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Binding of Host Cell Surface Protein Disulfide Isomerase by Anaplasma phagocytophilum Asp14 Enables Pathogen Infection.

Green RS, Naimi WA, Oliver LD Jr, O'Bier N, Cho J, Conrad DH, Martin RK, Marconi RT, Carlyon JA.

mBio. 2020 Jan 28;11(1). pii: e03141-19. doi: 10.1128/mBio.03141-19.


Correction: Naimi, W.A., et al. Differential Susceptibility of Male versus Female Laboratory Mice to Anaplasma phagocytophilum Infection. Trop. Med. Infect. Dis. 2018, 3, 78.

Naimi WA, Green RS, Cockburn CL, Carlyon JA.

Trop Med Infect Dis. 2019 Mar 23;4(1). pii: E51. doi: 10.3390/tropicalmed4010051.


Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.

Cockburn CL, Green RS, Damle SR, Martin RK, Ghahrai NN, Colonne PM, Fullerton MS, Conrad DH, Chalfant CE, Voth DE, Rucks EA, Gilk SD, Carlyon JA.

Life Sci Alliance. 2019 Mar 22;2(2). pii: e201800292. doi: 10.26508/lsa.201800292. Print 2019 Apr.


The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway.

Rodino KG, Adcox HE, Martin RK, Patel V, Conrad DH, Carlyon JA.

Infect Immun. 2019 Feb 21;87(3). pii: e00876-18. doi: 10.1128/IAI.00876-18. Print 2019 Mar.


Differential Susceptibility of Male Versus Female Laboratory Mice to Anaplasma phagocytophilum Infection.

Naimi WA, Green RS, Cockburn CL, Carlyon JA.

Trop Med Infect Dis. 2018 Jul 23;3(3). pii: E78. doi: 10.3390/tropicalmed3030078. Erratum in: Trop Med Infect Dis. 2019 Mar 23;4(1):.


Outer Membrane Protein A Conservation among Orientia tsutsugamushi Isolates Suggests Its Potential as a Protective Antigen and Diagnostic Target.

Evans SM, Adcox HE, VieBrock L, Green RS, Luce-Fedrow A, Chattopadhyay S, Jiang J, Marconi RT, Paris D, Richards AL, Carlyon JA.

Trop Med Infect Dis. 2018 Jun 11;3(2). pii: E63. doi: 10.3390/tropicalmed3020063.


Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.

Evans SM, Rodino KG, Adcox HE, Carlyon JA.

PLoS Pathog. 2018 May 7;14(5):e1007023. doi: 10.1371/journal.ppat.1007023. eCollection 2018 May.


Orientia tsutsugamushi Modulates Endoplasmic Reticulum-Associated Degradation To Benefit Its Growth.

Rodino KG, VieBrock L, Evans SM, Ge H, Richards AL, Carlyon JA.

Infect Immun. 2017 Dec 19;86(1). pii: e00596-17. doi: 10.1128/IAI.00596-17. Print 2018 Jan.


Anaplasma phagocytophilum-Occupied Vacuole Interactions with the Host Cell Cytoskeleton.

Truchan HK, Cockburn CL, May LJ, VieBrock L, Carlyon JA.

Vet Sci. 2016 Sep 21;3(3). pii: E25. doi: 10.3390/vetsci3030025.


Anaplasma phagocytophilum infection modulates expression of megakaryocyte cell cycle genes through phosphatidylinositol-3-kinase signaling.

Khanal S, Sultana H, Catravas JD, Carlyon JA, Neelakanta G.

PLoS One. 2017 Aug 10;12(8):e0182898. doi: 10.1371/journal.pone.0182898. eCollection 2017.


ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.

Damle SR, Martin RK, Cockburn CL, Lownik JC, Carlyon JA, Smith AD, Conrad DH.

Allergy. 2018 Jan;73(1):125-136. doi: 10.1111/all.13261. Epub 2017 Aug 31.


Engineering of obligate intracellular bacteria: progress, challenges and paradigms.

McClure EE, Chávez ASO, Shaw DK, Carlyon JA, Ganta RR, Noh SM, Wood DO, Bavoil PM, Brayton KA, Martinez JJ, McBride JW, Valdivia RH, Munderloh UG, Pedra JHF.

Nat Rev Microbiol. 2017 Sep;15(9):544-558. doi: 10.1038/nrmicro.2017.59. Epub 2017 Jun 19. Review.


