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Items: 24

1.

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.

Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G, Lu CC, Lu G, Riley M, Satoh Y, Schafer P, Daniel TO, Carmichael J, Cathers BE, Chamberlain PP.

J Med Chem. 2018 Jan 25;61(2):535-542. doi: 10.1021/acs.jmedchem.6b01921. Epub 2017 Apr 20.

PMID:
28425720
2.

Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1.

Hansen JD, Condroski K, Correa M, Muller G, Man HW, Ruchelman A, Zhang W, Vocanson F, Crea T, Liu W, Lu G, Baculi F, LeBrun L, Mahmoudi A, Carmel G, Hickman M, Lu CC.

J Med Chem. 2018 Jan 25;61(2):492-503. doi: 10.1021/acs.jmedchem.6b01911. Epub 2017 Apr 13.

PMID:
28358507
3.

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.

Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP.

Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22.

PMID:
27338790
4.

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

Chamberlain PP, Lopez-Girona A, Miller K, Carmel G, Pagarigan B, Chie-Leon B, Rychak E, Corral LG, Ren YJ, Wang M, Riley M, Delker SL, Ito T, Ando H, Mori T, Hirano Y, Handa H, Hakoshima T, Daniel TO, Cathers BE.

Nat Struct Mol Biol. 2014 Sep;21(9):803-9. doi: 10.1038/nsmb.2874. Epub 2014 Aug 10.

PMID:
25108355
5.

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity.

Gandhi AK, Mendy D, Waldman M, Chen G, Rychak E, Miller K, Gaidarova S, Ren Y, Wang M, Breider M, Carmel G, Mahmoudi A, Jackson P, Abbasian M, Cathers BE, Schafer PH, Daniel TO, Lopez-Girona A, Thakurta A, Chopra R.

Br J Haematol. 2014 Jan;164(2):233-44. doi: 10.1111/bjh.12622. Epub 2013 Oct 28.

6.

Previously unappreciated carotid artery stenosis diagnosed by cone beam computerized tomography.

Almog DM, Padberg FT Jr, Carmel G, Friedlander AH.

J Oral Maxillofac Surg. 2013 Apr;71(4):702-5. doi: 10.1016/j.joms.2012.09.021. Epub 2012 Dec 12.

PMID:
23245518
7.

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.

Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M, Mahmoudi A, Cathers B, Rychak E, Gaidarova S, Chen R, Schafer PH, Handa H, Daniel TO, Evans JF, Chopra R.

Leukemia. 2012 Nov;26(11):2326-35. doi: 10.1038/leu.2012.119. Epub 2012 May 3. Erratum in: Leukemia. 2012 Nov;26(11):2445.

8.

Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase.

Ling LL, Xian J, Ali S, Geng B, Fan J, Mills DM, Arvanites AC, Orgueira H, Ashwell MA, Carmel G, Xiang Y, Moir DT.

Antimicrob Agents Chemother. 2004 May;48(5):1541-7.

9.

Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme.

Krosky DJ, Alm R, Berg M, Carmel G, Tummino PJ, Xu B, Yang W.

Biochim Biophys Acta. 2002 Feb 11;1594(2):297-306.

PMID:
11904225
10.

Structure of the unliganded cAMP-dependent protein kinase catalytic subunit from Saccharomyces cerevisiae.

Mashhoon N, Carmel G, Pflugrath JW, Kuret J.

Arch Biochem Biophys. 2001 Mar 1;387(1):11-9.

PMID:
11368172
11.

Sensory impairment: a feature of chronic venous insufficiency.

Padberg FT Jr, Maniker AH, Carmel G, Pappas PJ, Silva MB Jr, Hobson RW 2nd.

J Vasc Surg. 1999 Nov;30(5):836-42.

12.

Helicobacter pylori physiology predicted from genomic comparison of two strains.

Doig P, de Jonge BL, Alm RA, Brown ED, Uria-Nickelsen M, Noonan B, Mills SD, Tummino P, Carmel G, Guild BC, Moir DT, Vovis GF, Trust TJ.

Microbiol Mol Biol Rev. 1999 Sep;63(3):675-707. Review.

13.

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.

Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, Smith DR, Noonan B, Guild BC, deJonge BL, Carmel G, Tummino PJ, Caruso A, Uria-Nickelsen M, Mills DM, Ives C, Gibson R, Merberg D, Mills SD, Jiang Q, Taylor DE, Vovis GF, Trust TJ.

Nature. 1999 Jan 14;397(6715):176-80. Erratum in: Nature 1999 Feb 25;397(6721):719.

PMID:
9923682
14.

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

Carmel G, Mager EM, Binder LI, Kuret J.

J Biol Chem. 1996 Dec 20;271(51):32789-95.

15.

Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors.

Xu RM, Carmel G, Kuret J, Cheng X.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6308-13.

16.

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X.

EMBO J. 1995 Mar 1;14(5):1015-23.

17.

Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity.

Hoekstra MF, Dhillon N, Carmel G, DeMaggio AJ, Lindberg RA, Hunter T, Kuret J.

Mol Biol Cell. 1994 Aug;5(8):877-86.

18.

Cytoplasmic forms of fission yeast casein kinase-1 associate primarily with the particulate fraction of the cell.

Wang PC, Vancura A, Desai A, Carmel G, Kuret J.

J Biol Chem. 1994 Apr 22;269(16):12014-23.

19.

Expression, purification, crystallization, and preliminary x-ray analysis of casein kinase-1 from Schizosaccharomyces pombe.

Carmel G, Leichus B, Cheng X, Patterson SD, Mirza U, Chait BT, Kuret J.

J Biol Chem. 1994 Mar 11;269(10):7304-9.

20.

A solid-phase screen for protein kinase substrate selectivity.

Carmel G, Kuret J.

Anal Biochem. 1992 Jun;203(2):274-80.

PMID:
1416023
21.
22.

Insertion mutagenesis of the gene encoding the ferrichrome-iron receptor of Escherichia coli K-12.

Carmel G, Hellstern D, Henning D, Coulton JW.

J Bacteriol. 1990 Apr;172(4):1861-9.

23.

Protein fusions of beta-galactosidase to the ferrichrome-iron receptor of Escherichia coli K-12.

Coulton JW, Mason P, Cameron DR, Carmel G, Jean R, Rode HN.

J Bacteriol. 1986 Jan;165(1):181-92.

24.

Composition and physical properties of lipids from plasma membranes of dog kidney.

Carmel G, Rodrigue F, Carrière S, Le Grimellec C.

Biochim Biophys Acta. 1985 Aug 27;818(2):149-57.

PMID:
4027245

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