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Fecal DNA Testing for Colorectal Cancer Screening.

Carethers JM.

Annu Rev Med. 2019 Aug 26. doi: 10.1146/annurev-med-103018-123125. [Epub ahead of print]


Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort.

Ashktorab H, Delker D, Kanth P, Goel A, Carethers JM, Brim H.

Gastroenterology. 2019 Aug;157(2):572-574. doi: 10.1053/j.gastro.2019.04.015. Epub 2019 Apr 17. No abstract available.


VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism.

Tang B, Wu J, Zhu MX, Sun X, Liu J, Xie R, Dong TX, Xiao Y, Carethers JM, Yang S, Dong H.

Oncogene. 2019 May;38(20):3946-3961. doi: 10.1038/s41388-019-0709-6. Epub 2019 Jan 28.


Clinical and Genetic Factors to Inform Reducing Colorectal Cancer Disparitites in African Americans.

Carethers JM.

Front Oncol. 2018 Nov 20;8:531. doi: 10.3389/fonc.2018.00531. eCollection 2018. Review.


Risk factors for colon location of cancer.

Carethers JM.

Transl Gastroenterol Hepatol. 2018 Oct 12;3:76. doi: 10.21037/tgh.2018.09.15. eCollection 2018. No abstract available.


Diversity Within US Gastroenterology Physician Practices: The Pipeline, Cultural Competencies, and Gastroenterology Societies Approaches.

Carethers JM, Quezada SM, Carr RM, Day LW.

Gastroenterology. 2019 Mar;156(4):829-833. doi: 10.1053/j.gastro.2018.10.056. Epub 2018 Nov 17. No abstract available.


Fusobacterium nucleatum Infection in Colorectal Cancer: Linking Inflammation, DNA Mismatch Repair and Genetic and Epigenetic Alterations.

Koi M, Okita Y, Carethers JM.

J Anus Rectum Colon. 2018;2(2):37-46. doi: 10.23922/jarc.2017-055. Epub 2018 Apr 25.


MBD4 frameshift mutation caused by DNA mismatch repair deficiency enhances cytotoxicity by trifluridine, an active antitumor agent of TAS-102, in colorectal cancer cells.

Suzuki S, Iwaizumi M, Yamada H, Sugiyama T, Hamaya Y, Furuta T, Kanaoka S, Sugimura H, Miyajima H, Osawa S, Carethers JM, Sugimoto K.

Oncotarget. 2017 Nov 15;9(14):11477-11488. doi: 10.18632/oncotarget.22484. eCollection 2018 Feb 20.


Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer.

Koi M, Tseng-Rogenski SS, Carethers JM.

World J Gastrointest Oncol. 2018 Jan 15;10(1):1-14. doi: 10.4251/wjgo.v10.i1.1. Review.


Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel.

Xie R, Xu J, Xiao Y, Wu J, Wan H, Tang B, Liu J, Fan Y, Wang S, Wu Y, Dong TX, Zhu MX, Carethers JM, Dong H, Yang S.

Cancer Res. 2017 Dec 1;77(23):6499-6512. doi: 10.1158/0008-5472.CAN-17-0360. Epub 2017 Sep 26.


The colorectal cancer immune microenvironment and approach to immunotherapies.

Koi M, Carethers JM.

Future Oncol. 2017 Aug;13(18):1633-1647. doi: 10.2217/fon-2017-0145. Epub 2017 Aug 22. Review. No abstract available.


Racial Disparity in Gastrointestinal Cancer Risk.

Ashktorab H, Kupfer SS, Brim H, Carethers JM.

Gastroenterology. 2017 Oct;153(4):910-923. doi: 10.1053/j.gastro.2017.08.018. Epub 2017 Aug 12. Review.


Charting the Future of Cancer Health Disparities Research: A Position Statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute.

Polite BN, Adams-Campbell LL, Brawley OW, Bickell N, Carethers JM, Flowers CR, Foti M, Gomez SL, Griggs JJ, Lathan CS, Li CI, Lichtenfeld JL, McCaskill-Stevens W, Paskett ED.

Cancer Res. 2017 Sep 1;77(17):4548-4555. doi: 10.1158/0008-5472.CAN-17-0623. Epub 2017 Jul 24. No abstract available.


Charting the future of cancer health disparities research: A position statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute.

Polite BN, Adams-Campbell LL, Brawley OW, Bickell N, Carethers JM, Flowers CR, Foti M, Gomez SL, Griggs JJ, Lathan CS, Li CI, Lichtenfeld JL, McCaskill-Stevens W, Paskett ED.

CA Cancer J Clin. 2017 Sep;67(5):353-361. doi: 10.3322/caac.21404. Epub 2017 Jul 24. No abstract available.


Charting the Future of Cancer Health Disparities Research: A Position Statement From the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute.

