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Na+/Ca2+ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function.

Papin J, Zummo FP, Pachera N, Guay C, Regazzi R, Cardozo AK, Herchuelz A.

J Endocr Soc. 2018 May 25;2(7):631-645. doi: 10.1210/js.2017-00370. eCollection 2018 Jul 1.


The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes.

Meyerovich K, Ortis F, Cardozo AK.

J Mol Endocrinol. 2018 Aug;61(2):F1-F6. doi: 10.1530/JME-16-0183. Epub 2018 May 4. Review.


Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition.

Nardelli TR, Vanzela EC, Benedicto KC, Brozzi F, Fujita A, Cardozo AK, Eizirik DL, Boschero AC, Ortis F.

J Mol Endocrinol. 2018 Jul;61(1):25-36. doi: 10.1530/JME-16-0257. Epub 2018 Apr 9.


Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis.

Lambelet M, Terra LF, Fukaya M, Meyerovich K, Labriola L, Cardozo AK, Allagnat F.

Cell Death Dis. 2018 Jan 24;9(2):96. doi: 10.1038/s41419-017-0121-5.


MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells.

Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK.

Diabetes. 2017 Sep;66(9):2446-2458. doi: 10.2337/db16-1252. Epub 2017 Jun 30.


Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.

Meyerovich K, Ortis F, Allagnat F, Cardozo AK.

J Mol Endocrinol. 2016 Jul;57(1):R1-R17. doi: 10.1530/JME-15-0306. Epub 2016 Apr 11. Review.


A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.

Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, Mortensen HB, Pociot F, van Loo G, Størling J, Cardozo AK.

Mol Endocrinol. 2016 Jan;30(1):48-61. doi: 10.1210/me.2015-1176. Epub 2015 Dec 10.


The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro.

Meyerovich K, Fukaya M, Terra LF, Ortis F, Eizirik DL, Cardozo AK.

Diabetologia. 2016 Mar;59(3):512-21. doi: 10.1007/s00125-015-3817-z. Epub 2015 Dec 3.


A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo.

Catrysse L, Fukaya M, Sze M, Meyerovich K, Beyaert R, Cardozo AK, van Loo G.

Cell Death Dis. 2015 Oct 15;6:e1918. doi: 10.1038/cddis.2015.301. No abstract available.


Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability.

Pachera N, Papin J, Zummo FP, Rahier J, Mast J, Meyerovich K, Cardozo AK, Herchuelz A.

Diabetologia. 2015 Dec;58(12):2843-50. doi: 10.1007/s00125-015-3745-y. Epub 2015 Sep 11.


JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.

Cunha DA, Gurzov EN, Naamane N, Ortis F, Cardozo AK, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

Cell Death Differ. 2014 Aug;21(8):1313-24. doi: 10.1038/cdd.2014.53. Epub 2014 May 2.


Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity.

Allagnat F, Klee P, Cardozo AK, Meda P, Haefliger JA.

Cell Death Differ. 2013 Dec;20(12):1742-52. doi: 10.1038/cdd.2013.134. Epub 2013 Oct 4.


Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.

Eizirik DL, Miani M, Cardozo AK.

Diabetologia. 2013 Feb;56(2):234-41. doi: 10.1007/s00125-012-2762-3. Epub 2012 Nov 7. Review.


C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.

Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L, Marchetti P, Haefliger JA, Eizirik DL, Cardozo AK.

Cell Death Differ. 2012 Nov;19(11):1836-46. doi: 10.1038/cdd.2012.67. Epub 2012 Jun 1.


Is ARE/poly(U)-binding factor 1 (AUF1) a new player in cytokine-mediated beta cell apoptosis?

Vanzela EC, Cardozo AK.

Diabetologia. 2012 Jun;55(6):1572-6. doi: 10.1007/s00125-012-2552-y. Epub 2012 Apr 19.


Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance.

Maris M, Overbergh L, Gysemans C, Waget A, Cardozo AK, Verdrengh E, Cunha JP, Gotoh T, Cnop M, Eizirik DL, Burcelin R, Mathieu C.

Diabetologia. 2012 Apr;55(4):1167-78. doi: 10.1007/s00125-011-2427-7. Epub 2012 Jan 12.


Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.

Colli ML, Nogueira TC, Allagnat F, Cunha DA, Gurzov EN, Cardozo AK, Roivainen M, Op de Beeck A, Eizirik DL.

PLoS Pathog. 2011 Sep;7(9):e1002267. doi: 10.1371/journal.ppat.1002267. Epub 2011 Sep 22.


Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.

Nguidjoe E, Sokolow S, Bigabwa S, Pachera N, D'Amico E, Allagnat F, Vanderwinden JM, Sener A, Manto M, Depreter M, Mast J, Joanny G, Montanya E, Rahier J, Cardozo AK, Eizirik DL, Schurmans S, Herchuelz A.

Diabetes. 2011 Aug;60(8):2076-85. doi: 10.2337/db10-0924. Epub 2011 Jun 9.


Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress.

D'Hertog W, Maris M, Ferreira GB, Verdrengh E, Lage K, Hansen DA, Cardozo AK, Workman CT, Moreau Y, Eizirik DL, Waelkens E, Overbergh L, Mathieu C.

J Proteome Res. 2010 Oct 1;9(10):5142-52. doi: 10.1021/pr1004086.


Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis.

Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK.

Cell Death Differ. 2011 Feb;18(2):328-37. doi: 10.1038/cdd.2010.105. Epub 2010 Aug 27.


Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells.

Jiang L, Allagnat F, Nguidjoe E, Kamagate A, Pachera N, Vanderwinden JM, Brini M, Carafoli E, Eizirik DL, Cardozo AK, Herchuelz A.

J Biol Chem. 2010 Oct 1;285(40):30634-43. doi: 10.1074/jbc.M110.116681. Epub 2010 Jul 26.


Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.

Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S, Eizirik DL, Cardozo AK.

Diabetologia. 2010 Jun;53(6):1120-30. doi: 10.1007/s00125-010-1699-7. Epub 2010 Mar 29.


Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.

Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL.

Cell Death Differ. 2009 Nov;16(11):1539-50. doi: 10.1038/cdd.2009.99. Epub 2009 Jul 24.


Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.

Tonnesen MF, Grunnet LG, Friberg J, Cardozo AK, Billestrup N, Eizirik DL, Størling J, Mandrup-Poulsen T.

Endocrinology. 2009 Sep;150(9):4094-103. doi: 10.1210/en.2009-0029. Epub 2009 Jun 25.


PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.

Diabetes. 2009 Jun;58(6):1283-91. doi: 10.2337/db08-1510. Epub 2009 Mar 31.


Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.


Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.

Pirot P, Cardozo AK, Eizirik DL.

Arq Bras Endocrinol Metabol. 2008 Mar;52(2):156-65. Review.


The role for endoplasmic reticulum stress in diabetes mellitus.

Eizirik DL, Cardozo AK, Cnop M.

Endocr Rev. 2008 Feb;29(1):42-61. Epub 2007 Nov 29. Review.


Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved.

D'Hertog W, Overbergh L, Lage K, Ferreira GB, Maris M, Gysemans C, Flamez D, Cardozo AK, Van den Bergh G, Schoofs L, Arckens L, Moreau Y, Hansen DA, Eizirik DL, Waelkens E, Mathieu C.

Mol Cell Proteomics. 2007 Dec;6(12):2180-99. Epub 2007 Oct 5.


Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.

Callewaert H, Gysemans C, Cardozo AK, Elsner M, Tiedge M, Eizirik DL, Mathieu C.

Cell Transplant. 2007;16(5):527-37.


Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.

Cardozo AK, Buchillier V, Mathieu M, Chen J, Ortis F, Ladrière L, Allaman-Pillet N, Poirot O, Kellenberger S, Beckmann JS, Eizirik DL, Bonny C, Maurer F.

Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. Epub 2007 Jun 14.


Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

Diabetes. 2007 Apr;56(4):1069-77.


Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.

Pirot P, Naamane N, Libert F, Magnusson NE, Ørntoft TF, Cardozo AK, Eizirik DL.

Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1.


Scanning electron microscopic and profilometric study of different sharpening stones.

Andrade Acevedo RA, Cardozo AK, Sampaio JE.

Braz Dent J. 2006;17(3):237-42.


Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.


Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms.

Pirot P, Eizirik DL, Cardozo AK.

Diabetologia. 2006 Jun;49(6):1229-36. Epub 2006 Apr 8.


Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.


Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis.

Magnusson NE, Cardozo AK, Kruhøffer M, Eizirik DL, Ørntoft TF, Jensen JL.

BMC Bioinformatics. 2005 Dec 29;6:311.


High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

Elouil H, Cardozo AK, Eizirik DL, Henquin JC, Jonas JC.

Diabetologia. 2005 Mar;48(3):496-505. Epub 2005 Mar 1. Erratum in: Diabetologia. 2005 Dec;48(12):2693.


Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL.

Diabetes. 2005 Feb;54(2):452-61.


1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.

Gysemans CA, Cardozo AK, Callewaert H, Giulietti A, Hulshagen L, Bouillon R, Eizirik DL, Mathieu C.

Endocrinology. 2005 Apr;146(4):1956-64. Epub 2005 Jan 6.


The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis.

Ohara-Imaizumi M, Cardozo AK, Kikuta T, Eizirik DL, Nagamatsu S.

J Biol Chem. 2004 Oct 1;279(40):41271-4. Epub 2004 Aug 18.


Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.


Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.

Eizirik DL, Kutlu B, Rasschaert J, Darville M, Cardozo AK.

Ann N Y Acad Sci. 2003 Nov;1005:55-74.


Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells.

Rasschaert J, Liu D, Kutlu B, Cardozo AK, Kruhøffer M, ØRntoft TF, Eizirik DL.

Diabetologia. 2003 Dec;46(12):1641-57. Epub 2003 Nov 5.


Gene microarray study corroborates proteomic findings in rodent islet cells.

Cardozo AK, Berthou L, Kruhøffer M, Orntoft T, Nicolls MR, Eizirik DL.

J Proteome Res. 2003 Sep-Oct;2(5):553-5.


Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.

Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL.

Diabetes. 2003 Nov;52(11):2701-19.


IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL.

Diabetologia. 2003 Feb;46(2):255-66. Epub 2003 Feb 12.


Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.

Kutlu B, Darville MI, Cardozo AK, Eizirik DL.

Diabetes. 2003 Feb;52(2):348-55.

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