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Items: 1 to 50 of 72

1.

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.

Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de La Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A.

Gut. 2018 Nov 10. pii: gutjnl-2018-317570. doi: 10.1136/gutjnl-2018-317570. [Epub ahead of print]

2.

Effects of liver ischemia-reperfusion injury on respiratory mechanics and driving pressure during orthotopic liver transplantation.

Fanelli V, Costamagna A, Carosso F, Rotondo G, Pivetta EE, Panio A, Cappello P, Mazzeo AT, Del Sorbo L, Grasso S, Mascia L, Brazzi L, Romagnoli R, Salizzoni M, Ranieri MV.

Minerva Anestesiol. 2018 Oct 30. doi: 10.23736/S0375-9393.18.12890-2. [Epub ahead of print]

PMID:
30394062
3.

Soluble stroma-related biomarkers of pancreatic cancer.

Resovi A, Bani MR, Porcu L, Anastasia A, Minoli L, Allavena P, Cappello P, Novelli F, Scarpa A, Morandi E, Falanga A, Torri V, Taraboletti G, Belotti D, Giavazzi R.

EMBO Mol Med. 2018 Aug;10(8). pii: e8741. doi: 10.15252/emmm.201708741.

4.

Extracorporeal CO2 Removal May Improve Renal Function of Patients with Acute Respiratory Distress Syndrome and Acute Kidney Injury: An Open-Label, Interventional Clinical Trial.

Fanelli V, Cantaluppi V, Alessandri F, Costamagna A, Cappello P, Brazzi L, Pugliese F, Biancone L, Terragni P, Ranieri VM.

Am J Respir Crit Care Med. 2018 Sep 1;198(5):687-690. doi: 10.1164/rccm.201712-2575LE. No abstract available.

PMID:
29708394
5.

The advanced glycation end-product Nϵ -carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes-associated risk and its prevention.

Menini S, Iacobini C, de Latouliere L, Manni I, Ionta V, Blasetti Fantauzzi C, Pesce C, Cappello P, Novelli F, Piaggio G, Pugliese G.

J Pathol. 2018 Jun;245(2):197-208. doi: 10.1002/path.5072. Epub 2018 Apr 4.

PMID:
29533466
6.

Next Generation Immunotherapy for Pancreatic Cancer: DNA Vaccination is Seeking New Combo Partners.

Cappello P, Curcio C, Mandili G, Roux C, Bulfamante S, Novelli F.

Cancers (Basel). 2018 Feb 16;10(2). pii: E51. doi: 10.3390/cancers10020051. Review.

7.

Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.

Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, Margaria JP, Martini M, Lazzarini E, Pirozzi F, Rossi L, Franco I, Bornbaum J, Heger J, Rohrbach S, Perino A, Tocchetti CG, Lima BHF, Teixeira MM, Porporato PE, Schulz R, Angelini A, Sandri M, Ameri P, Sciarretta S, Lima-Júnior RCP, Mongillo M, Zaglia T, Morello F, Novelli F, Hirsch E, Ghigo A.

Circulation. 2018 Aug 14;138(7):696-711. doi: 10.1161/CIRCULATIONAHA.117.030352.

PMID:
29348263
8.

Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype.

Borgoni S, Iannello A, Cutrupi S, Allavena P, D'Incalci M, Novelli F, Cappello P.

Oncoimmunology. 2017 Nov 13;7(2):e1393596. doi: 10.1080/2162402X.2017.1393596. eCollection 2018.

9.

Endogenous glutamine decrease is associated with pancreatic cancer progression.

Roux C, Riganti C, Borgogno SF, Curto R, Curcio C, Catanzaro V, Digilio G, Padovan S, Puccinelli MP, Isabello M, Aime S, Cappello P, Novelli F.

Oncotarget. 2017 Aug 24;8(56):95361-95376. doi: 10.18632/oncotarget.20545. eCollection 2017 Nov 10.

10.

FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.

Chattaragada MS, Riganti C, Sassoe M, Principe M, Santamorena MM, Roux C, Curcio C, Evangelista A, Allavena P, Salvia R, Rusev B, Scarpa A, Cappello P, Novelli F.

Oncogene. 2018 Feb 8;37(6):697-709. doi: 10.1038/onc.2017.358. Epub 2017 Oct 23.

11.

Next generation of cancer immunotherapy calls for combination.

Cappello P, Novelli F.

Oncoscience. 2017 Mar 31;4(3-4):19-20. doi: 10.18632/oncoscience.343. eCollection 2017 Mar. No abstract available.

12.

Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis.

