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Items: 1 to 50 of 82

1.

Enhancement of Cardiac Store Operated Calcium Entry (SOCE) within Novel Intercalated Disk Microdomains in Arrhythmic Disease.

Bonilla IM, Belevych AE, Baine S, Stepanov A, Mezache L, Bodnar T, Liu B, Volpe P, Priori S, Weisleder N, Sakuta G, Carnes CA, Radwański PB, Veeraraghavan R, Gyorke S.

Sci Rep. 2019 Jul 15;9(1):10179. doi: 10.1038/s41598-019-46427-x.

2.

Development and validation of a UPLC-MS/MS analytical method for dofetilide in mouse plasma and urine, and its application to pharmacokinetic study.

Uddin ME, Sun X, Huang KM, Hu S, Carnes CA, Sparreboom A, Fu Q.

J Pharm Biomed Anal. 2019 Aug 5;172:183-188. doi: 10.1016/j.jpba.2019.04.041. Epub 2019 Apr 19.

PMID:
31055183
3.

The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis.

Györke S, Belevych AE, Liu B, Kubasov IV, Carnes CA, Radwański PB.

J Gen Physiol. 2017 Sep 4;149(9):877-888. doi: 10.1085/jgp.201711808. Epub 2017 Aug 10. Review. No abstract available.

4.

The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts.

Belevych AE, Ho HT, Bonilla IM, Terentyeva R, Schober KE, Terentyev D, Carnes CA, Györke S.

Basic Res Cardiol. 2017 Jul;112(4):44. doi: 10.1007/s00395-017-0633-2. Epub 2017 Jun 13.

5.

Evaluation of a pharmacist-managed electrolyte protocol in outpatients on antiarrhythmic medications.

Long VP III, Carnes CA, Vecchiet J, Houmsse M, Hirsch A, Snider MJ.

J Am Pharm Assoc (2003). 2017 Jul - Aug;57(4):526-531. doi: 10.1016/j.japh.2017.05.001. Epub 2017 Jun 10.

PMID:
28610942
6.

In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood.

Tanwar V, Gorr MW, Velten M, Eichenseer CM, Long VP 3rd, Bonilla IM, Shettigar V, Ziolo MT, Davis JP, Baine SH, Carnes CA, Wold LE.

J Am Heart Assoc. 2017 Apr 11;6(4). pii: e005796. doi: 10.1161/JAHA.117.005796.

7.

Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II.

Ho HT, Belevych AE, Liu B, Bonilla IM, Radwański PB, Kubasov IV, Valdivia HH, Schober K, Carnes CA, Györke S.

Hypertension. 2016 Nov;68(5):1171-1178. Epub 2016 Sep 19. Review.

8.

Chronic Omega-3 Polyunsaturated Fatty Acid Treatment Variably Affects Cellular Repolarization in a Healed Post-MI Arrhythmia Model.

Bonilla IM, Nishijima Y, Vargas-Pinto P, Baine SH, Sridhar A, Li C, Billman GE, Carnes CA.

Front Physiol. 2016 Jun 14;7:225. doi: 10.3389/fphys.2016.00225. eCollection 2016.

9.

"Know Hepatitis B:" A Multilingual Communications Campaign Promoting Testing for Hepatitis B Among Asian Americans and Pacific Islanders.

Jorgensen C, Chen S, Carnes CA, Block J, Chen D, Caballero J, Moraras K, Cohen C.

Public Health Rep. 2016 May-Jun;131 Suppl 2:35-40.

10.
11.

Dysfunction of the β2-spectrin-based pathway in human heart failure.

Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1583-91. doi: 10.1152/ajpheart.00875.2015. Epub 2016 Apr 22.

12.

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ.

Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876.

13.

Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.

Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PM, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ.

J Am Heart Assoc. 2015 May 26;4(5). pii: e001762. doi: 10.1161/JAHA.114.001762.

14.

Treating cocaine cardiotoxicity: Does receptor subtype matter?

Long VP 3rd, Carnes CA.

Trends Cardiovasc Med. 2015 Aug;25(6):527-8. doi: 10.1016/j.tcm.2015.01.001. Epub 2015 Jan 12. No abstract available.

PMID:
25682914
15.

