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Integrating in vitro testing and physiologically-based pharmacokinetic (PBPK) modelling for chemical liver toxicity assessment-A case study of troglitazone.

Yu L, Li H, Zhang C, Zhang Q, Guo J, Li J, Yuan H, Li L, Carmichael P, Peng S.

Environ Toxicol Pharmacol. 2019 Nov 5;74:103296. doi: 10.1016/j.etap.2019.103296. [Epub ahead of print]


Serial Ottawa 3DY assessments to detect delirium in older emergency department community dwellers.

Yadav K, Boucher V, Carmichael PH, Voyer P, Eagles D, Pelletier M, Gouin É, Daoust R, Vu TTM, Berthelot S, Émond M.

Age Ageing. 2019 Nov 22. pii: afz144. doi: 10.1093/ageing/afz144. [Epub ahead of print]


Vision of a near future: Bridging the human health-environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessment.

Rivetti C, Allen TEH, Brown JB, Butler E, Carmichael PL, Colbourne JK, Dent M, Falciani F, Gunnarsson L, Gutsell S, Harrill JA, Hodges G, Jennings P, Judson R, Kienzler A, Margiotta-Casaluci L, Muller I, Owen SF, Rendal C, Russell PJ, Scott S, Sewell F, Shah I, Sorrel I, Viant MR, Westmoreland C, White A, Campos B.

Toxicol In Vitro. 2020 Feb;62:104692. doi: 10.1016/j.tiv.2019.104692. Epub 2019 Oct 25.


Is Benzodiazepine Use Associated With the Risk of Dementia and Cognitive Impairment-Not Dementia in Older Persons? The Canadian Study of Health and Aging.

Nafti M, Sirois C, Kröger E, Carmichael PH, Laurin D.

Ann Pharmacother. 2019 Oct 9:1060028019882037. doi: 10.1177/1060028019882037. [Epub ahead of print]


Time trends in referrals to child and adolescent gender identity services: a study in four Nordic countries and in the UK.

Kaltiala R, Bergman H, Carmichael P, de Graaf NM, Egebjerg Rischel K, Frisén L, Schorkopf M, Suomalainen L, Waehre A.

Nord J Psychiatry. 2019 Sep 26:1-5. doi: 10.1080/08039488.2019.1667429. [Epub ahead of print]


Nutrient Patterns, Cognitive Function, and Decline in Older Persons: Results from the Three-City and NuAge Studies.

Allès B, Samieri C, Jutand MA, Carmichael PH, Shatenstein B, Gaudreau P, Ferland G, Barberger-Gateau P, Laurin D.

Nutrients. 2019 Aug 5;11(8). pii: E1808. doi: 10.3390/nu11081808.


Unrecognized Incident Delirium in Older Emergency Department Patients.

Boucher V, Lamontagne ME, Nadeau A, Carmichael PH, Yadav K, Voyer P, Pelletier M, Gouin É, Daoust R, Berthelot S, Morin M, Lemire S, Minh Vu TT, Lee J, Émond M.

J Emerg Med. 2019 Oct;57(4):535-542. doi: 10.1016/j.jemermed.2019.05.024. Epub 2019 Jul 26.


Adapting the Canadian CT head rule age criteria for mild traumatic brain injury.

Fournier N, Gariepy C, Prévost JF, Belhumeur V, Fortier É, Carmichael PH, Gariepy JL, Le Sage N, Émond M.

Emerg Med J. 2019 Oct;36(10):617-619. doi: 10.1136/emermed-2018-208153. Epub 2019 Jul 20.


Acceptability of older patients' self-assessment in the Emergency Department (ACCEPTED)-a randomised cross-over pilot trial.

Boucher V, Lamontagne ME, Lee J, Carmichael PH, Déry J, Émond M.

Age Ageing. 2019 Nov 1;48(6):875-880. doi: 10.1093/ageing/afz084.


Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer's disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging.

Medehouenou TCM, Ayotte P, Carmichael PH, Kröger E, Verreault R, Lindsay J, Dewailly É, Tyas SL, Bureau A, Laurin D.

Environ Health. 2019 Jun 14;18(1):57. doi: 10.1186/s12940-019-0494-2.


A human-derived prostate co-culture microtissue model using epithelial (RWPE-1) and stromal (WPMY-1) cell lines.

Dent MP, Madnick SJ, Hall S, Vantangoli Policelli M, Bars C, Li H, Amin A, Carmichael PL, Martin FL, Boekelheide K.

Toxicol In Vitro. 2019 Oct;60:203-211. doi: 10.1016/j.tiv.2019.05.023. Epub 2019 May 30.


Validation of the O3DY French Version (O3DY-F) for the Screening of Cognitive Impairment in Community Seniors in the Emergency Department.

