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Items: 44

1.

Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.

Yang Z, Wang H, Salcedo TW, Suchard SJ, Xie JH, Schneeweis LA, Fleener CA, Calore JD, Shi R, Zhang SX, Rodrigues AD, Car BD, Marathe PH, Nadler SG.

J Pharmacol Exp Ther. 2015 Dec;355(3):506-15. doi: 10.1124/jpet.115.227249. Epub 2015 Oct 6.

PMID:
26442523
2.

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

Foster WR, Car BD, Shi H, Levesque PC, Obermeier MT, Gan J, Arezzo JC, Powlin SS, Dinchuk JE, Balog A, Salvati ME, Attar RM, Gottardis MM.

Prostate. 2011 Apr;71(5):480-8. doi: 10.1002/pros.21263. Epub 2010 Sep 28.

PMID:
20878947
3.

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

Fielden MR, Nie A, McMillian M, Elangbam CS, Trela BA, Yang Y, Dunn RT 2nd, Dragan Y, Fransson-Stehen R, Bogdanffy M, Adams SP, Foster WR, Chen SJ, Rossi P, Kasper P, Jacobson-Kram D, Tatsuoka KS, Wier PJ, Gollub J, Halbert DN, Roter A, Young JK, Sina JF, Marlowe J, Martus HJ, Aubrecht J, Olaharski AJ, Roome N, Nioi P, Pardo I, Snyder R, Perry R, Lord P, Mattes W, Car BD; Predictive Safety Testing Consortium; Carcinogenicity Working Group.

Toxicol Sci. 2008 May;103(1):28-34. doi: 10.1093/toxsci/kfn022. Epub 2008 Feb 14.

PMID:
18281259
4.

Urine acidification has no effect on peroxisome proliferator-activated receptor (PPAR) signaling or epidermal growth factor (EGF) expression in rat urinary bladder urothelium.

Achanzar WE, Moyer CF, Marthaler LT, Gullo R, Chen SJ, French MH, Watson LM, Rhodes JW, Kozlosky JC, White MR, Foster WR, Burgun JJ, Car BD, Cosma GN, Dominick MA.

Toxicol Appl Pharmacol. 2007 Sep 15;223(3):246-56. Epub 2007 Jul 3.

PMID:
17663016
5.

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

Foster WR, Chen SJ, He A, Truong A, Bhaskaran V, Nelson DM, Dambach DM, Lehman-McKeeman LD, Car BD.

Toxicol Pathol. 2007 Aug;35(5):621-35. Review.

PMID:
17654404
6.

Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777.

Ogawa M, Nomura S, Car BD, Goldenring JR.

Dig Dis Sci. 2006 Mar;51(3):431-9.

PMID:
16614949
7.

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.

Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Maddox JF, Ganey PE, Roth RA.

Toxicol Sci. 2006 Apr;90(2):569-85. Epub 2006 Jan 16.

PMID:
16415329
8.

Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.

Luyendyk JP, Lehman-McKeeman LD, Nelson DM, Bhaskaran VM, Reilly TP, Car BD, Cantor GH, Deng X, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2006 May;317(2):635-43. Epub 2006 Jan 9.

PMID:
16401727
9.

Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats.

Wong H, Lehman-McKeeman LD, Grubb MF, Grossman SJ, Bhaskaran VM, Solon EG, Shen HS, Gerson RJ, Car BD, Zhao B, Gemzik B.

Toxicol Sci. 2005 Apr;84(2):232-42. Epub 2005 Jan 26.

PMID:
15673846
10.

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.

Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C.

Toxicol Appl Pharmacol. 2003 Mar 15;187(3):137-46.

PMID:
12662897
11.

Special considerations in the evaluation of the hematology and hemostasis of mutant mice.

Car BD, Eng VM.

Vet Pathol. 2001 Jan;38(1):20-30. Review.

PMID:
11199161
12.

Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits.

Dumont RA, Car BD, Voitenok NN, Junker U, Moser B, Zak O, O'Reilly T.

