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Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine.

Fresta CG, Fidilio A, Lazzarino G, Musso N, Grasso M, Merlo S, Amorini AM, Bucolo C, Tavazzi B, Lazzarino G, Lunte SM, Caraci F, Caruso G.

Int J Mol Sci. 2020 Jan 25;21(3). pii: E776. doi: 10.3390/ijms21030776.


Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?

Caraci F, Coluzzi F, Marinangeli F, Mercadante S, Rinonapoli G, Romualdi P, Nicora M, Dickenson AH.

Curr Med Res Opin. 2019 Dec 11:1. doi: 10.1080/03007995.2019.1703664. [Epub ahead of print] Retraction in: Curr Med Res Opin. 2020 Jan 29;:1.


β-amyloid and Oxidative Stress: Perspectives in Drug Development.

Caruso G, Spampinato SF, Cardaci V, Caraci F, Sortino MA, Merlo S.

Curr Pharm Des. 2019;25(45):4771-4781. doi: 10.2174/1381612825666191209115431.


Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease

Hampel H, Vergallo A, Afshar M, Akman-Anderson L, Arenas J, Benda N, Batrla R, Broich K, Caraci F, Cuello AC, Emanuele E, Haberkamp M, Kiddle SJ, Lucía A, Mapstone M, Verdooner SR, Woodcock J, Lista S.

Dialogues Clin Neurosci. 2019;21(2):177-191.


Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation.

Caraci F, Merlo S, Drago F, Caruso G, Parenti C, Sortino MA.

Front Pharmacol. 2019 Sep 12;10:1024. doi: 10.3389/fphar.2019.01024. eCollection 2019. Review.


The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment.

Caruso G, Benatti C, Blom JMC, Caraci F, Tascedda F.

Front Pharmacol. 2019 Sep 10;10:995. doi: 10.3389/fphar.2019.00995. eCollection 2019. No abstract available.


Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages.

Caruso G, Fresta CG, Fidilio A, O'Donnell F, Musso N, Lazzarino G, Grasso M, Amorini AM, Tascedda F, Bucolo C, Drago F, Tavazzi B, Lazzarino G, Lunte SM, Caraci F.

Antioxidants (Basel). 2019 Aug 6;8(8). pii: E281. doi: 10.3390/antiox8080281.


Inflammation as the common biological link between depression and cardiovascular diseases: Can carnosine exert a protective role?

Caruso G, Fresta CG, Grasso M, Santangelo R, Lazzarino G, Lunte SM, Caraci F.

Curr Med Chem. 2019 Jul 11. doi: 10.2174/0929867326666190712091515. [Epub ahead of print]


Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1.

Torrisi SA, Geraci F, Tropea MR, Grasso M, Caruso G, Fidilio A, Musso N, Sanfilippo G, Tascedda F, Palmeri A, Salomone S, Drago F, Puzzo D, Leggio GM, Caraci F.

Front Pharmacol. 2019 Jun 21;10:693. doi: 10.3389/fphar.2019.00693. eCollection 2019.


Dietary Inflammatory Index and Sleep Quality in Southern Italian Adults.

Godos J, Ferri R, Caraci F, Cosentino FII, Castellano S, Shivappa N, Hebert JR, Galvano F, Grosso G.

Nutrients. 2019 Jun 13;11(6). pii: E1324. doi: 10.3390/nu11061324.


Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults.

Godos J, Ferri R, Caraci F, Cosentino FII, Castellano S, Galvano F, Grosso G.

Nutrients. 2019 Apr 28;11(5). pii: E976. doi: 10.3390/nu11050976.


Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain.

Vicario N, Pasquinucci L, Spitale FM, Chiechio S, Turnaturi R, Caraci F, Tibullo D, Avola R, Gulino R, Parenti R, Parenti C.

Mol Neurobiol. 2019 Nov;56(11):7338-7354. doi: 10.1007/s12035-019-1607-1. Epub 2019 Apr 28.


Impairment of Quality of Life Associated With Lifetime Diagnosis of Post-traumatic Stress Disorder in Women - A National Survey in Italy.

Sancassiani F, Carmassi C, Romano F, Balestrieri M, Caraci F, Di Sciascio G, Drago F, Faravelli C, Hardoy MC, Moro MF, Roncone R, Preti A, Dell'Osso L.

Clin Pract Epidemiol Ment Health. 2019 Feb 28;15:38-43. doi: 10.2174/1745017901915010038. eCollection 2019.


The Prevalence of Specific Phobia by Age in an Italian Nationwide Survey: How Much Does it Affect the Quality of Life?

Sancassiani F, Romano F, Balestrieri M, Caraci F, Di Sciascio G, Drago F, Hardoy MC, Moro MF, Roncone R, Piras M, Preti A, Dell'Osso L, Faravelli C, Carta MG.

Clin Pract Epidemiol Ment Health. 2019 Feb 20;15:30-37. doi: 10.2174/1745017901915010030. eCollection 2019.


Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia.

