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Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.

Weizman OE, Song E, Adams NM, Hildreth AD, Riggan L, Krishna C, Aguilar OA, Leslie CS, Carlyle JR, Sun JC, O'Sullivan TE.

Nat Immunol. 2019 Jul 1. doi: 10.1038/s41590-019-0430-1. [Epub ahead of print]


The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc.

Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, Sun JC, Glimcher LH.

Nat Immunol. 2019 Jul;20(7):865-878. doi: 10.1038/s41590-019-0388-z. Epub 2019 May 13.


Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition.

Balaji GR, Aguilar OA, Tanaka M, Shingu-Vazquez MA, Fu Z, Gully BS, Lanier LL, Carlyle JR, Rossjohn J, Berry R.

Nat Commun. 2018 Nov 5;9(1):4623. doi: 10.1038/s41467-018-06989-2.


NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.

Abou-Samra E, Hickey Z, Aguilar OA, Scur M, Mahmoud AB, Pyatibrat S, Tu MM, Francispillai J, Mortha A, Carlyle JR, Rahim MMA, Makrigiannis AP.

Cell Mol Immunol. 2018 Oct 1. doi: 10.1038/s41423-018-0169-x. [Epub ahead of print]


The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.

Bando JK, Gilfillan S, Song C, McDonald KG, Huang SC, Newberry RD, Kobayashi Y, Allan DSJ, Carlyle JR, Cella M, Colonna M.

Immunity. 2018 Jun 19;48(6):1208-1219.e4. doi: 10.1016/j.immuni.2018.04.012. Epub 2018 May 29.


The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance.

Tanaka M, Fine JH, Kirkham CL, Aguilar OA, Belcheva A, Martin A, Ketela T, Moffat J, Allan DSJ, Carlyle JR.

Cancer Res. 2018 Jul 1;78(13):3589-3603. doi: 10.1158/0008-5472.CAN-17-1688. Epub 2018 Apr 24.


Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.

Seshadri S, Allan DSJ, Carlyle JR, Zenewicz LA.

PLoS Pathog. 2017 Oct 23;13(10):e1006690. doi: 10.1371/journal.ppat.1006690. eCollection 2017 Oct.


Transcriptome analysis reveals similarities between human blood CD3- CD56bright cells and mouse CD127+ innate lymphoid cells.

Allan DSJ, Cerdeira AS, Ranjan A, Kirkham CL, Aguilar OA, Tanaka M, Childs RW, Dunbar CE, Strominger JL, Kopcow HD, Carlyle JR.

Sci Rep. 2017 Jun 14;7(1):3501. doi: 10.1038/s41598-017-03256-0.


A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popović B, Tanaka M, Fu Z, Balaji GR, Lau TNH, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpotić A, Allan DSJ, Makrigiannis AP, Jonjić S, Rossjohn J, Carlyle JR.

Cell. 2017 Mar 23;169(1):58-71.e14. doi: 10.1016/j.cell.2017.03.002.


Interferon-Dependent Induction of Clr-b during Mouse Cytomegalovirus Infection Protects Bystander Cells from Natural Killer Cells via NKR-P1B-Mediated Inhibition.

Kirkham CL, Aguilar OA, Yu T, Tanaka M, Mesci A, Chu KL, Fine JH, Mossman KL, Bremner R, Allan DSJ, Carlyle JR.

J Innate Immun. 2017;9(4):343-358. doi: 10.1159/000454926. Epub 2017 Mar 14.


Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection.

Rahim MM, Wight A, Mahmoud AB, Aguilar OA, Lee SH, Vidal SM, Carlyle JR, Makrigiannis AP.

J Immunol. 2016 Sep 15;197(6):2325-37. doi: 10.4049/jimmunol.1600776. Epub 2016 Aug 10.


Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.

Aguilar OA, Mesci A, Ma J, Chen P, Kirkham CL, Hundrieser J, Voigt S, Allan DS, Carlyle JR.

J Innate Immun. 2015;7(6):584-600. doi: 10.1159/000382032. Epub 2015 May 29.


Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.

Chen P, Aguilar OA, Rahim MM, Allan DS, Fine JH, Kirkham CL, Ma J, Tanaka M, Tu MM, Wight A, Kartsogiannis V, Gillespie MT, Makrigiannis AP, Carlyle JR.

J Immunol. 2015 Mar 15;194(6):2909-18. doi: 10.4049/jimmunol.1401523. Epub 2015 Feb 13.


The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.

