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Items: 1 to 50 of 213

1.

A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions.

Okamura H, Becker S, Tiede N, Wiedemann S, Feldmann J, Carell T.

Chem Commun (Camb). 2019 Feb 7;55(13):1939-1942. doi: 10.1039/c8cc09435g.

PMID:
30681091
2.

Publisher Correction: Non-canonical nucleosides and chemistry of the emergence of life.

Becker S, Schneider C, Crisp A, Carell T.

Nat Commun. 2019 Jan 15;10(1):325. doi: 10.1038/s41467-019-08340-9.

3.

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides.

Traube FR, Schiffers S, Iwan K, Kellner S, Spada F, Müller M, Carell T.

Nat Protoc. 2019 Jan;14(1):283-312. doi: 10.1038/s41596-018-0094-6.

PMID:
30559375
4.

Non-canonical nucleosides and chemistry of the emergence of life.

Becker S, Schneider C, Crisp A, Carell T.

Nat Commun. 2018 Dec 12;9(1):5174. doi: 10.1038/s41467-018-07222-w. Erratum in: Nat Commun. 2019 Jan 15;10(1):325.

5.

A Click-Chemistry Linked 2'3'-cGAMP Analogue.

Dialer CR, Stazzoni S, Drexler DJ, Müller FM, Veth S, Pichler A, Okamura H, Witte G, Hopfner KP, Carell T.

Chemistry. 2019 Feb 6;25(8):2089-2095. doi: 10.1002/chem.201805409. Epub 2019 Jan 17.

PMID:
30536650
6.

Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, Meissner A, Carell T, Rathert P, Jurkowska RZ, Jeltsch A.

Nucleic Acids Res. 2018 Sep 28;46(17):9044-9056. doi: 10.1093/nar/gky715.

7.

ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Ensfelder TT, Kurz MQ, Iwan K, Geiger S, Matheisl S, Müller M, Beckmann R, Carell T.

Chem Commun (Camb). 2018 Aug 11;54(62):8591-8593. doi: 10.1039/c8cc03980a. Epub 2018 Jul 16.

PMID:
30010678
8.

Rethinking the tools of the RNA world.

Crisp A, Carell T.

Elife. 2018 Jun 15;7. pii: e38297. doi: 10.7554/eLife.38297.

9.

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations.

Schneider C, Becker S, Okamura H, Crisp A, Amatov T, Stadlmeier M, Carell T.

Angew Chem Int Ed Engl. 2018 May 14;57(20):5943-5946. doi: 10.1002/anie.201801919. Epub 2018 Apr 17.

PMID:
29533524
10.

Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis.

Becker S, Schneider C, Okamura H, Crisp A, Amatov T, Dejmek M, Carell T.

Nat Commun. 2018 Jan 11;9(1):163. doi: 10.1038/s41467-017-02639-1.

11.

A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry.

Stadlmeier M, Bogena J, Wallner M, Wühr M, Carell T.

Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2958-2962. doi: 10.1002/anie.201708867. Epub 2018 Feb 15.

PMID:
29316131
12.

5-Formylcytosine to cytosine conversion by C-C bond cleavage in vivo.

Iwan K, Rahimoff R, Kirchner A, Spada F, Schröder AS, Kosmatchev O, Ferizaj S, Steinbacher J, Parsa E, Müller M, Carell T.

Nat Chem Biol. 2018 Jan;14(1):72-78. doi: 10.1038/nchembio.2531. Epub 2017 Nov 27.

PMID:
29176672
13.

Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.

Kitsera N, Allgayer J, Parsa E, Geier N, Rossa M, Carell T, Khobta A.

Nucleic Acids Res. 2017 Nov 2;45(19):11033-11042. doi: 10.1093/nar/gkx718.

14.

Non-canonical Bases in the Genome: The Regulatory Information Layer in DNA.

Carell T, Kurz MQ, Müller M, Rossa M, Spada F.

