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Items: 1 to 50 of 313


Imaging mass spectrometry reveals direct albumin fragmentation within the diabetic kidney.

Grove KJ, Lareau NM, Voziyan PA, Zeng F, Harris RC, Hudson BG, Caprioli RM.

Kidney Int. 2018 May 17. pii: S0085-2538(18)30202-3. doi: 10.1016/j.kint.2018.01.040. [Epub ahead of print]


Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

Kleinridders A, Ferris HA, Reyzer ML, Rath M, Soto M, Manier ML, Spraggins J, Yang Z, Stanton RC, Caprioli RM, Kahn CR.

Mol Metab. 2018 Jun;12:113-121. doi: 10.1016/j.molmet.2018.03.013. Epub 2018 Apr 6.


Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions.

Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaan6361. doi: 10.1126/scitranslmed.aan6361.


Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation.

Yang B, Patterson NH, Tsui T, Caprioli RM, Norris JL.

J Am Soc Mass Spectrom. 2018 May;29(5):1012-1020. doi: 10.1007/s13361-018-1899-9. Epub 2018 Mar 13.


Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level.

Charkoftaki G, Rattray NJW, Andrén PE, Caprioli RM, Castellino S, Duncan MW, Goodwin RJA, Schey KL, Shahidi-Latham SK, Veselkov KA, Johnson CH, Vasiliou V.

Hum Genomics. 2018 Feb 27;12(1):10. doi: 10.1186/s40246-018-0142-x. No abstract available.


Enhanced Ion Transmission Efficiency up to m/ z 24 000 for MALDI Protein Imaging Mass Spectrometry.

Prentice BM, Ryan DJ, Van de Plas R, Caprioli RM, Spraggins JM.

Anal Chem. 2018 Apr 17;90(8):5090-5099. doi: 10.1021/acs.analchem.7b05105. Epub 2018 Apr 2.


Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry.

Stark DT, Anderson DMG, Kwong JMK, Patterson NH, Schey KL, Caprioli RM, Caprioli J.

Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):212-222. doi: 10.1167/iovs.17-22509.


Pyruvate induces torpor in obese mice.

Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):810-815. doi: 10.1073/pnas.1717507115. Epub 2018 Jan 8.


Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas.

Anderson DMG, Ablonczy Z, Koutalos Y, Hanneken AM, Spraggins JM, Calcutt MW, Crouch RK, Caprioli RM, Schey KL.

Sci Rep. 2017 Dec 11;7(1):17352. doi: 10.1038/s41598-017-17402-1.


Protein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions.

Ryan DJ, Nei D, Prentice BM, Rose KL, Caprioli RM, Spraggins JM.

Rapid Commun Mass Spectrom. 2018 Mar 15;32(5):442-450. doi: 10.1002/rcm.8042.


Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP.

Cell Host Microbe. 2017 Oct 11;22(4):531-542.e8. doi: 10.1016/j.chom.2017.08.009. Epub 2017 Sep 21.


Label-free molecular imaging of the kidney.

Prentice BM, Caprioli RM, Vuiblet V.

Kidney Int. 2017 Sep;92(3):580-598. doi: 10.1016/j.kint.2017.03.052. Epub 2017 Jul 24. Review.


Imaging MS of Rodent Ocular Tissues and the Optic Nerve.

Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL.

Methods Mol Biol. 2017;1618:15-27. doi: 10.1007/978-1-4939-7051-3_3.


Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis.

Verbeeck N, Spraggins JM, Murphy MJM, Wang HD, Deutch AY, Caprioli RM, Van de Plas R.

Biochim Biophys Acta. 2017 Jul;1865(7):967-977. doi: 10.1016/j.bbapap.2017.02.016. Epub 2017 Feb 27.


Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma.

Lazova R, Yang Z, El Habr C, Lim Y, Choate KA, Seeley EH, Caprioli RM, Yangqun L.

Am J Dermatopathol. 2017 Sep;39(9):689-695. doi: 10.1097/DAD.0000000000000849.


High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling.

Prentice BM, Chumbley CW, Caprioli RM.

J Mass Spectrom. 2016 Aug;51(8):665. doi: 10.1002/jms.3798. No abstract available.


Enhanced Spatially Resolved Proteomics Using On-Tissue Hydrogel-Mediated Protein Digestion.

Rizzo DG, Prentice BM, Moore JL, Norris JL, Caprioli RM.

Anal Chem. 2017 Mar 7;89(5):2948-2955. doi: 10.1021/acs.analchem.6b04395. Epub 2017 Feb 17.


Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.

Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM.

J Proteome Res. 2017 Mar 3;16(3):1364-1375. doi: 10.1021/acs.jproteome.6b01004. Epub 2017 Feb 9.


MALDI Imaging Mass Spectrometry as a Lipidomic Approach to Heart Valve Research.

