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Deregulated Adhesion Program in Palatal Keratinocytes of Orofacial Cleft Patients.

Mammadova A, Carels CEL, Zhou J, Gilissen C, Helmich MPAC, Bian Z, Zhou H, Von den Hoff JW.

Genes (Basel). 2019 Oct 23;10(11). pii: E836. doi: 10.3390/genes10110836.


Retinoic acid disrupts osteogenesis in pre-osteoblasts by down-regulating WNT signaling.

Roa LA, Bloemen M, Carels CEL, Wagener FADTG, Von den Hoff JW.

Int J Biochem Cell Biol. 2019 Nov;116:105597. doi: 10.1016/j.biocel.2019.105597. Epub 2019 Aug 31.


Fgf8a mutation affects craniofacial development and skeletal gene expression in zebrafish larvae.

Gebuijs IGE, Raterman ST, Metz JR, Swanenberg L, Zethof J, Van den Bos R, Carels CEL, Wagener FADTG, Von den Hoff JW.

Biol Open. 2019 Sep 9;8(9). pii: bio039834. doi: 10.1242/bio.039834.


Deletions and loss-of-function variants in TP63 associated with orofacial clefting.

Khandelwal KD, van den Boogaard MH, Mehrem SL, Gebel J, Fagerberg C, van Beusekom E, van Binsbergen E, Topaloglu O, Steehouwer M, Gilissen C, Ishorst N, van Rooij IALM, Roeleveld N, Christensen K, Schoenaers J, Bergé S, Murray JC, Hens G, Devriendt K, Ludwig KU, Mangold E, Hoischen A, Zhou H, Dötsch V, Carels CEL, van Bokhoven H.

Eur J Hum Genet. 2019 Jul;27(7):1101-1112. doi: 10.1038/s41431-019-0370-0. Epub 2019 Mar 8.


Update on 13 Syndromes Affecting Craniofacial and Dental Structures.

Bartzela TN, Carels C, Maltha JC.

Front Physiol. 2017 Dec 14;8:1038. doi: 10.3389/fphys.2017.01038. eCollection 2017. Review.


A Comprehensive Craniofacial Study of 22q11.2 Deletion Syndrome.

Lewyllie A, Roosenboom J, Indencleef K, Claes P, Swillen A, Devriendt K, Carels C, Cadenas De Llano-Pérula M, Willems G, Hens G, Verdonck A.

J Dent Res. 2017 Nov;96(12):1386-1391. doi: 10.1177/0022034517720630. Epub 2017 Jul 21.


Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia.

Khandelwal KD, Ockeloen CW, Venselaar H, Boulanger C, Brichard B, Sokal E, Pfundt R, Rinne T, van Beusekom E, Bloemen M, Vriend G, Revencu N, Carels CEL, van Bokhoven H, Zhou H.

Am J Med Genet A. 2017 Jul;173(7):1813-1820. doi: 10.1002/ajmg.a.38274. Epub 2017 May 17.


Differential microRNA expression in cultured palatal fibroblasts from infants with cleft palate and controls.

Schoen C, Glennon JC, Abghari S, Bloemen M, Aschrafi A, Carels CEL, Von den Hoff JW.

Eur J Orthod. 2018 Jan 23;40(1):90-96. doi: 10.1093/ejo/cjx034.


MicroRNAs in Palatogenesis and Cleft Palate.

Schoen C, Aschrafi A, Thonissen M, Poelmans G, Von den Hoff JW, Carels CEL.

Front Physiol. 2017 Apr 4;8:165. doi: 10.3389/fphys.2017.00165. eCollection 2017. Review.


Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair.

Cremers NA, Wever KE, Wong RJ, van Rheden RE, Vermeij EA, van Dam GM, Carels CE, Lundvig DM, Wagener FA.

Int J Mol Sci. 2017 Feb 17;18(2). pii: E438. doi: 10.3390/ijms18020438.


