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Items: 1 to 50 of 146

1.

Vdr expression in osteoclast precursors is not critical in bone homeostasis.

Verlinden L, Janssens I, Doms S, Vanhevel J, Carmeliet G, Verstuyf A.

J Steroid Biochem Mol Biol. 2019 Dec;195:105478. doi: 10.1016/j.jsbmb.2019.105478. Epub 2019 Sep 24.

PMID:
31561003
2.

Hypoxia, hypoxia-inducible transcription factors and oxygen-sensing prolyl hydroxylases in bone development and homeostasis.

Stegen S, Carmeliet G.

Curr Opin Nephrol Hypertens. 2019 Jul;28(4):328-335. doi: 10.1097/MNH.0000000000000508.

PMID:
30985337
3.

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.

Elia I, Rossi M, Stegen S, Broekaert D, Doglioni G, van Gorsel M, Boon R, Escalona-Noguero C, Torrekens S, Verfaillie C, Verbeken E, Carmeliet G, Fendt SM.

Nature. 2019 Apr;568(7750):117-121. doi: 10.1038/s41586-019-0977-x. Epub 2019 Feb 27.

4.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R, Loopmans S, Bultynck G, Vinckier S, Meersman F, Maxwell PH, Rai J, Weis M, Eyre DR, Ghesquière B, Fendt SM, Carmeliet P, Carmeliet G.

Nature. 2019 Jan;565(7740):511-515. doi: 10.1038/s41586-019-0874-3. Epub 2019 Jan 16.

PMID:
30651640
5.

Androgen Receptor in Neurons Slows Age-Related Cortical Thinning in Male Mice.

Jardí F, Kim N, Laurent MR, Khalil R, Deboel L, Schollaert D, van Lenthe GH, Decallonne B, Carmeliet G, Claessens F, Vanderschueren D.

J Bone Miner Res. 2019 Mar;34(3):508-519. doi: 10.1002/jbmr.3625. Epub 2019 Jan 15.

PMID:
30496619
6.

Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation.

Stiers PJ, Stegen S, van Gastel N, Van Looveren R, Torrekens S, Carmeliet G.

J Bone Miner Res. 2019 Feb;34(2):333-348. doi: 10.1002/jbmr.3599. Epub 2018 Nov 19.

PMID:
30452097
7.

Vitamin D insufficiency: Definition, diagnosis and management.

Bouillon R, Carmeliet G.

Best Pract Res Clin Endocrinol Metab. 2018 Oct;32(5):669-684. doi: 10.1016/j.beem.2018.09.014. Epub 2018 Oct 3. Review.

PMID:
30449548
8.

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.

Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J.

Endocr Rev. 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126.

9.

An Ectopic Imaging Window for Intravital Imaging of Engineered Bone Tissue.

Stiers PJ, van Gastel N, Moermans K, Stockmans I, Carmeliet G.

JBMR Plus. 2018 Jan 31;2(2):92-102. doi: 10.1002/jbm4.10028. eCollection 2018 Mar.

10.

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.

Stegen S, Stockmans I, Moermans K, Thienpont B, Maxwell PH, Carmeliet P, Carmeliet G.

Nat Commun. 2018 Jul 2;9(1):2557. doi: 10.1038/s41467-018-04679-7.

11.

Thin bones: Vitamin D and calcium handling after bariatric surgery.

Corbeels K, Verlinden L, Lannoo M, Simoens C, Matthys C, Verstuyf A, Meulemans A, Carmeliet G, Van der Schueren B.

Bone Rep. 2018 Feb 2;8:57-63. doi: 10.1016/j.bonr.2018.02.002. eCollection 2018 Jun.

12.

Fine-tuning pro-angiogenic effects of cobalt for simultaneous enhancement of vascular endothelial growth factor secretion and implant neovascularization.

Chai YC, Mendes LF, van Gastel N, Carmeliet G, Luyten FP.

Acta Biomater. 2018 May;72:447-460. doi: 10.1016/j.actbio.2018.03.048. Epub 2018 Apr 4.

PMID:
29626696
13.

Testosterone boosts physical activity in male mice via dopaminergic pathways.

Jardí F, Laurent MR, Kim N, Khalil R, De Bundel D, Van Eeckhaut A, Van Helleputte L, Deboel L, Dubois V, Schollaert D, Decallonne B, Carmeliet G, Van den Bosch L, D'Hooge R, Claessens F, Vanderschueren D.