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4296-4312. doi: 10.1002/anie.201708228. Epub 2018 Mar 8. Review.

PMID:
28941008
15.

Synthesis of RNA Containing 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine.

Michaelides IN, Tago N, Viverge B, Carell T.

Chemistry. 2017 Nov 13;23(63):15894-15898. doi: 10.1002/chem.201704216. Epub 2017 Oct 20.

PMID:
28906048
16.

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis.

Edupuganti RR, Geiger S, Lindeboom RGH, Shi H, Hsu PJ, Lu Z, Wang SY, Baltissen MPA, Jansen PWTC, Rossa M, Müller M, Stunnenberg HG, He C, Carell T, Vermeulen M.

Nat Struct Mol Biol. 2017 Oct;24(10):870-878. doi: 10.1038/nsmb.3462. Epub 2017 Sep 4.

17.

5-Formyl- and 5-Carboxydeoxycytidines Do Not Cause Accumulation of Harmful Repair Intermediates in Stem Cells.

Rahimoff R, Kosmatchev O, Kirchner A, Pfaffeneder T, Spada F, Brantl V, Müller M, Carell T.

J Am Chem Soc. 2017 Aug 2;139(30):10359-10364. doi: 10.1021/jacs.7b04131. Epub 2017 Jul 21.

PMID:
28715893
18.

Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ.

Raddaoui N, Stazzoni S, Möckl L, Viverge B, Geiger F, Engelke H, Bräuchle C, Carell T.

Chembiochem. 2017 Sep 5;18(17):1716-1720. doi: 10.1002/cbic.201700209. Epub 2017 Jul 24.

PMID:
28640486
19.

Structural Insights into the Recognition of N2 -Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14.

Ebert C, Simon N, Schneider S, Carell T.

Chembiochem. 2017 Jul 18;18(14):1379-1382. doi: 10.1002/cbic.201700169. Epub 2017 May 30.

PMID:
28444956
20.

The chemistries and consequences of DNA and RNA methylation and demethylation.

Traube FR, Carell T.

RNA Biol. 2017 Sep 2;14(9):1099-1107. doi: 10.1080/15476286.2017.1318241. Epub 2017 Apr 25. Review.

21.

Quantitative LC-MS Provides No Evidence for m6 dA or m4 dC in the Genome of Mouse Embryonic Stem Cells and Tissues.

Schiffers S, Ebert C, Rahimoff R, Kosmatchev O, Steinbacher J, Bohne AV, Spada F, Michalakis S, Nickelsen J, Müller M, Carell T.

Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11268-11271. doi: 10.1002/anie.201700424. Epub 2017 Mar 30.

PMID:
28371147
22.

2'-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA polymerases and TET-enzymes.

Schröder AS, Parsa E, Iwan K, Traube FR, Wallner M, Serdjukow S, Carell T.

Chem Commun (Camb). 2016 Dec 13;52(100):14361-14364.

PMID:
27905578
23.

Direct observation of a deoxyadenosyl radical in an active enzyme environment.

Heidinger L, Kneuttinger AC, Kashiwazaki G, Weber S, Carell T, Schleicher E.

FEBS Lett. 2016 Dec;590(24):4489-4494. doi: 10.1002/1873-3468.12498. Epub 2016 Dec 16.

24.

Molecular mechanisms of xeroderma pigmentosum (XP) proteins.

Koch SC, Simon N, Ebert C, Carell T.

Q Rev Biophys. 2016 Jan;49:e5. Epub 2016 Feb 10.

PMID:
27660069
25.

Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex.

Dallmann A, Beribisky AV, Gnerlich F, Rübbelke M, Schiesser S, Carell T, Sattler M.

Chemistry. 2016 Oct 17;22(43):15350-15359. doi: 10.1002/chem.201602784. Epub 2016 Sep 8.

PMID:
27608298
26.

Erratum to: M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry.

Carell T, Vrabel M, Yang M, Yang Y, Chen PR, Dommerholt J, Rutjes FPJT, van Delft FL, Herner A, Lin Q, Wu H, Devaraj NK, Kath-Schorr S.