Principe M, Borgoni S, Cascione M, Chattaragada MS, Ferri-Borgogno S, Capello M, Bulfamante S, Chapelle J, Di Modugno F, Defilippi P, Nisticò P, Cappello P, Riganti C, Leporatti S, Novelli F.

J Hematol Oncol. 2017 Jan 13;10(1):16. doi: 10.1186/s13045-016-0385-8.

13.

Humoral immune responses toward tumor-derived antigens in previously untreated patients with chronic lymphocytic leukemia.

Griggio V, Mandili G, Vitale C, Capello M, Macor P, Serra S, Castella B, Peola S, Foglietta M, Drandi D, Omedé P, Sblattero D, Cappello P, Chiarle R, Deaglio S, Boccadoro M, Novelli F, Massaia M, Coscia M.

Oncotarget. 2017 Jan 10;8(2):3274-3288. doi: 10.18632/oncotarget.13712.

14.

Alpha-Enolase (ENO1), a potential target in novel immunotherapies.

Cappello P, Principe M, Bulfamante S, Novelli F.

Front Biosci (Landmark Ed). 2017 Jan 1;22:944-959. Review.

15.

Anti-α-enolase antibody limits the invasion of myeloid-derived suppressor cells and attenuates their restraining effector T cell response.

Cappello P, Tonoli E, Curto R, Giordano D, Giovarelli M, Novelli F.

Oncoimmunology. 2015 Dec 21;5(5):e1112940. doi: 10.1080/2162402X.2015.1112940. eCollection 2016 May.

16.

Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma.

Niccolai E, Cappello P, Taddei A, Ricci F, D'Elios MM, Benagiano M, Bechi P, Bencini L, Ringressi MN, Coratti A, Cianchi F, Bonello L, Di Celle PF, Prisco D, Novelli F, Amedei A.

Int J Oncol. 2016 Jul;49(1):393-401. doi: 10.3892/ijo.2016.3524. Epub 2016 May 16.

17.

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.

Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA.

Cancer Discov. 2016 Aug;6(8):870-85. doi: 10.1158/2159-8290.CD-15-1346. Epub 2016 May 13.

18.

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma.

Castino GF, Cortese N, Capretti G, Serio S, Di Caro G, Mineri R, Magrini E, Grizzi F, Cappello P, Novelli F, Spaggiari P, Roncalli M, Ridolfi C, Gavazzi F, Zerbi A, Allavena P, Marchesi F.

Oncoimmunology. 2015 Sep 11;5(4):e1085147. eCollection 2016 Apr.

19.

Regulation of Langerhans cell functions in a hypoxic environment.

Pierobon D, Raggi F, Cambieri I, Pelassa S, Occhipinti S, Cappello P, Novelli F, Musso T, Eva A, Castagnoli C, Varesio L, Giovarelli M, Bosco MC.

J Mol Med (Berl). 2016 Aug;94(8):943-55. doi: 10.1007/s00109-016-1400-9. Epub 2016 Mar 10.

20.

Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest.

Capello M, Ferri-Borgogno S, Riganti C, Chattaragada MS, Principe M, Roux C, Zhou W, Petricoin EF, Cappello P, Novelli F.

Oncotarget. 2016 Feb 2;7(5):5598-612. doi: 10.18632/oncotarget.6798.

21.

A bioluminescent mouse model of proliferation to highlight early stages of pancreatic cancer: A suitable tool for preclinical studies.

de Latouliere L, Manni I, Iacobini C, Pugliese G, Grazi GL, Perri P, Cappello P, Novelli F, Menini S, Piaggio G.

Ann Anat. 2016 Sep;207:2-8. doi: 10.1016/j.aanat.2015.11.010. Epub 2015 Dec 15.

22.

The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice.

Rolla S, Alchera E, Imarisio C, Bardina V, Valente G, Cappello P, Mombello C, Follenzi A, Novelli F, Carini R.

Clin Sci (Lond). 2016 Feb;130(3):193-203. doi: 10.1042/CS20150405. Epub 2015 Nov 11.

PMID:
26558403
23.

Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1.

Fanelli V, Morita Y, Cappello P, Ghazarian M, Sugumar B, Delsedime L, Batt J, Ranieri VM, Zhang H, Slutsky AS.

Anesthesiology. 2016 Jan;124(1):132-40. doi: 10.1097/ALN.0000000000000907.

PMID:
26540149
24.

Ventilatory Management During Normothermic Ex Vivo Lung Perfusion: Effects on Clinical Outcomes.

Terragni PP, Fanelli V, Boffini M, Filippini C, Cappello P, Ricci D, Del Sorbo L, Faggiano C, Brazzi L, Frati G, Venuta F, Mascia L, Rinaldi M, Ranieri VM.

