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Items: 27


Children with type 1 diabetes of early age at onset - immune and metabolic phenotypes.

Sales Luis M, Alcafache M, Ferreira S, Fitas AL, Simões Pereira J, Caramalho Í, Lopes L, Limbert C.

J Pediatr Endocrinol Metab. 2019 Jul 6. pii: /j/jpem.ahead-of-print/jpem-2019-0103/jpem-2019-0103.xml. doi: 10.1515/jpem-2019-0103. [Epub ahead of print]


Expansion of FOXP3+ regulatory CD4 T cells upon exposure to hymenoptera venom during the beekeeping season.

Santos MCP, Serra-Caetano A, Pedro E, Melo A, Caramalho I, Barbosa MP, Victorino RMM, Sousa AE.

Allergy. 2019 Jun;74(6):1182-1184. doi: 10.1111/all.13713. Epub 2019 Jan 17. No abstract available.


MonoMAC Syndrome Caused by a Novel GATA2 Mutation Successfully Treated by Allogeneic Hematopoietic Stem Cell Transplantation.

Moraes-Fontes MF, Caramalho Í, Hsu AP, Holland SM, Abecasis M.

J Clin Immunol. 2019 Jan;39(1):4-6. doi: 10.1007/s10875-018-0576-x. Epub 2018 Nov 26. No abstract available.


Fatal CTLA-4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation.

Moraes-Fontes MF, Hsu AP, Caramalho I, Martins C, Araújo AC, Lourenço F, Taulaigo AV, Lladó A, Holland SM, Uzel G.

Clin Case Rep. 2017 Nov 6;5(12):2066-2070. doi: 10.1002/ccr3.1257. eCollection 2017 Dec.


Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7.

Silva SL, Albuquerque AS, Serra-Caetano A, Foxall RB, Pires AR, Matoso P, Fernandes SM, Ferreira J, Cheynier R, Victorino RM, Caramalho I, Barata JT, Sousa AE.

Oncotarget. 2016 Mar 15;7(11):12163-75. doi: 10.18632/oncotarget.7512.


Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.

Correia A, Ferreirinha P, Botelho S, Belinha A, Leitão C, Caramalho Í, Teixeira L, González-Fernandéz Á, Appelberg R, Vilanova M.

Sci Rep. 2015 Oct 9;5:14913. doi: 10.1038/srep14913.


Regulatory T-Cell Development in the Human Thymus.

Caramalho Í, Nunes-Cabaço H, Foxall RB, Sousa AE.

Front Immunol. 2015 Aug 3;6:395. doi: 10.3389/fimmu.2015.00395. eCollection 2015. Review.


Bee venom enhances the differentiation of human regulatory T cells.

Caramalho I, Melo A, Pedro E, Barbosa MM, Victorino RM, Pereira Santos MC, Sousa AE.

Allergy. 2015 Oct;70(10):1340-5. doi: 10.1111/all.12691. Epub 2015 Jul 30.


Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus.

Caramalho I, Nunes-Silva V, Pires AR, Mota C, Pinto AI, Nunes-Cabaço H, Foxall RB, Sousa AE.

J Autoimmun. 2015 Jan;56:98-110. doi: 10.1016/j.jaut.2014.11.002. Epub 2014 Dec 4.


Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.

Mota C, Nunes-Silva V, Pires AR, Matoso P, Victorino RM, Sousa AE, Caramalho I.

J Immunol. 2014 Dec 15;193(12):5854-62. doi: 10.4049/jimmunol.1400198. Epub 2014 Nov 3.


The genetic basis of Escherichia coli pathoadaptation to macrophages.

Miskinyte M, Sousa A, Ramiro RS, de Sousa JA, Kotlinowski J, Caramalho I, Magalhães S, Soares MP, Gordo I.

PLoS Pathog. 2013;9(12):e1003802. doi: 10.1371/journal.ppat.1003802. Epub 2013 Dec 12.


Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery.