Bédard C, Boucher V, Voyer P, Yadav K, Eagles D, Nadeau A, Carmichael PH, Pelletier M, Gouin E, Berthelot S, Daoust R, Laguë A, Gagné AJ, Émond M.

J Emerg Med. 2019 Jul;57(1):59-65. doi: 10.1016/j.jemermed.2019.02.007. Epub 2019 Apr 22.


A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Desprez B, Birk B, Blaauboer B, Boobis A, Carmichael P, Cronin MTD, Curie R, Daston G, Hubesch B, Jennings P, Klaric M, Kroese D, Mahony C, Ouédraogo G, Piersma A, Richarz AN, Schwarz M, van Benthem J, van de Water B, Vinken M.

Toxicol In Vitro. 2019 Sep;59:44-50. doi: 10.1016/j.tiv.2019.04.005. Epub 2019 Apr 4.


An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis.

Ulmasov B, Noritake H, Carmichael P, Oshima K, Griggs DW, Neuschwander-Tetri BA.

Hepatol Commun. 2018 Dec 27;3(2):246-261. doi: 10.1002/hep4.1298. eCollection 2019 Feb.


Puberty blocking in gender dysphoria: suitable for all?

Butler G, Wren B, Carmichael P.

Arch Dis Child. 2019 Jun;104(6):509-510. doi: 10.1136/archdischild-2018-315984. Epub 2019 Jan 17. No abstract available.


Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.

Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, Escher SE, Ferguson SS, Grégoire S, Hewitt NJ, Hollnagel HM, Klaric M, Patel A, Salhi S, Schepky A, Schmitt BG, Wambaugh JF, Worth A.

Regul Toxicol Pharmacol. 2019 Apr;103:63-72. doi: 10.1016/j.yrtph.2019.01.016. Epub 2019 Jan 15. Review.


Reflections on emerging trends in clinical work with gender diverse children and adolescents.

de Graaf NM, Carmichael P.

Clin Child Psychol Psychiatry. 2019 Apr;24(2):353-364. doi: 10.1177/1359104518812924. Epub 2018 Nov 28.


Is the Drug Burden Index Related to Declining Functional Status at Follow-up in Community-Dwelling Seniors Consulting for Minor Injuries? Results from the Canadian Emergency Team Initiative Cohort Study.

Kröger E, Simard M, Sirois MJ, Giroux M, Sirois C, Kouladjian-O'Donnell L, Reeve E, Hilmer S, Carmichael PH, Émond M.

Drugs Aging. 2019 Jan;36(1):73-83. doi: 10.1007/s40266-018-0604-9.


Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data.

Dent MP, Li H, Carmichael PL, Martin FL.

Toxicol Sci. 2019 Feb 1;167(2):375-384. doi: 10.1093/toxsci/kfy245.


Seeing the child in context: Supporting gender diverse children and their families in multiple ways - An introduction to this special edition.

Langton T, Wren B, Carmichael P.

Clin Child Psychol Psychiatry. 2019 Apr;24(2):199-202. doi: 10.1177/1359104518800143. Epub 2018 Sep 15.


Evidence for a Change in the Sex Ratio of Children Referred for Gender Dysphoria: Data From the Gender Identity Development Service in London (2000-2017).

de Graaf NM, Carmichael P, Steensma TD, Zucker KJ.

J Sex Med. 2018 Oct;15(10):1381-1383. doi: 10.1016/j.jsxm.2018.08.002. Epub 2018 Sep 5.


The OptimaMed intervention to reduce inappropriate medications in nursing home residents with severe dementia: results from a quasi-experimental feasibility pilot study.

Wilchesky M, Mueller G, Morin M, Marcotte M, Voyer P, Aubin M, Carmichael PH, Champoux N, Monette J, Giguère A, Durand P, Verreault R, Arcand M, Kröger E.

BMC Geriatr. 2018 Sep 4;18(1):204. doi: 10.1186/s12877-018-0895-z.


Flutamide Induces Hepatic Cell Death and Mitochondrial Dysfunction via Inhibition of Nrf2-Mediated Heme Oxygenase-1.

Zhang L, Guo J, Zhang Q, Zhou W, Li J, Yin J, Cui L, Zhang T, Zhao J, Carmichael PL, Middleton A, Peng S.

Oxid Med Cell Longev. 2018 Jul 2;2018:8017073. doi: 10.1155/2018/8017073. eCollection 2018.


Tailoring and evaluating an intervention to improve shared decision-making among seniors with dementia, their caregivers, and healthcare providers: study protocol for a randomized controlled trial.

Giguere AMC, Lawani MA, Fortier-Brochu É, Carmichael PH, Légaré F, Kröger E, Witteman HO, Voyer P, Caron D, Rodríguez C.

