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Items: 1 to 50 of 644

1.

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P.

Cell Metab. 2018 Jul 6. pii: S1550-4131(18)30391-7. doi: 10.1016/j.cmet.2018.06.009. [Epub ahead of print]

PMID:
30017355
2.

Phenotype molding of stromal cells in the lung tumor microenvironment.

Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, Weynand B, Verbeken E, De Leyn P, Liston A, Vansteenkiste J, Carmeliet P, Aerts S, Thienpont B.

Nat Med. 2018 Aug;24(8):1277-1289. doi: 10.1038/s41591-018-0096-5. Epub 2018 Jul 9.

PMID:
29988129
3.

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.

Stegen S, Stockmans I, Moermans K, Thienpont B, Maxwell PH, Carmeliet P, Carmeliet G.

Nat Commun. 2018 Jul 2;9(1):2557. doi: 10.1038/s41467-018-04679-7.

4.

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.

Briant LJB, Dodd MS, Chibalina MV, Rorsman NJG, Johnson PRV, Carmeliet P, Rorsman P, Knudsen JG.

Cell Rep. 2018 Jun 12;23(11):3300-3311. doi: 10.1016/j.celrep.2018.05.035.

5.

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.

Laviña B, Castro M, Niaudet C, Cruys B, Álvarez-Aznar A, Carmeliet P, Bentley K, Brakebusch C, Betsholtz C, Gaengel K.

Development. 2018 Jul 2;145(13). pii: dev161182. doi: 10.1242/dev.161182.

PMID:
29853619
6.

Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW.

Angiogenesis. 2018 May 15. doi: 10.1007/s10456-018-9613-x. [Epub ahead of print] Review.

7.

Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development.

Wong BW, Zecchin A, García-Caballero M, Carmeliet P.

Dev Cell. 2018 May 7;45(3):289-301. doi: 10.1016/j.devcel.2018.03.021. Review.

PMID:
29738709
8.

Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish.

Zecchin A, Wong BW, Tembuyser B, Souffreau J, Van Nuffelen A, Wyns S, Vinckier S, Carmeliet P, Dewerchin M.

Biochem Biophys Res Commun. 2018 Sep 3;503(1):26-31. doi: 10.1016/j.bbrc.2018.04.233. Epub 2018 Jun 19.

PMID:
29730294
9.

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.

Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz ÖH.

Cell Stem Cell. 2018 May 3;22(5):769-778.e4. doi: 10.1016/j.stem.2018.04.001.

PMID:
29727683
10.

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF.

Cell Rep. 2018 May 1;23(5):1476-1490. doi: 10.1016/j.celrep.2018.04.019.

11.

Blockade of Myeloid-Derived Suppressor Cell Expansion with All-Trans Retinoic Acid Increases the Efficacy of Antiangiogenic Therapy.

Bauer R, Udonta F, Wroblewski M, Ben-Batalla I, Santos IM, Taverna F, Kuhlencord M, Gensch V, Päsler S, Vinckier S, Brandner JM, Pantel K, Bokemeyer C, Vogl T, Roth J, Carmeliet P, Loges S.

Cancer Res. 2018 Jun 15;78(12):3220-3232. doi: 10.1158/0008-5472.CAN-17-3415. Epub 2018 Apr 19.

PMID:
29674477
12.

Targeting angiogenic metabolism in disease.

Li X, Carmeliet P.

Science. 2018 Mar 23;359(6382):1335-1336. doi: 10.1126/science.aar5557. No abstract available.

PMID:
29567696
13.

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation.

Maybin JA, Murray AA, Saunders PTK, Hirani N, Carmeliet P, Critchley HOD.

Nat Commun. 2018 Jan 23;9(1):295. doi: 10.1038/s41467-017-02375-6.

14.

RAISEing VEGF-D's importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients.

Carmeliet P, Li X, Treps L, Conradi LC, Loges S.

Ann Oncol. 2018 Mar 1;29(3):527-529. doi: 10.1093/annonc/mdy028. No abstract available.

PMID:
29360914
15.

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors.

Zecchin A, Kalucka J, Dubois C, Carmeliet P.

Front Immunol. 2017 Dec 11;8:1750. doi: 10.3389/fimmu.2017.01750. eCollection 2017. Review.

16.

Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease.

Rabelink TJ, Carmeliet P.

Nat Rev Nephrol. 2018 Feb;14(2):75-76. doi: 10.1038/nrneph.2017.173. Epub 2017 Dec 18. No abstract available.

PMID:
29292369
17.

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism.

Draoui N, de Zeeuw P, Carmeliet P.

Open Biol. 2017 Dec;7(12). pii: 170219. doi: 10.1098/rsob.170219. Review.

18.

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development.

Teuwen LA, Geldhof V, Carmeliet P.

Dev Biol. 2017 Dec 7. pii: S0012-1606(17)30495-5. doi: 10.1016/j.ydbio.2017.12.001. [Epub ahead of print] Review.

PMID:
29224892
19.

Endothelial Cell Metabolism.

Eelen G, de Zeeuw P, Treps L, Harjes U, Wong BW, Carmeliet P.