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wei Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PM, Kilic A, Higgins RS, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ.

Circulation. 2015 Feb 24;131(8):695-708. doi: 10.1161/CIRCULATIONAHA.114.013708. Epub 2015 Jan 28.

16.

Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling.

Long VP 3rd, Bonilla IM, Vargas-Pinto P, Nishijima Y, Sridhar A, Li C, Mowrey K, Wright P, Velayutham M, Kumar S, Lee NY, Zweier JL, Mohler PJ, Györke S, Carnes CA.

Life Sci. 2015 Feb 15;123:61-71. doi: 10.1016/j.lfs.2014.12.024. Epub 2015 Jan 14.

17.

What is the role of pharmacogenetics in optimization of warfarin dosing?

Carnes CA.

Trends Cardiovasc Med. 2015 Jan;25(1):42-3. doi: 10.1016/j.tcm.2014.10.003. Epub 2014 Oct 17. No abstract available.

PMID:
25476743
18.

Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.

Bonilla IM, Long VP 3rd, Vargas-Pinto P, Wright P, Belevych A, Lou Q, Mowrey K, Yoo J, Binkley PF, Fedorov VV, Györke S, Janssen PM, Kilic A, Mohler PJ, Carnes CA.

PLoS One. 2014 Oct 1;9(10):e108824. doi: 10.1371/journal.pone.0108824. eCollection 2014.

19.

Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping.

Lou Q, Hansen BJ, Fedorenko O, Csepe TA, Kalyanasundaram A, Li N, Hage LT, Glukhov AV, Billman GE, Weiss R, Mohler PJ, Györke S, Biesiadecki BJ, Carnes CA, Fedorov VV.

Circulation. 2014 Jul 22;130(4):315-24. doi: 10.1161/CIRCULATIONAHA.113.007086. Epub 2014 May 16.

20.

Ibandronate and ventricular arrhythmia risk.

Bonilla IM, Vargas-Pinto P, Nishijima Y, Pedraza-Toscano A, Ho HT, Long VP 3rd, Belevych AE, Glynn P, Houmsse M, Rhodes T, Weiss R, Hund TJ, Hamlin RL, Györke S, Carnes CA.

J Cardiovasc Electrophysiol. 2014 Mar;25(3):299-306. doi: 10.1111/jce.12327. Epub 2013 Dec 20.

21.

Dietary omega-3 fatty acids promote arrhythmogenic remodeling of cellular Ca2+ handling in a postinfarction model of sudden cardiac death.

Belevych AE, Ho HT, Terentyeva R, Bonilla IM, Terentyev D, Carnes CA, Gyorke S, Billman GE.

PLoS One. 2013 Oct 18;8(10):e78414. doi: 10.1371/journal.pone.0078414. eCollection 2013.

22.

Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness.

Glukhov AV, Hage LT, Hansen BJ, Pedraza-Toscano A, Vargas-Pinto P, Hamlin RL, Weiss R, Carnes CA, Billman GE, Fedorov VV.

Circ Arrhythm Electrophysiol. 2013 Oct;6(5):984-94. doi: 10.1161/CIRCEP.113.000404. Epub 2013 Aug 19.

23.

'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failure.

Belevych AE, Radwański PB, Carnes CA, Györke S.

Cardiovasc Res. 2013 May 1;98(2):240-7. doi: 10.1093/cvr/cvt024. Epub 2013 Feb 12. Review.

24.

Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy.

Riesen SC, Schober KE, Bonagura JD, Carnes CA.

Schweiz Arch Tierheilkd. 2013 Feb;155(2):143-7. doi: 10.1024/0036-7281/a000431.

25.

Differential effects of the peroxynitrite donor, SIN-1, on atrial and ventricular myocyte electrophysiology.

Bonilla IM, Sridhar A, Nishijima Y, Györke S, Cardounel AJ, Carnes CA.

J Cardiovasc Pharmacol. 2013 May;61(5):401-7. doi: 10.1097/FJC.0b013e31828748ca.

26.

Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart.

DeGrande ST, Little SC, Nixon DJ, Wright P, Snyder J, Dun W, Murphy N, Kilic A, Higgins R, Binkley PF, Boyden PA, Carnes CA, Anderson ME, Hund TJ, Mohler PJ.

