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Items: 1 to 50 of 86

1.

Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device.

Buontempo F, Orsini E, Zironi I, Isolan L, Cappellini A, Rapino S, Tartari A, Mostacci D, Cucchi G, Martelli AM, Sumini M, Castellani G.

PLoS One. 2018 Jun 29;13(6):e0199312. doi: 10.1371/journal.pone.0199312. eCollection 2018. Erratum in: PLoS One. 2018 Sep 21;13(9):e0204692.

2.

Nuclear translocation of PKC-α is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs).

Poli A, Ratti S, Finelli C, Mongiorgi S, Clissa C, Lonetti A, Cappellini A, Catozzi A, Barraco M, Suh PG, Manzoli L, McCubrey JA, Cocco L, Follo MY.

FASEB J. 2018 Feb;32(2):681-692. doi: 10.1096/fj.201700690R. Epub 2018 Jan 4.

PMID:
28970249
3.

Therapeutic targeting of CK2 in acute and chronic leukemias.

Buontempo F, McCubrey JA, Orsini E, Ruzzene M, Cappellini A, Lonetti A, Evangelisti C, Chiarini F, Evangelisti C, Barata JT, Martelli AM.

Leukemia. 2018 Jan;32(1):1-10. doi: 10.1038/leu.2017.301. Epub 2017 Sep 27. Review.

4.

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia.

Evangelisti C, Cappellini A, Oliveira M, Fragoso R, Barata JT, Bertaina A, Locatelli F, Simioni C, Neri LM, Chiarini F, Lonetti A, Buontempo F, Orsini E, Pession A, Manzoli L, Martelli AM, Evangelisti C.

J Cell Physiol. 2018 Mar;233(3):1796-1811. doi: 10.1002/jcp.26135. Epub 2017 Sep 7.

PMID:
28777460
5.

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway.

Lonetti A, Cappellini A, Bertaina A, Locatelli F, Pession A, Buontempo F, Evangelisti C, Evangelisti C, Orsini E, Zambonin L, Neri LM, Martelli AM, Chiarini F.

J Hematol Oncol. 2016 Oct 24;9(1):114.

6.

Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.

Buontempo F, Orsini E, Lonetti A, Cappellini A, Chiarini F, Evangelisti C, Evangelisti C, Melchionda F, Pession A, Bertaina A, Locatelli F, Bertacchini J, Neri LM, McCubrey JA, Martelli AM.

Oncotarget. 2016 Jan 12;7(2):1323-40. doi: 10.18632/oncotarget.6361.

7.

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting.

Chiarini F, Lonetti A, Evangelisti C, Buontempo F, Orsini E, Evangelisti C, Cappellini A, Neri LM, McCubrey JA, Martelli AM.

Biochim Biophys Acta. 2016 Mar;1863(3):449-463. doi: 10.1016/j.bbamcr.2015.08.015. Epub 2015 Sep 1. Review.

8.

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors.

Lonetti A, Cappellini A, Spartà AM, Chiarini F, Buontempo F, Evangelisti C, Evangelisti C, Orsini E, McCubrey JA, Martelli AM.

Oncotarget. 2015 Apr 30;6(12):10399-414.

9.

Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (review).

Evangelisti C, Evangelisti C, Chiarini F, Lonetti A, Buontempo F, Bressanin D, Cappellini A, Orsini E, McCubrey JA, Martelli AM.

Int J Oncol. 2014 Sep;45(3):909-18. doi: 10.3892/ijo.2014.2525. Epub 2014 Jun 26. Review.

PMID:
24968804
10.

Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia.

Spartà AM, Bressanin D, Chiarini F, Lonetti A, Cappellini A, Evangelisti C, Evangelisti C, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Martelli AM.

Cell Cycle. 2014;13(14):2237-47. doi: 10.4161/cc.29267. Epub 2014 May 29.

11.

Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells.

Martelli AM, Lonetti A, Buontempo F, Ricci F, Tazzari PL, Evangelisti C, Bressanin D, Cappellini A, Orsini E, Chiarini F.

Adv Biol Regul. 2014 Sep;56:6-21. doi: 10.1016/j.jbior.2014.04.004. Epub 2014 Apr 30. Review.

PMID:
24819383
12.

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling.

Buontempo F, Orsini E, Martins LR, Antunes I, Lonetti A, Chiarini F, Tabellini G, Evangelisti C, Evangelisti C, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Cappellini A, Barata JT, Martelli AM.

