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Items: 1 to 50 of 75

1.

Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus.

Baggen J, Thibaut HJ, Hurdiss DL, Wahedi M, Marceau CD, van Vliet ALW, Carette JE, van Kuppeveld FJM.

MBio. 2019 Aug 13;10(4). pii: e01780-19. doi: 10.1128/mBio.01780-19.

2.

Capsid engineering overcomes barriers toward Adeno-associated viral (AAV) vector-mediated transduction of endothelial cells.

Zhang L, Rossi A, Lange L, Meumann N, Koitzsch U, Christie K, Nesbit A, Moore T, Hacker U, Morgan MA, Hoffmann D, Zengel JR, Carette JE, Schambach A, Salvetti A, Odenthal M, Büning H.

Hum Gene Ther. 2019 Aug 13. doi: 10.1089/hum.2019.027. [Epub ahead of print]

PMID:
31407607
3.

An RNA-centric dissection of host complexes controlling flavivirus infection.

Ooi YS, Majzoub K, Flynn RA, Mata MA, Diep J, Li JK, van Buuren N, Rumachik N, Johnson AG, Puschnik AS, Marceau CD, Mlera L, Grabowski JM, Kirkegaard K, Bloom ME, Sarnow P, Bertozzi CR, Carette JE.

Nat Microbiol. 2019 Aug 5. doi: 10.1038/s41564-019-0518-2. [Epub ahead of print]

PMID:
31384002
4.

Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.

McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T.

Cell Chem Biol. 2019 Jun 20;26(6):863-877.e7. doi: 10.1016/j.chembiol.2019.03.010. Epub 2019 Apr 25.

PMID:
31031142
5.

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity.

Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ.

Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043.

6.

Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens.

Patel BB, Lebensohn AM, Pusapati GV, Carette JE, Salzman J, Rohatgi R.

PLoS One. 2019 Jan 29;14(1):e0198463. doi: 10.1371/journal.pone.0198463. eCollection 2019.

7.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O.

Nature. 2019 Jan;565(7739):372-376. doi: 10.1038/s41586-018-0821-8. Epub 2018 Dec 10.

8.

Differential and convergent utilization of autophagy components by positive-strand RNA viruses.

Abernathy E, Mateo R, Majzoub K, van Buuren N, Bird SW, Carette JE, Kirkegaard K.

PLoS Biol. 2019 Jan 4;17(1):e2006926. doi: 10.1371/journal.pbio.2006926. eCollection 2019 Jan.

9.

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.

Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC.

Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4.

10.

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity.

Shah J, Rouaud F, Guerrera D, Vasileva E, Popov LM, Kelley WL, Rubinstein E, Carette JE, Amieva MR, Citi S.

Cell Rep. 2018 Nov 20;25(8):2132-2147.e7. doi: 10.1016/j.celrep.2018.10.088.

11.

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.

Rinis N, Golden JE, Marceau CD, Carette JE, Van Zandt MC, Gilmore R, Contessa JN.

Cell Chem Biol. 2018 Oct 18;25(10):1231-1241.e4. doi: 10.1016/j.chembiol.2018.07.005. Epub 2018 Aug 2.

PMID:
30078634
12.

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1.

Guo H, Gilley RP, Fisher A, Lane R, Landsteiner VJ, Ragan KB, Dovey CM, Carette JE, Upton JW, Mocarski ES, Kaiser WJ.

Cell Death Dis. 2018 Jul 26;9(8):816. doi: 10.1038/s41419-018-0868-3.

13.

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE.

Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7.

14.

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR.

Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19.

15.

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection.

Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon DA, Carette JE, Greenberg HB.

Nat Commun. 2018 Apr 16;9(1):1485. doi: 10.1038/s41467-018-03782-z.

16.

RNA-protein interaction detection in living cells.

Ramanathan M, Majzoub K, Rao DS, Neela PH, Zarnegar BJ, Mondal S, Roth JG, Gai H, Kovalski JR, Siprashvili Z, Palmer TD, Carette JE, Khavari PA.

Nat Methods. 2018 Mar;15(3):207-212. doi: 10.1038/nmeth.4601. Epub 2018 Feb 5.

17.

An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor.

Dudek AM, Pillay S, Puschnik AS, Nagamine CM, Cheng F, Qiu J, Carette JE, Vandenberghe LH.

J Virol. 2018 Mar 14;92(7). pii: e02213-17. doi: 10.1128/JVI.02213-17. Print 2018 Apr 1.

