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Items: 1 to 50 of 125

1.

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.

Cristini A, Ricci G, Britton S, Salimbeni S, Huang SN, Marinello J, Calsou P, Pommier Y, Favre G, Capranico G, Gromak N, Sordet O.

Cell Rep. 2019 Sep 17;28(12):3167-3181.e6. doi: 10.1016/j.celrep.2019.08.041.

2.

DROPA: DRIP-seq optimized peak annotator.

Russo M, De Lucca B, Flati T, Gioiosa S, Chillemi G, Capranico G.

BMC Bioinformatics. 2019 Aug 6;20(1):414. doi: 10.1186/s12859-019-3009-9.

3.

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells.

De Magis A, Manzo SG, Russo M, Marinello J, Morigi R, Sordet O, Capranico G.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):816-825. doi: 10.1073/pnas.1810409116. Epub 2018 Dec 27.

4.

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives.

Marinello J, Delcuratolo M, Capranico G.

Int J Mol Sci. 2018 Nov 6;19(11). pii: E3480. doi: 10.3390/ijms19113480. Review.

5.

DNA Topoisomerase I differentially modulates R-loops across the human genome.

Manzo SG, Hartono SR, Sanz LA, Marinello J, De Biasi S, Cossarizza A, Capranico G, Chedin F.

Genome Biol. 2018 Jul 30;19(1):100. doi: 10.1186/s13059-018-1478-1.

6.

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.

Miglietta G, Cogoi S, Marinello J, Capranico G, Tikhomirov AS, Shchekotikhin A, Xodo LE.

J Med Chem. 2017 Dec 14;60(23):9448-9461. doi: 10.1021/acs.jmedchem.7b00622. Epub 2017 Dec 1.

PMID:
29140695
7.

Mapping DNA Breaks by Next-Generation Sequencing.

Baranello L, Kouzine F, Wojtowicz D, Cui K, Zhao K, Przytycka TM, Capranico G, Levens D.

Methods Mol Biol. 2018;1672:155-166. doi: 10.1007/978-1-4939-7306-4_13.

PMID:
29043624
8.

Type I DNA Topoisomerases.

Capranico G, Marinello J, Chillemi G.

J Med Chem. 2017 Mar 23;60(6):2169-2192. doi: 10.1021/acs.jmedchem.6b00966. Epub 2017 Jan 24. Review.

PMID:
28072526
9.

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.

Beretta GL, Ribaudo G, Menegazzo I, Supino R, Capranico G, Zunino F, Zagotto G.

Arch Pharm (Weinheim). 2017 Jan;350(1). doi: 10.1002/ardp.201600286. Epub 2016 Dec 19.

PMID:
27990691
10.

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Amato J, Pagano A, Cosconati S, Amendola G, Fotticchia I, Iaccarino N, Marinello J, De Magis A, Capranico G, Novellino E, Pagano B, Randazzo A.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1271-1280. doi: 10.1016/j.bbagen.2016.11.008. Epub 2016 Nov 9.

PMID:
27836755
11.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht S, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A.

J Med Chem. 2016 Jun 23;59(12):5706-20. doi: 10.1021/acs.jmedchem.6b00129. Epub 2016 Jun 6.

PMID:
27223049
12.

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.

Marinello J, Bertoncini S, Aloisi I, Cristini A, Malagoli Tagliazucchi G, Forcato M, Sordet O, Capranico G.

PLoS One. 2016 Jan 19;11(1):e0147053. doi: 10.1371/journal.pone.0147053. eCollection 2016.

13.

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

Cristini A, Park JH, Capranico G, Legube G, Favre G, Sordet O.

Nucleic Acids Res. 2016 Feb 18;44(3):1161-78. doi: 10.1093/nar/gkv1196. Epub 2015 Nov 17.

14.

Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.

Drwal MN, Marinello J, Manzo SG, Wakelin LP, Capranico G, Griffith R.

PLoS One. 2014 Dec 9;9(12):e114904. doi: 10.1371/journal.pone.0114904. eCollection 2014.

15.

Novel ametantrone-amsacrine related hybrids as topoisomerase IIβ poisons and cytotoxic agents.

Zagotto G, Gianoncelli A, Sissi C, Marzano C, Gandin V, Pasquale R, Capranico G, Ribaudo G, Palumbo M.

Arch Pharm (Weinheim). 2014 Oct;347(10):728-37. doi: 10.1002/ardp.201400111. Epub 2014 Jul 17.

PMID:
25042690
16.

The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells.

Bertozzi D, Marinello J, Manzo SG, Fornari F, Gramantieri L, Capranico G.