Top Curr Chem (Cham). 2016 Apr 13;374(3):23. doi: 10.1007/s41061-016-0024-4. No abstract available.

PMID:
27573263
27.

M. Vrabel and T. Carell for Cycloadditions in Bioorthogonal Chemistry.

Carell T, Vrabel M, Yang M, Yang Y, Chen PR, Dommerholt J, Rutjes FPJT, van Delft FL, Herner A, Lin Q, Wu H, Devaraj NK, Kath-Schorr S.

Top Curr Chem (Cham). 2016 Apr;374(2):15. doi: 10.1007/s41061-016-0017-3. Epub 2016 Mar 16. No abstract available. Erratum in: Top Curr Chem (J). 2016 Jun;374(3):23.

PMID:
27573140
28.

Erratum to: Bioorthogonal Chemistry-Introduction and Overview.

Carell T, Vrabel M.

Top Curr Chem (Cham). 2016 Feb 25;374(2):12. doi: 10.1007/s41061-016-0014-6. No abstract available.

PMID:
27573137
29.

Bioorthogonal Chemistry—Introduction and Overview [corrected].

Carell T, Vrabel M.

Top Curr Chem (Cham). 2016 Feb;374(1):9. doi: 10.1007/s41061-016-0010-x. Epub 2016 Feb 1. Review. Erratum in: Top Curr Chem (J). 2016 Apr;374(2):12.

PMID:
27572992
30.

5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites.

Su M, Kirchner A, Stazzoni S, Müller M, Wagner M, Schröder A, Carell T.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):11797-800. doi: 10.1002/anie.201605994. Epub 2016 Aug 25.

PMID:
27561097
31.

Synthesis of (R)-Configured 2'-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides.

Schröder AS, Kotljarova O, Parsa E, Iwan K, Raddaoui N, Carell T.

Org Lett. 2016 Sep 2;18(17):4368-71. doi: 10.1021/acs.orglett.6b02110. Epub 2016 Aug 19.

PMID:
27541290
32.

Tumour hypoxia causes DNA hypermethylation by reducing TET activity.

Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D.

Nature. 2016 Sep 1;537(7618):63-68. doi: 10.1038/nature19081. Epub 2016 Aug 17.

33.

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy.

Greco CM, Kunderfranco P, Rubino M, Larcher V, Carullo P, Anselmo A, Kurz K, Carell T, Angius A, Latronico MV, Papait R, Condorelli G.

Nat Commun. 2016 Aug 4;7:12418. doi: 10.1038/ncomms12418.

34.

A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway.

Becker S, Thoma I, Deutsch A, Gehrke T, Mayer P, Zipse H, Carell T.

Science. 2016 May 13;352(6287):833-6. doi: 10.1126/science.aad2808.

35.

Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release.

Datz S, Argyo C, Gattner M, Weiss V, Brunner K, Bretzler J, von Schirnding C, Torrano AA, Spada F, Vrabel M, Engelke H, Bräuchle C, Carell T, Bein T.

Nanoscale. 2016 Apr 21;8(15):8101-10. doi: 10.1039/c5nr08163g.

PMID:
27021414
36.

Active DNA demethylation at enhancers during the vertebrate phylotypic period.

Bogdanović O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M, Gómez-Skarmeta JL, Lister R.

Nat Genet. 2016 Apr;48(4):417-26. doi: 10.1038/ng.3522. Epub 2016 Feb 29.

37.

Lewis Acid Triggered Regioselective Magnesiation and Zincation of Uracils, Uridines, and Cytidines.

Klier L, Aranzamendi E, Ziegler D, Nickel J, Karaghiosoff K, Carell T, Knochel P.

Org Lett. 2016 Mar 4;18(5):1068-71. doi: 10.1021/acs.orglett.6b00190. Epub 2016 Feb 17.

PMID:
26883782
38.

UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair.

