Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 35

1.

Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.

Swidorski JJ, Liu Z, Yin Z, Wang T, Carini DJ, Rahematpura S, Zheng M, Johnson K, Zhang S, Lin PF, Parker DD, Li W, Meanwell NA, Hamann LG, Regueiro-Ren A.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):160-7. doi: 10.1016/j.bmcl.2015.11.009. Epub 2015 Nov 5.

PMID:
26584882
2.

Developments in antiviral drug design, discovery and development in 2004.

Meanwell NA, Belema M, Carini DJ, D'Andrea SV, Kadow JF, Krystal M, Naidu BN, Regueiro-Ren A, Scola PM, Sit SY, Walker MA, Wang T, Yeung KS.

Curr Drug Targets Infect Disord. 2005 Dec;5(4):307-400. Review.

PMID:
16535860
3.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).

Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL.

J Med Chem. 2002 Nov 21;45(24):5233-48.

PMID:
12431051
4.

Comparative QSAR: angiotensin II antagonists.

Kurup A, Garg R, Carini DJ, Hansch C.

Chem Rev. 2001 Sep;101(9):2727-50. Review. No abstract available.

PMID:
11749394
5.

Identification of selective inhibitors of cyclin dependent kinase 4.

Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2209-11.

PMID:
11514172
6.

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.

Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR.

J Med Chem. 1999 Jul 29;42(15):2752-9.

PMID:
10425086
7.

The discovery and development of angiotensin II antagonists.

Carini DJ, Christ DD, Duncia JV, Pierce ME.

Pharm Biotechnol. 1998;11:29-56. Review. No abstract available.

PMID:
9760675
8.

Discovery of losartan, the first angiotensin II receptor antagonist.

Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD.

J Hum Hypertens. 1995 Nov;9 Suppl 5:S3-18. Review.

PMID:
8583479
9.

Pharmacology and pharmacokinetics of a novel nonpeptide angiotensin II receptor antagonist--DMP 811.

Wong PC, Huang SM, Ardecky RJ, Carini DJ, Chiu AT, Price WA Jr, Agra AM, Wexler RR, Timmermans PB.

Clin Exp Hypertens. 1995 Nov;17(8):1233-56.

PMID:
8563699
10.

Angiotensin II receptors and angiotensin II receptor antagonists.

Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD.

Pharmacol Rev. 1993 Jun;45(2):205-51. Review. No abstract available.

PMID:
8372104
11.

Rationale for the chemical development of angiotensin II receptor antagonists.

Wexler RR, Carini DJ, Duncia JV, Johnson AL, Wells GJ, Chiu AT, Wong PC, Timmermans PB.

Am J Hypertens. 1992 Dec;5(12 Pt 2):209S-220S. Review.

PMID:
1290616
12.

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.

Duncia JV, Carini DJ, Chiu AT, Johnson AL, Price WA, Wong PC, Wexler RR, Timmermans PB.

Med Res Rev. 1992 Mar;12(2):149-91. Review. No abstract available.

PMID:
1619965
13.

Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL.

Hypertension. 1991 Nov;18(5 Suppl):III136-42. Review.

PMID:
1937677
14.

Pharmacology of DuP 532, a selective and noncompetitive AT1 receptor antagonist.

Wong PC, Hart SD, Chiu AT, Herblin WF, Carini DJ, Smith RD, Wexler RR, Timmermans PB.

J Pharmacol Exp Ther. 1991 Nov;259(2):861-70.

PMID:
1941632
15.

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME, Price WA, Santella JB 3rd, Wells GJ, Wexler RR, et al.

J Med Chem. 1991 Aug;34(8):2525-47.

PMID:
1875348
16.

DuP 532: a second generation of nonpeptide angiotensin II receptor antagonists.

Chiu AT, Carini DJ, Duncia JV, Leung KH, McCall DE, Price WA Jr, Wong PC, Smith RD, Wexler RR, Timmermans PB.

Biochem Biophys Res Commun. 1991 May 31;177(1):209-17.

PMID:
2043107
17.

In vivo pharmacology of DuP 753.

Wong PC, Price WA Jr, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.

Am J Hypertens. 1991 Apr;4(4 Pt 2):288S-298S. Review.

PMID:
1854454
18.

In vitro pharmacology of DuP 753.

Chiu AT, McCall DE, Price WA Jr, Wong PC, Carini DJ, Duncia JV, Wexler RR, Yoo SE, Johnson AL, Timmermans PB.