J Biol Chem. 2013 Jan 11;288(2):1032-46. doi: 10.1074/jbc.M112.426957. Epub 2012 Nov 30.

27.

Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

Kalyanasundaram A, Lacombe VA, Belevych AE, Brunello L, Carnes CA, Janssen PM, Knollmann BC, Periasamy M, Gyørke S.

Cardiovasc Res. 2013 May 1;98(2):297-306. doi: 10.1093/cvr/cvs334. Epub 2012 Nov 6.

28.

Store-dependent deactivation: cooling the chain-reaction of myocardial calcium signaling.

Radwański PB, Belevych AE, Brunello L, Carnes CA, Györke S.

J Mol Cell Cardiol. 2013 May;58:77-83. doi: 10.1016/j.yjmcc.2012.10.008. Epub 2012 Oct 27. Review.

29.

Endurance exercise training normalizes repolarization and calcium-handling abnormalities, preventing ventricular fibrillation in a model of sudden cardiac death.

Bonilla IM, Belevych AE, Sridhar A, Nishijima Y, Ho HT, He Q, Kukielka M, Terentyev D, Terentyeva R, Liu B, Long VP, Györke S, Carnes CA, Billman GE.

J Appl Physiol (1985). 2012 Dec 1;113(11):1772-83. doi: 10.1152/japplphysiol.00175.2012. Epub 2012 Oct 4.

30.

Tachy-brady arrhythmias: the critical role of adenosine-induced sinoatrial conduction block in post-tachycardia pauses.

Lou Q, Glukhov AV, Hansen B, Hage L, Vargas-Pinto P, Billman GE, Carnes CA, Fedorov VV.

Heart Rhythm. 2013 Jan;10(1):110-8. doi: 10.1016/j.hrthm.2012.09.012. Epub 2012 Sep 14.

31.

Lessons learned from exploratory research about viral hepatitis.

Jorgensen CM, Carnes CA.

Health Promot Pract. 2013 May;14(3):364-9. doi: 10.1177/1524839912455643. Epub 2012 Sep 14.

PMID:
22982703
32.

Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes.

Wang H, Bonilla IM, Huang X, He Q, Kohr MJ, Carnes CA, Ziolo MT.

J Signal Transduct. 2012;2012:645721. doi: 10.1155/2012/645721. Epub 2012 Aug 28.

33.

Nitric oxide synthases and atrial fibrillation.

Bonilla IM, Sridhar A, Györke S, Cardounel AJ, Carnes CA.

Front Physiol. 2012 Apr 23;3:105. doi: 10.3389/fphys.2012.00105. eCollection 2012.

34.

Differential regulation of EHD3 in human and mammalian heart failure.

Gudmundsson H, Curran J, Kashef F, Snyder JS, Smith SA, Vargas-Pinto P, Bonilla IM, Weiss RM, Anderson ME, Binkley P, Felder RB, Carnes CA, Band H, Hund TJ, Mohler PJ.

J Mol Cell Cardiol. 2012 May;52(5):1183-90. doi: 10.1016/j.yjmcc.2012.02.008. Epub 2012 Mar 3.

35.

Dietary omega-3 fatty acids and susceptibility to ventricular fibrillation: lack of protection and a proarrhythmic effect.

Billman GE, Carnes CA, Adamson PB, Vanoli E, Schwartz PJ.

Circ Arrhythm Electrophysiol. 2012 Jun 1;5(3):553-60. doi: 10.1161/CIRCEP.111.966739. Epub 2012 Feb 14. Erratum in: Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):e89.

36.

Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.

Belevych AE, Terentyev D, Terentyeva R, Ho HT, Gyorke I, Bonilla IM, Carnes CA, Billman GE, Györke S.

Circ Res. 2012 Feb 17;110(4):569-77. doi: 10.1161/CIRCRESAHA.111.260455. Epub 2012 Jan 5.

37.

MicroRNA-1 and -133 increase arrhythmogenesis in heart failure by dissociating phosphatase activity from RyR2 complex.

Belevych AE, Sansom SE, Terentyeva R, Ho HT, Nishijima Y, Martin MM, Jindal HK, Rochira JA, Kunitomo Y, Abdellatif M, Carnes CA, Elton TS, Györke S, Terentyev D.

