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Items: 1 to 50 of 76


Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes.

Scott ML, Coleman DT, Kelly KC, Carroll JL, Woodby B, Songock WK, Cardelli JA, Bodily JM.

Virology. 2018 Jun;519:1-11. doi: 10.1016/j.virol.2018.03.021. Epub 2018 Mar 31.


Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers.

Dykes SS, Steffan JJ, Cardelli JA.

BMC Cancer. 2017 Oct 4;17(1):672. doi: 10.1186/s12885-017-3660-3.


Zinc finger E-box binding homeobox-1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ Exchanger-1 (NHE1).

Dykes SS, Gao C, Songock WK, Bigelow RL, Woude GV, Bodily JM, Cardelli JA.

Mol Carcinog. 2017 Feb;56(2):722-734. doi: 10.1002/mc.22528. Epub 2016 Aug 22.


Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.

Mohyeldin MM, Busnena BA, Akl MR, Dragoi AM, Cardelli JA, El Sayed KA.

Eur J Med Chem. 2016 Aug 8;118:299-315. doi: 10.1016/j.ejmech.2016.04.043.


Monocarboxylate transporter 1 contributes to growth factor-induced tumor cell migration independent of transporter activity.

Gray AL, Coleman DT, Shi R, Cardelli JA.

Oncotarget. 2016 May 31;7(22):32695-706. doi: 10.18632/oncotarget.9016.


The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo.

Dykes SS, Gray AL, Coleman DT, Saxena M, Stephens CA, Carroll JL, Pruitt K, Cardelli JA.

Oncotarget. 2016 May 24;7(21):31037-52. doi: 10.18632/oncotarget.8832.


The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor.

Mohyeldin MM, Akl MR, Ebrahim HY, Dragoi AM, Dykes S, Cardelli JA, El Sayed KA.

Oncotarget. 2016 May 31;7(22):32247-73. doi: 10.18632/oncotarget.8681.


Palmitoylation regulates the intracellular trafficking and stability of c-Met.

Coleman DT, Gray AL, Kridel SJ, Cardelli JA.

Oncotarget. 2016 May 31;7(22):32664-77. doi: 10.18632/oncotarget.8706.


Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-associated fibroblast differentiation.

Coleman DT, Gray AL, Stephens CA, Scott ML, Cardelli JA.

Oncotarget. 2016 May 31;7(22):32200-9. doi: 10.18632/oncotarget.8609.


Characterization of an Oncolytic Adenovirus Vector Constructed to Target the cMet Receptor.

Sakr HI, Coleman DT, Cardelli JA, Mathis JM.

Oncolytic Virother. 2015;4:119-132.


Isothiocyanatostilbenes as novel c-Met inhibitors.

Gray AL, Coleman DT, Castore RF, Mohyeldin MM, El Sayed KA, Cardelli JA.

Oncotarget. 2015 Dec 1;6(38):41180-93. doi: 10.18632/oncotarget.5748.


Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses.

Navratil AR, Vozenilek AE, Cardelli JA, Green JM, Thomas MJ, Sorci-Thomas MG, Orr AW, Woolard MD.

Atherosclerosis. 2015 Oct;242(2):424-32. doi: 10.1016/j.atherosclerosis.2015.08.012. Epub 2015 Aug 10.


PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability.

Abu-Fayyad A, Behery F, Sallam AA, Alqahtani S, Ebrahim H, El Sayed KA, Kaddoumi A, Sylvester PW, Carroll JL, Cardelli JA, Nazzal S.

Eur J Pharm Biopharm. 2015 Oct;96:185-95. doi: 10.1016/j.ejpb.2015.07.022. Epub 2015 Jul 30.


The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity.

Dykes SS, Friday E, Pruitt K, Cardelli JA.

Biochem Biophys Rep. 2015 Jul 26;3:83-93. doi: 10.1016/j.bbrep.2015.07.015. eCollection 2015 Sep.


Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells.

Coleman DT, Soung YH, Surh YJ, Cardelli JA, Chung J.

PLoS One. 2015 May 4;10(5):e0125399. doi: 10.1371/journal.pone.0125399. eCollection 2015.


The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-β-induced myofibroblast phenotypes through RhoA and ERK inhibition.

Gray AL, Stephens CA, Bigelow RL, Coleman DT, Cardelli JA.

PLoS One. 2014 Oct 1;9(10):e109208. doi: 10.1371/journal.pone.0109208. eCollection 2014.


Supporting a role for the GTPase Rab7 in prostate cancer progression.

Steffan JJ, Dykes SS, Coleman DT, Adams LK, Rogers D, Carroll JL, Williams BJ, Cardelli JA.

PLoS One. 2014 Feb 5;9(2):e87882. doi: 10.1371/journal.pone.0087882. eCollection 2014.


The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.

Saxena M, Dykes SS, Malyarchuk S, Wang AE, Cardelli JA, Pruitt K.

Oncogene. 2015 Jan 8;34(2):188-98. doi: 10.1038/onc.2013.549. Epub 2013 Dec 23.


Host interferon-γ inducible protein contributes to Brucella survival.

Ritchie JA, Rupper A, Cardelli JA, Bellaire BH.

