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Items: 50

1.

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis.

Hamilton JD, Suárez-Fariñas M, Dhingra N, Cardinale I, Li X, Kostic A, Ming JE, Radin AR, Krueger JG, Graham N, Yancopoulos GD, Pirozzi G, Guttman-Yassky E.

J Allergy Clin Immunol. 2014 Dec;134(6):1293-1300. doi: 10.1016/j.jaci.2014.10.013.

2.

Residual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence.

Rozenblit M, Suarez-Farinas M, Shemer A, Khattri S, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2014 Oct;134(4):955-7. doi: 10.1016/j.jaci.2014.05.024. Epub 2014 Jul 2. No abstract available.

3.

IL32 is progressively expressed in mycosis fungoides independent of helper T-cell 2 and helper T-cell 9 polarization.

Ohmatsu H, Humme D, Gulati N, Gonzalez J, Möbs M, Suárez-Fariñas M, Cardinale I, Mitsui H, Guttman-Yassky E, Sterry W, Krueger JG.

Cancer Immunol Res. 2014 Sep;2(9):890-900. doi: 10.1158/2326-6066.CIR-13-0199-T. Epub 2014 Jun 17.

4.

Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology.

Khattri S, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Finney R, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, de Guzman Strong C, Gonzalez J, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2014 Jun;133(6):1626-34. doi: 10.1016/j.jaci.2014.03.003. Epub 2014 Apr 29. Erratum in: J Allergy Clin Immunol. 2014 Sep;134(3):764.

5.

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response.

Dhingra N, Shemer A, Correa da Rosa J, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2014 Aug;134(2):362-72. doi: 10.1016/j.jaci.2014.03.009. Epub 2014 Apr 25.

PMID:
24768652
6.

IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model.

Chiricozzi A, Nograles KE, Johnson-Huang LM, Fuentes-Duculan J, Cardinale I, Bonifacio KM, Gulati N, Mitsui H, Guttman-Yassky E, Suárez-Fariñas M, Krueger JG.

PLoS One. 2014 Feb 28;9(2):e90284. doi: 10.1371/journal.pone.0090284. eCollection 2014.

7.

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis.

Suárez-Fariñas M, Dhingra N, Gittler J, Shemer A, Cardinale I, de Guzman Strong C, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2013 Aug;132(2):361-70. doi: 10.1016/j.jaci.2013.04.046. Epub 2013 Jun 15.

8.

Residual genomic signature of atopic dermatitis despite clinical resolution with narrow-band UVB.

Suárez-Fariñas M, Gittler JK, Shemer A, Cardinale I, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2013 Feb;131(2):577-9. doi: 10.1016/j.jaci.2012.11.010. Epub 2012 Dec 21. No abstract available.

PMID:
23265860
9.

Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis.

Gittler JK, Shemer A, Suárez-Fariñas M, Fuentes-Duculan J, Gulewicz KJ, Wang CQ, Mitsui H, Cardinale I, de Guzman Strong C, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2012 Dec;130(6):1344-54. doi: 10.1016/j.jaci.2012.07.012. Epub 2012 Aug 27.

10.

Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.

Wada Y, Cardinale I, Khatcherian A, Chu J, Kantor AB, Gottlieb AB, Tatsuta N, Jacobson E, Barsoum J, Krueger JG.

PLoS One. 2012;7(4):e35069. doi: 10.1371/journal.pone.0035069. Epub 2012 Apr 6.

11.

Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response.

Tintle S, Shemer A, Suárez-Fariñas M, Fujita H, Gilleaudeau P, Sullivan-Whalen M, Johnson-Huang L, Chiricozzi A, Cardinale I, Duan S, Bowcock A, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2011 Sep;128(3):583-93.e1-4. doi: 10.1016/j.jaci.2011.05.042. Epub 2011 Jul 16.

12.

Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets.

Fujita H, Shemer A, Suárez-Fariñas M, Johnson-Huang LM, Tintle S, Cardinale I, Fuentes-Duculan J, Novitskaya I, Carucci JA, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2011 Sep;128(3):574-82.e1-12. doi: 10.1016/j.jaci.2011.05.016. Epub 2011 Jun 25.

PMID:
21704361
13.

Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities.

Suárez-Fariñas M, Tintle SJ, Shemer A, Chiricozzi A, Nograles K, Cardinale I, Duan S, Bowcock AM, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2011 Apr;127(4):954-64.e1-4. doi: 10.1016/j.jaci.2010.12.1124.

14.

TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier.

Kim BE, Howell MD, Guttman-Yassky E, Gilleaudeau PM, Cardinale IR, Boguniewicz M, Krueger JG, Leung DY.

J Invest Dermatol. 2011 Jun;131(6):1272-9. doi: 10.1038/jid.2011.24. Epub 2011 Feb 24. Erratum in: J Invest Dermatol. 2011 Jun;131(6):1388. Guttman, Emma [corrected to Guttman-Yassky, Emma].

