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Items: 1 to 50 of 67

1.

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.

Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L.

Front Neurosci. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889. eCollection 2019.

2.

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.

Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C.

J Clin Invest. 2019 May 6;129(6):2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6.

3.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10809-E10818. doi: 10.1073/pnas.1705372114. Epub 2017 Nov 21.

4.

Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.

Daldin M, Fodale V, Cariulo C, Azzollini L, Verani M, Martufi P, Spiezia MC, Deguire SM, Cherubini M, Macdonald D, Weiss A, Bresciani A, Vonsattel JG, Petricca L, Marsh JL, Gines S, Santimone I, Marano M, Lashuel HA, Squitieri F, Caricasole A.

Sci Rep. 2017 Jul 11;7(1):5070. doi: 10.1038/s41598-017-05336-7.

5.

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.

Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Füllgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC.

Neuron. 2017 Mar 8;93(5):1015-1034. doi: 10.1016/j.neuron.2017.01.022. Review.

6.

Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins.

Verani M, Bustamante M, Martufi P, Daldin M, Cariulo C, Azzollini L, Fodale V, Puglisi F, Weiss A, Macdonald D, Petricca L, Caricasole A.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):949-55. doi: 10.1016/j.bbrc.2016.08.057. Epub 2016 Aug 9.

PMID:
27520369
7.

Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.

Ceccarelli I, Fiengo P, Remelli R, Miragliotta V, Rossini L, Biotti I, Cappelli A, Petricca L, La Rosa S, Caricasole A, Pollio G, Scali C.

Neurobiol Dis. 2016 Feb;86:41-51. doi: 10.1016/j.nbd.2015.11.019. Epub 2015 Nov 25.

PMID:
26626080
8.

Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ.

Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):1317-22. doi: 10.1016/j.bbrc.2015.06.116. Epub 2015 Jun 21.

PMID:
26106822
9.

siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Dami TE, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC.

Nat Chem Biol. 2015 May;11(5):347-354. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6.

10.

Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.

Fodale V, Kegulian NC, Verani M, Cariulo C, Azzollini L, Petricca L, Daldin M, Boggio R, Padova A, Kuhn R, Pacifici R, Macdonald D, Schoenfeld RC, Park H, Isas JM, Langen R, Weiss A, Caricasole A.

PLoS One. 2014 Dec 2;9(12):e112262. doi: 10.1371/journal.pone.0112262. eCollection 2014. Erratum in: PLoS One. 2015;10(6):e0129986.

11.

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease.

Barbaro BA, Lukacsovich T, Agrawal N, Burke J, Bornemann DJ, Purcell JM, Worthge SA, Caricasole A, Weiss A, Song W, Morozova OA, Colby DW, Marsh JL.

Hum Mol Genet. 2015 Feb 15;24(4):913-25. doi: 10.1093/hmg/ddu504. Epub 2014 Oct 9.

12.

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.

Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi-Carter R, Westerberg G, Marsh JL.

Hum Mol Genet. 2014 Jun 1;23(11):2995-3007. doi: 10.1093/hmg/ddu010. Epub 2014 Jan 16.

13.

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.

Massai L, Petricca L, Magnoni L, Rovetini L, Haider S, Andre R, Tabrizi SJ, Süssmuth SD, Landwehrmeyer BG, Caricasole A, Pollio G, Bernocco S.

BMC Biochem. 2013 Nov 25;14:34. doi: 10.1186/1471-2091-14-34.

14.

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.

De Robertis A, Valensin S, Rossi M, Tunici P, Verani M, De Rosa A, Giordano C, Varrone M, Nencini A, Pratelli C, Benicchi T, Bakker A, Hill J, Sangthongpitag K, Pendharkar V, Liu B, Ng FM, Then SW, Jing Tai S, Cheong SM, He X, Caricasole A, Salerno M.

Mol Cancer Ther. 2013 Jul;12(7):1180-9. doi: 10.1158/1535-7163.MCT-12-1176-T. Epub 2013 Apr 25.