Sci Rep. 2018 Jan 17;8(1):957. doi: 10.1038/s41598-017-19104-0.

14.

Simultaneous three-dimensional visualization of mineralized and soft skeletal tissues by a novel microCT contrast agent with polyoxometalate structure.

Kerckhofs G, Stegen S, van Gastel N, Sap A, Falgayrac G, Penel G, Durand M, Luyten FP, Geris L, Vandamme K, Parac-Vogt T, Carmeliet G.

Biomaterials. 2018 Mar;159:1-12. doi: 10.1016/j.biomaterials.2017.12.016. Epub 2017 Dec 22.

PMID:
29306094
15.

Phosphate-dependent luminal ATP metabolism regulates transcellular calcium transport in intestinal epithelial cells.

Uekawa A, Yamanaka H, Lieben L, Kimira Y, Uehara M, Yamamoto Y, Kato S, Ito K, Carmeliet G, Masuyama R.

FASEB J. 2018 Apr;32(4):1903-1915. doi: 10.1096/fj.201700631R. Epub 2018 Jan 5.

PMID:
29282249
16.

How Important Is Vitamin D for Calcium Homeostasis During Pregnancy and Lactation?

Carmeliet G, Bouillon R.

J Bone Miner Res. 2018 Jan;33(1):13-15. doi: 10.1002/jbmr.3344. Epub 2018 Jan 3. No abstract available.

17.

Transgenic Expression of the Vitamin D Receptor Restricted to the Ileum, Cecum, and Colon of Vitamin D Receptor Knockout Mice Rescues Vitamin D Receptor-Dependent Rickets.

Dhawan P, Veldurthy V, Yehia G, Hsaio C, Porta A, Kim KI, Patel N, Lieben L, Verlinden L, Carmeliet G, Christakos S.

Endocrinology. 2017 Nov 1;158(11):3792-3804. doi: 10.1210/en.2017-00258.

18.

Regulatory elements driving the expression of skeletal lineage reporters differ during bone development and adulthood.

Stiers PJ, van Gastel N, Moermans K, Stockmans I, Carmeliet G.

Bone. 2017 Dec;105:154-162. doi: 10.1016/j.bone.2017.08.029. Epub 2017 Aug 31.

PMID:
28863946
19.

The skeletal vascular system - Breathing life into bone tissue.

Stegen S, Carmeliet G.

Bone. 2018 Oct;115:50-58. doi: 10.1016/j.bone.2017.08.022. Epub 2017 Aug 26. Review.

PMID:
28844835
20.

A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton.

Jardí F, Laurent MR, Dubois V, Khalil R, Deboel L, Schollaert D, Van Den Bosch L, Decallonne B, Carmeliet G, Claessens F, Vanderschueren D.

Mol Cell Endocrinol. 2017 Sep 5;452:57-63. doi: 10.1016/j.mce.2017.05.012. Epub 2017 May 11.

PMID:
28504114
21.

Impact on Experimental Colitis of Vitamin D Receptor Deletion in Intestinal Epithelial or Myeloid Cells.

Leyssens C, Verlinden L, De Hertogh G, Kato S, Gysemans C, Mathieu C, Carmeliet G, Verstuyf A.

Endocrinology. 2017 Jul 1;158(7):2354-2366. doi: 10.1210/en.2017-00139.

PMID:
28472309
22.

1β,25-Dihydroxyvitamin D3: A new vitamin D metabolite in human serum.

Pauwels S, Jans I, Billen J, Heijboer A, Verstuyf A, Carmeliet G, Mathieu C, Maestro M, Waelkens E, Evenepoel P, Bouillon R, Vanderschueren D, Vermeersch P.

J Steroid Biochem Mol Biol. 2017 Oct;173:341-348. doi: 10.1016/j.jsbmb.2017.02.004. Epub 2017 Feb 11.

PMID:
28193495
23.

Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy.

Laurent MR, Jardí F, Dubois V, Schollaert D, Khalil R, Gielen E, Carmeliet G, Claessens F, Vanderschueren D.

Bone. 2016 Dec;93:33-42. doi: 10.1016/j.bone.2016.09.011. Epub 2016 Sep 10.

PMID:
27622887
24.

Changes in bone macro- and microstructure in diabetic obese mice revealed by high resolution microfocus X-ray computed tomography.

Kerckhofs G, Durand M, Vangoitsenhoven R, Marin C, Van der Schueren B, Carmeliet G, Luyten FP, Geris L, Vandamme K.