Trials. 2018 Jun 25;19(1):332. doi: 10.1186/s13063-018-2697-1.


Performance of the French version of the 4AT for screening the elderly for delirium in the emergency department.

Gagné AJ, Voyer P, Boucher V, Nadeau A, Carmichael PH, Pelletier M, Gouin E, Berthelot S, Daoust R, Wilchesky M, Richard H, Pelletier I, Ballard S, Laguë A, Émond M.

CJEM. 2018 Nov;20(6):903-910. doi: 10.1017/cem.2018.367. Epub 2018 May 17.


Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway.

Yin J, Guo J, Zhang Q, Cui L, Zhang L, Zhang T, Zhao J, Li J, Middleton A, Carmichael PL, Peng S.

Toxicol In Vitro. 2018 Sep;51:1-10. doi: 10.1016/j.tiv.2018.05.001. Epub 2018 May 3.


Sex Ratio in Children and Adolescents Referred to the Gender Identity Development Service in the UK (2009-2016).

de Graaf NM, Giovanardi G, Zitz C, Carmichael P.

Arch Sex Behav. 2018 Jul;47(5):1301-1304. doi: 10.1007/s10508-018-1204-9. Epub 2018 Apr 25. No abstract available.


Assessment and support of children and adolescents with gender dysphoria.

Butler G, De Graaf N, Wren B, Carmichael P.

Arch Dis Child. 2018 Jul;103(7):631-636. doi: 10.1136/archdischild-2018-314992. Epub 2018 Apr 12. Review. No abstract available.


mRNA transfection retrofits cell-based assays with xenobiotic metabolism.

DeGroot DE, Swank A, Thomas RS, Strynar M, Lee MY, Carmichael PL, Simmons SO.

J Pharmacol Toxicol Methods. 2018 Jul - Aug;92:77-94. doi: 10.1016/j.vascn.2018.03.002. Epub 2018 Mar 16.


Incidence of delirium in the Canadian emergency department and its consequences on hospital length of stay: a prospective observational multicentre cohort study.

Émond M, Boucher V, Carmichael PH, Voyer P, Pelletier M, Gouin É, Daoust R, Berthelot S, Lamontagne ME, Morin M, Lemire S, Minh Vu TT, Nadeau A, Rheault M, Juneau L, Le Sage N, Lee J.

BMJ Open. 2018 Mar 8;8(3):e018190. doi: 10.1136/bmjopen-2017-018190.


What Do Clinical Supervisors Require to Teach Residents in Family Medicine How to Care for Seniors?

Giguere AMC, Lebel P, Morin M, Proust F, Rodríguez C, Carnovale V, Champagne L, Légaré F, Carmichael PH, Martineau B, Karazivan P, Durand PJ.

Can J Aging. 2018 Mar;37(1):32-49. doi: 10.1017/S0714980817000460. Epub 2018 Jan 9.


Psychological functioning in adolescents referred to specialist gender identity clinics across Europe: a clinical comparison study between four clinics.

de Graaf NM, Cohen-Kettenis PT, Carmichael P, de Vries ALC, Dhondt K, Laridaen J, Pauli D, Ball J, Steensma TD.

Eur Child Adolesc Psychiatry. 2018 Jul;27(7):909-919. doi: 10.1007/s00787-017-1098-4. Epub 2017 Dec 18.


Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults.

Bernier PJ, Gourdeau C, Carmichael PH, Beauchemin JP, Verreault R, Bouchard RW, Kröger E, Laforce R Jr.

CMAJ. 2017 Dec 4;189(48):E1472-E1480. doi: 10.1503/cmaj.160792.


Older Adults' Knowledge of Anxiety Disorders.

Beaunoyer E, Landreville P, Carmichael PH.

J Gerontol B Psychol Sci Soc Sci. 2019 Jun 14;74(5):806-814. doi: 10.1093/geronb/gbx128.


Characterization of fungal communities of developmental stages in table grape grown in the northern region of South Africa.

Carmichael PC, Siyoum N, Chidamba L, Korsten L.

J Appl Microbiol. 2017 Nov;123(5):1251-1262. doi: 10.1111/jam.13577.


Quasi-experimental evaluation of a multifaceted intervention to improve quality of end-of-life care and quality of dying for patients with advanced dementia in long-term care institutions.

Verreault R, Arcand M, Misson L, Durand PJ, Kroger E, Aubin M, Savoie M, Hadjistavropoulos T, Kaasalainen S, Bédard A, Grégoire A, Carmichael PH.

Palliat Med. 2018 Mar;32(3):613-621. doi: 10.1177/0269216317719588. Epub 2017 Jul 21.


Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.