15.

Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis.

Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, Nograles KE, Tian S, Cardinale I, Chimenti S, Krueger JG.

J Invest Dermatol. 2011 Mar;131(3):677-87. doi: 10.1038/jid.2010.340. Epub 2010 Nov 18.

16.

The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C.

Moussai D, Mitsui H, Pettersen JS, Pierson KC, Shah KR, Suárez-Fariñas M, Cardinale IR, Bluth MJ, Krueger JG, Carucci JA.

J Invest Dermatol. 2011 Jan;131(1):229-36. doi: 10.1038/jid.2010.266. Epub 2010 Sep 9.

17.

Atopic dermatitis keratinocytes exhibit normal T(H)17 cytokine responses.

Nograles KE, Suárez-Fariñas M, Shemer A, Fuentes-Duculan J, Chiricozzi A, Cardinale I, Zaba LC, Kikuchi T, Ramon M, Bergman R, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2010 Mar;125(3):744-6, 746.e1-746.e2. doi: 10.1016/j.jaci.2009.12.934. No abstract available.

18.

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis.

Guttman-Yassky E, Suárez-Fariñas M, Chiricozzi A, Nograles KE, Shemer A, Fuentes-Duculan J, Cardinale I, Lin P, Bergman R, Bowcock AM, Krueger JG.

J Allergy Clin Immunol. 2009 Dec;124(6):1235-1244.e58. doi: 10.1016/j.jaci.2009.09.031.

PMID:
20004782
19.

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes.

Zaba LC, Suárez-Fariñas M, Fuentes-Duculan J, Nograles KE, Guttman-Yassky E, Cardinale I, Lowes MA, Krueger JG.

J Allergy Clin Immunol. 2009 Nov;124(5):1022-10.e1-395. doi: 10.1016/j.jaci.2009.08.046.

20.

IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells.

Nograles KE, Zaba LC, Shemer A, Fuentes-Duculan J, Cardinale I, Kikuchi T, Ramon M, Bergman R, Krueger JG, Guttman-Yassky E.

J Allergy Clin Immunol. 2009 Jun;123(6):1244-52.e2. doi: 10.1016/j.jaci.2009.03.041. Epub 2009 May 12.

21.

Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis.

Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG.

J Immunol. 2008 Nov 15;181(10):7420-7.

22.

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.

Nograles KE, Zaba LC, Guttman-Yassky E, Fuentes-Duculan J, Suárez-Fariñas M, Cardinale I, Khatcherian A, Gonzalez J, Pierson KC, White TR, Pensabene C, Coats I, Novitskaya I, Lowes MA, Krueger JG.

Br J Dermatol. 2008 Nov;159(5):1092-102. doi: 10.1111/j.1365-2133.2008.08769.x. Epub 2008 Aug 5.

23.

Identification of cellular pathways of "type 1," Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis.

Haider AS, Lowes MA, Suárez-Fariñas M, Zaba LC, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG.

J Immunol. 2008 Feb 1;180(3):1913-20.

24.

Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.

Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS, Bowman EP, Krueger JG.

J Invest Dermatol. 2008 May;128(5):1207-11. doi: 10.1038/sj.jid.5701213. Epub 2008 Jan 17.

25.

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.

Zaba LC, Cardinale I, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Fuentes-Duculan J, Novitskaya I, Khatcherian A, Bluth MJ, Lowes MA, Krueger JG.

J Exp Med. 2007 Dec 24;204(13):3183-94. Epub 2007 Nov 26. Erratum in: J Exp Med. 2008 Aug 4;205(8):1941. Suárez Fariñas, Mayte [corrected to Suárez-Fariñas, Mayte].

26.

Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome.

Haider AS, Cohen J, Fei J, Zaba LC, Cardinale I, Toyoko K, Ott J, Krueger JG.

J Invest Dermatol. 2008 Mar;128(3):655-66. Epub 2007 Oct 11.

27.

Cellular genomic maps help dissect pathology in human skin disease.

Haider AS, Lowes MA, Suàrez-Fariñas M, Zaba LC, Cardinale I, Blumenberg M, Krueger JG.

J Invest Dermatol. 2008 Mar;128(3):606-15. Epub 2007 Oct 11.

28.

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.

Chamian F, Lin SL, Lee E, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG, Lowes MA.

J Transl Med. 2007 Jun 7;5:27.

29.

Novel insight into the agonistic mechanism of alefacept in vivo: differentially expressed genes may serve as biomarkers of response in psoriasis patients.

Haider AS, Lowes MA, Gardner H, Bandaru R, Darabi K, Chamian F, Kikuchi T, Gilleaudeau P, Whalen MS, Cardinale I, Novitskaya I, Krueger JG.

J Immunol. 2007 Jun 1;178(11):7442-9.

30.

Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment.