Sci Rep. 2016 Oct 19;6:35517. doi: 10.1038/srep35517.

25.

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis.

Laurent MR, Hammond GL, Blokland M, Jardí F, Antonio L, Dubois V, Khalil R, Sterk SS, Gielen E, Decallonne B, Carmeliet G, Kaufman JM, Fiers T, Huhtaniemi IT, Vanderschueren D, Claessens F.

Sci Rep. 2016 Oct 17;6:35539. doi: 10.1038/srep35539.

26.

Bone disorders: Mechanisms and targets.

Vanderschueren D, Laurent MR, Carmeliet G.

Mol Cell Endocrinol. 2016 Sep 5;432:1-2. doi: 10.1016/j.mce.2016.06.001. No abstract available.

PMID:
27288843
27.

SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma.

Heusschen R, Muller J, Binsfeld M, Marty C, Plougonven E, Dubois S, Mahli N, Moermans K, Carmeliet G, Léonard A, Baron F, Beguin Y, Menu E, Cohen-Solal M, Caers J.

Oncotarget. 2016 May 24;7(21):30712-29. doi: 10.18632/oncotarget.8750.

28.

Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved.

Dauwe D, Pelacho B, Wibowo A, Walravens AS, Verdonck K, Gillijns H, Caluwe E, Pokreisz P, van Gastel N, Carmeliet G, Depypere M, Maes F, Vanden Driessche N, Droogne W, Van Cleemput J, Vanhaecke J, Prosper F, Verfaillie C, Luttun A, Janssens S.

J Am Heart Assoc. 2016 Apr 18;5(4):e002288. doi: 10.1161/JAHA.115.002288.

29.

Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration.

Stegen S, Deprez S, Eelen G, Torrekens S, Van Looveren R, Goveia J, Ghesquière B, Carmeliet P, Carmeliet G.

Bone. 2016 Jun;87:176-86. doi: 10.1016/j.bone.2016.03.014. Epub 2016 Apr 4.

PMID:
27058876
30.

Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model.

Cielen N, Heulens N, Maes K, Carmeliet G, Mathieu C, Janssens W, Gayan-Ramirez G.

J Endocrinol. 2016 May;229(2):97-108. doi: 10.1530/JOE-15-0491. Epub 2016 Feb 23.

31.

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.

Stegen S, van Gastel N, Eelen G, Ghesquière B, D'Anna F, Thienpont B, Goveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt SM, Carmeliet P, Carmeliet G.

Cell Metab. 2016 Feb 9;23(2):265-79. doi: 10.1016/j.cmet.2016.01.002.

32.

Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration.

Stiers PJ, van Gastel N, Carmeliet G.

Mol Cell Endocrinol. 2016 Sep 5;432:96-105. doi: 10.1016/j.mce.2015.12.024. Epub 2016 Jan 6. Review.

PMID:
26768117
33.

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G.

Physiol Rev. 2016 Jan;96(1):365-408. doi: 10.1152/physrev.00014.2015. Review.

34.

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.

Manesia JK, Xu Z, Broekaert D, Boon R, van Vliet A, Eelen G, Vanwelden T, Stegen S, Van Gastel N, Pascual-Montano A, Fendt SM, Carmeliet G, Carmeliet P, Khurana S, Verfaillie CM.

Stem Cell Res. 2015 Nov;15(3):715-721. doi: 10.1016/j.scr.2015.11.001. Epub 2015 Nov 9.

35.

Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice.

Dubois V, Laurent MR, Jardi F, Antonio L, Lemaire K, Goyvaerts L, Deldicque L, Carmeliet G, Decallonne B, Vanderschueren D, Claessens F.

Endocrinology. 2016 Feb;157(2):648-65. doi: 10.1210/en.2015-1713. Epub 2015 Nov 12.

PMID:
26562264
36.

Interaction between Physical Activity and Smoking on Lung, Muscle, and Bone in Mice.

Cielen N, Maes K, Heulens N, Troosters T, Carmeliet G, Janssens W, Gayan-Ramirez GN.

Am J Respir Cell Mol Biol. 2016 May;54(5):674-82. doi: 10.1165/rcmb.2015-0181OC.

PMID:
26448063
37.

Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response.

Vandersmissen I, Craps S, Depypere M, Coppiello G, van Gastel N, Maes F, Carmeliet G, Schrooten J, Jones EA, Umans L, Devlieger R, Koole M, Gheysens O, Zwijsen A, Aranguren XL, Luttun A.