Transplantation. 2016 May;100(5):1128-35. doi: 10.1097/TP.0000000000000929.

PMID:
26425874
25.

Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells.

Principe M, Ceruti P, Shih NY, Chattaragada MS, Rolla S, Conti L, Bestagno M, Zentilin L, Yang SH, Migliorini P, Cappello P, Burrone O, Novelli F.

Oncotarget. 2015 May 10;6(13):11098-113.

26.

Class II transactivator-induced MHC class II expression in pancreatic cancer cells leads to tumor rejection and a specific antitumor memory response.

Ekkirala CR, Cappello P, Accolla RS, Giovarelli M, Romero I, Garrido C, Garcia-Lora AM, Novelli F.

Pancreas. 2014 Oct;43(7):1066-72. doi: 10.1097/MPA.0000000000000160.

27.

Chimeric rat/human HER2 efficiently circumvents HER2 tolerance in cancer patients.

Occhipinti S, Sponton L, Rolla S, Caorsi C, Novarino A, Donadio M, Bustreo S, Satolli MA, Pecchioni C, Marchini C, Amici A, Cavallo F, Cappello P, Pierobon D, Novelli F, Giovarelli M.

Clin Cancer Res. 2014 Jun 1;20(11):2910-21. doi: 10.1158/1078-0432.CCR-13-2663. Epub 2014 Mar 25.

28.

Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis.

Celesti G, Di Caro G, Bianchi P, Grizzi F, Marchesi F, Basso G, Rahal D, Delconte G, Catalano M, Cappello P, Roncalli M, Zerbi A, Montorsi M, Novelli F, Mantovani A, Allavena P, Malesci A, Laghi L.

Br J Cancer. 2013 Oct 29;109(9):2424-33. doi: 10.1038/bjc.2013.565. Epub 2013 Oct 1.

29.

Autoantibodies to Ezrin are an early sign of pancreatic cancer in humans and in genetically engineered mouse models.

Capello M, Cappello P, Linty FC, Chiarle R, Sperduti I, Novarino A, Salacone P, Mandili G, Naccarati A, Sacerdote C, Beghelli S, Bersani S, Barbi S, Bassi C, Scarpa A, Nisticò P, Giovarelli M, Vineis P, Milella M, Novelli F.

J Hematol Oncol. 2013 Sep 6;6:67. doi: 10.1186/1756-8722-6-67.

30.

A self antigen reopens the games in pancreatic cancer.

Cappello P, Novelli F.

Oncoimmunology. 2013 Jun 1;2(6):e24384. Epub 2013 May 10.

31.

Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells.

Cappello P, Blaser H, Gorrini C, Lin DC, Elia AJ, Wakeham A, Haider S, Boutros PC, Mason JM, Miller NA, Youngson B, Done SJ, Mak TW.

Oncogene. 2014 May 1;33(18):2375-84. doi: 10.1038/onc.2013.183. Epub 2013 May 27.

32.

Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions.

Amedei A, Niccolai E, Benagiano M, Della Bella C, Cianchi F, Bechi P, Taddei A, Bencini L, Farsi M, Cappello P, Prisco D, Novelli F, D'Elios MM.

Cancer Immunol Immunother. 2013 Jul;62(7):1249-60. doi: 10.1007/s00262-013-1429-3. Epub 2013 May 3.

PMID:
23640603
33.

Three are better than one: plasminogen receptors as cancer theranostic targets.

Ceruti P, Principe M, Capello M, Cappello P, Novelli F.

Exp Hematol Oncol. 2013 Apr 17;2(1):12. doi: 10.1186/2162-3619-2-12.

34.

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression.

Pierobon D, Bosco MC, Blengio F, Raggi F, Eva A, Filippi M, Musso T, Novelli F, Cappello P, Varesio L, Giovarelli M.

Eur J Immunol. 2013 Apr;43(4):949-66. doi: 10.1002/eji.201242709. Epub 2013 Mar 6.

35.

Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer.

Cappello P, Rolla S, Chiarle R, Principe M, Cavallo F, Perconti G, Feo S, Giovarelli M, Novelli F.

Gastroenterology. 2013 May;144(5):1098-106. doi: 10.1053/j.gastro.2013.01.020. Epub 2013 Jan 16.

36.

The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells.

Blengio F, Raggi F, Pierobon D, Cappello P, Eva A, Giovarelli M, Varesio L, Bosco MC.

Immunobiology. 2013 Jan;218(1):76-89. doi: 10.1016/j.imbio.2012.02.002. Epub 2012 Feb 10.

PMID:
22465745
37.