Orientia tsutsugamushi Ank9 is a multifunctional effector that utilizes a novel GRIP-like Golgi localization domain for Golgi-to-endoplasmic reticulum trafficking and interacts with host COPB2.

Beyer AR, Rodino KG, VieBrock L, Green RS, Tegels BK, Oliver LD Jr, Marconi RT, Carlyon JA.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12727. Epub 2017 Feb 3.


Anaplasma marginale Outer Membrane Protein A Is an Adhesin That Recognizes Sialylated and Fucosylated Glycans and Functionally Depends on an Essential Binding Domain.

Hebert KS, Seidman D, Oki AT, Izac J, Emani S, Oliver LD Jr.,, Miller DP, Tegels BK, Kannagi R, Marconi RT, Carlyon JA.

Infect Immun. 2017 Feb 23;85(3). pii: e00968-16. doi: 10.1128/IAI.00968-16. Print 2017 Mar.


Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions.

Mallory KL, Miller DP, Oliver LD Jr, Freedman JC, Kostick-Dunn JL, Carlyon JA, Marion JD, Bell JK, Marconi RT.

Pathog Dis. 2016 Nov;74(8). pii: ftw105. Epub 2016 Oct 18.


Anaplasma phagocytophilum APH0032 Is Exposed on the Cytosolic Face of the Pathogen-Occupied Vacuole and Co-opts Host Cell SUMOylation.

Oki AT, Huang B, Beyer AR, May LJ, Truchan HK, Walker NJ, Galloway NL, Borjesson DL, Carlyon JA.

Front Cell Infect Microbiol. 2016 Sep 22;6:108. eCollection 2016.


The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH.

PLoS Pathog. 2016 Aug 2;12(8):e1005803. doi: 10.1371/journal.ppat.1005803. eCollection 2016 Aug.


Chimeric Coupling Proteins Mediate Transfer of Heterologous Type IV Effectors through the Escherichia coli pKM101-Encoded Conjugation Machine.

Whitaker N, Berry TM, Rosenthal N, Gordon JE, Gonzalez-Rivera C, Sheehan KB, Truchan HK, VieBrock L, Newton IL, Carlyon JA, Christie PJ.

J Bacteriol. 2016 Sep 9;198(19):2701-18. doi: 10.1128/JB.00378-16. Print 2016 Oct 1.


The Pathogen-Occupied Vacuoles of Anaplasma phagocytophilum and Anaplasma marginale Interact with the Endoplasmic Reticulum.

Truchan HK, Cockburn CL, Hebert KS, Magunda F, Noh SM, Carlyon JA.

Front Cell Infect Microbiol. 2016 Mar 1;6:22. doi: 10.3389/fcimb.2016.00022. eCollection 2016.


Intracellular bacterial pathogens: a reemerging field of research rich with breakthroughs and opportunities.

Greub G, Bleeker-Rovers CP, Carlyon J, Fournier PE, Ojcius D, Puolakkainen M.

Microbes Infect. 2015 Nov-Dec;17(11-12):721-2. doi: 10.1016/j.micinf.2015.10.002. Epub 2015 Oct 19. No abstract available.


Dendrimer-enabled transformation of Anaplasma phagocytophilum.

Oki AT, Seidman D, Lancina MG 3rd, Mishra MK, Kannan RM, Yang H, Carlyon JA.

Microbes Infect. 2015 Nov-Dec;17(11-12):817-22. doi: 10.1016/j.micinf.2015.09.001. Epub 2015 Sep 11.


Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle.

Truchan HK, VieBrock L, Cockburn CL, Ojogun N, Griffin BP, Wijesinghe DS, Chalfant CE, Carlyon JA.

Cell Microbiol. 2016 Feb;18(2):260-81. doi: 10.1111/cmi.12500. Epub 2015 Oct 7.


Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells.

Dikshit N, Bist P, Fenlon SN, Pulloor NK, Chua CE, Scidmore MA, Carlyon JA, Tang BL, Chen SL, Sukumaran B.

PLoS Pathog. 2015 Aug 6;11(8):e1005083. doi: 10.1371/journal.ppat.1005083. eCollection 2015 Aug.


Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs.

Beyer AR, VieBrock L, Rodino KG, Miller DP, Tegels BK, Marconi RT, Carlyon JA.