Front Cell Infect Microbiol. 2012 Apr 27;2:55. doi: 10.3389/fcimb.2012.00055. eCollection 2012.


The HGF-met signaling axis: emerging themes and targets of inhibition.

Steffan JJ, Coleman DT, Cardelli JA.

Curr Protein Pept Sci. 2011 Feb;12(1):12-22. Review.


The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells.

Duhon D, Bigelow RL, Coleman DT, Steffan JJ, Yu C, Langston W, Kevil CG, Cardelli JA.

Mol Carcinog. 2010 Aug;49(8):739-49. doi: 10.1002/mc.20649.


HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers.

Steffan JJ, Williams BC, Welbourne T, Cardelli JA.

J Cell Sci. 2010 Apr 1;123(Pt 7):1151-9. doi: 10.1242/jcs.063644. Epub 2010 Mar 9.


Thiazolidinediones induce Rab7-RILP-MAPK-dependent juxtanuclear lysosome aggregation and reduce tumor cell invasion.

Steffan JJ, Cardelli JA.

Traffic. 2010 Feb;11(2):274-86. doi: 10.1111/j.1600-0854.2009.01012.x. Epub 2009 Dec 5.


The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells.

Milligan SA, Burke P, Coleman DT, Bigelow RL, Steffan JJ, Carroll JL, Williams BJ, Cardelli JA.

Clin Cancer Res. 2009 Aug 1;15(15):4885-94. doi: 10.1158/1078-0432.CCR-09-0109. Epub 2009 Jul 28.


Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols.

Shutava TG, Balkundi SS, Vangala P, Steffan JJ, Bigelow RL, Cardelli JA, O'Neal DP, Lvov YM.

ACS Nano. 2009 Jul 28;3(7):1877-85. doi: 10.1021/nn900451a. Epub 2009 Jun 17.


Helicobacter pylori induces cancer cell motility independent of the c-Met receptor.

Snider JL, Cardelli JA.

J Carcinog. 2009;8:7. doi: 10.4103/1477-3163.50892.


Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells.

Steffan JJ, Snider JL, Skalli O, Welbourne T, Cardelli JA.

Traffic. 2009 Jun;10(6):737-53. doi: 10.1111/j.1600-0854.2009.00904.x.


Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation.

Coleman DT, Bigelow R, Cardelli JA.

Mol Cancer Ther. 2009 Jan;8(1):214-24. doi: 10.1158/1535-7163.MCT-08-0722.


TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro.

Bigelow RL, Williams BJ, Carroll JL, Daves LK, Cardelli JA.

Breast Cancer Res Treat. 2009 Sep;117(1):31-44. doi: 10.1007/s10549-008-0170-7. Epub 2008 Sep 12.


The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells.

Snider JL, Allison C, Bellaire BH, Ferrero RL, Cardelli JA.

J Biol Chem. 2008 May 16;283(20):13952-63. doi: 10.1074/jbc.M800289200. Epub 2008 Mar 20.


Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways.

Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S.

Oncogene. 2006 Nov 9;25(53):7029-40. Epub 2006 May 22.


GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP.

Reed BC, Cefalu C, Bellaire BH, Cardelli JA, Louis T, Salamon J, Bloecher MA, Bunn RC.

Mol Biol Cell. 2005 Sep;16(9):4183-201. Epub 2005 Jun 22.


Adaptation of the Brucellae to their intracellular niche.

Roop RM 2nd, Bellaire BH, Valderas MW, Cardelli JA.

Mol Microbiol. 2004 May;52(3):621-30. Review.


RacB regulates cytoskeletal function in Dictyostelium spp.

Lee E, Seastone DJ, Harris E, Cardelli JA, Knecht DA.

Eukaryot Cell. 2003 Jun;2(3):474-85.


p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium.

Rupper AC, Rodriguez-Paris JM, Grove BD, Cardelli JA.

J Cell Sci. 2001 Apr;114(Pt 7):1283-95.


Dictyostelium lysosomal proteins with different sugar modifications sort to functionally distinct compartments.

Souza GM, Mehta DP, Lammertz M, Rodriguez-Paris J, Wu R, Cardelli JA, Freeze HH.

J Cell Sci. 1997 Sep;110 ( Pt 18):2239-48.


Phagosomal proteins of Dictyostelium discoideum.

Rezabek BL, Rodriguez-Paris JM, Cardelli JA, Chia CP.

J Eukaryot Microbiol. 1997 Jul-Aug;44(4):284-92.


Examination of the endosomal and lysosomal pathways in Dictyostelium discoideum myosin I mutants.

Temesvari LA, Bush JM, Peterson MD, Novak KD, Titus MA, Cardelli JA.

J Cell Sci. 1996 Mar;109 ( Pt 3):663-73.


The abundance of heavy elements in interstellar gas.

Cardelli JA.

Science. 1994 Jul 8;265(5169):209-13.


Clathrin heavy chain functions in sorting and secretion of lysosomal enzymes in Dictyostelium discoideum.

Ruscetti T, Cardelli JA, Niswonger ML, O'Halloran TJ.

J Cell Biol. 1994 Jul;126(2):343-52.

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