Novel IRF6 Mutations Detected in Orofacial Cleft Patients by Targeted Massively Parallel Sequencing.

Khandelwal KD, Ishorst N, Zhou H, Ludwig KU, Venselaar H, Gilissen C, Thonissen M, van Rooij IA, Dreesen K, Steehouwer M, van de Vorst M, Bloemen M, van Beusekom E, Roosenboom J, Borstlap W, Admiraal R, Dormaar T, Schoenaers J, Vander Poorten V, Hens G, Verdonck A, Bergé S, Roeleveldt N, Vriend G, Devriendt K, Brunner HG, Mangold E, Hoischen A, van Bokhoven H, Carels CE.

J Dent Res. 2017 Feb;96(2):179-185. doi: 10.1177/0022034516678829. Epub 2016 Nov 13.


Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis.

Ockeloen CW, Khandelwal KD, Dreesen K, Ludwig KU, Sullivan R, van Rooij IALM, Thonissen M, Swinnen S, Phan M, Conte F, Ishorst N, Gilissen C, RoaFuentes L, van de Vorst M, Henkes A, Steehouwer M, van Beusekom E, Bloemen M, Vankeirsbilck B, Bergé S, Hens G, Schoenaers J, Poorten VV, Roosenboom J, Verdonck A, Devriendt K, Roeleveldt N, Jhangiani SN, Vissers LELM, Lupski JR, de Ligt J, Von den Hoff JW, Pfundt R, Brunner HG, Zhou H, Dixon J, Mangold E, van Bokhoven H, Dixon MJ, Kleefstra T, Hoischen A, Carels CEL.

Genet Med. 2016 Nov;18(11):1158-1162. doi: 10.1038/gim.2016.10. Epub 2016 Mar 10.


Tooth agenesis and orofacial clefting: genetic brothers in arms?

Phan M, Conte F, Khandelwal KD, Ockeloen CW, Bartzela T, Kleefstra T, van Bokhoven H, Rubini M, Zhou H, Carels CE.

Hum Genet. 2016 Dec;135(12):1299-1327. Epub 2016 Oct 3. Review.


MSX1 mutations and associated disease phenotypes: genotype-phenotype relations.

Liang J, Von den Hoff J, Lange J, Ren Y, Bian Z, Carels CE.

Eur J Hum Genet. 2016 Dec;24(12):1663-1670. doi: 10.1038/ejhg.2016.78. Epub 2016 Jul 6. Review.


Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate.

Mammadova A, Zhou H, Carels CE, Von den Hoff JW.

Differentiation. 2016 Dec;92(5):326-335. doi: 10.1016/j.diff.2016.05.001. Epub 2016 May 26. Review.


AGORA, a data- and biobank for birth defects and childhood cancer.

van Rooij IA, van der Zanden LF, Bongers EM, Renkema KY, Wijers CH, Thonissen M, Dokter EM, Marcelis CL, de Blaauw I, Wijnen MH, Hoogerbrugge PM, Bokkerink JP, Schreuder MF, Koster-Kamphuis L, Cornelissen EA, Kapusta L, van Heijst AF, Liem KD, de Gier RP, Kuijpers-Jagtman AM, Admiraal RJ, Bergé SJ, van der Biezen JJ, Verdonck A, Vander Poorten V, Hens G, Roosenboom J, Lilien MR, de Jong TP, Broens P, Wijnen R, Brooks A, Franke B, Brunner HG, Carels CE, Knoers NV, Feitz WF, Roeleveld N.

Birth Defects Res A Clin Mol Teratol. 2016 Aug;106(8):675-84. doi: 10.1002/bdra.23512. Epub 2016 May 6.


Mechanical Stress Changes the Complex Interplay Between HO-1, Inflammation and Fibrosis, During Excisional Wound Repair.

Cremers NA, Suttorp M, Gerritsen MM, Wong RJ, van Run-van Breda C, van Dam GM, Brouwer KM, Kuijpers-Jagtman AM, Carels CE, Lundvig DM, Wagener FA.