Mol Cancer Ther. 2014 Jan;13(1):239-48. doi: 10.1158/1535-7163.MCT-13-0729. Epub 2013 Nov 19.

17.

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation.

Marinello J, Chillemi G, Bueno S, Manzo SG, Capranico G.

Nucleic Acids Res. 2013 Dec;41(22):10110-23. doi: 10.1093/nar/gkt778. Epub 2013 Sep 2.

18.

Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation.

Petronzi C, Festa M, Peduto A, Castellano M, Marinello J, Massa A, Capasso A, Capranico G, La Gatta A, De Rosa M, Caraglia M, Filosa R.

J Exp Clin Cancer Res. 2013 Apr 30;32:24. doi: 10.1186/1756-9966-32-24.

19.

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A.

PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17.

20.

Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.

Manzo SG, Zhou ZL, Wang YQ, Marinello J, He JX, Li YC, Ding J, Capranico G, Miao ZH.

Cancer Res. 2012 Oct 15;72(20):5363-73. doi: 10.1158/0008-5472.CAN-12-1006. Epub 2012 Aug 27.

21.

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin.

D'Annessa I, Tesauro C, Fiorani P, Chillemi G, Castelli S, Vassallo O, Capranico G, Desideri A.

J Amino Acids. 2012;2012:206083. doi: 10.1155/2012/206083. Epub 2012 Jan 19.

22.

In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2.

Fornari F, Milazzo M, Chieco P, Negrini M, Marasco E, Capranico G, Mantovani V, Marinello J, Sabbioni S, Callegari E, Cescon M, Ravaioli M, Croce CM, Bolondi L, Gramantieri L.

J Pathol. 2012 Jul;227(3):275-85. doi: 10.1002/path.3995. Epub 2012 Apr 18.

PMID:
22262409
23.

Characterization of novel antisense HIF-1α transcripts in human cancers.

Bertozzi D, Iurlaro R, Sordet O, Marinello J, Zaffaroni N, Capranico G.

Cell Cycle. 2011 Sep 15;10(18):3189-97. Epub 2011 Sep 15.

PMID:
21897117
24.

Electron paramagnetic resonance (EPR) study of spin-labeled camptothecin derivatives: a different look of the ternary complex.

Ricci A, Marinello J, Bortolus M, Sánchez A, Grandas A, Pedroso E, Pommier Y, Capranico G, Maniero AL, Zagotto G.

J Med Chem. 2011 Feb 24;54(4):1003-9. doi: 10.1021/jm101232t. Epub 2011 Jan 21.

PMID:
21254781
25.

Metallothionein cDNA cloning, metallothionein expression and heavy metals in Scapharca inaequivalvis along the Northern Adriatic coast of Italy.

Andreani G, Carpenè E, Capranico G, Isani G.

Ecotoxicol Environ Saf. 2011 Mar;74(3):366-72. doi: 10.1016/j.ecoenv.2010.12.008. Epub 2011 Jan 17.

PMID:
21247635
26.

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity.

Capranico G, Marinello J, Baranello L.

Biochim Biophys Acta. 2010 Dec;1806(2):240-50. doi: 10.1016/j.bbcan.2010.06.003. Epub 2010 Jun 27. Review.

PMID:
20600630
27.

Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.

Tumiatti V, Milelli A, Minarini A, Micco M, Gasperi Campani A, Roncuzzi L, Baiocchi D, Marinello J, Capranico G, Zini M, Stefanelli C, Melchiorre C.

J Med Chem. 2009 Dec 10;52(23):7873-7. doi: 10.1021/jm901131m.

PMID:
19954251
28.

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus.

Baranello L, Bertozzi D, Fogli MV, Pommier Y, Capranico G.

Nucleic Acids Res. 2010 Jan;38(1):159-71. doi: 10.1093/nar/gkp817. Epub 2009 Oct 23.

29.

A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors.

Lotito L, Russo A, Bueno S, Chillemi G, Fogli MV, Capranico G.

Eur J Pharmacol. 2009 Jan 28;603(1-3):29-36. doi: 10.1016/j.ejphar.2008.12.002. Epub 2008 Dec 9.

PMID:
19094980
30.

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors.

Filosa R, Peduto A, Micco SD, Caprariis Pd, Festa M, Petrella A, Capranico G, Bifulco G.

Bioorg Med Chem. 2009 Jan 1;17(1):13-24. doi: 10.1016/j.bmc.2008.11.024. Epub 2008 Nov 18.

PMID:
19058969
31.

Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion.

Lotito L, Russo A, Chillemi G, Bueno S, Cavalieri D, Capranico G.