Rahim MM, Chen P, Mottashed AN, Mahmoud AB, Thomas MJ, Zhu Q, Brooks CG, Kartsogiannis V, Gillespie MT, Carlyle JR, Makrigiannis AP.

Blood. 2015 Apr 2;125(14):2217-27. doi: 10.1182/blood-2014-02-556142. Epub 2015 Jan 22.


An in vitro model of innate lymphoid cell function and differentiation.

Allan DS, Kirkham CL, Aguilar OA, Qu LC, Chen P, Fine JH, Serra P, Awong G, Gommerman JL, Zúñiga-Pflücker JC, Carlyle JR.

Mucosal Immunol. 2015 Mar;8(2):340-51. doi: 10.1038/mi.2014.71. Epub 2014 Aug 20.


A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.

Karimi MA, Aguilar O, Zou B, Bachmann MH, Carlyle JR, Baldwin CL, Kambayashi T.

J Immunol. 2014 Sep 15;193(6):2764-2771. doi: 10.4049/jimmunol.1400920. Epub 2014 Aug 4.


Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems.

Kirkham CL, Carlyle JR.

Front Immunol. 2014 Jun 2;5:214. doi: 10.3389/fimmu.2014.00214. eCollection 2014. Review.


The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

Male V, Nisoli I, Kostrzewski T, Allan DS, Carlyle JR, Lord GM, Wack A, Brady HJ.

J Exp Med. 2014 Apr 7;211(4):635-42. doi: 10.1084/jem.20132398. Epub 2014 Mar 24.


Optimized tetramer analysis reveals Ly49 promiscuity for MHC ligands.

McFall E, Tu MM, Al-Khattabi N, Tai LH, St-Laurent AS, Tzankova V, Hall CW, Belanger S, Troke AD, Wight A, Mahmoud AB, Zein HS, Rahim MM, Carlyle JR, Makrigiannis AP.

J Immunol. 2013 Dec 1;191(11):5722-9. doi: 10.4049/jimmunol.1300726. Epub 2013 Oct 23.


Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.

Zhang Q, Rahim MM, Allan DS, Tu MM, Belanger S, Abou-Samra E, Ma J, Sekhon HS, Fairhead T, Zein HS, Carlyle JR, Anderson SK, Makrigiannis AP.

PLoS One. 2012;7(12):e50561. doi: 10.1371/journal.pone.0050561. Epub 2012 Dec 4.


Poxvirus infection-associated downregulation of C-type lectin-related-b prevents NK cell inhibition by NK receptor protein-1B.

Williams KJ, Wilson E, Davidson CL, Aguilar OA, Fu L, Carlyle JR, Burshtyn DN.

J Immunol. 2012 May 15;188(10):4980-91. doi: 10.4049/jimmunol.1103425. Epub 2012 Apr 9.


Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity.

Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5. doi: 10.1073/pnas.1118834109. Epub 2011 Dec 13.


CELLISA: reporter cell-based immunization and screening of hybridomas specific for cell surface antigens.

Chen P, Mesci A, Carlyle JR.

Methods Mol Biol. 2011;748:209-25. doi: 10.1007/978-1-61779-139-0_15.


Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor-ligand interactions despite significant allelic polymorphism.

Chen P, Bélanger S, Aguilar OA, Zhang Q, St-Laurent A, Rahim MM, Makrigiannis AP, Carlyle JR.

Immunogenetics. 2011 Oct;63(10):627-40. doi: 10.1007/s00251-011-0542-8. Epub 2011 Jun 11.


Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missing-self recognition.

Fine JH, Chen P, Mesci A, Allan DS, Gasser S, Raulet DH, Carlyle JR.

Cancer Res. 2010 Sep 15;70(18):7102-13. doi: 10.1158/0008-5472.CAN-10-1316. Epub 2010 Sep 7.


TGF-β affects development and differentiation of human natural killer cell subsets.

Allan DS, Rybalov B, Awong G, Zúñiga-Pflücker JC, Kopcow HD, Carlyle JR, Strominger JL.

Eur J Immunol. 2010 Aug;40(8):2289-95. doi: 10.1002/eji.200939910.


Altering the specificity of NK:target cell interactions by genetic manipulation of NK receptor expression on primary mouse NK cells.

Tran J, Mahmood S, Carlyle JR, Kung SK.

Vaccine. 2010 May 14;28(22):3767-72. doi: 10.1016/j.vaccine.2010.03.013. Epub 2010 Mar 23.


Evolution of the Ly49 and Nkrp1 recognition systems.