Physiol Rev. 2018 Jan 1;98(1):3-58. doi: 10.1152/physrev.00001.2017. Review.

PMID:
29167330
20.

Endothelial Cell Metabolism in Health and Disease.

Rohlenova K, Veys K, Miranda-Santos I, De Bock K, Carmeliet P.

Trends Cell Biol. 2018 Mar;28(3):224-236. doi: 10.1016/j.tcb.2017.10.010. Epub 2017 Nov 16. Review.

PMID:
29153487
21.

PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.

Sents W, Meeusen B, Kalev P, Radaelli E, Sagaert X, Miermans E, Haesen D, Lambrecht C, Dewerchin M, Carmeliet P, Westermarck J, Sablina A, Janssens V.

Cancer Res. 2017 Dec 15;77(24):6825-6837. doi: 10.1158/0008-5472.CAN-16-2911. Epub 2017 Oct 18.

PMID:
29046336
22.

Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW.

Circulation. 2017 Dec 19;136(25):2451-2467. doi: 10.1161/CIRCULATIONAHA.117.028034. Epub 2017 Sep 26.

PMID:
28971999
23.

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.

Conradi LC, Brajic A, Cantelmo AR, Bouché A, Kalucka J, Pircher A, Brüning U, Teuwen LA, Vinckier S, Ghesquière B, Dewerchin M, Carmeliet P.

Angiogenesis. 2017 Nov;20(4):599-613. doi: 10.1007/s10456-017-9573-6. Epub 2017 Sep 5.

PMID:
28875379
24.

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity.

Knobloch M, Pilz GA, Ghesquière B, Kovacs WJ, Wegleiter T, Moore DL, Hruzova M, Zamboni N, Carmeliet P, Jessberger S.

Cell Rep. 2017 Aug 29;20(9):2144-2155. doi: 10.1016/j.celrep.2017.08.029.

25.

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.

26.

Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes.

Bachor TP, Karbanová J, Büttner E, Bermúdez V, Marquioni-Ramella M, Carmeliet P, Corbeil D, Suburo AM.

Neurobiol Dis. 2017 Dec;108:13-28. doi: 10.1016/j.nbd.2017.07.010. Epub 2017 Jul 23.

PMID:
28743634
27.

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.

Tavernier SJ, Vanlangenakker N, Vetters J, Carmeliet P, Janssens S, Lambrecht BN.

J Leukoc Biol. 2017 Oct;102(4):1115-1126. doi: 10.1189/jlb.3A0916-405R. Epub 2017 Jul 17.

PMID:
28716863
28.

A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice.

Ciarlillo D, Celeste C, Carmeliet P, Boerboom D, Theoret C.

PLoS One. 2017 Jul 7;12(7):e0180586. doi: 10.1371/journal.pone.0180586. eCollection 2017.

29.

Role of glutamine and interlinked asparagine metabolism in vessel formation.

Huang H, Vandekeere S, Kalucka J, Bierhansl L, Zecchin A, Brüning U, Visnagri A, Yuldasheva N, Goveia J, Cruys B, Brepoels K, Wyns S, Rayport S, Ghesquière B, Vinckier S, Schoonjans L, Cubbon R, Dewerchin M, Eelen G, Carmeliet P.

EMBO J. 2017 Aug 15;36(16):2334-2352. doi: 10.15252/embj.201695518. Epub 2017 Jun 28.

30.

Influences of placental growth factor on mouse retinal vascular development.

Kay VR, Tayade C, Carmeliet P, Croy BA.

Dev Dyn. 2017 Sep;246(9):700-712. doi: 10.1002/dvdy.24540. Epub 2017 Jul 24.

PMID:
28646507
31.

Endothelial cell metabolism in health and disease: impact of hypoxia.

Wong BW, Marsch E, Treps L, Baes M, Carmeliet P.

EMBO J. 2017 Aug 1;36(15):2187-2203. doi: 10.15252/embj.201696150. Epub 2017 Jun 21. Review.

32.

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.

Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ.

Nat Commun. 2017 Jun 19;8:15889. doi: 10.1038/ncomms15889.

33.

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.

Heggermont WA, Papageorgiou AP, Quaegebeur A, Deckx S, Carai P, Verhesen W, Eelen G, Schoors S, van Leeuwen R, Alekseev S, Elzenaar I, Vinckier S, Pokreisz P, Walravens AS, Gijsbers R, Van Den Haute C, Nickel A, Schroen B, van Bilsen M, Janssens S, Maack C, Pinto Y, Carmeliet P, Heymans S.

Circulation. 2017 Aug 22;136(8):747-761. doi: 10.1161/CIRCULATIONAHA.116.024171. Epub 2017 Jun 13.

PMID:
28611091
34.

FGF-dependent metabolic control of vascular development.

Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M.

Nature. 2017 May 11;545(7653):224-228. doi: 10.1038/nature22322. Epub 2017 May 3.

35.

How to Cross the Lymphatic Fence: Lessons From Solute Transport.

Kalucka J, Teuwen LA, Geldhof V, Carmeliet P.