J Bacteriol. 2015 Oct;197(19):3097-109. doi: 10.1128/JB.00276-15. Epub 2015 Jul 13.


Of goats and men: rethinking anaplasmoses as zoonotic infections.

Beyer AR, Carlyon JA.

Lancet Infect Dis. 2015 Jun;15(6):619-20. doi: 10.1016/S1473-3099(15)70097-6. Epub 2015 Mar 29. No abstract available.


Orientia tsutsugamushi ankyrin repeat-containing protein family members are Type 1 secretion system substrates that traffic to the host cell endoplasmic reticulum.

VieBrock L, Evans SM, Beyer AR, Larson CL, Beare PA, Ge H, Singh S, Rodino KG, Heinzen RA, Richards AL, Carlyon JA.

Front Cell Infect Microbiol. 2015 Feb 3;4:186. doi: 10.3389/fcimb.2014.00186. eCollection 2014.


Essential domains of Anaplasma phagocytophilum invasins utilized to infect mammalian host cells.

Seidman D, Hebert KS, Truchan HK, Miller DP, Tegels BK, Marconi RT, Carlyon JA.

PLoS Pathog. 2015 Feb 6;11(2):e1004669. doi: 10.1371/journal.ppat.1004669. eCollection 2015 Feb.


The Anaplasma phagocytophilum effector AmpA hijacks host cell SUMOylation.

Beyer AR, Truchan HK, May LJ, Walker NJ, Borjesson DL, Carlyon JA.

Cell Microbiol. 2015 Apr;17(4):504-19. doi: 10.1111/cmi.12380. Epub 2014 Nov 22.


Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells.

Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA.

Cell Microbiol. 2014 Aug;16(8):1133-45. doi: 10.1111/cmi.12286. Epub 2014 Apr 3.


Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity.

Earnhart CG, Rhodes DV, Smith AA, Yang X, Tegels B, Carlyon JA, Pal U, Marconi RT.

Pathog Dis. 2014 Mar;70(2):176-84. doi: 10.1111/2049-632X.12119. Epub 2014 Feb 3.


Breaking in and grabbing a meal: Anaplasma phagocytophilum cellular invasion, nutrient acquisition, and promising tools for their study.

Truchan HK, Seidman D, Carlyon JA.

Microbes Infect. 2013 Dec;15(14-15):1017-25. doi: 10.1016/j.micinf.2013.10.010. Epub 2013 Oct 18. Review.


Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection.

Kahlon A, Ojogun N, Ragland SA, Seidman D, Troese MJ, Ottens AK, Mastronunzio JE, Truchan HK, Walker NJ, Borjesson DL, Fikrig E, Carlyon JA.

Infect Immun. 2013 Jan;81(1):65-79. doi: 10.1128/IAI.00932-12. Epub 2012 Oct 15.


Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells.

Ojogun N, Kahlon A, Ragland SA, Troese MJ, Mastronunzio JE, Walker NJ, Viebrock L, Thomas RJ, Borjesson DL, Fikrig E, Carlyon JA.

Infect Immun. 2012 Nov;80(11):3748-60. doi: 10.1128/IAI.00654-12. Epub 2012 Aug 20.


Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.

Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ.

J Immunol. 2012 May 1;188(9):4360-8. doi: 10.4049/jimmunol.1003223. Epub 2012 Mar 26.


Monoubiquitinated proteins decorate the Anaplasma phagocytophilum-occupied vacuolar membrane.

Huang B, Ojogun N, Ragland SA, Carlyon JA.

FEMS Immunol Med Microbiol. 2012 Feb;64(1):32-41. doi: 10.1111/j.1574-695X.2011.00873.x.


Proteomic analysis of Anaplasma phagocytophilum during infection of human myeloid cells identifies a protein that is pronouncedly upregulated on the infectious dense-cored cell.

Troese MJ, Kahlon A, Ragland SA, Ottens AK, Ojogun N, Nelson KT, Walker NJ, Borjesson DL, Carlyon JA.

Infect Immun. 2011 Nov;79(11):4696-707. doi: 10.1128/IAI.05658-11. Epub 2011 Aug 15.


Anaplasma phagocytophilum infects mast cells via alpha1,3-fucosylated but not sialylated glycans and inhibits IgE-mediated cytokine production and histamine release.