Infect Immun. 2000 Oct;68(10):5756-63.

13.

Reversible drug-induced oxyntic atrophy in rats.

Goldenring JR, Ray GS, Coffey RJ, Meunier PC, Haley PJ, Barnes TB, Car BD.

Gastroenterology. 2000 Jun;118(6):1080-93.

PMID:
10833483
14.

Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil-induced myelotoxicity in mice.

Lorenz M, Slaughter HS, Wescott DM, Carter SI, Schnyder B, Dinchuk JE, Car BD.

Exp Hematol. 1999 Oct;27(10):1494-502.

PMID:
10517490
15.

Commentary: Discovery Toxicology--a nascent science.

Car BD, Robertson RT.

Toxicol Pathol. 1999 Jul-Aug;27(4):481-3. No abstract available.

PMID:
10485835
16.

The toxicology of interleukin-12: a review.

Car BD, Eng VM, Lipman JM, Anderson TD.

Toxicol Pathol. 1999 Jan-Feb;27(1):58-63. Review.

PMID:
10367675
17.

Atypical antipsychotic-induced neutropenia in dogs.

Lorenz M, Evering WE, Provencher A, Blue JT, Lewis HB, Hazelette JR, Rajagopalan P, Meunier PC, Car BD.

Toxicol Appl Pharmacol. 1999 Mar 15;155(3):227-36.

PMID:
10079208
18.

Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.

Schnyder B, Meunier PC, Car BD.

Biochem J. 1998 Apr 15;331 ( Pt 2):489-95.

19.

Distribution pattern of tenascin-C in normal and neoplastic mesenchymal tissues.

Schnyder B, Semadeni RO, Fischer RW, Vaughan L, Car BD, Heitz PU, Winterhalter KH, Odermatt BF.

Int J Cancer. 1997 Jul 17;72(2):217-24.

20.

Interferon-gamma enhances tumor necrosis factor-alpha production by inhibiting early phase interleukin-10 transcription.

Shakhov AN, Woerly G, Car BD, Ryffel B.

Eur Cytokine Netw. 1996 Dec;7(4):741-50.

PMID:
9010676
21.

Biochemical and morphological characterization of vascular and lymphocytic interleukin-4 receptors.

Schnyder B, Lugli SM, Schnyder-Candrian S, Eng VM, Moser R, Banchereau J, Ryffel B, Car BD.

Am J Pathol. 1996 Oct;149(4):1369-79.

22.
23.

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.

Klement JF, Rice NR, Car BD, Abbondanzo SJ, Powers GD, Bhatt PH, Chen CH, Rosen CA, Stewart CL.

Mol Cell Biol. 1996 May;16(5):2341-9.

24.

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice.

Eugster HP, Muller M, Karrer U, Car BD, Schnyder B, Eng VM, Woerly G, Le Hir M, di Padova F, Aguet M, Zinkernagel R, Bluethmann H, Ryffel B.

Int Immunol. 1996 Jan;8(1):23-36.

PMID:
8671586
25.

Role of interferon-gamma in interleukin 12-induced pathology in mice.

Car BD, Eng VM, Schnyder B, LeHir M, Shakhov AN, Woerly G, Huang S, Aguet M, Anderson TD, Ryffel B.

Am J Pathol. 1995 Dec;147(6):1693-707.

26.

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, et al.

Nature. 1995 Nov 23;378(6555):406-9.

PMID:
7477380
28.

The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo.

Eng VM, Car BD, Schnyder B, Lorenz M, Lugli S, Aguet M, Anderson TD, Ryffel B, Quesniaux VF.

J Exp Med. 1995 May 1;181(5):1893-8.

29.

Bovine ENA, a new monocyte-macrophage derived cytokine of the interleukin-8 family. Structure, function, and expression in acute pulmonary inflammation.

Allmann-Iselin I, Car BD, Zwahlen RD, Mueller-Schüpbach R, Wyder-Walther M, Steckholzer U, Walz A.