Circ Res. 2017 Apr 28;120(9):1376-1378. doi: 10.1161/CIRCRESAHA.117.310916. No abstract available.

PMID:
28450356
36.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

37.

CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions.

Feng Y, Cui P, Lu X, Hsueh B, Möller Billig F, Zarnescu Yanez L, Tomer R, Boerboom D, Carmeliet P, Deisseroth K, Hsueh AJ.

Sci Rep. 2017 Mar 23;7:44810. doi: 10.1038/srep44810.

38.

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells.

Van der Borght K, Scott CL, Nindl V, Bouché A, Martens L, Sichien D, Van Moorleghem J, Vanheerswynghels M, De Prijck S, Saeys Y, Ludewig B, Gillebert T, Guilliams M, Carmeliet P, Lambrecht BN.

Cell Rep. 2017 Mar 21;18(12):3005-3017. doi: 10.1016/j.celrep.2017.02.079.

39.

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

Schweisgut J, Schutt C, Wüst S, Wietelmann A, Ghesquière B, Carmeliet P, Dröse S, Korach KS, Braun T, Boettger T.

EMBO J. 2017 May 2;36(9):1199-1214. doi: 10.15252/embj.201695988. Epub 2017 Mar 17.

40.

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling.

van Vliet AR, Giordano F, Gerlo S, Segura I, Van Eygen S, Molenberghs G, Rocha S, Houcine A, Derua R, Verfaillie T, Vangindertael J, De Keersmaecker H, Waelkens E, Tavernier J, Hofkens J, Annaert W, Carmeliet P, Samali A, Mizuno H, Agostinis P.

Mol Cell. 2017 Mar 2;65(5):885-899.e6. doi: 10.1016/j.molcel.2017.01.020. Epub 2017 Feb 23.

41.

Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling.

Kalucka J, Bierhansl L, Wielockx B, Carmeliet P, Eelen G.

Pflugers Arch. 2017 Apr;469(3-4):473-483. doi: 10.1007/s00424-017-1946-6. Epub 2017 Feb 24. Review.

PMID:
28236120
42.

Endothelial cell metabolism: an update anno 2017.

Teuwen LA, Draoui N, Dubois C, Carmeliet P.

Curr Opin Hematol. 2017 May;24(3):240-247. doi: 10.1097/MOH.0000000000000335. Review.

PMID:
28212191
43.

Central Role of Metabolism in Endothelial Cell Function and Vascular Disease.

Bierhansl L, Conradi LC, Treps L, Dewerchin M, Carmeliet P.

Physiology (Bethesda). 2017 Mar;32(2):126-140. doi: 10.1152/physiol.00031.2016. Review.

44.

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson IR, McNeish I, Ennis D, Ali H, Kugeratski FG, Al Khamici H, van den Biggelaar M, van den Berghe PV, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC, Zanivan S.

Nat Commun. 2017 Feb 15;8:14206. doi: 10.1038/ncomms14206.

45.

Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective.

Missiaen R, Morales-Rodriguez F, Eelen G, Carmeliet P.

Vascul Pharmacol. 2017 Mar;90:8-18. doi: 10.1016/j.vph.2017.01.001. Epub 2017 Jan 7. Review.

PMID:
28082117
46.

Vessel pruning or healing: endothelial metabolism as a novel target?

Cantelmo AR, Pircher A, Kalucka J, Carmeliet P.

Expert Opin Ther Targets. 2017 Mar;21(3):239-247. doi: 10.1080/14728222.2017.1282465. Epub 2017 Jan 27. Review.

47.

The role of fatty acid β-oxidation in lymphangiogenesis.

Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P.

Nature. 2017 Feb 2;542(7639):49-54. doi: 10.1038/nature21028. Epub 2016 Dec 26.

PMID:
28024299
48.

The Link Between Angiogenesis and Endothelial Metabolism.

Potente M, Carmeliet P.

Annu Rev Physiol. 2017 Feb 10;79:43-66. doi: 10.1146/annurev-physiol-021115-105134. Epub 2016 Dec 15. Review.

PMID:
27992732
49.

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.

Van Welden S, De Vos M, Wielockx B, Tavernier SJ, Dullaers M, Neyt S, Descamps B, Devisscher L, Devriese S, Van den Bossche L, Holvoet T, Baeyens A, Correale C, D'Alessio S, Vanhove C, De Vos F, Verhasselt B, Breier G, Lambrecht BN, Janssens S, Carmeliet P, Danese S, Elewaut D, Laukens D, Hindryckx P.

J Pathol. 2017 Mar;241(4):547-558. doi: 10.1002/path.4861. Epub 2017 Jan 27.

PMID:
27981571
50.

Nogo-A regulates vascular network architecture in the postnatal brain.

Wälchli T, Ulmann-Schuler A, Hintermüller C, Meyer E, Stampanoni M, Carmeliet P, Emmert MY, Bozinov O, Regli L, Schwab ME, Vogel J, Hoerstrup SP.

J Cereb Blood Flow Metab. 2017 Feb;37(2):614-631. doi: 10.1177/0271678X16675182. Epub 2016 Nov 13.

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