18.

A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity.

Puschnik AS, Marceau CD, Ooi YS, Majzoub K, Rinis N, Contessa JN, Carette JE.

Cell Rep. 2017 Dec 12;21(11):3032-3039. doi: 10.1016/j.celrep.2017.11.054.

19.

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.

Lumb JH, Li Q, Popov LM, Ding S, Keith MT, Merrill BD, Greenberg HB, Li JB, Carette JE.

Cell Rep. 2017 Jul 25;20(4):819-831. doi: 10.1016/j.celrep.2017.06.085.

20.

Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor.

Pillay S, Zou W, Cheng F, Puschnik AS, Meyer NL, Ganaie SS, Deng X, Wosen JE, Davulcu O, Yan Z, Engelhardt JF, Brown KE, Chapman MS, Qiu J, Carette JE.

J Virol. 2017 Aug 24;91(18). pii: e00391-17. doi: 10.1128/JVI.00391-17. Print 2017 Sep 15.

21.

Host determinants of adeno-associated viral vector entry.

Pillay S, Carette JE.

Curr Opin Virol. 2017 Jun;24:124-131. doi: 10.1016/j.coviro.2017.06.003. Epub 2017 Jun 30. Review.

22.

A CRISPR toolbox to study virus-host interactions.

Puschnik AS, Majzoub K, Ooi YS, Carette JE.

Nat Rev Microbiol. 2017 Jun;15(6):351-364. doi: 10.1038/nrmicro.2017.29. Epub 2017 Apr 19. Review.

23.

Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation.

Realegeno S, Puschnik AS, Kumar A, Goldsmith C, Burgado J, Sambhara S, Olson VA, Carroll D, Damon I, Hirata T, Kinoshita T, Carette JE, Satheshkumar PS.

J Virol. 2017 May 12;91(11). pii: e00011-17. doi: 10.1128/JVI.00011-17. Print 2017 Jun 1.

24.

PLA2G16 represents a switch between entry and clearance of Picornaviridae.

Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J, Janssen H, van Kuppeveld FJ, Perrakis A, Carette JE, Brummelkamp TR.

Nature. 2017 Jan 19;541(7637):412-416. doi: 10.1038/nature21032. Epub 2017 Jan 11.

PMID:
28077878
25.

Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R.

Elife. 2016 Dec 20;5. pii: e21459. doi: 10.7554/eLife.21459.

26.

Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.

Napier BA, Brubaker SW, Sweeney TE, Monette P, Rothmeier GH, Gertsvolf NA, Puschnik A, Carette JE, Khatri P, Monack DM.

J Exp Med. 2016 Oct 17;213(11):2365-2382. Epub 2016 Oct 3.

27.

Corrigendum: An essential receptor for adeno-associated virus infection.

Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE.

Nature. 2016 Nov 17;539(7629):456. doi: 10.1038/nature19835. Epub 2016 Sep 28. No abstract available.

PMID:
27680708
28.

Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1.

Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R.

Cancer Res. 2016 Oct 1;76(19):5810-5821. Epub 2016 Aug 8.

29.

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

Marceau CD, Puschnik AS, Majzoub K, Ooi YS, Brewer SM, Fuchs G, Swaminathan K, Mata MA, Elias JE, Sarnow P, Carette JE.

Nature. 2016 Jul 7;535(7610):159-63. Epub 2016 Jun 17.

30.

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.

Ndungo E, Herbert AS, Raaben M, Obernosterer G, Biswas R, Miller EH, Wirchnianski AS, Carette JE, Brummelkamp TR, Whelan SP, Dye JM, Chandran K.

mSphere. 2016 Mar 30;1(2). pii: e00007-16. doi: 10.1128/mSphere.00007-16. eCollection 2016 Mar-Apr.

31.

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.

Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC.

Nat Chem Biol. 2016 May;12(5):361-6. doi: 10.1038/nchembio.2050. Epub 2016 Mar 28.

32.

Hunting Viral Receptors Using Haploid Cells.

Pillay S, Carette JE.

Annu Rev Virol. 2015 Nov;2(1):219-39. doi: 10.1146/annurev-virology-100114-055119. Epub 2015 Jul 2. Review.

33.

An essential receptor for adeno-associated virus infection.

Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE.

Nature. 2016 Feb 4;530(7588):108-12. doi: 10.1038/nature16465. Epub 2016 Jan 27. Erratum in: Nature. 2016 Nov 17;539(7629):456.