15.

A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.

Lazzeroni G, Benicchi T, Heitz F, Magnoni L, Diamanti D, Rossini L, Massai L, Federico C, Fecke W, Caricasole A, La Rosa S, Porcari V.

J Biomol Screen. 2013 Oct;18(9):984-96. doi: 10.1177/1087057113484802. Epub 2013 Apr 5.

PMID:
23562876
16.

Reference genes selection for transcriptional profiling in blood of HD patients and R6/2 mice.

Diamanti D, Lahiri N, Tarditi A, Magnoni L, Fondelli C, Morena E, Malusa F, Pollio G, Diodato E, Tripepi G, Tabrizi SJ, Caricasole A, Mori E.

J Huntingtons Dis. 2013;2(2):185-200. doi: 10.3233/JHD-120042.

PMID:
25063515
17.

BLUEPRINT to decode the epigenetic signature written in blood.

Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B, Campo E, Caricasole A, Dahl F, Dermitzakis ET, Enver T, Esteller M, Estivill X, Ferguson-Smith A, Fitzgibbon J, Flicek P, Giehl C, Graf T, Grosveld F, Guigo R, Gut I, Helin K, Jarvius J, Küppers R, Lehrach H, Lengauer T, Lernmark Å, Leslie D, Loeffler M, Macintyre E, Mai A, Martens JH, Minucci S, Ouwehand WH, Pelicci PG, Pendeville H, Porse B, Rakyan V, Reik W, Schrappe M, Schübeler D, Seifert M, Siebert R, Simmons D, Soranzo N, Spicuglia S, Stratton M, Stunnenberg HG, Tanay A, Torrents D, Valencia A, Vellenga E, Vingron M, Walter J, Willcocks S.

Nat Biotechnol. 2012 Mar 7;30(3):224-6. doi: 10.1038/nbt.2153. No abstract available.

PMID:
22398613
18.

Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction.

Iozzi S, Remelli R, Lelli B, Diamanti D, Pileri S, Bracci L, Roncarati R, Caricasole A, Bernocco S.

ISRN Mol Biol. 2012 Jan 23;2012:823875. doi: 10.5402/2012/823875. eCollection 2012.

19.

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.

Rossini L, Hashimoto Y, Suzuki H, Kurita M, Gianfriddo M, Scali C, Roncarati R, Franceschini D, Pollio G, Trabalzini L, Terstappen GC, Matsuoka M, Caricasole A.

FASEB J. 2011 Jun;25(6):1983-2000. doi: 10.1096/fj.10-163535. Epub 2011 Mar 10.

PMID:
21393573
20.

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.

Rosi MC, Luccarini I, Grossi C, Fiorentini A, Spillantini MG, Prisco A, Scali C, Gianfriddo M, Caricasole A, Terstappen GC, Casamenti F.

J Neurochem. 2010 Mar;112(6):1539-51. doi: 10.1111/j.1471-4159.2009.06566.x. Epub 2009 Dec 29.

21.

How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach).

Bakker A, Caricasole A, Gaviraghi G, Pollio G, Robertson G, Terstappen GC, Salerno M, Tunici P.

ChemMedChem. 2009 Jun;4(6):923-33. doi: 10.1002/cmdc.200900056.

PMID:
19434656
22.

Therapeutic targets for Alzheimer's disease.

Tarditi A, Caricasole A, Terstappen G.

Expert Opin Ther Targets. 2009 May;13(5):551-67. doi: 10.1517/14728220902865614 . Review.

PMID:
19368497
23.

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

Mastroiacovo F, Busceti CL, Biagioni F, Moyanova SG, Meisler MH, Battaglia G, Caricasole A, Bruno V, Nicoletti F.

J Cereb Blood Flow Metab. 2009 Feb;29(2):264-76. doi: 10.1038/jcbfm.2008.111. Epub 2008 Oct 1.