Front Med (Lausanne). 2015 Dec 15;2:86. doi: 10.3389/fmed.2015.00086. eCollection 2015.


Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.

Conte F, Oti M, Dixon J, Carels CE, Rubini M, Zhou H.

Hum Genet. 2016 Jan;135(1):41-59. doi: 10.1007/s00439-015-1606-x. Epub 2015 Nov 11.


Further delineation of the KBG syndrome caused by ANKRD11 aberrations.

Ockeloen CW, Willemsen MH, de Munnik S, van Bon BW, de Leeuw N, Verrips A, Kant SG, Jones EA, Brunner HG, van Loon RL, Smeets EE, van Haelst MM, van Haaften G, Nordgren A, Malmgren H, Grigelioniene G, Vermeer S, Louro P, Ramos L, Maal TJ, van Heumen CC, Yntema HG, Carels CE, Kleefstra T.

Eur J Hum Genet. 2015 Sep;23(9):1270. doi: 10.1038/ejhg.2015.130. No abstract available.


[WNT 10A-mutations as explanation for tooth agenesis].

Backaert H, Carels CE.

Ned Tijdschr Tandheelkd. 2014 Nov;121(11):541-4. doi: 10.5177/ntvt.2014.11.13207. Dutch.


Genotypic and phenotypic variation in six patients with solitary median maxillary central incisor syndrome.

Poelmans S, Kawamoto T, Cristofoli F, Politis C, Vermeesch J, Bailleul-Forestier I, Hens G, Devriendt K, Verdonck A, Carels C.

Am J Med Genet A. 2015 Oct;167A(10):2451-8. doi: 10.1002/ajmg.a.37207. Epub 2015 Jun 16.


Short Stature in KBG Syndrome: First Responses to Growth Hormone Treatment.

Reynaert N, Ockeloen CW, Sävendahl L, Beckers D, Devriendt K, Kleefstra T, Carels CE, Grigelioniene G, Nordgren A, Francois I, de Zegher F, Casteels K.

Horm Res Paediatr. 2015;83(5):361-4. doi: 10.1159/000380908. Epub 2015 Apr 1.


Clinical problems with a double tooth and a macrodont in the maxillary anterior area: a case report.

Ghijselings E, van Gastel J, Verdonck A, Carels C.

Aust Orthod J. 2014 Nov;30(2):221-9.


Further delineation of the KBG syndrome phenotype caused by ANKRD11 aberrations.

Ockeloen CW, Willemsen MH, de Munnik S, van Bon BW, de Leeuw N, Verrips A, Kant SG, Jones EA, Brunner HG, van Loon RL, Smeets EE, van Haelst MM, van Haaften G, Nordgren A, Malmgren H, Grigelioniene G, Vermeer S, Louro P, Ramos L, Maal TJ, van Heumen CC, Yntema HG, Carels CE, Kleefstra T.

Eur J Hum Genet. 2015 Sep;23(9):1176-85. doi: 10.1038/ejhg.2014.253. Epub 2014 Nov 26. Erratum in: Eur J Hum Genet. 2015 Sep;23(9):1270.


Evaluation of transverse maxillary expansion after a segmental posterior subapical maxillary osteotomy in cleft lip and palate patients with severe collapse of the lateral maxillary segments.

Carpentier S, van Gastel J, Schoenaers J, Carels C, Vander Poorten V, Coucke W, Verdonck A.

Cleft Palate Craniofac J. 2014 Nov;51(6):651-7. doi: 10.1597/113-232.


Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells.

Cremers NA, Lundvig DM, van Dalen SC, Schelbergen RF, van Lent PL, Szarek WA, Regan RF, Carels CE, Wagener FA.

Int J Mol Sci. 2014 Oct 8;15(10):17974-99. doi: 10.3390/ijms151017974.


[Solitary median maxillary central incisor syndrome].