Leukemia. 2014 Mar;28(3):543-53. doi: 10.1038/leu.2013.349. Epub 2013 Nov 20.

PMID:
24253024
13.

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia.

Chiarini F, Lonetti A, Teti G, Orsini E, Bressanin D, Cappellini A, Ricci F, Tazzari PL, Ognibene A, Falconi M, Pagliaro P, Iacobucci I, Martinelli G, Amadori S, McCubrey JA, Martelli AM.

Oncotarget. 2012 Dec;3(12):1615-28.

14.

Dual Inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin: a Therapeutic Strategy for Acute Leukemias.

Chiarini F, Evangelisti C, Buontempo F, Bressanin D, Fini M, Cocco L, Cappellini A, McCubrey JA, Martelli AM.

Curr Cancer Drug Targets. 2012 Nov 21. [Epub ahead of print]

PMID:
23215723
15.

Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.

Martelli AM, Chiarini F, Evangelisti C, Ognibene A, Bressanin D, Billi AM, Manzoli L, Cappellini A, McCubrey JA.

Expert Opin Ther Targets. 2012 Jul;16(7):729-42. doi: 10.1517/14728222.2012.694869. Epub 2012 Jun 12. Review.

PMID:
22686561
16.

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.

Martelli AM, Chiarini F, Evangelisti C, Cappellini A, Buontempo F, Bressanin D, Fini M, McCubrey JA.

Oncotarget. 2012 Apr;3(4):371-94. Review.

17.

Body mass index correlates with waist circumference in school aged Italian children.

Pratesi S, Paternostro F, Tani A, Sassoli C, Cappellini AC.

Diabetes Res Clin Pract. 2012 Apr;96(1):e7-9. doi: 10.1016/j.diabres.2011.12.005. Epub 2012 Jan 9.

PMID:
22226511
18.

Virtual surgical pathology in underdeveloped countries: The Zambia Project.

Pagni F, Bono F, Di Bella C, Faravelli A, Cappellini A.

Arch Pathol Lab Med. 2011 Feb;135(2):215-9. doi: 10.1043/1543-2165-135.2.215.

PMID:
21284441
19.

Reliability of the first-trimester cardiac scan by ultrasound-trained obstetricians with high-frequency transabdominal probes in fetuses with increased nuchal translucency.

Bellotti M, Fesslova V, De Gasperi C, Rognoni G, Bee V, Zucca I, Cappellini A, Bulfamante G, Lombardi CM.

Ultrasound Obstet Gynecol. 2010 Sep;36(3):272-8. doi: 10.1002/uog.7685.

20.

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.

Martelli AM, Evangelisti C, Chiarini F, Grimaldi C, Cappellini A, Ognibene A, McCubrey JA.

Biochim Biophys Acta. 2010 Sep;1803(9):991-1002. doi: 10.1016/j.bbamcr.2010.04.005. Epub 2010 Apr 23. Review.

21.

Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.

Martelli AM, Papa V, Tazzari PL, Ricci F, Evangelisti C, Chiarini F, Grimaldi C, Cappellini A, Martinelli G, Ottaviani E, Pagliaro P, Horn S, Bäsecke J, Lindner LH, Eibl H, McCubrey JA.

Leukemia. 2010 Apr;24(4):687-98. doi: 10.1038/leu.2010.32. Epub 2010 Mar 4.

PMID:
20200557
22.

Muscular dystrophy: central nervous system alpha-dystroglycan glycosylation defects and brain malformation.

Fagiolari G, Cappellini A, Cagliani R, Prelle A, Lucchini V, Fortunato F, Locatelli F, Crugnola V, Comi GP, Bresolin N, Moggio M, Lamperti C.

J Child Neurol. 2010 Mar;25(3):312-20. doi: 10.1177/0883073809338958. Epub 2009 Jul 25.

PMID:
19633331
23.

Neuropathological study of skeletal muscle, heart, liver, and brain in a neonatal form of glycogen storage disease type IV associated with a new mutation in GBE1 gene.

Lamperti C, Salani S, Lucchiari S, Bordoni A, Ripolone M, Fagiolari G, Fruguglietti ME, Crugnola V, Colombo C, Cappellini A, Prelle A, Bresolin N, Comi GP, Moggio M.

J Inherit Metab Dis. 2009 Dec;32 Suppl 1:S161-8. doi: 10.1007/s10545-009-1134-8. Epub 2009 Apr 8.

PMID:
19357989
25.

Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.

Contestabile A, Fila T, Cappellini A, Bartesaghi R, Ciani E.