PMID:
18827832
24.

Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors.

Seredenina T, Ferraro T, Terstappen GC, Caricasole A, Roncarati R.

Biosci Rep. 2008 Dec;28(6):299-306. doi: 10.1042/BSR20080055.

PMID:
18691158
25.

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.

Pollio G, Hoozemans JJ, Andersen CA, Roncarati R, Rosi MC, van Haastert ES, Seredenina T, Diamanti D, Gotta S, Fiorentini A, Magnoni L, Raggiaschi R, Rozemuller AJ, Casamenti F, Caricasole A, Terstappen GC.

Neurobiol Dis. 2008 Jul;31(1):145-58. doi: 10.1016/j.nbd.2008.04.004. Epub 2008 Apr 29.

PMID:
18571100
26.

Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene.

Gaviraghi M, Caricasole A, Costanzo C, Diamanti D, Dandrea M, Donadelli M, Scarpa A, Palmieri M.

BMC Mol Biol. 2008 Jun 12;9:56. doi: 10.1186/1471-2199-9-56.

27.

A reporter assay for target validation in primary neuronal cultures.

Pollio G, Roncarati R, Seredenina T, Terstappen GC, Caricasole A.

J Neurosci Methods. 2008 Jul 15;172(1):34-7. doi: 10.1016/j.jneumeth.2008.03.018. Epub 2008 Apr 7.

PMID:
18485484
28.

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti F.

Neurochem Res. 2008 Dec;33(12):2401-6. doi: 10.1007/s11064-008-9710-0. Epub 2008 Apr 22. Review.

PMID:
18427981
29.

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

Busceti CL, Biagioni F, Riozzi B, Battaglia G, Storto M, Cinque C, Molinaro G, Gradini R, Caricasole A, Canudas AM, Bruno V, Nicoletti F, Fornai F.

J Neurosci. 2008 Mar 19;28(12):3234-45. doi: 10.1523/JNEUROSCI.0159-08.2008.

30.

Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification.

Cocconcelli G, Diodato E, Caricasole A, Gaviraghi G, Genesio E, Ghiron C, Magnoni L, Pecchioli E, Plazzi PV, Terstappen GC.

Bioorg Med Chem. 2008 Feb 15;16(4):2043-52. Epub 2007 Nov 4.

PMID:
18024137
31.

Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells.

Spinsanti P, De Vita T, Caruso A, Melchiorri D, Misasi R, Caricasole A, Nicoletti F.

J Neurochem. 2008 Mar;104(6):1588-98. Epub 2007 Nov 5.

32.

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy.

Busceti CL, Biagioni F, Aronica E, Riozzi B, Storto M, Battaglia G, Giorgi FS, Gradini R, Fornai F, Caricasole A, Nicoletti F, Bruno V.

Epilepsia. 2007 Apr;48(4):694-705.

33.

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

Scali C, Caraci F, Gianfriddo M, Diodato E, Roncarati R, Pollio G, Gaviraghi G, Copani A, Nicoletti F, Terstappen GC, Caricasole A.

Neurobiol Dis. 2006 Nov;24(2):254-65. Epub 2006 Aug 17.

PMID:
16919965
34.

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.

Caruso A, Motolese M, Iacovelli L, Caraci F, Copani A, Nicoletti F, Terstappen GC, Gaviraghi G, Caricasole A.

J Neurochem. 2006 Jul;98(2):364-71.

35.

The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

Terstappen GC, Gaviraghi G, Caricasole A.

IDrugs. 2006 Jan;9(1):35-8.

PMID:
16374731
36.

Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology.

Raggiaschi R, Lorenzetto C, Diodato E, Caricasole A, Gotta S, Terstappen GC.

Proteomics. 2006 Feb;6(3):748-56.

PMID:
16372257
37.

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

Caricasole A, Bakker A, Copani A, Nicoletti F, Gaviraghi G, Terstappen GC.