Angel PM, Bayoumi AS, Hinton RB, Ru Su Y, Bichell D, Mayer JE, Scott Baldwin H, Caprioli RM.

J Heart Valve Dis. 2016 Mar;25(2):240-252.


Life history linked to immune investment in developing amphibians.

Woodhams DC, Bell SC, Bigler L, Caprioli RM, Chaurand P, Lam BA, Reinert LK, Stalder U, Vazquez VM, Schliep K, Hertz A, Rollins-Smith LA.

Conserv Physiol. 2016 Aug 26;4(1):cow025. eCollection 2016.


Erratum: Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502d. No abstract available.


Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging.

Nye-Wood MG, Spraggins JM, Caprioli RM, Schey KL, Donaldson PJ, Grey AC.

Exp Eye Res. 2017 Jan;154:70-78. doi: 10.1016/j.exer.2016.11.008. Epub 2016 Nov 9.


Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP.

Nat Med. 2016 Nov;22(11):1330-1334. doi: 10.1038/nm.4174. Epub 2016 Sep 26. Erratum in: Nat Med. 2016 Dec 6;22(12 ):1502.


3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma.

Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM.

J Proteomics. 2016 Oct 21;149:77-84. doi: 10.1016/j.jprot.2016.02.004. Epub 2016 Feb 13.


Trypsin and MALDI matrix pre-coated targets simplify sample preparation for mapping proteomic distributions within biological tissues by imaging mass spectrometry.

Zubair F, Laibinis PE, Swisher WG, Yang J, Spraggins JM, Norris JL, Caprioli RM.

J Mass Spectrom. 2016 Dec;51(12):1168-1179. doi: 10.1002/jms.3888.


Absolute Quantification of Rifampicin by MALDI Imaging Mass Spectrometry Using Multiple TOF/TOF Events in a Single Laser Shot.

Prentice BM, Chumbley CW, Caprioli RM.

J Am Soc Mass Spectrom. 2017 Jan;28(1):136-144. doi: 10.1007/s13361-016-1501-2. Epub 2016 Sep 21.


Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification.

Prentice BM, Chumbley CW, Hachey BC, Norris JL, Caprioli RM.

Anal Chem. 2016 Oct 4;88(19):9780-9788. Epub 2016 Sep 14.


Correction to Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues.

Chumbley CW, Reyzer ML, Allen JL, Marriner GA, Via LE, Barry CE 3rd, Caprioli RM.

Anal Chem. 2016 Sep 6;88(17):8920. doi: 10.1021/acs.analchem.6b03125. Epub 2016 Aug 19. No abstract available.


Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms.

Lazova R, Seeley EH, Kutzner H, Scolyer RA, Scott G, Cerroni L, Fried I, Kozovska ME, Rosenberg AS, Prieto VG, Shehata BM, Durham MM, Henry G, Rodriguez-Peralto JL, Riveiro-Falkenbach E, Schaefer JT, Danialan R, Fraitag S, Vollenweider-Roten S, Sepehr A, Sangueza M, Hijazi N, Corredoira Y, Kowal R, Harris OM, Bravo F, Boyd AS, Gueorguieva R, Caprioli RM.

J Am Acad Dermatol. 2016 Dec;75(6):1176-1186.e4. doi: 10.1016/j.jaad.2016.07.007. Epub 2016 Aug 5.


The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction.

Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP.

Nat Commun. 2016 Jun 15;7:11951. doi: 10.1038/ncomms11951.


Standard Reticle Slide To Objectively Evaluate Spatial Resolution and Instrument Performance in Imaging Mass Spectrometry.

Zubair F, Prentice BM, Norris JL, Laibinis PE, Caprioli RM.

Anal Chem. 2016 Jul 19;88(14):7302-11. doi: 10.1021/acs.analchem.6b01655. Epub 2016 Jun 27.


Imaging mass spectrometry for accessing molecular changes during burn wound healing.

Taverna D, Pollins AC, Sindona G, Caprioli RM, Nanney LB.

Wound Repair Regen. 2016 Sep;24(5):775-785. doi: 10.1111/wrr.12450. Epub 2016 Jul 26.


Potential of MALDI imaging for the toxicological evaluation of environmental pollutants.

Lagarrigue M, Caprioli RM, Pineau C.

J Proteomics. 2016 Jul 20;144:133-9. doi: 10.1016/j.jprot.2016.05.008. Epub 2016 May 10. Review.


Imaging mass spectrometry: Molecular microscopy for the new age of biology and medicine.

Caprioli RM.

Proteomics. 2016 Jun;16(11-12):1607-12. doi: 10.1002/pmic.201600133. Epub 2016 May 27.


Pathology interface for the molecular analysis of tissue by mass spectrometry.

