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Items: 16


High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

Radke JB, Carey KL, Shaw S, Metkar SR, Mulrooney C, Gale JP, Bittker JA, Hilgraf R, Comer E, Schreiber SL, Virgin HW, Perez JR, Sibley LD.

ACS Infect Dis. 2018 Oct 12;4(10):1499-1507. doi: 10.1021/acsinfecdis.8b00135. Epub 2018 Aug 28.


The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.

Ranaghan MJ, Durney MA, Mesleh MF, McCarren PR, Garvie CW, Daniels DS, Carey KL, Skepner AP, Levine B, Perez JR.

Biochemistry. 2017 Dec 26;56(51):6639-6651. doi: 10.1021/acs.biochem.7b00936. Epub 2017 Dec 14.


Non-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics.

Wilmes GM, Carey KL, Hicks SW, Russell HH, Stevenson JA, Kocjan P, Lutz SR, Quesenberry RS, Shulga-Morskoy SV, Lewis ME, Clark E, Medik V, Cooper AB, Reczek EE.

MAbs. 2014 Jul-Aug;6(4):957-67. doi: 10.4161/mabs.28917. Epub 2014 Apr 23.


The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.

Carey KL, Newton HJ, Lührmann A, Roy CR.

PLoS Pathog. 2011 May;7(5):e1002056. doi: 10.1371/journal.ppat.1002056. Epub 2011 May 26.


Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein.

Lührmann A, Nogueira CV, Carey KL, Roy CR.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18997-9001. doi: 10.1073/pnas.1004380107. Epub 2010 Oct 13.


A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity.

Heaslip AT, Leung JM, Carey KL, Catti F, Warshaw DM, Westwood NJ, Ballif BA, Ward GE.

PLoS Pathog. 2010 Jan 15;6(1):e1000720. doi: 10.1371/journal.ppat.1000720.


Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue.

Wen S, Carey KL, Nakao Y, Fusetani N, Packham G, Ganesan A.

Org Lett. 2007 Mar 15;9(6):1105-8. Epub 2007 Feb 21.


A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii.

Carey KL, Westwood NJ, Mitchison TJ, Ward GE.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7433-8. Epub 2004 May 3.


Using small molecules to study big questions in cellular microbiology.

Ward GE, Carey KL, Westwood NJ.

Cell Microbiol. 2002 Aug;4(8):471-82. Review.


Identification and molecular characterization of GRA8, a novel, proline-rich, dense granule protein of Toxoplasma gondii.

Carey KL, Donahue CG, Ward GE.

Mol Biochem Parasitol. 2000 Jan 5;105(1):25-37.


Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

Richards SA, Carey KL, Macara IG.

Science. 1997 Jun 20;276(5320):1842-4.


Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization.

Lounsbury KM, Richards SA, Carey KL, Macara IG.

J Biol Chem. 1996 Dec 20;271(51):32834-41.


A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

Richards SA, Lounsbury KM, Carey KL, Macara IG.

J Cell Biol. 1996 Sep;134(5):1157-68.

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