Biosci Rep. 2005 Oct-Dec;25(5-6):309-27. Review.

PMID:
16307379
38.

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

Cappuccio I, Calderone A, Busceti CL, Biagioni F, Pontarelli F, Bruno V, Storto M, Terstappen GT, Gaviraghi G, Fornai F, Battaglia G, Melchiorri D, Zukin RS, Nicoletti F, Caricasole A.

J Neurosci. 2005 Mar 9;25(10):2647-57. Erratum in: J Neurosci. 2005 Mar 23;25(12):table of contents. Zukin, Suzanne [corrected to Zukin, R Suzanne].

39.

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F.

J Neurosci. 2004 Jun 30;24(26):6021-7.

40.

Activation of Fas receptor is required for the increased formation of the disialoganglioside GD3 in cultured cerebellar granule cells committed to apoptotic death.

Castiglione M, Spinsanti P, Iacovelli L, Lenti L, Martini F, Gradini R, Di Giorgi Gerevini V, Caricasole A, Caruso A, De Maria R, Nicoletti F, Melchiorri D.

Neuroscience. 2004;126(4):889-98.

PMID:
15207324
41.

Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.

Caruso A, Di Giorgi Gerevini V, Castiglione M, Marinelli F, Tomassini V, Pozzilli C, Caricasole A, Bruno V, Caciagli F, Moretti A, Nicoletti F, Melchiorri D.

J Neurochem. 2004 Mar;88(5):1179-85.

42.

Relationship between learning, stress and hippocampal brain-derived neurotrophic factor.

Scaccianoce S, Del Bianco P, Caricasole A, Nicoletti F, Catalani A.

Neuroscience. 2003;121(4):825-8.

PMID:
14580931
43.

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.

Caricasole A, Ferraro T, Iacovelli L, Barletta E, Caruso A, Melchiorri D, Terstappen GC, Nicoletti F.

J Biol Chem. 2003 Sep 26;278(39):37024-31. Epub 2003 Jul 11.

44.

Group II metabotropic glutamate receptors regulate the vulnerability to hypoxic brain damage.

Poli A, Beraudi A, Villani L, Storto M, Battaglia G, Di Giorgi Gerevini V, Cappuccio I, Caricasole A, D'Onofrio M, Nicoletti F.

J Neurosci. 2003 Jul 9;23(14):6023-9.

45.

The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?

Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA, Terstappen GC, Nicoletti F.

Trends Pharmacol Sci. 2003 May;24(5):233-8. Review.

PMID:
12767722
46.

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

Scaccianoce S, Matrisciano F, Del Bianco P, Caricasole A, Di Giorgi Gerevini V, Cappuccio I, Melchiorri D, Battaglia G, Nicoletti F.

Neuropharmacology. 2003 Apr;44(5):555-61.

PMID:
12668041
47.

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

Copani A, Sortino MA, Caricasole A, Chiechio S, Chisari M, Battaglia G, Giuffrida-Stella AM, Vancheri C, Nicoletti F.

FASEB J. 2002 Dec;16(14):2006-8. Epub 2002 Oct 18.

PMID:
12397084
48.

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.

Caricasole A, Bruno V, Cappuccio I, Melchiorri D, Copani A, Nicoletti F.

FASEB J. 2002 Aug;16(10):1331-3. Epub 2002 Jun 21.

PMID:
12154011
49.

Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus.

Matrisciano F, Storto M, Ngomba RT, Cappuccio I, Caricasole A, Scaccianoce S, Riozzi B, Melchiorri D, Nicoletti F.

Neuropharmacology. 2002 Jun;42(8):1008-15.

PMID:
12128001
50.

Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways.

Iacovelli L, Bruno V, Salvatore L, Melchiorri D, Gradini R, Caricasole A, Barletta E, De Blasi A, Nicoletti F.

J Neurochem. 2002 Jul;82(2):216-23.

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