Carlyle JR, Mesci A, Fine JH, Chen P, Bélanger S, Tai LH, Makrigiannis AP.

Semin Immunol. 2008 Dec;20(6):321-30. doi: 10.1016/j.smim.2008.05.004. Epub 2008 Jul 2. Review.


Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.

Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C.

J Clin Invest. 2008 Jun;118(6):2098-110. doi: 10.1172/JCI34584.


Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis.

Voigt S, Mesci A, Ettinger J, Fine JH, Chen P, Chou W, Carlyle JR.

Immunity. 2007 May;26(5):617-27. Epub 2007 Apr 26.


A rapid and efficient method for the generation and screening of monoclonal antibodies specific for cell surface antigens.

Mesci A, Carlyle JR.

J Immunol Methods. 2007 May 31;323(1):78-87. Epub 2007 Mar 15.


Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.

Tai LH, Goulet ML, Belanger S, Troke AD, St-Laurent AG, Mesci A, Toyama-Sorimachi N, Carlyle JR, Makrigiannis AP.

Mol Immunol. 2007 Apr;44(10):2638-46. Epub 2007 Jan 22.


NKR-P1 biology: from prototype to missing self.

Mesci A, Ljutic B, Makrigiannis AP, Carlyle JR.

Immunol Res. 2006;35(1-2):13-26. Review.


Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells.

Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP.

J Immunol. 2006 Jun 15;176(12):7511-24.


AID mutates a non-immunoglobulin transgene independent of chromosomal position.

Parsa JY, Basit W, Wang CL, Gommerman JL, Carlyle JR, Martin A.

Mol Immunol. 2007 Jan;44(4):567-75. Epub 2006 Mar 20.


Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors.

Ljutic B, Carlyle JR, Filipp D, Nakagawa R, Julius M, Zúñiga-Pflücker JC.

J Immunol. 2005 Apr 15;174(8):4789-96.


Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.

Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27.


Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C.

Ljutic B, Carlyle JR, Zúñiga-Pflücker JC.

J Biol Chem. 2003 Aug 22;278(34):31909-17. Epub 2003 Jun 17.


In vitro generation of T lymphocytes from embryonic stem cell-derived prehematopoietic progenitors.

de Pooter RF, Cho SK, Carlyle JR, Zúñiga-Pflücker JC.

Blood. 2003 Sep 1;102(5):1649-53. Epub 2003 May 8.


The role of the NKG2D immunoreceptor in immune cell activation and natural killing.

Jamieson AM, Diefenbach A, McMahon CW, Xiong N, Carlyle JR, Raulet DH.

Immunity. 2002 Jul;17(1):19-29. Erratum in: Immunity. 2004 Jun;20(6):799.


Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus.

Michie AM, Carlyle JR, Schmitt TM, Ljutic B, Cho SK, Fong Q, Zúñiga-Pflücker JC.

J Immunol. 2000 Feb 15;164(4):1730-3.


Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.

Cho SK, Webber TD, Carlyle JR, Nakano T, Lewis SM, Zúñiga-Pflücker JC.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9797-802.


Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.

Carlyle JR, Martin A, Mehra A, Attisano L, Tsui FW, Zúñiga-Pflücker JC.

J Immunol. 1999 May 15;162(10):5917-23.


Regulation of NK1.1 expression during lineage commitment of progenitor thymocytes.

Carlyle JR, Zúñiga-Pflücker JC.

J Immunol. 1998 Dec 15;161(12):6544-51.


Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse.

Carlyle JR, Zúñiga-Pflücker JC.

Immunol Rev. 1998 Oct;165:63-74. Review.


Requirement for the thymus in alphabeta T lymphocyte lineage commitment.

Carlyle JR, Zúñiga-Pflücker JC.

Immunity. 1998 Aug;9(2):187-97.


Natural killer cell development and function precede alpha beta T cell differentiation in mouse fetal thymic ontogeny.

Carlyle JR, Michie AM, Cho SK, Zúñiga-Pflücker JC.

J Immunol. 1998 Jan 15;160(2):744-53.


Early intrathymic precursor cells acquire a CD4(low) phenotype.

Michie AM, Carlyle JR, Zúñiga-Pflücker JC.

J Immunol. 1998 Feb 15;160(4):1735-41.


Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes.

Carlyle JR, Michie AM, Furlonger C, Nakano T, Lenardo MJ, Paige CJ, Zúñiga-Pflücker JC.

J Exp Med. 1997 Jul 21;186(2):173-82.

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