Ojogun N, Barnstein B, Huang B, Oskeritzian CA, Homeister JW, Miller D, Ryan JJ, Carlyon JA.

Infect Immun. 2011 Jul;79(7):2717-26. doi: 10.1128/IAI.00181-11. Epub 2011 May 2.


Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane.

Huang B, Troese MJ, Howe D, Ye S, Sims JT, Heinzen RA, Borjesson DL, Carlyon JA.

Microb Pathog. 2010 Nov;49(5):273-84. doi: 10.1016/j.micpath.2010.06.009. Epub 2010 Jun 30.


Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium.

Schaff UY, Trott KA, Chase S, Tam K, Johns JL, Carlyon JA, Genetos DC, Walker NJ, Simon SI, Borjesson DL.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C87-96. doi: 10.1152/ajpcell.00165.2009. Epub 2010 Apr 14.


The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes.

Huang B, Hubber A, McDonough JA, Roy CR, Scidmore MA, Carlyon JA.

Cell Microbiol. 2010 Sep 1;12(9):1292-307. doi: 10.1111/j.1462-5822.2010.01468.x. Epub 2010 Mar 25.


Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane.

Huang B, Troese MJ, Ye S, Sims JT, Galloway NL, Borjesson DL, Carlyon JA.

Infect Immun. 2010 May;78(5):1864-73. doi: 10.1128/IAI.01418-09. Epub 2010 Mar 8.


Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis.

Thomas RJ, Dumler JS, Carlyon JA.

Expert Rev Anti Infect Ther. 2009 Aug;7(6):709-22. doi: 10.1586/eri.09.44. Review.


Anaplasma phagocytophilum dense-cored organisms mediate cellular adherence through recognition of human P-selectin glycoprotein ligand 1.

Troese MJ, Carlyon JA.

Infect Immun. 2009 Sep;77(9):4018-27. doi: 10.1128/IAI.00527-09. Epub 2009 Jul 13.


Differential expression and glycosylation of anaplasma phagocytophilum major surface protein 2 paralogs during cultivation in sialyl Lewis x-deficient host cells.

Troese MJ, Sarkar M, Galloway NL, Thomas RJ, Kearns SA, Reneer DV, Yang T, Carlyon JA.

Infect Immun. 2009 May;77(5):1746-56. doi: 10.1128/IAI.01530-08. Epub 2009 Feb 17.


Laboratory Maintenance of Anaplasma phagocytophilum.

Carlyon JA.

Curr Protoc Microbiol. 2005 Jul;Chapter 3:Unit 3A.2. doi: 10.1002/9780471729259.mc03a02s00.


Anaplasma phagocytophilum PSGL-1-independent infection does not require Syk and leads to less efficient AnkA delivery.

Reneer DV, Troese MJ, Huang B, Kearns SA, Carlyon JA.

Cell Microbiol. 2008 Sep;10(9):1827-38. doi: 10.1111/j.1462-5822.2008.01168.x. Epub 2008 May 13.


Anaplasma phagocytophilum infects cells of the megakaryocytic lineage through sialylated ligands but fails to alter platelet production.

Granick JL, Reneer DV, Carlyon JA, Borjesson DL.

J Med Microbiol. 2008 Apr;57(Pt 4):416-23. doi: 10.1099/jmm.0.47551-0.


Anaplasma phagocytophilum MSP2(P44)-18 predominates and is modified into multiple isoforms in human myeloid cells.

Sarkar M, Troese MJ, Kearns SA, Yang T, Reneer DV, Carlyon JA.

Infect Immun. 2008 May;76(5):2090-8. doi: 10.1128/IAI.01594-07. Epub 2008 Feb 19.


Sialyl-Lewis x-independent infection of human myeloid cells by Anaplasma phagocytophilum strains HZ and HGE1.

Sarkar M, Reneer DV, Carlyon JA.

Infect Immun. 2007 Dec;75(12):5720-5. Epub 2007 Sep 24.


Characterization of a sialic acid- and P-selectin glycoprotein ligand-1-independent adhesin activity in the granulocytotropic bacterium Anaplasma phagocytophilum.

Reneer DV, Kearns SA, Yago T, Sims J, Cummings RD, McEver RP, Carlyon JA.

Cell Microbiol. 2006 Dec;8(12):1972-84. Epub 2006 Jul 26.


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