP, Kotsikorou E, Shore DM, Caron MG, Rao N, Barak LS, Abood ME, Reggio PH, Croatt MP.

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1827-1830. doi: 10.1016/j.bmcl.2016.02.030. Epub 2016 Feb 16.


A rapid and affordable screening platform for membrane protein trafficking.

Snyder JC, Pack TF, Rochelle LK, Chakraborty SK, Zhang M, Eaton AW, Bai Y, Ernst LA, Barak LS, Waggoner AS, Caron MG.

BMC Biol. 2015 Dec 17;13:107. doi: 10.1186/s12915-015-0216-3.


Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.

Peterson SM, Pack TF, Caron MG.

PLoS One. 2015 Oct 30;10(10):e0141637. doi: 10.1371/journal.pone.0141637. eCollection 2015.


Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.

Sutton LP, Caron MG.

Neuropharmacology. 2015 Dec;99:610-9. doi: 10.1016/j.neuropharm.2015.08.024. Epub 2015 Aug 24.


Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.

Park SM, Chen M, Schmerberg CM, Dulman RS, Rodriguiz RM, Caron MG, Jin J, Wetsel WC.

Neuropsychopharmacology. 2016 Feb;41(3):704-15. doi: 10.1038/npp.2015.196. Epub 2015 Jul 1.


Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.

Peterson SM, Pack TF, Wilkins AD, Urs NM, Urban DJ, Bass CE, Lichtarge O, Caron MG.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7097-102. doi: 10.1073/pnas.1502742112. Epub 2015 May 11.


Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.

Urs NM, Bido S, Peterson SM, Daigle TL, Bass CE, Gainetdinov RR, Bezard E, Caron MG.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2517-26. doi: 10.1073/pnas.1502740112. Epub 2015 Apr 27.


Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions.

Gao Y, Peterson S, Masri B, Hougland MT, Adham N, Gyertyán I, Kiss B, Caron MG, El-Mallakh RS.

Pharmacol Res Perspect. 2015 Feb;3(1):e00073. doi: 10.1002/prp2.73. Epub 2014 Dec 2.


Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA.

Mol Psychiatry. 2015 Nov;20(11):1479-80. doi: 10.1038/mp.2015.8. Epub 2015 Feb 17. No abstract available.


Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress.

Sachs BD, Ni JR, Caron MG.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2557-62. doi: 10.1073/pnas.1416866112. Epub 2015 Feb 9.


Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.

Snyder JC, Rochelle LK, Marion S, Lyerly HK, Barak LS, Caron MG.

J Cell Sci. 2015 Mar 15;128(6):1230-40. doi: 10.1242/jcs.166322. Epub 2015 Feb 4.


Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.

Sachs BD, Rodriguiz RM, Tran HL, Iyer A, Wetsel WC, Caron MG.

Psychoneuroendocrinology. 2015 Mar;53:69-81. doi: 10.1016/j.psyneuen.2014.12.019. Epub 2015 Jan 6.


Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice.

Sachs BD, Caron MG.

Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu029. doi: 10.1093/ijnp/pyu029.


Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF 3rd, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA.

Mol Psychiatry. 2015 Nov;20(11):1406-19. doi: 10.1038/mp.2014.167. Epub 2015 Jan 6. Erratum in: Mol Psychiatry. 2015 Nov;20(11):1479-80.


Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.

Burczyk M, Burkhalter MD, Blätte T, Matysik S, Caron MG, Barak LS, Philipp M.

Biochemistry. 2015 Jan 27;54(3):765-75. doi: 10.1021/bi501061h. Epub 2015 Jan 15.


Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, Salahpour A.

Neurobiol Dis. 2015 Feb;74:66-75. doi: 10.1016/j.nbd.2014.10.016. Epub 2014 Oct 30.


G Protein and β-arrestin signaling bias at the ghrelin receptor.

Evron T, Peterson SM, Urs NM, Bai Y, Rochelle LK, Caron MG, Barak LS.

J Biol Chem. 2014 Nov 28;289(48):33442-55. doi: 10.1074/jbc.M114.581397. Epub 2014 Sep 26.


Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.

Philipp M, Berger IM, Just S, Caron MG.

J Biol Chem. 2014 Sep 19;289(38):26119-30. doi: 10.1074/jbc.M114.551952. Epub 2014 Aug 7.


Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.


The physiological relevance of functional selectivity in dopamine signalling.

Urs NM, Caron MG.

Int J Obes Suppl. 2014 Jul;4(Suppl 1):S5-8. doi: 10.1038/ijosup.2014.3. Epub 2014 Jul 8. Review.


The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.

Jacobsen JP, Plenge P, Sachs BD, Pehrson AL, Cajina M, Du Y, Roberts W, Rudder ML, Dalvi P, Robinson TJ, O'Neill SP, Khoo KS, Morillo CS, Zhang X, Caron MG.

Psychopharmacology (Berl). 2014 Dec;231(23):4527-40. doi: 10.1007/s00213-014-3595-1. Epub 2014 May 9.


Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission.

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG.

Neuropsychopharmacology. 2014 Sep;39(10):2450-62. doi: 10.1038/npp.2014.97. Epub 2014 Apr 29.


Integrated approaches to understanding antipsychotic drug action at GPCRs.

Urs NM, Nicholls PJ, Caron MG.

Curr Opin Cell Biol. 2014 Apr;27:56-62. doi: 10.1016/ Epub 2013 Dec 14. Review.


Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein.

Marion S, Urs NM, Peterson SM, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Caron MG.

J Biol Chem. 2014 Apr 25;289(17):11715-24. doi: 10.1074/jbc.M113.544312. Epub 2014 Mar 11.


Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Li Y, Milewski M, Gosalia P, Gray W, Mehta A, Sugarman E, Hood B, Suyama E, Nguyen K, Heynen-Genel S, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Roth GP, Smith LH, Chung TD, Hanson GR, Thomas JB, Caron MG, Barak LS, Pinkerton AB.

ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.


Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists).

Hershberger P, Hedrick M, Peddibhotla S, Maloney P, Li Y, Milewski M, Gosalia P, Gray W, Mehta A, Sugarman E, Hood B, Suyama E, Nguyen K, Heynen-Genel S, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Smith LH, Roth G, Diwan J, Chung TDY, Caron MG, Thomas JB, Pinkerton AB, Barak LR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 8 [updated 2013 Mar 7].


Sex differences in response to chronic mild stress and congenital serotonin deficiency.

Sachs BD, Ni JR, Caron MG.

Psychoneuroendocrinology. 2014 Feb;40:123-9. doi: 10.1016/j.psyneuen.2013.11.008. Epub 2013 Nov 19.

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