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Items: 1 to 50 of 164

1.

CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.

Penfold L, Woods A, Muckett P, Nikitin AY, Kent TR, Zhang S, Graham R, Pollard A, Carling D.

Cancer Res. 2018 Dec 15;78(24):6747-6761. doi: 10.1158/0008-5472.CAN-18-0585. Epub 2018 Sep 21.

PMID:
30242113
2.

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP.

J Biol Chem. 2018 Nov 2;293(44):17208-17217. doi: 10.1074/jbc.RA118.002579. Epub 2018 Sep 19.

3.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM.

Biochem J. 2018 Sep 25;475(18):2969-2983. doi: 10.1042/BCJ20180475.

4.

Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.

5.

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.

Willows R, Sanders MJ, Xiao B, Patel BR, Martin SR, Read J, Wilson JR, Hubbard J, Gamblin SJ, Carling D.

Biochem J. 2017 Aug 22;474(17):3059-3073. doi: 10.1042/BCJ20170458.

6.

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet.

Woods A, Williams JR, Muckett PJ, Mayer FV, Liljevald M, Bohlooly-Y M, Carling D.

Cell Rep. 2017 Mar 28;18(13):3043-3051. doi: 10.1016/j.celrep.2017.03.011.

7.

Effect of different γ-subunit isoforms on the regulation of AMPK.

Willows R, Navaratnam N, Lima A, Read J, Carling D.

Biochem J. 2017 May 9;474(10):1741-1754. doi: 10.1042/BCJ20170046.

8.

AMPK signalling in health and disease.

Carling D.

Curr Opin Cell Biol. 2017 Apr;45:31-37. doi: 10.1016/j.ceb.2017.01.005. Epub 2017 Feb 21. Review.

9.

Time-lapse 3-D measurements of a glucose biosensor in multicellular spheroids by light sheet fluorescence microscopy in commercial 96-well plates.

Maioli V, Chennell G, Sparks H, Lana T, Kumar S, Carling D, Sardini A, Dunsby C.

Sci Rep. 2016 Nov 25;6:37777. doi: 10.1038/srep37777.

10.

Erratum. Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells. Diabetes 2007;56:1387-1394.

Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A.

Diabetes. 2016 Oct;65(10):3218. doi: 10.2337/db16-er10a. No abstract available.

11.

Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM.

Chennell G, Willows RJ, Warren SC, Carling D, French PM, Dunsby C, Sardini A.

Sensors (Basel). 2016 Aug 19;16(8). pii: E1312. doi: 10.3390/s16081312.

12.

Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.

Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B, Cornall RJ.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3706-15. doi: 10.1073/pnas.1607592113. Epub 2016 Jun 14.

13.

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.

Trousil S, Kaliszczak M, Schug Z, Nguyen QD, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, Aboagye EO.

Oncotarget. 2016 Jun 14;7(24):37103-37120. doi: 10.18632/oncotarget.9466.

14.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.

15.

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH.

Nat Commun. 2016 Mar 8;7:10856. doi: 10.1038/ncomms10856.

16.

Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism.

Carling D, Viollet B.

Cell Metab. 2015 Jun 2;21(6):799-804. doi: 10.1016/j.cmet.2015.05.005. Review.

17.

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.

Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.

Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9.

18.

A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice.

Rousset CI, Leiper FC, Kichev A, Gressens P, Carling D, Hagberg H, Thornton C.

J Neurochem. 2015 Apr;133(2):242-52. doi: 10.1111/jnc.13034. Epub 2015 Feb 24.

19.

Glucokinase activity in the arcuate nucleus regulates glucose intake.

Hussain S, Richardson E, Ma Y, Holton C, De Backer I, Buckley N, Dhillo W, Bewick G, Zhang S, Carling D, Bloom S, Gardiner J.

J Clin Invest. 2015 Jan;125(1):337-49. doi: 10.1172/JCI77172. Epub 2014 Dec 8.

20.

The mammalian AMP-activated protein kinase complex mediates glucose regulation of gene expression in the yeast Saccharomyces cerevisiae.

Ye T, Bendrioua L, Carmena D, García-Salcedo R, Dahl P, Carling D, Hohmann S.

FEBS Lett. 2014 Jun 5;588(12):2070-7. doi: 10.1016/j.febslet.2014.04.039. Epub 2014 May 8.

21.

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism.

Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD.

Nat Commun. 2014 Apr 29;5:3611. doi: 10.1038/ncomms4611.

22.

Structural basis of AMPK regulation by small molecule activators.

Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ.

Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017.

23.

5'-AMP-activated protein kinase-activating transcription factor 1 cascade modulates human monocyte-derived macrophages to atheroprotective functions in response to heme or metformin.

Wan X, Huo Y, Johns M, Piper E, Mason JC, Carling D, Haskard DO, Boyle JJ.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2470-80. doi: 10.1161/ATVBAHA.113.300986. Epub 2013 Sep 19. Erratum in: Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):e80.

PMID:
24051143
24.

AMPK, insulin resistance, and the metabolic syndrome.

Ruderman NB, Carling D, Prentki M, Cacicedo JM.

J Clin Invest. 2013 Jul;123(7):2764-72. doi: 10.1172/JCI67227. Epub 2013 Jul 1. Review.

25.

Potassium channel KCNA1 modulates oncogene-induced senescence and transformation.

Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D.

Cancer Res. 2013 Aug 15;73(16):5253-65. doi: 10.1158/0008-5472.CAN-12-3690. Epub 2013 Jun 17.

26.