Scholtes E, Kawamoto T, Ockeloen CW, Kleefstra T, Carels CE.

Ned Tijdschr Tandheelkd. 2014 Sep;121(9):435-42. Review. Dutch.


Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression.

Lundvig DM, Scharstuhl A, Cremers NA, Pennings SW, te Paske J, van Rheden R, van Run-van Breda C, Regan RF, Russel FG, Carels CE, Maltha JC, Wagener FA.

J Cell Mol Med. 2014 Dec;18(12):2488-98. doi: 10.1111/jcmm.12389. Epub 2014 Sep 16.


Evaluation of Transverse Maxillary Expansion After a Segmental Posterior Subapical Maxillary Osteotomy in Cleft Lip and Palate Patients With Severe Collapse of the Lateral Maxillary Segments.

Carpentier S, van Gastel J, Schoenaers J, Carels C, Vander Poorten V, Coucke W, Verdonck A.

Cleft Palate Craniofac J. 2014 Jun 11. [Epub ahead of print]


[Tooth eruption disturbances and syndromes].

Oosterkamp BC, Ockeloen CW, Carels CE, Kuijpers-Jagtman AM.

Ned Tijdschr Tandheelkd. 2014 Apr;121(4):233-8. Review. Dutch.


[Genetics and tooth eruption disorders: a future exploration].

Carels CE, Kuijpers-Jagtman AM, Oosterkamp BC.

Ned Tijdschr Tandheelkd. 2014 Apr;121(4):191. Dutch. No abstract available.


Three-dimensional imaging methods for quantitative analysis of facial soft tissues and skeletal morphology in patients with orofacial clefts: a systematic review.

Kuijpers MA, Chiu YT, Nada RM, Carels CE, Fudalej PS.

PLoS One. 2014 Apr 7;9(4):e93442. doi: 10.1371/journal.pone.0093442. eCollection 2014. Review.


Cranio-maxillofacial, orthodontic and dental treatment in three patients with Apert syndrome.

Carpentier S, Schoenaers J, Carels C, Verdonck A.

Eur Arch Paediatr Dent. 2014 Aug;15(4):281-9. doi: 10.1007/s40368-013-0105-9. Epub 2014 Mar 19.


Effects of retinoic acid on proliferation and gene expression of cleft and non-cleft palatal keratinocytes.

Mammadova A, Ackermans MM, Bloemen M, Oostendorp C, Zhou H, Carels CE, Von den Hoff JW.

Eur J Orthod. 2014 Dec;36(6):727-34. doi: 10.1093/ejo/cjt104. Epub 2014 Feb 7.


Variability in dentofacial phenotypes in four families with WNT10A mutations.

Vink CP, Ockeloen CW, ten Kate S, Koolen DA, Ploos van Amstel JK, Kuijpers-Jagtman AM, van Heumen CC, Kleefstra T, Carels CE.

Eur J Hum Genet. 2014 Sep;22(9):1063-70. doi: 10.1038/ejhg.2013.300. Epub 2014 Jan 8.


Genomic approaches for studying craniofacial disorders.

Khandelwal KD, van Bokhoven H, Roscioli T, Carels CE, Zhou H.

Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):218-31. doi: 10.1002/ajmg.c.31379. Epub 2013 Oct 18. Review.


Enamel defects on the maxillary premolars in patients with cleft lip and/or palate: a retrospective case-control study.

Carpentier S, Ghijselings E, Schoenaers J, Carels C, Verdonck A.

Eur Arch Paediatr Dent. 2014 Jun;15(3):159-65. doi: 10.1007/s40368-013-0078-8. Epub 2013 Oct 8.


Long-term changes in microbiology and clinical periodontal variables after completion of fixed orthodontic appliances.

Ghijselings E, Coucke W, Verdonck A, Teughels W, Quirynen M, Pauwels M, Carels C, van Gastel J.