Am J Pathol. 1994 Dec;145(6):1382-9.

30.

Growth inhibition of human colorectal-carcinoma cells by interleukin-4 and expression of functional interleukin-4 receptors.

Lahm H, Schnyder B, Wyniger J, Borbenyi Z, Yilmaz A, Car BD, Fischer JR, Givel JC, Ryffel B.

Int J Cancer. 1994 Nov 1;59(3):440-7.

PMID:
7927955
31.

Interleukin-6 exacerbates glomerulonephritis in (NZB x NZW)F1 mice.

Ryffel B, Car BD, Gunn H, Roman D, Hiestand P, Mihatsch MJ.

Am J Pathol. 1994 May;144(5):927-37.

32.

Interferon gamma receptor deficient mice are resistant to endotoxic shock.

Car BD, Eng VM, Schnyder B, Ozmen L, Huang S, Gallay P, Heumann D, Aguet M, Ryffel B.

J Exp Med. 1994 May 1;179(5):1437-44.

33.

Long-term interleukin-6 administration stimulates sustained thrombopoiesis and acute-phase protein synthesis in a small primate--the marmoset.

Ryffel B, Car BD, Woerly G, Weber M, DiPadova F, Kammüller M, Klug S, Neubert R, Neubert D.

Blood. 1994 Apr 15;83(8):2093-102.

34.

Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.

Car BD, Meloni F, Luisetti M, Semenzato G, Gialdroni-Grassi G, Walz A.

Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):655-9.

PMID:
8118632
35.

Effects of recombinant human interleukin 6 (rhIL-6) in marmosets (Callithrix jacchus). 1. General toxicity and hematological changes.

Klug S, Neubert R, Stahlmann R, Thiel R, Ryffel B, Car BD, Neubert D.

Arch Toxicol. 1994;68(10):619-31.

PMID:
7857201
36.

Expression and kinetics of induced procoagulant activity in bovine pulmonary alveolar macrophages.

Car BD, Slauson DO, Suyemoto MM, Doré M, Neilsen NR.

Exp Lung Res. 1991 Sep-Oct;17(5):939-57.

PMID:
1959504
38.

The role of leukocytes in the pathogenesis of fibrin deposition in bovine acute lung injury.

Car BD, Suyemoto MM, Neilsen NR, Slauson DO.

Am J Pathol. 1991 May;138(5):1191-8.

39.

Endotoxin-mediated bovine alveolar macrophage procoagulant induction is dependent on protein kinase C activation.

Car BD, Slauson DO, Doré M, Suyemoto MM.

Inflammation. 1990 Dec;14(6):681-9.

PMID:
2090587
40.

Bilateral testicular seminoma in a New Zealand white rabbit (Oryctolagus cuniculus).

Anderson WI, Car BD, Kenny K, Schlafer DH.

Lab Anim Sci. 1990 Jul;40(4):420-1. No abstract available.

PMID:
2166876
41.

Giant cell hepatopathy in three aborted midterm equine fetuses.

Car BD, Anderson WI.

Vet Pathol. 1988 Sep;25(5):389-91. No abstract available.

PMID:
3232312
42.

Prevention of intraabdominal adhesions in ponies by low-dose heparin therapy.

Parker JE, Fibini SL, Car BD, Erb HN.

Vet Surg. 1987 Nov-Dec;16(6):459-62.

PMID:
3507182
43.

Ileocolostomy. A technique for surgical management of equine cecal impaction.

Craig DR, Pankowski RL, Car BD, Hackett RP, Erb HN.

Vet Surg. 1987 Nov-Dec;16(6):451-5.

PMID:
3507180
44.

Pancreatic atrophy and fibrosis associated with Eurytrema procyonis in a domestic cat.

Anderson WI, Georgi ME, Car BD.

Vet Rec. 1987 Mar 7;120(10):235-6. No abstract available.

PMID:
3576924

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