Norris JL, Tsui T, Gutierrez DB, Caprioli RM.

J Pathol Inform. 2016 Apr 11;7:13. doi: 10.4103/2153-3539.179903. eCollection 2016.


Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis.

Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM.

Proteomics. 2016 Jun;16(11-12):1678-89. doi: 10.1002/pmic.201600003. Epub 2016 May 10.


Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.

Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV.

Oncotarget. 2016 Mar 15;7(11):12582-97. doi: 10.18632/oncotarget.7179.


Pragmatic pharmacology: population pharmacokinetic analysis of fentanyl using remnant samples from children after cardiac surgery.

Van Driest SL, Marshall MD, Hachey B, Beck C, Crum K, Owen J, Smith AH, Kannankeril PJ, Woodworth A, Caprioli RM, Choi L.

Br J Clin Pharmacol. 2016 Jun;81(6):1165-74. doi: 10.1111/bcp.12903. Epub 2016 Apr 15.


Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues.

Chumbley CW, Reyzer ML, Allen JL, Marriner GA, Via LE, Barry CE 3rd, Caprioli RM.

Anal Chem. 2016 Feb 16;88(4):2392-8. doi: 10.1021/acs.analchem.5b04409. Epub 2016 Feb 5.


Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix.

Gessel M, Spraggins JM, Voziyan P, Hudson BG, Caprioli RM.

J Mass Spectrom. 2015 Nov;50(11):1288-93. doi: 10.1002/jms.3696.


Histology-guided protein digestion/extraction from formalin-fixed and paraffin-embedded pressure ulcer biopsies.

Taverna D, Pollins AC, Nanney LB, Sindona G, Caprioli RM.

Exp Dermatol. 2016 Feb;25(2):143-6. doi: 10.1111/exd.12870. Epub 2015 Nov 23.


Are clear cell carcinomas of the ovary and endometrium phenotypically identical? A proteomic analysis.

Fata CR, Seeley EH, Desouki MM, Du L, Gwin K, Hanley KZ, Hecht JL, Jarboe EA, Liang SX, Parkash V, Quick CM, Zheng W, Shyr Y, Caprioli RM, Fadare O.

Hum Pathol. 2015 Oct;46(10):1427-36. doi: 10.1016/j.humpath.2015.06.009. Epub 2015 Jun 23.


High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling.

Prentice BM, Chumbley CW, Caprioli RM.

J Mass Spectrom. 2015 Apr;50(4):703-10. doi: 10.1002/jms.3579. Erratum in: J Mass Spectrom. 2016 Aug;51(8):665.


EXIMS: an improved data analysis pipeline based on a new peak picking method for EXploring Imaging Mass Spectrometry data.

Wijetunge CD, Saeed I, Boughton BA, Spraggins JM, Caprioli RM, Bacic A, Roessner U, Halgamuge SK.

Bioinformatics. 2015 Oct 1;31(19):3198-206. doi: 10.1093/bioinformatics/btv356. Epub 2015 Jun 10.


Congenital nevi versus metastatic melanoma in a newborn to a mother with malignant melanoma - diagnosis supported by sex chromosome analysis and Imaging Mass Spectrometry.

Alomari AK, Glusac EJ, Choi J, Hui P, Seeley EH, Caprioli RM, Watsky KL, Urban J, Lazova R.

J Cutan Pathol. 2015 Oct;42(10):757-64. doi: 10.1111/cup.12523. Epub 2015 Jun 12.


MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data.

Spraggins JM, Rizzo DG, Moore JL, Rose KL, Hammer ND, Skaar EP, Caprioli RM.

J Am Soc Mass Spectrom. 2015 Jun;26(6):974-85. doi: 10.1007/s13361-015-1147-5. Epub 2015 Apr 23.


Peptide spectra in Wilms tumor that associate with adverse outcomes.

Murphy AJ, Pierce J, Seeley EH, Sullivan LM, Ruchelli ED, Nance ML, Caprioli RM, Lovvorn HN 3rd.

J Surg Res. 2015 Jun 15;196(2):332-8. doi: 10.1016/j.jss.2015.03.020. Epub 2015 Mar 18.


Imaging mass spectrometry: enabling a new age of discovery in biology and medicine through molecular microscopy.

Caprioli RM.

J Am Soc Mass Spectrom. 2015 Jun;26(6):850-2. doi: 10.1007/s13361-015-1108-z. Epub 2015 Mar 24.


Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles.

Marien E, Meister M, Muley T, Fieuws S, Bordel S, Derua R, Spraggins J, Van de Plas R, Dehairs J, Wouters J, Bagadi M, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Waelkens E, Swinnen JV.

Int J Cancer. 2015 Oct 1;137(7):1539-48. doi: 10.1002/ijc.29517. Epub 2015 Apr 7.

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