Orthod Craniofac Res. 2014 Feb;17(1):49-59. doi: 10.1111/ocr.12031. Epub 2013 Sep 1.


Targeting the redox balance in inflammatory skin conditions.

Wagener FA, Carels CE, Lundvig DM.

Int J Mol Sci. 2013 Apr 26;14(5):9126-67. doi: 10.3390/ijms14059126. Review.


Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees.

Dreesen K, Swinnen S, Devriendt K, Carels C.

Eur J Orthod. 2014 Feb;36(1):99-106. doi: 10.1093/ejo/cjt021. Epub 2013 Apr 18.


Novel BCOR mutations in patients with oculofaciocardiodental (OFCD) syndrome.

Feberwee HE, Feenstra I, Oberoi S, Sama IE, Ockeloen CW, Clum F, Slavotinek A, Kuijpers MA, Dooijes D, Kuijpers-Jagtman AM, Kleefstra T, Carels CE.

Clin Genet. 2014 Feb;85(2):194-7. doi: 10.1111/cge.12125. Epub 2013 Apr 5. No abstract available.


Tooth agenesis patterns in unilateral cleft lip and palate in humans.

Bartzela TN, Carels CE, Bronkhorst EM, Kuijpers-Jagtman AM.

Arch Oral Biol. 2013 Jun;58(6):596-602. doi: 10.1016/j.archoralbio.2012.12.007. Epub 2013 Jan 5.


Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts.

Vogelaar IP, Figueiredo J, van Rooij IA, Simões-Correia J, van der Post RS, Melo S, Seruca R, Carels CE, Ligtenberg MJ, Hoogerbrugge N.

Hum Mol Genet. 2013 Mar 1;22(5):919-26. doi: 10.1093/hmg/dds497. Epub 2012 Nov 29.


Three-dimensional analysis of tooth dimensions in the MSX1-missense mutation.

Créton M, van den Boogaard MJ, Maal T, Verhamme L, Fennis W, Carels C, Kuijpers-Jagtman AM, Cune M.

Clin Oral Investig. 2013 Jun;17(5):1437-45. doi: 10.1007/s00784-012-0828-8. Epub 2012 Aug 31.


Reduced masticatory function is related to lower satellite cell numbers in masseter muscle.

Kuijpers MA, Grefte S, Bronkhorst EM, Carels CE, Kiliaridis S, Von den Hoff JW.

Eur J Orthod. 2014 Jun;36(3):262-7. doi: 10.1093/ejo/cjs044. Epub 2012 Jul 24.


[The impact of bisphosphonates on orthodontic treatment].

Poelmans S, Carels CE.

Ned Tijdschr Tandheelkd. 2012 Apr;119(4):186-90. Review. Dutch.


Vitamin A and clefting: putative biological mechanisms.

Ackermans MM, Zhou H, Carels CE, Wagener FA, Von den Hoff JW.

Nutr Rev. 2011 Oct;69(10):613-24. doi: 10.1111/j.1753-4887.2011.00425.x. Review.


Longitudinal changes in gingival crevicular fluid after placement of fixed orthodontic appliances.

van Gastel J, Teughels W, Quirynen M, Struyf S, Van Damme J, Coucke W, Carels C.

Am J Orthod Dentofacial Orthop. 2011 Jun;139(6):735-44. doi: 10.1016/j.ajodo.2009.10.043.


Dental development in hemifacial microsomia.

Ongkosuwito EM, de Gijt P, Wattel E, Carels CE, Kuijpers-Jagtman AM.

J Dent Res. 2010 Dec;89(12):1368-72. doi: 10.1177/0022034510378425. Epub 2010 Aug 25.


Longitudinal changes in microbiology and clinical periodontal parameters after removal of fixed orthodontic appliances.

van Gastel J, Quirynen M, Teughels W, Coucke W, Carels C.

Eur J Orthod. 2011 Feb;33(1):15-21. doi: 10.1093/ejo/cjq032. Epub 2010 Jul 29.


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