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Items: 20


An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY.

Cancer Cell. 2019 Jan 14;35(1):33-45.e6. doi: 10.1016/j.ccell.2018.12.001.


Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

Katlinski KV, Gui J, Katlinskaya YV, Ortiz A, Chakraborty R, Bhattacharya S, Carbone CJ, Beiting DP, Girondo MA, Peck AR, Puré E, Chatterji P, Rustgi AK, Diehl JA, Koumenis C, Rui H, Fuchs SY.

Cancer Cell. 2017 Feb 13;31(2):194-207. doi: 10.1016/j.ccell.2017.01.004.


Type 1 interferons contribute to the clearance of senescent cell.

Katlinskaya YV, Carbone CJ, Yu Q, Fuchs SY.

Cancer Biol Ther. 2015;16(8):1214-9. doi: 10.1080/15384047.2015.1056419. Epub 2015 Jun 5.


DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

Yu Q, Katlinskaya YV, Carbone CJ, Zhao B, Katlinski KV, Zheng H, Guha M, Li N, Chen Q, Yang T, Lengner CJ, Greenberg RA, Johnson FB, Fuchs SY.

Cell Rep. 2015 May 5;11(5):785-797. doi: 10.1016/j.celrep.2015.03.069. Epub 2015 Apr 23.


Type I interferon controls propagation of long interspersed element-1.

Yu Q, Carbone CJ, Katlinskaya YV, Zheng H, Zheng K, Luo M, Wang PJ, Greenberg RA, Fuchs SY.

J Biol Chem. 2015 Apr 17;290(16):10191-9. doi: 10.1074/jbc.M114.612374. Epub 2015 Feb 25.


Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury.

Bhattacharya S, Katlinski KV, Reichert M, Takano S, Brice A, Zhao B, Yu Q, Zheng H, Carbone CJ, Katlinskaya YV, Leu NA, McCorkell KA, Srinivasan S, Girondo M, Rui H, May MJ, Avadhani NG, Rustgi AK, Fuchs SY.

EMBO Mol Med. 2014 Mar;6(3):384-97. doi: 10.1002/emmm.201303236. Epub 2014 Jan 30.


A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B, Carbone CJ, Aressy B, Fuchs SY, Greenberg RA.

Cell Rep. 2013 Oct 17;5(1):180-93. doi: 10.1016/j.celrep.2013.08.025. Epub 2013 Sep 26.


Eliminative signaling by Janus kinases: role in the downregulation of associated receptors.

Carbone CJ, Fuchs SY.

J Cell Biochem. 2014 Jan;115(1):8-16. doi: 10.1002/jcb.24647. Review.


Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.

Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Reiter AM, Henthorn P, Zhang ZY, Baker DP, Ukkiramapandian R, Bence KK, Fuchs SY.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19226-31. doi: 10.1073/pnas.1211491109. Epub 2012 Nov 5.


Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis.

Zheng H, Qian J, Carbone CJ, Leu NA, Baker DP, Fuchs SY.

Blood. 2011 Oct 6;118(14):4003-6. doi: 10.1182/blood-2011-06-359745. Epub 2011 Aug 10.


Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1.

Qian J, Zheng H, Huangfu WC, Liu J, Carbone CJ, Leu NA, Baker DP, Fuchs SY.

PLoS Pathog. 2011 Jun;7(6):e1002065. doi: 10.1371/journal.ppat.1002065. Epub 2011 Jun 9.


Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.

Liu J, Carvalho LP, Bhattacharya S, Carbone CJ, Kumar KG, Leu NA, Yau PM, Donald RG, Weiss MJ, Baker DP, McLaughlin KJ, Scott P, Fuchs SY.

Mol Cell Biol. 2009 Dec;29(24):6401-12. doi: 10.1128/MCB.00478-09. Epub 2009 Oct 5.


Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway.

Varghese B, Barriere H, Carbone CJ, Banerjee A, Swaminathan G, Plotnikov A, Xu P, Peng J, Goffin V, Lukacs GL, Fuchs SY.

Mol Cell Biol. 2008 Sep;28(17):5275-87. doi: 10.1128/MCB.00350-08. Epub 2008 Jun 23.


Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2.

Swaminathan G, Varghese B, Thangavel C, Carbone CJ, Plotnikov A, Kumar KG, Jablonski EM, Clevenger CV, Goffin V, Deng L, Frank SJ, Fuchs SY.

J Endocrinol. 2008 Feb;196(2):R1-7. doi: 10.1677/JOE-07-0554.


Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.

Kumar KG, Barriere H, Carbone CJ, Liu J, Swaminathan G, Xu P, Li Y, Baker DP, Peng J, Lukacs GL, Fuchs SY.

J Cell Biol. 2007 Dec 3;179(5):935-50.


The growth enhancing effects of allograft inflammatory Factor-1 (AIF-1) in VSMC are dose-dependent and mediated by its ability to bind calcium.

Autieri MV, Carbone CJ, Eisen H.

J Heart Lung Transplant. 2001 Feb;20(2):198. No abstract available.


Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer.

Lehman TA, Haffty BG, Carbone CJ, Bishop LR, Gumbs AA, Krishnan S, Shields PG, Modali R, Turner BC.

Cancer Res. 2000 Feb 15;60(4):1062-9.


Mutant p53 protein overexpression in women with ipsilateral breast tumor recurrence following lumpectomy and radiation therapy.

Turner BC, Gumbs AA, Carbone CJ, Carter D, Glazer PM, Haffty BG.

Cancer. 2000 Mar 1;88(5):1091-8.


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