Kaporis HG, Guttman-Yassky E, Lowes MA, Haider AS, Fuentes-Duculan J, Darabi K, Whynot-Ertelt J, Khatcherian A, Cardinale I, Novitskaya I, Krueger JG, Carucci JA.

J Invest Dermatol. 2007 Oct;127(10):2391-8. Epub 2007 May 17.

31.

Effects of etanercept are distinct from infliximab in modulating proinflammatory genes in activated human leukocytes.

Haider AS, Cardinale IR, Whynot JA, Krueger JG.

J Investig Dermatol Symp Proc. 2007 May;12(1):9-15.

32.

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.

Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Whynot J, Novitskaya I, Cardinale I, Haider A, Khatcherian A, Carucci JA, Bergman R, Krueger JG.

J Allergy Clin Immunol. 2007 May;119(5):1210-7.

PMID:
17472813
33.

Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects.

Wang F, Lee E, Lowes MA, Haider AS, Fuentes-Duculan J, Abello MV, Chamian F, Cardinale I, Krueger JG.

J Invest Dermatol. 2006 Jul;126(7):1590-9. Epub 2006 Apr 27.

34.

Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia.

Haider AS, Peters SB, Kaporis H, Cardinale I, Fei J, Ott J, Blumenberg M, Bowcock AM, Krueger JG, Carucci JA.

J Invest Dermatol. 2006 Apr;126(4):869-81.

35.

Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).

Lowes MA, Chamian F, Abello MV, Fuentes-Duculan J, Lin SL, Nussbaum R, Novitskaya I, Carbonaro H, Cardinale I, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Wittkowski KM, Papp K, Garovoy M, Dummer W, Steinman RM, Krueger JG.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19057-62.

36.

TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques.

Gottlieb AB, Chamian F, Masud S, Cardinale I, Abello MV, Lowes MA, Chen F, Magliocco M, Krueger JG.

J Immunol. 2005 Aug 15;175(4):2721-9.

37.

Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris.

Chamian F, Lowes MA, Lin SL, Lee E, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2075-80. Epub 2005 Jan 25.

38.

Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin (IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level.

Walters IB, Ozawa M, Cardinale I, Gilleaudeau P, Trepicchio WL, Bliss J, Krueger JG.

Arch Dermatol. 2003 Feb;139(2):155-61.

PMID:
12588221
39.

Clinical clearing of psoriasis by 6-thioguanine correlates with cutaneous T-cell depletion via apoptosis: evidence for selective effects on activated T lymphocytes.

Murphy FP, Coven TR, Burack LH, Gilleaudeau P, Cardinale I, Auerbach R, Krueger JG.

Arch Dermatol. 1999 Dec;135(12):1495-502.

PMID:
10606055
40.

PUVA-induced lymphocyte apoptosis: mechanism of action in psoriasis.

Coven TR, Walters IB, Cardinale I, Krueger JG.

Photodermatol Photoimmunol Photomed. 1999 Feb;15(1):22-7.

PMID:
9990665
41.

312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions.

Ozawa M, Ferenczi K, Kikuchi T, Cardinale I, Austin LM, Coven TR, Burack LH, Krueger JG.

J Exp Med. 1999 Feb 15;189(4):711-8.

42.

Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris. Evidence that epidermal immunocytes are direct therapeutic targets.

Coven TR, Murphy FP, Gilleaudeau P, Cardinale I, Krueger JG.

Arch Dermatol. 1998 Oct;134(10):1263-8.

PMID:
9801682
43.

Altered expression of keratinocyte growth factor and its receptor in psoriasis.

Finch PW, Murphy F, Cardinale I, Krueger JG.

Am J Pathol. 1997 Dec;151(6):1619-28.

44.

Cellular actions of etretinate in psoriasis: enhanced epidermal differentiation and reduced cell-mediated inflammation are unexpected outcomes.

Gottlieb S, Hayes E, Gilleaudeau P, Cardinale I, Gottlieb AB, Krueger JG.

J Cutan Pathol. 1996 Oct;23(5):404-18.

PMID:
8915849
45.

PUVA treatment selectively induces a cell cycle block and subsequent apoptosis in human T-lymphocytes.

Johnson R, Staiano-Coico L, Austin L, Cardinale I, Nabeya-Tsukifuji R, Krueger JG.

Photochem Photobiol. 1996 May;63(5):566-71.

PMID:
8628746
46.

E-cadherin distribution in interleukin 6-induced cell-cell separation of ductal breast carcinoma cells.

Tamm I, Cardinale I, Kikuchi T, Krueger JG.

Proc Natl Acad Sci U S A. 1994 May 10;91(10):4338-42.

47.

Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells.

Tamm I, Kikuchi T, Cardinale I, Krueger JG.

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3329-33.

48.
50.

Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells.

Tamm I, Cardinale I, Krueger J, Murphy JS, May LT, Sehgal PB.

J Exp Med. 1989 Nov 1;170(5):1649-69.

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