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Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC subtype diffuse large B cell lymphoma.

Vockerodt M, Vrzalikova K, Ibrahim M, Nagy E, Margielewska S, Hollows R, Lupino L, Tooze R, Care M, Simmons W, Schrader A, Perry T, Abdullah M, Foster S, Reynolds G, Dowell A, Rudski Z, Krappmann D, Kube D, Woodman C, Wei W, Taylor G, Murray PG.

J Pathol. 2019 Jan 21. doi: 10.1002/path.5237. [Epub ahead of print]


Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.

Stephenson S, Care MA, Fan I, Zougman A, Westhead DR, Doody GM, Tooze RM.

J Immunol. 2019 Feb 15;202(4):1287-1300. doi: 10.4049/jimmunol.1801407. Epub 2019 Jan 14.


Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy.

Sha C, Barrans S, Cucco F, Bentley MA, Care MA, Cummin T, Kennedy H, Thompson JS, Uddin R, Worrillow L, Chalkley R, van Hoppe M, Ahmed S, Maishman T, Caddy J, Schuh A, Mamot C, Burton C, Tooze R, Davies A, Du MQ, Johnson PWM, Westhead DR.

J Clin Oncol. 2019 Jan 20;37(3):202-212. doi: 10.1200/JCO.18.01314. Epub 2018 Dec 3.


Next-Generation Service Delivery: A Scoping Review of Patient Outcomes Associated with Alternative Models of Genetic Counseling and Genetic Testing for Hereditary Cancer.

McCuaig JM, Armel SR, Care M, Volenik A, Kim RH, Metcalfe KA.

Cancers (Basel). 2018 Nov 13;10(11). pii: E435. doi: 10.3390/cancers10110435. Review.


Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity.

Al-Maskari M, Care MA, Robinson E, Cocco M, Tooze RM, Doody GM.

Sci Rep. 2018 Sep 25;8(1):14338. doi: 10.1038/s41598-018-32705-7.


Pediatric Emergencies: Imaging of Pediatric Head Trauma.

O'Brien WT Sr, Caré MM, Leach JL.

Semin Ultrasound CT MR. 2018 Oct;39(5):495-514. doi: 10.1053/j.sult.2018.01.007. Epub 2018 Jan 31. Review.


Differences in the respiratory response to temperature and hypoxia across four life-stages of the intertidal porcelain crab Petrolisthes laevigatus.

Leiva FP, Garcés C, Verberk WCEP, Care M, Paschke K, Gebauer P.

Mar Biol. 2018;165(9):146. doi: 10.1007/s00227-018-3406-z. Epub 2018 Aug 23.


Reappraisal of Reported Genes for Sudden Arrhythmic Death.

Hosseini SM, Kim R, Udupa S, Costain G, Jobling R, Liston E, Jamal SM, Szybowska M, Morel CF, Bowdin S, Garcia J, Care M, Sturm AC, Novelli V, Ackerman MJ, Ware JS, Hershberger RE, Wilde AAM, Gollob MH; National Institutes of Health Clinical Genome Resource Consortium.

Circulation. 2018 Sep 18;138(12):1195-1205. doi: 10.1161/CIRCULATIONAHA.118.035070.


T-Wave Morphology Analysis in Congenital Long QT Syndrome Discriminates Patients From Healthy Individuals.

Porta-Sánchez A, Spillane DR, Harris L, Xue J, Dorsey P, Care M, Chauhan V, Gollob MH, Spears DA.

JACC Clin Electrophysiol. 2017 Apr;3(4):374-381. doi: 10.1016/j.jacep.2016.10.013. Epub 2016 Dec 21.


Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation.

Bigley V, Maisuria S, Cytlak U, Jardine L, Care MA, Green K, Gunawan M, Milne P, Dickinson R, Wiscombe S, Parry D, Doffinger R, Laurence A, Fonseca C, Stoevesandt O, Gennery A, Cant A, Tooze R, Simpson AJ, Hambleton S, Savic S, Doody G, Collin M.

J Allergy Clin Immunol. 2018 Jun;141(6):2234-2248. doi: 10.1016/j.jaci.2017.08.044. Epub 2017 Nov 8.


S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.

Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG.

Leukemia. 2018 Jan;32(1):214-223. doi: 10.1038/leu.2017.275. Epub 2017 Sep 7.


Genetic Testing in Inherited Heart Diseases: Practical Considerations for Clinicians.

Care M, Chauhan V, Spears D.

Curr Cardiol Rep. 2017 Aug 16;19(9):88. doi: 10.1007/s11886-017-0885-3. Review.


Prevalence and Clinical Implication of Double Mutations in Hypertrophic Cardiomyopathy: Revisiting the Gene-Dose Effect.

