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Items: 43


Intranasal nanoemulsion-adjuvanted HSV-2 subunit vaccine is effective as a prophylactic and therapeutic vaccine using the guinea pig model of genital herpes.

Bernstein DI, Cardin RD, Bravo FJ, Hamouda T, Pullum DA, Cohen G, Bitko V, Fattom A.

Vaccine. 2019 Oct 8;37(43):6470-6477. doi: 10.1016/j.vaccine.2019.08.077. Epub 2019 Sep 9.


The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor.

Farkas T, Yang K, Le Pendu J, Baines JD, Cardin RD.

J Virol. 2019 Oct 29;93(22). pii: e00869-19. doi: 10.1128/JVI.00869-19. Print 2019 Nov 15.


Successful application of prime and pull strategy for a therapeutic HSV vaccine.

Bernstein DI, Cardin RD, Bravo FJ, Awasthi S, Lu P, Pullum DA, Dixon DA, Iwasaki A, Friedman HM.

NPJ Vaccines. 2019 Aug 1;4:33. doi: 10.1038/s41541-019-0129-1. eCollection 2019.


Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials.

Bernstein DI, Cardin RD, Pullum DA, Bravo FJ, Kousoulas KG, Dixon DA.

PLoS One. 2019 Mar 27;14(3):e0213401. doi: 10.1371/journal.pone.0213401. eCollection 2019.


The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes.

Bernstein DI, Pullum DA, Cardin RD, Bravo FJ, Dixon DA, Kousoulas KG.

Vaccine. 2019 Jan 3;37(1):61-68. doi: 10.1016/j.vaccine.2018.11.042. Epub 2018 Nov 22.


Tissue-specific control of latent CMV reactivation by regulatory T cells.

Almanan M, Raynor J, Sholl A, Wang M, Chougnet C, Cardin RD, Hildeman DA.

PLoS Pathog. 2017 Aug 10;13(8):e1006507. doi: 10.1371/journal.ppat.1006507. eCollection 2017 Aug.


Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus.

Farrell HE, Bruce K, Lawler C, Cardin RD, Davis-Poynter NJ, Stevenson PG.

PLoS Pathog. 2016 Dec 7;12(12):e1006069. doi: 10.1371/journal.ppat.1006069. eCollection 2016 Dec.


Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection.

Cardin RD, Bravo FJ, Pullum DA, Orlinger K, Watson EM, Aspoeck A, Fuhrmann G, Guirakhoo F, Monath T, Bernstein DI.

Vaccine. 2016 Apr 12;34(17):1993-9. doi: 10.1016/j.vaccine.2016.03.005. Epub 2016 Mar 10.


Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs.

Bernstein DI, Bravo FJ, Pullum DA, Shen H, Wang M, Rahman A, Glazer RI, Cardin RD.

Antivir Chem Chemother. 2015 Feb;24(1):19-27. doi: 10.1177/2040206614566581.


Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM.

Sci Transl Med. 2014 Dec 3;6(265):265ra169. doi: 10.1126/scitranslmed.3010643.


Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model.

Farrell HE, Abraham AM, Cardin RD, Mølleskov-Jensen AS, Rosenkilde MM, Davis-Poynter N.

J Virol. 2013 Apr;87(7):4112-7. doi: 10.1128/JVI.03406-12. Epub 2013 Jan 23.


Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes.

Bernstein DI, Cardin RD, Bravo FJ, Earwood J, Clark JR, Li Y, Mishra P, Li C, Nayak BP, Miller AT, Wu TY, Cooke MP, Valiante NM.

Antivir Chem Chemother. 2014 Apr 11;23(5):189-96. doi: 10.3851/IMP2499.


N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs.

Bernstein DI, Bravo FJ, Clark JR, Earwood JD, Rahman A, Glazer R, Cardin RD.

Antiviral Res. 2011 Nov;92(2):386-8. doi: 10.1016/j.antiviral.2011.08.021. Epub 2011 Sep 7.


Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues.

Farrell HE, Abraham AM, Cardin RD, Sparre-Ulrich AH, Rosenkilde MM, Spiess K, Jensen TH, Kledal TN, Davis-Poynter N.

J Virol. 2011 Jun;85(12):6091-5. doi: 10.1128/JVI.02113-10. Epub 2011 Apr 13.


Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig.

Bernstein DI, Earwood JD, Bravo FJ, Cohen GH, Eisenberg RJ, Clark JR, Fairman J, Cardin RD.

Vaccine. 2011 Mar 3;29(11):2071-8. doi: 10.1016/j.vaccine.2011.01.005. Epub 2011 Jan 14.


Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection.

Bravo FJ, Bernstein DI, Beadle JR, Hostetler KY, Cardin RD.

Antimicrob Agents Chemother. 2011 Jan;55(1):35-41. doi: 10.1128/AAC.00971-10. Epub 2010 Nov 15.


Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy.

Farley N, Bernstein DI, Bravo FJ, Earwood J, Sawtell N, Cardin RD.

Antiviral Res. 2010 May;86(2):188-95. doi: 10.1016/j.antiviral.2010.02.317. Epub 2010 Feb 16.


Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection.

Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A.

Virol J. 2009 Dec 2;6:214. doi: 10.1186/1743-422X-6-214.


The M33 chemokine receptor homolog of murine cytomegalovirus exhibits a differential tissue-specific role during in vivo replication and latency.

Cardin RD, Schaefer GC, Allen JR, Davis-Poynter NJ, Farrell HE.

J Virol. 2009 Aug;83(15):7590-601. doi: 10.1128/JVI.00386-09. Epub 2009 May 13.


Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines.

Bernstein DI, Cardin RD, Bravo FJ, Strasser JE, Farley N, Chalk C, Lay M, Fairman J.

Clin Vaccine Immunol. 2009 May;16(5):699-705. doi: 10.1128/CVI.00370-08. Epub 2009 Mar 11.


A model of human cytomegalovirus infection in severe combined immunodeficient mice.

Bravo FJ, Cardin RD, Bernstein DI.

Antiviral Res. 2007 Nov;76(2):104-10. Epub 2007 Jul 10.


Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection.

Bravo FJ, Cardin RD, Bernstein DI.

J Infect Dis. 2006 Feb 15;193(4):591-7. Epub 2006 Jan 13.


Factors controlling levels of CD8+ T-cell lymphocytosis associated with murine gamma-herpesvirus infection.

Hardy CL, Flaño E, Cardin RD, Kim IJ, Nguyen P, King S, Woodland DL, Blackman MA.

Viral Immunol. 2001;14(4):391-402.


Kinetics of murine gammaherpesvirus 68 gene expression following infection of murine cells in culture and in mice.

Rochford R, Lutzke ML, Alfinito RS, Clavo A, Cardin RD.

J Virol. 2001 Jun;75(11):4955-63.


Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus.

Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, Myers LK, Doherty PC.

J Immunol. 2000 Feb 15;164(4):1820-8.


Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome.

Brooks JW, Hamilton-Easton AM, Christensen JP, Cardin RD, Hardy CL, Doherty PC.

J Virol. 1999 Nov;73(11):9650-4.


Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infection.

Coppola MA, Flaño E, Nguyen P, Hardy CL, Cardin RD, Shastri N, Woodland DL, Blackman MA.

J Immunol. 1999 Aug 1;163(3):1481-9.


CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma.

Christensen JP, Cardin RD, Branum KC, Doherty PC.

Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5135-40.


Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.

Stevenson PG, Cardin RD, Christensen JP, Doherty PC.

J Gen Virol. 1999 Feb;80 ( Pt 2):477-83.


Pathogenesis of murine gammaherpesvirus-68 infection in interleukin-6-deficient mice.

Sarawar SR, Brooks JW, Cardin RD, Mehrpooya M, Doherty PC.

Virology. 1998 Sep 30;249(2):359-66.


Consequences of viral infections for lymphocyte compartmentalization and homeostasis.

Doherty PC, Hamilton-Easton AM, Topham DJ, Riberdy J, Brooks JW, Cardin RD.

Semin Immunol. 1997 Dec;9(6):365-73. Review.


Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections.

Doherty PC, Topham DJ, Tripp RA, Cardin RD, Brooks JW, Stevenson PG.

Immunol Rev. 1997 Oct;159:105-17. Review.


Tuning into immunological dissonance: an experimental model for infectious mononucleosis.

Doherty PC, Tripp RA, Hamilton-Easton AM, Cardin RD, Woodland DL, Blackman MA.

Curr Opin Immunol. 1997 Aug;9(4):477-83. Review.


Immunological control of murine gammaherpesvirus infection is independent of perforin.

Usherwood EJ, Brooks JW, Sarawar SR, Cardin RD, Young WD, Allen DJ, Doherty PC, Nash AA.

J Gen Virol. 1997 Aug;78 ( Pt 8):2025-30.


Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen?

Tripp RA, Hamilton-Easton AM, Cardin RD, Nguyen P, Behm FG, Woodland DL, Doherty PC, Blackman MA.

J Exp Med. 1997 May 5;185(9):1641-50.


Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68.

Sarawar SR, Cardin RD, Brooks JW, Mehrpooya M, Hamilton-Easton AM, Mo XY, Doherty PC.

J Virol. 1997 May;71(5):3916-21.


Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

Cardin RD, Brooks JW, Sarawar SR, Doherty PC.

J Exp Med. 1996 Sep 1;184(3):863-71.


Cytokine production in the immune response to murine gammaherpesvirus 68.

Sarawar SR, Cardin RD, Brooks JW, Mehrpooya M, Tripp RA, Doherty PC.

J Virol. 1996 May;70(5):3264-8.


Murine cytomegalovirus IE2, an activator of gene expression, is dispensable for growth and latency in mice.

Cardin RD, Abenes GB, Stoddart CA, Mocarski ES.

Virology. 1995 May 10;209(1):236-41.


Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus.

Stoddart CA, Cardin RD, Boname JM, Manning WC, Abenes GB, Mocarski ES.

J Virol. 1994 Oct;68(10):6243-53.


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