PLoS One. 2011;6(12):e28324. doi: 10.1371/journal.pone.0028324. Epub 2011 Dec 6.

38.

Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters.

Ware B, Bevier M, Nishijima Y, Rogers S, Carnes CA, Lacombe VA.

Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1300-6. doi: 10.1152/ajpregu.00822.2010. Epub 2011 Aug 17.

39.

Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.

Ho HT, Stevens SC, Terentyeva R, Carnes CA, Terentyev D, Györke S.

J Physiol. 2011 Oct 1;589(Pt 19):4697-708. doi: 10.1113/jphysiol.2011.210005. Epub 2011 Aug 1.

40.

Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.

Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA.

Cardiovasc Res. 2011 Jul 1;91(1):71-9. doi: 10.1093/cvr/cvr087. Epub 2011 Apr 1.

41.

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function.

Belevych AE, Terentyev D, Terentyeva R, Nishijima Y, Sridhar A, Hamlin RL, Carnes CA, Györke S.

Cardiovasc Res. 2011 Jun 1;90(3):493-502. doi: 10.1093/cvr/cvr025. Epub 2011 Jan 27.

42.

Pharmacokinetics of oral ivabradine in healthy cats.

Riesen SC, Ni W, Carnes CA, Lindsey KJ, Phelps MA, Schober KE.

J Vet Pharmacol Ther. 2011 Oct;34(5):469-75. doi: 10.1111/j.1365-2885.2010.01253.x. Epub 2010 Dec 1.

PMID:
21118419
43.

Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.

Billman GE, Nishijima Y, Belevych AE, Terentyev D, Xu Y, Haizlip KM, Monasky MM, Hiranandani N, Harris WS, Gyorke S, Carnes CA, Janssen PM.

Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1219-28. doi: 10.1152/ajpheart.01065.2009. Epub 2010 Jan 22.

44.

Initial experience with antiarrhythmic medication monitoring by clinical pharmacists in an outpatient setting: a retrospective review.

Snider M, Kalbfleisch S, Carnes CA.

Clin Ther. 2009 Jun;31(6):1209-18. doi: 10.1016/j.clinthera.2009.06.014.

PMID:
19695388
45.

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death.

Belevych AE, Terentyev D, Viatchenko-Karpinski S, Terentyeva R, Sridhar A, Nishijima Y, Wilson LD, Cardounel AJ, Laurita KR, Carnes CA, Billman GE, Gyorke S.

Cardiovasc Res. 2009 Dec 1;84(3):387-95. doi: 10.1093/cvr/cvp246. Epub 2009 Jul 17.

46.

Chronic heart failure and the substrate for atrial fibrillation.

Sridhar A, Nishijima Y, Terentyev D, Khan M, Terentyeva R, Hamlin RL, Nakayama T, Gyorke S, Cardounel AJ, Carnes CA.

Cardiovasc Res. 2009 Nov 1;84(2):227-36. doi: 10.1093/cvr/cvp216. Epub 2009 Jun 30.

47.

Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure.

Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S.

Circ Res. 2008 Dec 5;103(12):1466-72. doi: 10.1161/CIRCRESAHA.108.184457. Epub 2008 Nov 13.

48.

Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction.

Mohan IK, Khan M, Wisel S, Selvendiran K, Sridhar A, Carnes CA, Bognar B, Kálai T, Hideg K, Kuppusamy P.

Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H140-51. doi: 10.1152/ajpheart.00687.2008. Epub 2008 Oct 31.

49.

Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death.

Sridhar A, Nishijima Y, Terentyev D, Terentyeva R, Uelmen R, Kukielka M, Bonilla IM, Robertson GA, Györke S, Billman GE, Carnes CA.

Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1463-72. doi: 10.1152/ajpregu.90583.2008. Epub 2008 Sep 3.

50.

Amiodarone use in patients with documented hypersensitivity to intravenous contrast dye.

Snider M, Boyd M, Carnes CA.

Ann Pharmacother. 2008 Sep;42(9):1349-50. doi: 10.1345/aph.1L158. Epub 2008 Jul 22. No abstract available.

PMID:
18648017

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