Fluorescence lifetime readouts of Troponin-C-based calcium FRET sensors: a quantitative comparison of CFP and mTFP1 as donor fluorophores.

Laine R, Stuckey DW, Manning H, Warren SC, Kennedy G, Carling D, Dunsby C, Sardini A, French PM.

PLoS One. 2012;7(11):e49200. doi: 10.1371/journal.pone.0049200. Epub 2012 Nov 9.

27.

AMP-activated protein kinase: new regulation, new roles?

Carling D, Thornton C, Woods A, Sanders MJ.

Biochem J. 2012 Jul 1;445(1):11-27. doi: 10.1042/BJ20120546. Review.

PMID:
22702974
28.

The role of ATM in response to metformin treatment and activation of AMPK.

Woods A, Leiper JM, Carling D.

Nat Genet. 2012 Mar 28;44(4):360-1. doi: 10.1038/ng.2235. No abstract available.

PMID:
22456733
29.

AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes.

Oliveira SM, Zhang YH, Solis RS, Isackson H, Bellahcene M, Yavari A, Pinter K, Davies JK, Ge Y, Ashrafian H, Walker JW, Carling D, Watkins H, Casadei B, Redwood C.

Circ Res. 2012 Apr 27;110(9):1192-201. doi: 10.1161/CIRCRESAHA.111.259952. Epub 2012 Mar 27.

PMID:
22456184
30.

Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK.

Fritah A, Steel JH, Parker N, Nikolopoulou E, Christian M, Carling D, Parker MG.

PLoS One. 2012;7(2):e32520. doi: 10.1371/journal.pone.0032520. Epub 2012 Feb 28.

31.

LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis.

Denison FC, Smith LB, Muckett PJ, O'Hara L, Carling D, Woods A.

PLoS One. 2011;6(12):e28306. doi: 10.1371/journal.pone.0028306. Epub 2011 Dec 1.

32.

ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

Mayer FV, Heath R, Underwood E, Sanders MJ, Carmena D, McCartney RR, Leiper FC, Xiao B, Jing C, Walker PA, Haire LF, Ogrodowicz R, Martin SR, Schmidt MC, Gamblin SJ, Carling D.

Cell Metab. 2011 Nov 2;14(5):707-14. doi: 10.1016/j.cmet.2011.09.009. Epub 2011 Oct 20.

33.

5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.

Tsuchiya Y, Denison FC, Heath RB, Carling D, Saggerson D.

Biosci Rep. 2012 Apr 1;32(2):197-213. doi: 10.1042/BSR20110076.

PMID:
21851339
34.

AMP-activated protein kinase: also regulated by ADP?

Hardie DG, Carling D, Gamblin SJ.

Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23. Review.

PMID:
21782450
35.

AMP-activated protein kinase: nature's energy sensor.

Carling D, Mayer FV, Sanders MJ, Gamblin SJ.

Nat Chem Biol. 2011 Jul 18;7(8):512-8. doi: 10.1038/nchembio.610. Review.

PMID:
21769098
36.

Structure of mammalian AMPK and its regulation by ADP.

Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ.

Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.

37.

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055. Epub 2011 Jan 24.

38.

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D.

Biochem J. 2011 Mar 15;434(3):503-12. doi: 10.1042/BJ20101485.

PMID:
21204788
39.

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice.

Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, Ashworth A, Withers DJ, Carling D.

Biochem J. 2011 Feb 15;434(1):49-60. doi: 10.1042/BJ20101721.

40.

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.

López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.

Nat Med. 2010 Sep;16(9):1001-8. doi: 10.1038/nm.2207. Epub 2010 Aug 29.

41.

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation.

Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL.

Science. 2010 Sep 3;329(5996):1201-5. doi: 10.1126/science.1191241. Epub 2010 Jul 15.

42.

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford ML.

Biochem J. 2010 Jul 15;429(2):323-33. doi: 10.1042/BJ20100231.

43.

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase.

Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, Viollet B, Carling D, Heller R.

J Biol Chem. 2010 Apr 2;285(14):10638-52. doi: 10.1074/jbc.M110.108688. Epub 2010 Feb 3.

44.

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D.

EMBO J. 2010 Jan 20;29(2):376-86. doi: 10.1038/emboj.2009.342. Epub 2009 Nov 19.

45.

AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators.

García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A.

Biochem Pharmacol. 2010 Mar 15;79(6):853-63. doi: 10.1016/j.bcp.2009.10.022. Epub 2009 Nov 5.

PMID:
19896469
46.

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.

Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.

Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Erratum in: Science. 2011 Oct 7;334(6052):39.

47.

Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: a cautionary tale.

Renz B, Davies JK, Carling D, Watkins H, Redwood C.

Protein Expr Purif. 2009 Aug;66(2):181-4. doi: 10.1016/j.pep.2009.02.016. Epub 2009 Mar 6.

48.

Taking the stress out of melanoma.

Martin MJ, Carling D, Marais R.

Cancer Cell. 2009 Mar 3;15(3):163-4. doi: 10.1016/j.ccr.2009.02.006. Review.

49.

The regulation and function of mammalian AMPK-related kinases.

Bright NJ, Thornton C, Carling D.

Acta Physiol (Oxf). 2009 May;196(1):15-26. doi: 10.1111/j.1748-1716.2009.01971.x. Epub 2009 Feb 19. Review.

PMID:
19245655
50.

Branching out on AMPK Regulation.

Carling D.

Cell Metab. 2009 Jan 7;9(1):7-8. doi: 10.1016/j.cmet.2008.12.007.

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