Cui L, Guo J, Zhang Q, Yin J, Li J, Zhou W, Zhang T, Yuan H, Zhao J, Zhang L, Carmichael PL, Peng S.

Toxicol Lett. 2017 Jun 5;275:28-38. doi: 10.1016/j.toxlet.2017.04.018. Epub 2017 Apr 27.


Five shared decision-making tools in 5 months: use of rapid reviews to develop decision boxes for seniors living with dementia and their caregivers.

Lawani MA, Valéra B, Fortier-Brochu É, Légaré F, Carmichael PH, Côté L, Voyer P, Kröger E, Witteman H, Rodriguez C, Giguere AM.

Syst Rev. 2017 Mar 15;6(1):56. doi: 10.1186/s13643-017-0446-2.


General Practitioners' Clinical Impression in the Screening for Frailty: Data From the FAP Study Pilot.

Fougère B, Sirois MJ, Carmichael PH, Batomen-Kuimi BL, Chicoulaa B, Escourrou E, Nourhashémi F, Oustric S, Vellas B; FAP group.

J Am Med Dir Assoc. 2017 Feb 1;18(2):193.e1-193.e5. doi: 10.1016/j.jamda.2016.11.008.


Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline.

Basambombo LL, Carmichael PH, Côté S, Laurin D.

Ann Pharmacother. 2017 Feb;51(2):118-124. doi: 10.1177/1060028016673072. Epub 2016 Oct 5.


International Harmonization and Cooperation in the Validation of Alternative Methods.

Barroso J, Ahn IY, Caldeira C, Carmichael PL, Casey W, Coecke S, Curren R, Desprez B, Eskes C, Griesinger C, Guo J, Hill E, Roi AJ, Kojima H, Li J, Lim CH, Moura W, Nishikawa A, Park H, Peng S, Presgrave O, Singer T, Sohn SJ, Westmoreland C, Whelan M, Yang X, Yang Y, Zuang V.

Adv Exp Med Biol. 2016;856:343-386. Review.


Pathway Based Toxicology and Fit-for-Purpose Assays.

Clewell RA, McMullen PD, Adeleye Y, Carmichael PL, Andersen ME.

Adv Exp Med Biol. 2016;856:205-230.


Psychometric properties of the French Canadian version of the Geriatric Anxiety Inventory.

Champagne A, Landreville P, Gosselin P, Carmichael PH.

Aging Ment Health. 2018 Jan;22(1):40-45. doi: 10.1080/13607863.2016.1226767. Epub 2016 Sep 22.


Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells.

Zhang T, Zhang Q, Guo J, Yuan H, Peng H, Cui L, Yin J, Zhang L, Zhao J, Li J, White A, Carmichael PL, Westmoreland C, Peng S.

Environ Toxicol Pharmacol. 2016 Sep;46:71-79. doi: 10.1016/j.etap.2016.06.030. Epub 2016 Jul 1.


To treat or not to treat: puberty suppression in childhood-onset gender dysphoria.

Costa R, Carmichael P, Colizzi M.

Nat Rev Urol. 2016 Aug;13(8):456-62. doi: 10.1038/nrurol.2016.128. Epub 2016 Jul 19. Review.


Urging AVMA BOD support of the Equality Act of 2015.

Hazanow S, Chaddock M, McGuill M, Carmichael P; Advocacy Team Lesbian and Gay Veterinary Medical Association.

J Am Vet Med Assoc. 2016 Mar 15;248(6):601-2. No abstract available.


Nutrient Patterns and Their Food Sources in Older Persons from France and Quebec: Dietary and Lifestyle Characteristics.

Allès B, Samieri C, Lorrain S, Jutand MA, Carmichael PH, Shatenstein B, Gaudreau P, Payette H, Laurin D, Barberger-Gateau P.

Nutrients. 2016 Apr 19;8(4):225. doi: 10.3390/nu8040225.


Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME.

Mutat Res Rev Mutat Res. 2016 Jan-Mar;767:77-91. doi: 10.1016/j.mrrev.2015.11.001. Epub 2015 Dec 2. Review.


Assessment of inattention in the context of delirium screening: one size does not fit all!

Voyer P, Champoux N, Desrosiers J, Landreville P, Monette J, Savoie M, Carmichael PH, Richard S, Bédard A.

Int Psychogeriatr. 2016 Aug;28(8):1293-301. doi: 10.1017/S1041610216000533. Epub 2016 Mar 23.


A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C.

Yuan H, Zhang Q, Guo J, Zhang T, Zhao J, Li J, White A, Carmichael PL, Westmoreland C, Peng S.

Toxicol Sci. 2016 Apr;150(2):400-17. doi: 10.1093/toxsci/kfw006. Epub 2016 Jan 18.


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