Fourey D, Care M, Siminovitch KA, Weissler-Snir A, Hindieh W, Chan RH, Gollob MH, Rakowski H, Adler A.

Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001685. doi: 10.1161/CIRCGENETICS.116.001685.


Pediatric Spinal Ultrasound: Neonatal and Intraoperative Applications.

Alvarado E, Leach J, Caré M, Mangano F, O Hara S.

Semin Ultrasound CT MR. 2017 Apr;38(2):126-142. doi: 10.1053/j.sult.2016.07.003. Epub 2016 Jul 12. Review.


Structured assessment and followup for patients with hereditary kidney tumour syndromes.

Lattouf JB, Pautler SE, Reaume MN, Kim RH, Care M, Green J, So A, Violette PD, Saliba I, Major P, Silver S, Leicht R, Basiuk J, Tanguay S, Jewett MA, Drachenberg D; Kidney Cancer Research Network of Canada.

Can Urol Assoc J. 2016 Jul-Aug;10(7-8):E214-E222. doi: 10.5489/cuaj.3798. Epub 2016 Jul 12. Erratum in: Can Urol Assoc J. 2017 Aug;11(8):E325.


Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (β-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy.

Weissler-Snir A, Hindieh W, Gruner C, Fourey D, Appelbaum E, Rowin E, Care M, Lesser JR, Haas TS, Udelson JE, Manning WJ, Olivotto I, Tomberli B, Maron BJ, Maron MS, Crean AM, Rakowski H, Chan RH.

Circ Cardiovasc Imaging. 2017 Feb;10(2). pii: e005311. doi: 10.1161/CIRCIMAGING.116.005311.


Evaluation of Prolonged QT Interval: Structural Heart Disease Mimicking Long QT Syndrome.

Weissler-Snir A, Gollob MH, Chauhan V, Care M, Spears DA.

Pacing Clin Electrophysiol. 2017 Apr;40(4):417-424. doi: 10.1111/pace.13040. Epub 2017 Mar 16.


Biallelic mutations in IRF8 impair human NK cell maturation and function.

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS.

J Clin Invest. 2017 Jan 3;127(1):306-320. doi: 10.1172/JCI86276. Epub 2016 Nov 28.


Clinical validation of synthetic brain MRI in children: initial experience.

West H, Leach JL, Jones BV, Care M, Radhakrishnan R, Merrow AC, Alvarado E, Serai SD.

Neuroradiology. 2017 Jan;59(1):43-50. doi: 10.1007/s00234-016-1765-z. Epub 2016 Nov 26.


TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism.

New M, Sheikh S, Bekheet M, Olzscha H, Thezenas ML, Care MA, Fotheringham S, Tooze RM, Kessler B, La Thangue NB.

Cancer Res. 2016 Dec 1;76(23):6975-6987. Epub 2016 Oct 12.


Usefulness of 14-Day Holter for Detection of Nonsustained Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy.

Weissler-Snir A, Chan RH, Adler A, Care M, Chauhan V, Gollob MH, Ziv-Baran T, Fourey D, Hindieh W, Rakowski H, Spears DA.

Am J Cardiol. 2016 Oct 15;118(8):1258-1263. doi: 10.1016/j.amjcard.2016.07.043. Epub 2016 Jul 29.


Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.

Care MA, Stephenson SJ, Barnes NA, Fan I, Zougman A, El-Sherbiny YM, Vital EM, Westhead DR, Tooze RM, Doody GM.

J Immunol. 2016 Aug 15;197(4):1447-59. doi: 10.4049/jimmunol.1600624. Epub 2016 Jun 29.


An ultra-deep sequencing strategy to detect sub-clonal TP53 mutations in presentation chronic lymphocytic leukaemia cases using multiple polymerases.

Worrillow L, Baskaran P, Care MA, Varghese A, Munir T, Evans PA, O'Connor SJ, Rawstron A, Hazelwood L, Tooze RM, Hillmen P, Newton DJ.

Oncogene. 2016 Oct 6;35(40):5328-5336. doi: 10.1038/onc.2016.73. Epub 2016 Apr 4.


Reduced Field of View Diffusion-Weighted Imaging in the Evaluation of Congenital Spine Malformations.

Radhakrishnan R, Betts AM, Care MM, Serai S, Zhang B, Jones BV.

J Neuroimaging. 2016 May;26(3):273-7. doi: 10.1111/jon.12317. Epub 2015 Nov 24.


Everolimus for subependymal giant cell astrocytoma: 5-year final analysis.

Franz DN, Agricola K, Mays M, Tudor C, Care MM, Holland-Bouley K, Berkowitz N, Miao S, Peyrard S, Krueger DA.

Ann Neurol. 2015 Dec;78(6):929-38. doi: 10.1002/ana.24523. Epub 2015 Nov 9.


Transferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas.