Polite BN, Adams-Campbell LL, Brawley OW, Bickell N, Carethers JM, Flowers CR, Foti M, Gomez SL, Griggs JJ, Lathan CS, Li CI, Lichtenfeld JL, McCaskill-Stevens W, Paskett ED.

J Clin Oncol. 2017 Sep 10;35(26):3075-3082. doi: 10.1200/JCO.2017.73.6546. Epub 2017 Jul 24. No abstract available.


Anti-proliferative Effects of Nucleotides on Gastric Cancer via a Novel P2Y6/SOCE/Ca2+/β-catenin Pathway.

Wan H, Xie R, Xu J, He J, Tang B, Liu Q, Wang S, Guo Y, Yang X, Dong TX, Carethers JM, Yang S, Dong H.

Sci Rep. 2017 May 26;7(1):2459. doi: 10.1038/s41598-017-02562-x.


Microsatellite Instability Pathway and EMAST in Colorectal Cancer.

Carethers JM.

Curr Colorectal Cancer Rep. 2017 Feb;13(1):73-80. doi: 10.1007/s11888-017-0352-y. Epub 2017 Feb 2.


International Exchange and American Medicine.

Armstrong K, Anderson ME, Carethers JM, Loscalzo J, Parmacek MS, Wachter RM, Zeidel ML.

N Engl J Med. 2017 May 11;376(19):e40. doi: 10.1056/NEJMp1701339. Epub 2017 Feb 1. No abstract available.


Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity.

Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, Kano Y, Nishikawa S, Fukusumi T, Takahashi Y, Hata T, Nishimura J, Takemasa I, Mizushima T, Ikenaga M, Kato T, Murata K, Carethers JM, Yamamoto H, Doki Y, Mori M.

Clin Cancer Res. 2016 Nov 1;22(21):5277-5286. Epub 2016 May 10.


The Increasing Incidence of Colorectal Cancers Diagnosed in Subjects Under Age 50 Among Races: CRaCking the Conundrum.

Carethers JM.

Dig Dis Sci. 2016 Oct;61(10):2767-2769. doi: 10.1007/s10620-016-4268-1. No abstract available.


Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans.

Basa RC, Davies V, Li X, Murali B, Shah J, Yang B, Li S, Khan MW, Tian M, Tejada R, Hassan A, Washington A Jr, Mukherjee B, Carethers JM, McGuire KL.

PLoS One. 2016 Jun 16;11(6):e0156660. doi: 10.1371/journal.pone.0156660. eCollection 2016.


Gastroenterology 2011-2016: Looking Back and Forward.

Omary MB, Carethers JM, Owyang C.

Gastroenterology. 2016 Jun;150(7):1496-1502. doi: 10.1053/j.gastro.2016.04.005. No abstract available.


Presentation of the Julius M. Friedenwald Medal to C. Richard Boland, MD, AGAF.

Carethers JM, Goel A.

Gastroenterology. 2016 Jun;150(7):1673-1677. doi: 10.1053/j.gastro.2016.04.031. Epub 2016 Apr 30. No abstract available.


A meta-analysis of MSI frequency and race in colorectal cancer.

Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis NA, Xicola RM, Laiyemo AO, Carethers JM, Brim H, Nouraie M.

Oncotarget. 2016 Apr 23;7(23):34546-57. doi: 10.18632/oncotarget.8945.


Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status.

Suzuki S, Iwaizumi M, Tseng-Rogenski S, Hamaya Y, Miyajima H, Kanaoka S, Sugimoto K, Carethers JM.

Cancer Biol Ther. 2016 Jul 2;17(7):760-8. doi: 10.1080/15384047.2016.1178430. Epub 2016 Apr 26.


Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/β-catenin signaling pathway.

Tang B, Chow JY, Dong TX, Yang SM, Lu DS, Carethers JM, Dong H.

Cancer Lett. 2016 Jul 10;377(1):44-54. doi: 10.1016/j.canlet.2016.04.027. Epub 2016 Apr 20.


Facilitating Minority Medical Education, Research, and Faculty.

Carethers JM.

Dig Dis Sci. 2016 Jun;61(6):1436-9. doi: 10.1007/s10620-016-4057-x. No abstract available.


GRG Profiles: John M. Carethers.

Carethers JM.

Dig Dis Sci. 2016 Jun;61(6):1429-35. doi: 10.1007/s10620-016-4058-9. No abstract available.


Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis.

Koi M, Garcia M, Choi C, Kim HR, Koike J, Hemmi H, Nagasaka T, Okugawa Y, Toiyama Y, Kitajima T, Imaoka H, Kusunoki M, Chen YH, Mukherjee B, Boland CR, Carethers JM.