J Mol Biol. 2008 Mar 21;377(2):311-22. doi: 10.1016/j.jmb.2008.01.037. Epub 2008 Jan 26.

PMID:
18272174
32.

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

Dal Ben D, Palumbo M, Zagotto G, Capranico G, Moro S.

Curr Pharm Des. 2007;13(27):2766-80. Review.

PMID:
17897022
33.

DNA topoisomerase i as a transcription protein and a lethal cellular toxin.

Lotito L, Ferri F, Russo A, Capranico G.

Ital J Biochem. 2007 Jun;56(2):122-9. Review.

PMID:
17722653
34.

Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation.

Salaroli R, Russo A, Ceccarelli C, Mina GD, Arcella A, Martinelli GN, Giangaspero F, Capranico G, Cenacchi G.

Ultrastruct Pathol. 2007 Jan-Feb;31(1):33-44.

PMID:
17455096
35.

The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I.

Capranico G, Ferri F, Fogli MV, Russo A, Lotito L, Baranello L.

Biochimie. 2007 Apr;89(4):482-9. Epub 2007 Jan 21. Review.

PMID:
17336444
36.

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent.

Tonelli R, Sartini R, Fronza R, Freccero F, Franzoni M, Dongiovanni D, Ballarini M, Ferrari S, D'Apolito M, Di Cola G, Capranico G, Khobta A, Campanini R, Paolucci P, Minucci S, Pession A.

Leukemia. 2006 Jul;20(7):1307-10. Epub 2006 Apr 13. No abstract available.

PMID:
16617320
37.

Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells.

Khobta A, Ferri F, Lotito L, Montecucco A, Rossi R, Capranico G.

J Mol Biol. 2006 Mar 17;357(1):127-38. Epub 2006 Jan 6.

PMID:
16427078
38.

Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.

Leo E, Gould KA, Pan XS, Capranico G, Sanderson MR, Palumbo M, Fisher LM.

J Biol Chem. 2005 Apr 8;280(14):14252-63. Epub 2005 Jan 18.

39.

A rational selection of drug targets needs deeper insights into general regulation mechanisms.

Capranico G.

Curr Med Chem Anticancer Agents. 2004 Sep;4(5):393-4. Review.

PMID:
15379690
40.

Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges.

Capranico G, Zagotto G, Palumbo M.

Curr Med Chem Anticancer Agents. 2004 Jul;4(4):335-45. Review.

PMID:
15281906
41.

Interaction model for anthracycline activity against DNA topoisomerase II.

Moro S, Beretta GL, Dal Ben D, Nitiss J, Palumbo M, Capranico G.

Biochemistry. 2004 Jun 15;43(23):7503-13.

PMID:
15182192
42.

Effects of common buffer systems on drug activity: the case of clerocidin.

Richter S, Fabris D, Binaschi M, Gatto B, Capranico G, Palumbo M.

Chem Res Toxicol. 2004 Apr;17(4):492-501.

PMID:
15089091
43.
44.

Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins.

Alessandri M, Beretta GL, Ferretti E, Mancia A, Khobta A, Capranico G.

J Mol Biol. 2004 Mar 19;337(2):295-305.

PMID:
15003448
45.

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers.

Sissi C, Leo E, Moro S, Capranico G, Mancia A, Menta E, Krapcho AP, Palumbo M.

Biochem Pharmacol. 2004 Feb 15;67(4):631-42.

PMID:
14757163
46.

Anthracyclines: selected new developments.

Binaschi M, Bigioni M, Cipollone A, Rossi C, Goso C, Maggi CA, Capranico G, Animati F.

Curr Med Chem Anticancer Agents. 2001 Aug;1(2):113-30. Review.

PMID:
12678762
47.

The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.

Gatto B, Richter S, Moro S, Capranico G, Palumbo M.

Nucleic Acids Res. 2001 Oct 15;29(20):4224-30.

48.

A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts.

Supino R, Polizzi D, Pavesi R, Pratesi G, Guano F, Capranico G, Palumbo M, Sissi C, Richter S, Beggiolin G, Menta E, Pezzoni G, Spinelli S, Torriani D, Carenini N, Dal Bo L, Facchinetti F, Tortoreto M, Zunino F.

Oncology. 2001;61(3):234-42.

PMID:
11574780
49.

Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I.

Scaldaferro S, Tinelli S, Borgnetto ME, Azzini A, Capranico G.

Chem Biol. 2001 Sep;8(9):871-81.

50.

10th Conference on DNA Topoisomerases in therapy.

Giaccone G, Capranico G.

Drug Resist Updat. 1999 Dec;2(6):347-350.

PMID:
11498349

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