Molecular and genetic bases of pancreatic cancer.

Vaccaro V, Gelibter A, Bria E, Iapicca P, Cappello P, Di Modugno F, Pino MS, Nuzzo C, Cognetti F, Novelli F, Nistico P, Milella M.

Curr Drug Targets. 2012 Jun;13(6):731-43. Review.

38.

HCG hastens both the development of mammary carcinoma and the metastatization of HCG/LH and ERBB-2 receptor-positive cells in mice.

Iezzi M, Quaglino E, Cappello P, Toto V, Sabatini F, Curcio C, Garotta G, Musiani P, Cavallo F.

Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):621-30.

PMID:
21978694
39.

α-Enolase: a promising therapeutic and diagnostic tumor target.

Capello M, Ferri-Borgogno S, Cappello P, Novelli F.

FEBS J. 2011 Apr;278(7):1064-74. doi: 10.1111/j.1742-4658.2011.08025.x. Epub 2011 Feb 24. Review.

40.

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L.

Blood. 2011 Mar 3;117(9):2625-39. doi: 10.1182/blood-2010-06-292136. Epub 2010 Dec 10.

41.

Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes.

Boselli D, Ragimbeau J, Orlando L, Cappello P, Capello M, Ambrogio C, Chiarle R, Marsili G, Battistini A, Giovarelli M, Pellegrini S, Novelli F.

Immunol Lett. 2010 Nov 30;134(1):17-25. doi: 10.1016/j.imlet.2010.08.005. Epub 2010 Aug 13.

PMID:
20709103
42.

The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity.

Gugliesi F, De Andrea M, Mondini M, Cappello P, Giovarelli M, Shoenfeld Y, Meroni P, Gariglio M, Landolfo S.

J Autoimmun. 2010 Sep;35(2):114-23. doi: 10.1016/j.jaut.2010.04.001. Epub 2010 May 21.

43.

The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response.

Baggetta R, De Andrea M, Gariano GR, Mondini M, Rittà M, Caposio P, Cappello P, Giovarelli M, Gariglio M, Landolfo S.

Eur J Immunol. 2010 Aug;40(8):2182-9. doi: 10.1002/eji.200939995.

44.

Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer.

Tomaino B, Cappello P, Capello M, Fredolini C, Sperduti I, Migliorini P, Salacone P, Novarino A, Giacobino A, Ciuffreda L, Alessio M, Nisticò P, Scarpa A, Pederzoli P, Zhou W, Petricoin Iii EF, Liotta LA, Giovarelli M, Milella M, Novelli F.

J Proteome Res. 2011 Jan 7;10(1):105-12. doi: 10.1021/pr100213b. Epub 2010 Jun 10.

45.

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.

Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M.

J Immunol. 2009 Sep 1;183(5):3004-13. doi: 10.4049/jimmunol.0804384. Epub 2009 Aug 5.

46.

An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen.

Cappello P, Tomaino B, Chiarle R, Ceruti P, Novarino A, Castagnoli C, Migliorini P, Perconti G, Giallongo A, Milella M, Monsurrò V, Barbi S, Scarpa A, Nisticò P, Giovarelli M, Novelli F.

Int J Cancer. 2009 Aug 1;125(3):639-48. doi: 10.1002/ijc.24355.

47.

CCL16 enhances the CD8+ and CD4+ T cell reactivity to human HER-2 elicited by dendritic cells loaded with rat ortholog HER-2.

Caorsi C, Cappello P, Ceruti P, Amici A, Marchini C, Novelli F, Forni G, Giovarelli M.

Int J Immunopathol Pharmacol. 2008 Oct-Dec;21(4):867-77.

PMID:
19144272
48.

Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration.

Bosco MC, Puppo M, Blengio F, Fraone T, Cappello P, Giovarelli M, Varesio L.

Immunobiology. 2008;213(9-10):733-49. doi: 10.1016/j.imbio.2008.07.031. Epub 2008 Sep 21. Review.

PMID:
18926289
49.

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile.

Elia AR, Cappello P, Puppo M, Fraone T, Vanni C, Eva A, Musso T, Novelli F, Varesio L, Giovarelli M.

J Leukoc Biol. 2008 Dec;84(6):1472-82. doi: 10.1189/jlb.0208082. Epub 2008 Aug 25.

PMID:
18725395
50.

Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression.

Ricciardi A, Elia AR, Cappello P, Puppo M, Vanni C, Fardin P, Eva A, Munroe D, Wu X, Giovarelli M, Varesio L.

Mol Cancer Res. 2008 Feb;6(2):175-85. doi: 10.1158/1541-7786.MCR-07-0391.

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