Sha C, Barrans S, Care MA, Cunningham D, Tooze RM, Jack A, Westhead DR.

Genome Med. 2015 Jul 1;7(1):64. doi: 10.1186/s13073-015-0187-6. eCollection 2015.


The striated MR nephrogram, not a reflection of pathology.

Trout AT, Zhang B, Care MM, Towbin AJ.

Pediatr Radiol. 2015 Oct;45(11):1644-50. doi: 10.1007/s00247-015-3388-7. Epub 2015 May 27.


Adding Insult to Injury: Nonconvulsive Seizures in Abusive Head Trauma.

Greiner MV, Greiner HM, Caré MM, Owens D, Shapiro R, Holland K.

J Child Neurol. 2015 Nov;30(13):1778-84. doi: 10.1177/0883073815580285. Epub 2015 Apr 21.


Knowledge of genetic testing for hereditary kidney cancer in Canada is lacking: The results of the Canadian national hereditary kidney cancer needs assessment survey.

Violette PD, Kamel-Reid S, Graham GE, Reaume MN, Jewett MA, Care M, Basiuk J, Pautler SE.

Can Urol Assoc J. 2014 Nov;8(11-12):E832-40. doi: 10.5489/cuaj.2415.


Genotype-positive status in patients with hypertrophic cardiomyopathy is associated with higher rates of heart failure events.

Li Q, Gruner C, Chan RH, Care M, Siminovitch K, Williams L, Woo A, Rakowski H.

Circ Cardiovasc Genet. 2014 Aug;7(4):416-22. doi: 10.1161/CIRCGENETICS.113.000331. Epub 2014 Jun 8.


SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.

Care MA, Cocco M, Laye JP, Barnes N, Huang Y, Wang M, Barrans S, Du M, Jack A, Westhead DR, Doody GM, Tooze RM.

Nucleic Acids Res. 2014 Jul;42(12):7591-610. doi: 10.1093/nar/gku451. Epub 2014 May 29.


Significance of left ventricular apical-basal muscle bundle identified by cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy.

Gruner C, Chan RH, Crean A, Rakowski H, Rowin EJ, Care M, Deva D, Williams L, Appelbaum E, Gibson CM, Lesser JR, Haas TS, Udelson JE, Manning WJ, Siminovitch K, Ralph-Edwards AC, Rastegar H, Maron BJ, Maron MS.

Eur Heart J. 2014 Oct 14;35(39):2706-13. doi: 10.1093/eurheartj/ehu154. Epub 2014 May 8.


Utility of head computed tomography in children with a single extremity fracture.

Wilson PM, Chua M, Care M, Greiner MV, Keeshin B, Bennett B.

J Pediatr. 2014 Jun;164(6):1274-9. doi: 10.1016/j.jpeds.2013.12.041. Epub 2014 Feb 5.


Combined analysis of sMRI and fMRI imaging data provides accurate disease markers for hearing impairment.

Tan L, Chen Y, Maloney TC, Caré MM, Holland SK, Lu LJ.

Neuroimage Clin. 2013 Oct 11;3:416-28. doi: 10.1016/j.nicl.2013.09.008. eCollection 2013.


Canadian guideline on genetic screening for hereditary renal cell cancers.

Reaume MN, Graham GE, Tomiak E, Kamel-Reid S, Jewett MA, Bjarnason GA, Blais N, Care M, Drachenberg D, Gedye C, Grant R, Heng DY, Kapoor A, Kollmannsberger C, Lattouf JB, Maher ER, Pause A, Ruether D, Soulieres D, Tanguay S, Turcotte S, Violette PD, Wood L, Basiuk J, Pautler SE; Kidney Cancer Research Network of Canada.

Can Urol Assoc J. 2013 Sep-Oct;7(9-10):319-23. doi: 10.5489/cuaj.1496.


Prevalence of subdural collections in children with macrocrania.

Greiner MV, Richards TJ, Care MM, Leach JL.

AJNR Am J Neuroradiol. 2013 Dec;34(12):2373-8. doi: 10.3174/ajnr.A3588. Epub 2013 Jul 18.


Deep basal inferoseptal crypts occur more commonly in patients with hypertrophic cardiomyopathy due to disease-causing myofilament mutations.

Deva DP, Williams LK, Care M, Siminovitch KA, Moshonov H, Wintersperger BJ, Rakowski H, Crean AM.

Radiology. 2013 Oct;269(1):68-76. doi: 10.1148/radiol.13122344. Epub 2013 Jun 14.


A microarray platform-independent classification tool for cell of origin class allows comparative analysis of gene expression in diffuse large B-cell lymphoma.

Care MA, Barrans S, Worrillow L, Jack A, Westhead DR, Tooze RM.

PLoS One. 2013;8(2):e55895. doi: 10.1371/journal.pone.0055895. Epub 2013 Feb 12.


Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma.

Krueger DA, Care MM, Agricola K, Tudor C, Mays M, Franz DN.

Neurology. 2013 Feb 5;80(6):574-80. doi: 10.1212/WNL.0b013e3182815428. Epub 2013 Jan 16.


Toronto hypertrophic cardiomyopathy genotype score for prediction of a positive genotype in hypertrophic cardiomyopathy.

Gruner C, Ivanov J, Care M, Williams L, Moravsky G, Yang H, Laczay B, Siminovitch K, Woo A, Rakowski H.

Circ Cardiovasc Genet. 2013 Feb;6(1):19-26. doi: 10.1161/CIRCGENETICS.112.963363. Epub 2012 Dec 13.


In vitro generation of long-lived human plasma cells.

Cocco M, Stephenson S, Care MA, Newton D, Barnes NA, Davison A, Rawstron A, Westhead DR, Doody GM, Tooze RM.

J Immunol. 2012 Dec 15;189(12):5773-85. doi: 10.4049/jimmunol.1103720. Epub 2012 Nov 16.


Whole genome expression profiling based on paraffin embedded tissue can be used to classify diffuse large B-cell lymphoma and predict clinical outcome.

Barrans SL, Crouch S, Care MA, Worrillow L, Smith A, Patmore R, Westhead DR, Tooze R, Roman E, Jack AS.

Br J Haematol. 2012 Nov;159(4):441-53. doi: 10.1111/bjh.12045. Epub 2012 Sep 13.


Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q.

Nair K, Pekhletski R, Harris L, Care M, Morel C, Farid T, Backx PH, Szabo E, Nanthakumar K.

Heart Rhythm. 2012 Oct;9(10):1681-1688.e1. doi: 10.1016/j.hrthm.2012.06.029. Epub 2012 Jun 16.


Systolic myocardial mechanics in patients with Anderson-Fabry disease with and without left ventricular hypertrophy and in comparison to nonobstructive hypertrophic cardiomyopathy.

Gruner C, Verocai F, Carasso S, Vannan MA, Jamorski M, Clarke JT, Care M, Iwanochko RM, Rakowski H.

Echocardiography. 2012 Aug;29(7):810-7. doi: 10.1111/j.1540-8175.2012.01704.x. Epub 2012 Apr 13.


Genetic testing for dilated cardiomyopathy in clinical practice.

Lakdawala NK, Funke BH, Baxter S, Cirino AL, Roberts AE, Judge DP, Johnson N, Mendelsohn NJ, Morel C, Care M, Chung WK, Jones C, Psychogios A, Duffy E, Rehm HL, White E, Seidman JG, Seidman CE, Ho CY.

J Card Fail. 2012 Apr;18(4):296-303. doi: 10.1016/j.cardfail.2012.01.013. Epub 2012 Feb 15.


Management of kidney cancer: canadian kidney cancer forum consensus update 2011.

Jewett M, Finelli A, Kollmannsberger C, Wood L, Legere L, Basiuk J, Canil C, Heng D, Reaume N, Tanguay S, Atkins M, Bjarnason G, Dancey J, Evans M, Fleshner N, Haider M, Kapoor A, Uzzo R, Maskens D, Soulieres D, Yousef G, Basappa N, Bendali N, Black P, Blais N, Cagiannos I, Care M, Chow R, Chung H, Czaykowski P, Derosa D, Durrant K, Ellard S, Farquharson G, Filion-Brulotte C, Gingerich J, Godbout L, Grant R, Hamilton W, Kassouf W, Kurban G, Lane K, Lattouf J, Lau D, Leveridge M, McCarthy J, Moore R, North S, O'brien P, Pituskin E, Racine P, Rendon R, So A, Sridhar S, Stubbs K, Su Z, Taylor L, Udall T, Venner P, Vogel W, Yap S, Yau P, Cooper M, Giroux N, Miron D, Mosher D, Ross K, Willacy J.

Can Urol Assoc J. 2012 Feb;6(1):16-22. doi: 10.5489/cuaj.11273. No abstract available.


Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J, Hoogenkamp M, Wu M, Care M, McNeill H, Cauchy P, Cullen M, Tooze RM, Tenen DG, Young BD, Cockerill PN, Westhead DR, Heidenreich O, Bonifer C.

Leukemia. 2012 Aug;26(8):1829-41. doi: 10.1038/leu.2012.49. Epub 2012 Feb 20.


Retrospective review to determine the utility of follow-up skeletal surveys in child abuse evaluations when the initial skeletal survey is normal.

Bennett BL, Chua MS, Care M, Kachelmeyer A, Mahabee-Gittens M.

BMC Res Notes. 2011 Sep 12;4:354. doi: 10.1186/1756-0500-4-354.

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