Nicoletti F, Orlando R, Di Menna L, Cannella M, Notartomaso S, Mascio G, Iacovelli L, Matrisciano F, Fazio F, Caraci F, Copani A, Battaglia G, Bruno V.

Front Psychiatry. 2019 Feb 14;10:49. doi: 10.3389/fpsyt.2019.00049. eCollection 2019. Review.


Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation.

Pasquinucci L, Turnaturi R, Montenegro L, Caraci F, Chiechio S, Parenti C.

Eur J Pharmacol. 2019 Mar 15;847:97-102. doi: 10.1016/j.ejphar.2019.01.031. Epub 2019 Jan 25.


Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1.

Caruso G, Fresta CG, Musso N, Giambirtone M, Grasso M, Spampinato SF, Merlo S, Drago F, Lazzarino G, Sortino MA, Lunte SM, Caraci F.

Cells. 2019 Jan 17;8(1). pii: E64. doi: 10.3390/cells8010064.


Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders.

Caruso G, Caraci F, Jolivet RB.

Prog Neurobiol. 2019 Apr;175:35-53. doi: 10.1016/j.pneurobio.2018.12.004. Epub 2018 Dec 26. Review.


Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F.

Front Mol Neurosci. 2018 Nov 13;11:414. doi: 10.3389/fnmol.2018.00414. eCollection 2018. Review.


Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells.

Caruso G, Fresta CG, Lazzarino G, Distefano DA, Parlascino P, Lunte SM, Lazzarino G, Caraci F.

Int J Mol Sci. 2018 Nov 20;19(11). pii: E3659. doi: 10.3390/ijms19113659.


International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.

Caraci F, Calabrese F, Molteni R, Bartova L, Dold M, Leggio GM, Fabbri C, Mendlewicz J, Racagni G, Kasper S, Riva MA, Drago F.

Pharmacol Rev. 2018 Jul;70(3):475-504. doi: 10.1124/pr.117.014977. Review.


Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells.

Fresta CG, Chakraborty A, Wijesinghe MB, Amorini AM, Lazzarino G, Lazzarino G, Tavazzi B, Lunte SM, Caraci F, Dhar P, Caruso G.

Cell Death Dis. 2018 Feb 14;9(2):245. doi: 10.1038/s41419-018-0280-z.


Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.

Caraci F, Spampinato SF, Morgese MG, Tascedda F, Salluzzo MG, Giambirtone MC, Caruso G, Munafò A, Torrisi SA, Leggio GM, Trabace L, Nicoletti F, Drago F, Sortino MA, Copani A.

Pharmacol Res. 2018 Apr;130:374-384. doi: 10.1016/j.phrs.2018.02.007. Epub 2018 Feb 10. Review.


Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease.

Caraci F, Nicoletti F, Copani A.

Curr Opin Pharmacol. 2018 Feb;38:1-7. doi: 10.1016/j.coph.2017.12.001. Epub 2017 Dec 23. Review.


Preface Drug discovery in neurodegenerative disorders: a defeat for pharmacology?

Caraci F, Kraneveld A, Krzan M, Luca MD.

Eur J Pharmacol. 2017 Dec 15;817:1. doi: 10.1016/j.ejphar.2017.11.014. No abstract available.


Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F.

Neuropharmacology. 2018 Jan;128:301-313. doi: 10.1016/j.neuropharm.2017.10.026. Epub 2017 Oct 25.


Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.

Torrisi SA, Salomone S, Geraci F, Caraci F, Bucolo C, Drago F, Leggio GM.

Front Pharmacol. 2017 Oct 4;8:710. doi: 10.3389/fphar.2017.00710. eCollection 2017.


Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome.

Caraci F, Iulita MF, Pentz R, Flores Aguilar L, Orciani C, Barone C, Romano C, Drago F, Cuello AC.

Eur J Pharmacol. 2017 Dec 15;817:7-19. doi: 10.1016/j.ejphar.2017.10.004. Epub 2017 Oct 5. Review.


Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases.

Platania CBM, Fisichella V, Fidilio A, Geraci F, Lazzara F, Leggio GM, Salomone S, Drago F, Pignatello R, Caraci F, Bucolo C.

Int J Mol Sci. 2017 Sep 30;18(10). pii: E2076. doi: 10.3390/ijms18102076.


New drugs in psychiatry: focus on new pharmacological targets.

Caraci F, Leggio GM, Salomone S, Drago F.

F1000Res. 2017 Mar 30;6:397. doi: 10.12688/f1000research.10233.1. eCollection 2017. Review.


A new nomenclature for classifying psychotropic drugs.

Caraci F, Enna SJ, Zohar J, Racagni G, Zalsman G, van den Brink W, Kasper S, Koob GF, Pariante CM, Piazza PV, Yamada K, Spedding M, Drago F.

Br J Clin Pharmacol. 2017 Aug;83(8):1614-1616. doi: 10.1111/bcp.13302. Epub 2017 May 24.


Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs.

Caraci F, Sultana J, Drago F, Spina E.

CNS Neurol Disord Drug Targets. 2017;16(4):501-513. doi: 10.2174/1871527316666170303144817. Review.


Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M.

ACS Med Chem Lett. 2016 Sep 26;7(12):1145-1150. eCollection 2016 Dec 8.


Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability.

Malaguarnera G, Bertino G, Chisari G, Motta M, Vecchio M, Vacante M, Caraci F, Greco C, Drago F, Nunnari G, Malaguarnera M.

BMC Psychiatry. 2016 Nov 15;16(1):398.


Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.

Caraci F, Tascedda F, Merlo S, Benatti C, Spampinato SF, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A.

Front Pharmacol. 2016 Oct 25;7:389. eCollection 2016.


Corrigendum: Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.

Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E.

Chembiochem. 2016 Oct 17;17(20):1993. doi: 10.1002/cbic.201600502. Epub 2016 Sep 23. No abstract available.


Propranolol: Effectiveness and Failure in Infantile Cutaneous Hemangiomas.

Praticò AD, Caraci F, Pavone P, Falsaperla R, Drago F, Ruggieri M.

Drug Saf Case Rep. 2015 Dec;2(1):6.


Selective Serotonin Reuptake Inhibitors and Serotonin and Noradrenaline Reuptake Inhibitors Improve Cognitive Function in Partial Responders Depressed Patients: Results from a Prospective Observational Cohort Study.

Castellano S, Ventimiglia A, Salomone S, Ventimiglia A, De Vivo S, Signorelli MS, Bellelli E, Santagati M, Cantarella RA, Fazio E, Aguglia E, Drago F, Di Nuovo S, Caraci F.

CNS Neurol Disord Drug Targets. 2016;15(10):1290-1298.


An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation.

Iulita MF, Ower A, Barone C, Pentz R, Gubert P, Romano C, Cantarella RA, Elia F, Buono S, Recupero M, Romano C, Castellano S, Bosco P, Di Nuovo S, Drago F, Caraci F, Cuello AC.

Alzheimers Dement. 2016 Nov;12(11):1132-1148. doi: 10.1016/j.jalz.2016.05.001. Epub 2016 Jul 21.


Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.

Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E.

Chembiochem. 2016 Aug 17;17(16):1541-9. doi: 10.1002/cbic.201600243. Epub 2016 Jul 7. Erratum in: Chembiochem. 2016 Oct 17;17 (20):1993.


The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

Bruno V, Caraci F, Copani A, Matrisciano F, Nicoletti F, Battaglia G.

Neuropharmacology. 2017 Mar 15;115:180-192. doi: 10.1016/j.neuropharm.2016.04.044. Epub 2016 Apr 30. Review.


Editorial: Linkage of CNS and Immunology with Psychology: Searching for New Pharmacological Targets.

Caraci F, Kamal MA.

CNS Neurol Disord Drug Targets. 2016;15(4):378-80. No abstract available.


A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome.

Iulita MF, Caraci F, Cuello AC.

CNS Neurol Disord Drug Targets. 2016;15(4):434-47. Review.


The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice.

Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F.

Pharmacol Res. 2016 Apr;106:10-20. doi: 10.1016/j.phrs.2016.02.007. Epub 2016 Feb 10.


TGF-β1 prevents rat retinal insult induced by amyloid-β (1-42) oligomers.

Fisichella V, Giurdanella G, Platania CB, Romano GL, Leggio GM, Salomone S, Drago F, Caraci F, Bucolo C.

Eur J Pharmacol. 2016 Sep 15;787:72-7. doi: 10.1016/j.ejphar.2016.02.002. Epub 2016 Feb 2.


Silybin-vitamin E-phospholipids complex reduces liver fibrosis in patients with chronic hepatitis C treated with pegylated interferon α and ribavirin.

Malaguarnera M, Motta M, Vacante M, Malaguarnera G, Caraci F, Nunnari G, Gagliano C, Greco C, Chisari G, Drago F, Bertino G.

Am J Transl Res. 2015 Nov 15;7(11):2510-8. eCollection 2015.


Italian psychiatrists' perception on cognitive symptoms in major depressive disorder.

Albert U, Brugnoli R, Caraci F, Dell'Osso B, Di Sciascio G, Tortorella A, Vampini C, Cataldo N, Pegoraro V.

Int J Psychiatry Clin Pract. 2016;20(1):2-9. doi: 10.3109/13651501.2015.1093147. Epub 2015 Nov 2.


Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons.

Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A.

Front Cell Neurosci. 2015 Aug 7;9:297. doi: 10.3389/fncel.2015.00297. eCollection 2015.


Folate status in type 2 diabetic patients with and without retinopathy.

Malaguarnera G, Gagliano C, Salomone S, Giordano M, Bucolo C, Pappalardo A, Drago F, Caraci F, Avitabile T, Motta M.

Clin Ophthalmol. 2015 Aug 7;9:1437-42. doi: 10.2147/OPTH.S77538. eCollection 2015.


Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity.

Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S.

Eur J Pharmacol. 2015 Oct 5;764:256-63. doi: 10.1016/j.ejphar.2015.07.015. Epub 2015 Jul 7.


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