Gastroenterology. 2016 Apr;150(4):944-55. doi: 10.1053/j.gastro.2015.12.032. Epub 2016 Jan 2.


Biomarker-directed Targeted Therapy in Colorectal Cancer.

Carethers JM.

J Dig Cancer Rep. 2015 Jun;3(1):5-10.


Genetics, Genetic Testing, and Biomarkers of Digestive Diseases.

Carethers JM, Braun J, Sands BE.

Gastroenterology. 2015 Oct;149(5):1131-3. doi: 10.1053/j.gastro.2015.08.049. Epub 2015 Aug 29. Review. No abstract available.


Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer.

Carethers JM, Stoffel EM.

World J Gastroenterol. 2015 Aug 21;21(31):9253-61. doi: 10.3748/wjg.v21.i31.9253. Review.


Reducing colorectal cancer risk among African Americans.

Kupfer SS, Carr RM, Carethers JM.

Gastroenterology. 2015 Nov;149(6):1302-4. doi: 10.1053/j.gastro.2015.08.033. Epub 2015 Aug 22. No abstract available.


Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer.

Carethers JM, Jung BH.

Gastroenterology. 2015 Oct;149(5):1177-1190.e3. doi: 10.1053/j.gastro.2015.06.047. Epub 2015 Jul 26. Review.


Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer.

Hamaya Y, Guarinos C, Tseng-Rogenski SS, Iwaizumi M, Das R, Jover R, Castells A, Llor X, Andreu M, Carethers JM.

PLoS One. 2015 May 21;10(5):e0127591. doi: 10.1371/journal.pone.0127591. eCollection 2015.


Martin F. Kagnoff, MD: 1941-2014.

Barrett KE, Eckmann L, Carethers JM.

Mucosal Immunol. 2015 May;8(3):441-3. doi: 10.1038/mi.2015.8. No abstract available.


EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression.

Carethers JM, Koi M, Tseng-Rogenski SS.

Genes (Basel). 2015 Mar 31;6(2):185-205. doi: 10.3390/genes6020185. Review.


Martin F. Kagnoff, MD, January 19, 1941--November 16, 2014.

Eckmann L, Barrett KE, Carethers JM.

Gastroenterology. 2015 Mar;148(3):457-8. doi: 10.1053/j.gastro.2015.01.028. Epub 2015 Jan 22. No abstract available.


Screening for colorectal cancer in African Americans: determinants and rationale for an earlier age to commence screening.

Carethers JM.

Dig Dis Sci. 2015 Mar;60(3):711-21. doi: 10.1007/s10620-014-3443-5. Epub 2014 Dec 25. Review.


Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells.

Tseng-Rogenski SS, Hamaya Y, Choi DY, Carethers JM.

Gastroenterology. 2015 Mar;148(3):579-89. doi: 10.1053/j.gastro.2014.11.027. Epub 2014 Nov 20.


Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome.

Fearon ER, Carethers JM.

Gastroenterology. 2015 Jan;148(1):10-3. doi: 10.1053/j.gastro.2014.11.024. Epub 2014 Nov 22. No abstract available.


The imperative to invest in science has never been greater.

Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S.

J Clin Invest. 2014 Sep;124(9):3680-1. doi: 10.1172/JCI77894. Epub 2014 Sep 2. No abstract available.


Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer.

Carethers JM, Murali B, Yang B, Doctolero RT, Tajima A, Basa R, Smith EJ, Lee M, Janke R, Ngo T, Tejada R, Ji M, Kinseth M, Cabrera BL, Miyai K, Keku TO, Martin CF, Galanko JA, Sandler RS, McGuire KL.

PLoS One. 2014 Jun 23;9(6):e100461. doi: 10.1371/journal.pone.0100461. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e103699.


Differentiating Lynch-like from Lynch syndrome.

Carethers JM.

Gastroenterology. 2014 Mar;146(3):602-4. doi: 10.1053/j.gastro.2014.01.041. Epub 2014 Jan 24. No abstract available.


DNA testing and molecular screening for colon cancer.

Carethers JM.

Clin Gastroenterol Hepatol. 2014 Mar;12(3):377-81. doi: 10.1016/j.cgh.2013.12.007. Epub 2013 Dec 17. Review.


Toward a comprehensive and systematic methylome signature in colorectal cancers.

Ashktorab H, Rahi H, Wansley D, Varma S, Shokrani B, Lee E, Daremipouran M, Laiyemo A, Goel A, Carethers JM, Brim H.

Epigenetics. 2013 Aug;8(8):807-15. doi: 10.4161/epi.25497. Epub 2013 Jul 10.


Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.

Iwaizumi M, Tseng-Rogenski S, Carethers JM.

Mutat Res. 2013 Jul-Aug;747-748:19-27. doi: 10.1016/j.mrfmmm.2013.04.006. Epub 2013 Apr 30.

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