Bucher DB, Kufner CL, Schlueter A, Carell T, Zinth W.

J Am Chem Soc. 2016 Jan 13;138(1):186-90. doi: 10.1021/jacs.5b09753. Epub 2015 Dec 21.

PMID:
26651219
39.

Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.

Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T.

Sci Signal. 2015 Nov 24;8(404):ra119. doi: 10.1126/scisignal.aac7695.

PMID:
26602018
40.

DNA Repair.

Carell T.

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15330-3. doi: 10.1002/anie.201509770. Epub 2015 Nov 19.

PMID:
26582712
41.

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.

Wagner M, Steinbacher J, Kraus TF, Michalakis S, Hackner B, Pfaffeneder T, Perera A, Müller M, Giese A, Kretzschmar HA, Carell T.

Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12511-4. doi: 10.1002/anie.201502722. Epub 2015 Jul 3.

42.

Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases.

Bucher DB, Pilles BM, Carell T, Zinth W.

J Phys Chem B. 2015 Jul 16;119(28):8685-92. doi: 10.1021/acs.jpcb.5b04694. Epub 2015 Jul 2.

PMID:
26103527
43.

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA).

Koch SC, Kuper J, Gasteiger KL, Simon N, Strasser R, Eisen D, Geiger S, Schneider S, Kisker C, Carell T.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8272-7. doi: 10.1073/pnas.1508509112. Epub 2015 Jun 22.

44.

Effect of Opalescence® bleaching gels on the elution of dental composite components.

Schuster L, Rothmund L, He X, Van Landuyt KL, Schweikl H, Hellwig E, Carell T, Hickel R, Reichl FX, Högg C.

Dent Mater. 2015 Jun;31(6):745-57. doi: 10.1016/j.dental.2015.03.016. Epub 2015 Apr 18.

PMID:
25900623
45.

Orchestrating the biosynthesis of an unnatural pyrrolysine amino Acid for its direct incorporation into proteins inside living cells.

Ehrlich M, Gattner MJ, Viverge B, Bretzler J, Eisen D, Stadlmeier M, Vrabel M, Carell T.

Chemistry. 2015 May 18;21(21):7701-4. doi: 10.1002/chem.201500971. Epub 2015 Apr 2.

PMID:
25845346
46.

TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.

Perera A, Eisen D, Wagner M, Laube SK, Künzel AF, Koch S, Steinbacher J, Schulze E, Splith V, Mittermeier N, Müller M, Biel M, Carell T, Michalakis S.

Cell Rep. 2015 Apr 14;11(2):283-94. doi: 10.1016/j.celrep.2015.03.020. Epub 2015 Apr 2.

47.

Release and protein binding of components from resin based composites in native saliva and other extraction media.

Rothmund L, Shehata M, Van Landuyt KL, Schweikl H, Carell T, Geurtsen W, Hellwig E, Hickel R, Reichl FX, Högg C.

Dent Mater. 2015 May;31(5):496-504. doi: 10.1016/j.dental.2015.01.016. Epub 2015 Feb 24.

PMID:
25724383
48.

A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.

Penter L, Maier B, Frede U, Hackner B, Carell T, Hagemeier C, Truss M.

Target Oncol. 2015 Dec;10(4):523-33. doi: 10.1007/s11523-014-0354-5. Epub 2015 Jan 6.

PMID:
25559288
49.

DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides.

Su M, Tomás-Gamasa M, Carell T.

Chem Sci. 2015 Jan 1;6(1):632-638. doi: 10.1039/c4sc01567c. Epub 2014 Aug 11.

50.

Cell-penetrating and neurotargeting dendritic siRNA nanostructures.

Brunner K, Harder J, Halbach T, Willibald J, Spada F, Gnerlich F, Sparrer K, Beil A, Möckl L, Bräuchle C, Conzelmann KK, Carell T.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1946-9. doi: 10.1002/anie.201409803. Epub 2014 Dec 17.

PMID:
25522332

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