Paiva RS, Lino AC, Bergman ML, Caramalho I, Sousa AE, Zelenay S, Demengeot J.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6494-9. doi: 10.1073/pnas.1221955110. Epub 2013 Apr 1.


Differentiation of human thymic regulatory T cells at the double positive stage.

Nunes-Cabaço H, Caramalho I, Sepúlveda N, Sousa AE.

Eur J Immunol. 2011 Dec;41(12):3604-14. doi: 10.1002/eji.201141614. Epub 2011 Oct 24.


Regulatory T cells contribute to diabetes protection in lipopolysaccharide-treated non-obese diabetic mice.

Caramalho I, Rodrigues-Duarte L, Perez A, Zelenay S, Penha-Gonçalves C, Demengeot J.

Scand J Immunol. 2011 Dec;74(6):585-95. doi: 10.1111/j.1365-3083.2011.02627.x.


Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression.

Nunes-Cabaço H, Ribot JC, Caramalho I, Serra-Caetano A, Silva-Santos B, Sousa AE.

Immunol Cell Biol. 2010 Jul;88(5):523-8. doi: 10.1038/icb.2010.4. Epub 2010 Feb 9.


Inhibition of murine gammadelta lymphocyte expansion and effector function by regulatory alphabeta T cells is cell-contact-dependent and sensitive to GITR modulation.

Gonçalves-Sousa N, Ribot JC, deBarros A, Correia DV, Caramalho I, Silva-Santos B.

Eur J Immunol. 2010 Jan;40(1):61-70. doi: 10.1002/eji.200939715.


Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease.

Moraes-Fontes MF, Rebelo M, Caramalho I, Zelenay S, Bergman ML, Coutinho A, Demengeot J.

J Autoimmun. 2009 Sep;33(2):109-20. doi: 10.1016/j.jaut.2009.03.008. Epub 2009 Apr 11.


Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.

Dushek O, Mueller S, Soubies S, Depoil D, Caramalho I, Coombs D, Valitutti S.

PLoS One. 2008;3(12):e3913. doi: 10.1371/journal.pone.0003913. Epub 2008 Dec 11.


Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation.

Caramalho I, Faroudi M, Padovan E, Müller S, Valitutti S.

J Cell Mol Med. 2009 Sep;13(9B):3834-46. doi: 10.1111/j.1582-4934.2008.00586.x. Epub 2008 Oct 6.


When three is not a crowd: a Crossregulation model of the dynamics and repertoire selection of regulatory CD4+ T cells.

Carneiro J, Leon K, Caramalho I, van den Dool C, Gardner R, Oliveira V, Bergman ML, Sepúlveda N, Paixão T, Faro J, Demengeot J.

Immunol Rev. 2007 Apr;216:48-68. Review.


Regulatory T cells in microbial infection.

Demengeot J, Zelenay S, Moraes-Fontes MF, Caramalho I, Coutinho A.

Springer Semin Immunopathol. 2006 Aug;28(1):41-50. Epub 2006 Jul 28. Review.


Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.

Coutinho A, Caramalho I, Seixas E, Demengeot J.

Curr Top Microbiol Immunol. 2005;293:43-71. Review.


Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion.

Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4091-6. Epub 2005 Mar 7.


Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2.

Vilanova M, Teixeira L, Caramalho I, Torrado E, Marques A, Madureira P, Ribeiro A, Ferreira P, Gama M, Demengeot J.

Immunology. 2004 Mar;111(3):334-42.


Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide.

Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J.

J Exp Med. 2003 Feb 17;197(4):403-11.


IFN-alpha/beta enhances BCR-dependent B cell responses.

Braun D, Caramalho I, Demengeot J.

Int Immunol. 2002 Apr;14(4):411-9.


Regulatory T cells: the physiology of autoreactivity in dominant tolerance and "quality control" of immune responses.

Coutinho A, Hori S, Carvalho T, Caramalho I, Demengeot J.

Immunol Rev. 2001 Aug;182:89-98. Review.


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