34.

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.

Gowen BG, Chim B, Marceau CD, Greene TT, Burr P, Gonzalez JR, Hesser CR, Dietzen PA, Russell T, Iannello A, Coscoy L, Sentman CL, Carette JE, Muljo SA, Raulet DH.

Elife. 2015 Nov 13;4. pii: e08474. doi: 10.7554/eLife.08474.

35.

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin.

Popov LM, Marceau CD, Starkl PM, Lumb JH, Shah J, Guerrera D, Cooper RL, Merakou C, Bouley DM, Meng W, Kiyonari H, Takeichi M, Galli SJ, Bagnoli F, Citi S, Carette JE, Amieva MR.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14337-42. doi: 10.1073/pnas.1510265112. Epub 2015 Oct 21.

36.

Gene essentiality and synthetic lethality in haploid human cells.

Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR.

Science. 2015 Nov 27;350(6264):1092-6. doi: 10.1126/science.aac7557. Epub 2015 Oct 15.

37.

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S.

Elife. 2015 Sep 1;4. doi: 10.7554/eLife.08467.

38.

Identifying multi-locus chromatin contacts in human cells using tethered multiple 3C.

Ay F, Vu TH, Zeitz MJ, Varoquaux N, Carette JE, Vert JP, Hoffman AR, Noble WS.

BMC Genomics. 2015 Feb 25;16:121. doi: 10.1186/s12864-015-1236-7.

39.

Kinetic pathway of 40S ribosomal subunit recruitment to hepatitis C virus internal ribosome entry site.

Fuchs G, Petrov AN, Marceau CD, Popov LM, Chen J, O'Leary SE, Wang R, Carette JE, Sarnow P, Puglisi JD.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):319-25. doi: 10.1073/pnas.1421328111. Epub 2014 Dec 16.

40.

RIP3 induces apoptosis independent of pronecrotic kinase activity.

Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, Casillas LN, Haile PA, Sehon CA, Marquis RW, Upton J, Daley-Bauer LP, Roback L, Ramia N, Dovey CM, Carette JE, Chan FK, Bertin J, Gough PJ, Mocarski ES, Kaiser WJ.

Mol Cell. 2014 Nov 20;56(4):481-95. doi: 10.1016/j.molcel.2014.10.021. Epub 2014 Nov 20.

41.

GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin.

Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL.

J Biol Chem. 2014 Aug 29;289(35):24005-18. doi: 10.1074/jbc.M114.589275. Epub 2014 Jul 16.

42.

Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform.

Sharma A, Marceau C, Hamaguchi R, Burridge PW, Rajarajan K, Churko JM, Wu H, Sallam KI, Matsa E, Sturzu AC, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC.

Circ Res. 2014 Aug 29;115(6):556-66. doi: 10.1161/CIRCRESAHA.115.303810. Epub 2014 Jul 11.

43.

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM.

Cell Rep. 2014 Apr 10;7(1):27-34. doi: 10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27.

44.

A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.

Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM.

Nat Cell Biol. 2013 Dec;15(12):1473-85. doi: 10.1038/ncb2865. Epub 2013 Nov 3.

45.

A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB.

Lee CC, Carette JE, Brummelkamp TR, Ploegh HL.

PLoS One. 2013 Jul 8;8(7):e70339. doi: 10.1371/journal.pone.0070339. Print 2013.

46.

Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.

Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, Brummelkamp TR.

Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21.

47.

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.

Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM.

Nat Genet. 2013 Jan;45(1):104-8. doi: 10.1038/ng.2471. Epub 2012 Dec 2.

48.

Attachment of Chlamydia trachomatis L2 to host cells requires sulfation.

Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10059-64. doi: 10.1073/pnas.1120244109. Epub 2012 Jun 6.

49.

Ebola virus entry requires the host-programmed recognition of an intracellular receptor.

Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K.

EMBO J. 2012 Apr 18;31(8):1947-60. doi: 10.1038/emboj.2012.53. Epub 2012 Mar 6.

50.

Identification of host cell factors required for intoxication through use of modified cholera toxin.

Guimaraes CP, Carette JE, Varadarajan M, Antos J, Popp MW, Spooner E, Brummelkamp TR, Ploegh HL.

J Cell Biol. 2011 Nov 28;195(5):751-64. doi: 10.1083/jcb.201108103.

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