Am J Hypertens. 1991 Apr;4(4 Pt 2):282S-287S. Review.

PMID:
1854453
19.

The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Johnson AL, Wexler RR.

Am J Hypertens. 1991 Apr;4(4 Pt 2):275S-281S. Review.

PMID:
1854452
20.

Angiotensin II receptor heterogeneity.

Herblin WF, Chiu AT, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL, et al.

Am J Hypertens. 1991 Apr;4(4 Pt 2):299S-302S.

PMID:
1854455
21.

Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.

Wong PC, Price WA Jr, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.

J Pharmacol Exp Ther. 1990 Oct;255(1):211-7.

PMID:
2213556
22.

Nonpeptide angiotensin II receptor antagonists.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL.

Am J Hypertens. 1990 Aug;3(8 Pt 1):599-604. Review.

PMID:
2222950
23.

Nonpeptide angiotensin II receptor antagonists. Studies with EXP9270 and DuP 753.

Wong PC, Price WA Jr, Chiu AT, Carini DJ, Duncia JV, Johnson AL, Wexler RR, Timmermans PB.

Hypertension. 1990 Jun;15(6 Pt 2):823-34.

PMID:
2351436
24.

Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives.

Carini DJ, Duncia JV, Johnson AL, Chiu AT, Price WA, Wong PC, Timmermans PB.

J Med Chem. 1990 May;33(5):1330-6.

PMID:
2329554
25.

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives.

Duncia JV, Chiu AT, Carini DJ, Gregory GB, Johnson AL, Price WA, Wells GJ, Wong PC, Calabrese JC, Timmermans PB.

J Med Chem. 1990 May;33(5):1312-29.

PMID:
2329553
26.

Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.

Wong PC, Price WA Jr, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.

Hypertension. 1990 May;15(5):459-68.

PMID:
2185150
27.

Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent.

Chiu AT, McCall DE, Price WA, Wong PC, Carini DJ, Duncia JV, Wexler RR, Yoo SE, Johnson AL, Timmermans PB.

J Pharmacol Exp Ther. 1990 Feb;252(2):711-8.

PMID:
2313596
28.

Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent.

Wong PC, Price WA, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.

J Pharmacol Exp Ther. 1990 Feb;252(2):726-32.

PMID:
2179532
29.

Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent.

Wong PC, Price WA, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.

J Pharmacol Exp Ther. 1990 Feb;252(2):719-25.

PMID:
2179531
30.

Nonpeptide angiotensin II receptor antagonists: a novel class of antihypertensive agents.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL.

Blood Vessels. 1990;27(2-5):295-300. Review.

PMID:
1978694
31.

Identification of angiotensin II receptor subtypes.

Chiu AT, Herblin WF, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL, et al.

Biochem Biophys Res Commun. 1989 Nov 30;165(1):196-203.

PMID:
2590220
32.

Discrimination of angiotensin II receptor subtypes by dithiothreitol.

Chiu AT, McCall DE, Nguyen TT, Carini DJ, Duncia JV, Herblin WF, Uyeda RT, Wong PC, Wexler RR, Johnson AL, et al.

Eur J Pharmacol. 1989 Oct 24;170(1-2):117-8. No abstract available.

PMID:
2612561
33.

Nonpeptide angiotensin II receptor antagonists. III. Structure-function studies.

Chiu AT, Duncia JV, McCall DE, Wong PC, Price WA Jr, Thoolen MJ, Carini DJ, Johnson AL, Timmermans PB.

J Pharmacol Exp Ther. 1989 Sep;250(3):867-74.

PMID:
2778716
34.

Non-peptide angiotensin II receptor antagonists. II. Pharmacology of S-8308.

Chiu AT, Carini DJ, Johnson AL, McCall DE, Price WA, Thoolen MJ, Wong PC, Taber RI, Timmermans PB.

Eur J Pharmacol. 1988 Nov 15;157(1):13-21.

PMID:
3234494
35.

Nonpeptide angiotensin II receptor antagonists. I. Pharmacological characterization of 2-n-butyl-4-chloro-1-(2-chlorobenzyl)imidazole-5-acetic acid, sodium salt (S-8307).

Wong PC, Chiu AT, Price WA, Thoolen MJ, Carini DJ, Johnson AL, Taber RI, Timmermans PB.

J Pharmacol Exp Ther. 1988 Oct;247(1):1-7.

PMID:
3171969

Supplemental Content

Loading ...
Support Center