J Cell Biol. 2015 Sep 28;210(7):1239-56. doi: 10.1083/jcb.201502003. Epub 2015 Sep 21.

38.

Extra-intestinal calcium handling contributes to normal serum calcium levels when intestinal calcium absorption is suboptimal.

Lieben L, Verlinden L, Masuyama R, Torrekens S, Moermans K, Schoonjans L, Carmeliet P, Carmeliet G.

Bone. 2015 Dec;81:502-512. doi: 10.1016/j.bone.2015.08.023. Epub 2015 Aug 28.

PMID:
26319498
39.

Vitamin D signaling in calcium and bone homeostasis: a delicate balance.

Carmeliet G, Dermauw V, Bouillon R.

Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):621-31. doi: 10.1016/j.beem.2015.06.001. Epub 2015 Jun 30. Review.

PMID:
26303088
40.

Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.

Eelen G, Verlinden L, Maes C, Beullens I, Gysemans C, Paik JH, DePinho RA, Bouillon R, Carmeliet G, Verstuyf A.

J Steroid Biochem Mol Biol. 2016 Nov;164:337-343. doi: 10.1016/j.jsbmb.2015.07.015. Epub 2015 Jul 29.

PMID:
26232637
41.

Tight junction CLDN2 gene is a direct target of the vitamin D receptor.

Zhang YG, Wu S, Lu R, Zhou D, Zhou J, Carmeliet G, Petrof E, Claud EC, Sun J.

Sci Rep. 2015 Jul 27;5:10642. doi: 10.1038/srep10642.

42.

Response to letter regarding article, "Vitamin D promotes vascular regeneration".

Ka Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP.

Circulation. 2015 Jun 2;131(22):e515-6. doi: 10.1161/CIRCULATIONAHA.114.014781. No abstract available.

PMID:
26034089
43.

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.

Sinnesael M, Jardi F, Deboel L, Laurent MR, Dubois V, Zajac JD, Davey RA, Carmeliet G, Claessens F, Vanderschueren D.

Mol Cell Endocrinol. 2015 Aug 15;411:198-206. doi: 10.1016/j.mce.2015.04.030. Epub 2015 May 6.

PMID:
25958043
44.

Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies.

Suda T, Masuyama R, Bouillon R, Carmeliet G.

Curr Opin Pharmacol. 2015 Jun;22:87-99. doi: 10.1016/j.coph.2015.04.001. Epub 2015 May 14. Review.

PMID:
25938686
45.

Deletion of macrophage Vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice.

Oh J, Riek AE, Darwech I, Funai K, Shao J, Chin K, Sierra OL, Carmeliet G, Ostlund RE Jr, Bernal-Mizrachi C.

Cell Rep. 2015 Mar 24;10(11):1872-86.

46.

Androgens inhibit the osteogenic response to mechanical loading in adult male mice.

Sinnesael M, Laurent MR, Jardi F, Dubois V, Deboel L, Delisser P, Behets GJ, D'Haese PC, Carmeliet G, Claessens F, Vanderschueren D.

Endocrinology. 2015 Apr;156(4):1343-53. doi: 10.1210/en.2014-1673. Epub 2015 Feb 5.

PMID:
25654322
47.

The vasculature: a vessel for bone metastasis.

Raymaekers K, Stegen S, van Gastel N, Carmeliet G.

Bonekey Rep. 2015 Sep 9;4:742. doi: 10.1038/bonekey.2015.111. eCollection 2015. Review.

48.

Oxygen as a critical determinant of bone fracture healing-a multiscale model.

Carlier A, Geris L, van Gastel N, Carmeliet G, Van Oosterwyck H.

J Theor Biol. 2015 Jan 21;365:247-64. doi: 10.1016/j.jtbi.2014.10.012. Epub 2014 Oct 24. Erratum in: J Theor Biol. 2016 Mar 7;392:124.

49.

Size does matter: an integrative in vivo-in silico approach for the treatment of critical size bone defects.

Carlier A, van Gastel N, Geris L, Carmeliet G, Van Oosterwyck H.

PLoS Comput Biol. 2014 Nov 6;10(11):e1003888. doi: 10.1371/journal.pcbi.1003888. eCollection 2014 Nov.

50.

Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration.

Stegen S, van Gastel N, Carmeliet G.

Bone. 2015 Jan;70:19-27. doi: 10.1016/j.bone.2014.09.017. Epub 2014 Sep 28. Review.

PMID:
25263520

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