Cell Prolif. 2009 Apr;42(2):171-81. doi: 10.1111/j.1365-2184.2009.00587.x.

PMID:
19317805
26.

Psychomotor, cognitive and social interactions in elderly and old Italians. Preliminary report.

Cappellini AC, Paternostro F, Sassoli C, Mancini S, Boddi V, Formenti D.

Anthropol Anz. 2008 Dec;66(4):395-400.

PMID:
19216179
27.

Radiobiologic response of medulloblastoma cell lines: involvement of beta-catenin?

Salaroli R, Di Tomaso T, Ronchi A, Ceccarelli C, Cammelli S, Cappellini A, Martinelli GN, Barbieri E, Giangaspero F, Cenacchi G.

J Neurooncol. 2008 Dec;90(3):243-51. doi: 10.1007/s11060-008-9659-5. Epub 2008 Aug 8.

PMID:
18688572
28.

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.

Falà F, Blalock WL, Tazzari PL, Cappellini A, Chiarini F, Martinelli G, Tafuri A, McCubrey JA, Cocco L, Martelli AM.

Mol Pharmacol. 2008 Sep;74(3):884-95. doi: 10.1124/mol.108.047639. Epub 2008 Jun 24.

29.

Environmental effects on school age child psychomotricity.

Cappellini AC, Mancini S, Zuffellato S, Bini F, Polcaro P, Conti AA, Molino Lova R, Macchi C.

Minerva Pediatr. 2008 Jun;60(3):277-84.

PMID:
18487974
30.

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.

Chiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I, Follo MY, McCubrey JA, Martelli AM.

Leukemia. 2008 Jun;22(6):1106-16. doi: 10.1038/leu.2008.79. Epub 2008 Apr 3.

PMID:
18385752
31.

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells.

Papa V, Tazzari PL, Chiarini F, Cappellini A, Ricci F, Billi AM, Evangelisti C, Ottaviani E, Martinelli G, Testoni N, McCubrey JA, Martelli AM.

Leukemia. 2008 Jan;22(1):147-60. Epub 2007 Oct 11.

PMID:
17928881
32.

Fetal trisomy 5 mosaicism: case report and literature review.

Villa N, Redaelli S, Borroni C, Colombo C, Roncaglia N, Sala E, Crosti F, Cappellini A, Dalprà L.

Am J Med Genet A. 2007 Oct 1;143A(19):2343-6. Review. No abstract available.

PMID:
17702005
33.

The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation.

Follo MY, Mongiorgi S, Bosi C, Cappellini A, Finelli C, Chiarini F, Papa V, Libra M, Martinelli G, Cocco L, Martelli AM.

Cancer Res. 2007 May 1;67(9):4287-94.

34.

Endometrioid-like yolk sac and Sertoli-Leydig cell tumors in a carrier of a Y heterochromatin insertion into 1qh region: a causal association?

Sala E, Villa N, Crosti F, Miozzo M, Perego P, Cappellini A, Bonazzi C, Barisani D, Dalprà L.

Cancer Genet Cytogenet. 2007 Mar;173(2):164-9.

PMID:
17321334
35.

Fetal echocardiography at the time of the nuchal translucency scan.

Lombardi CM, Bellotti M, Fesslova V, Cappellini A.

Ultrasound Obstet Gynecol. 2007 Mar;29(3):249-57.

36.

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.

Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T, Martinelli G, Conte R, Cocco L, McCubrey JA, Martelli AM.

Leukemia. 2007 Mar;21(3):427-38. Epub 2007 Jan 11.

PMID:
17215852
38.

Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells.

Mantovani I, Cappellini A, Tazzari PL, Papa V, Cocco L, Martelli AM.

J Cell Physiol. 2006 Jun;207(3):836-44.

PMID:
16526059
39.

Primary progressive multifocal leukoencephalopathy: report of a case.

Isella V, Marzorati L, Curtò N, Cappellini A, Appollonio I.

Funct Neurol. 2005 Jul-Sep;20(3):139-42.

PMID:
16324239
40.

Application of flow cytometry to molecular medicine: detection of tumor necrosis factor-related apoptosis-inducing ligand receptors in acute myeloid leukaemia blasts.

Cappellini A, Mantovani I, Tazzari PL, Grafone T, Martinelli G, Cocco L, Martelli AM.

Int J Mol Med. 2005 Dec;16(6):1041-8.

PMID:
16273284
41.

Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway.

Bortul R, Tazzari PL, Billi AM, Tabellini G, Mantovani I, Cappellini A, Grafone T, Martinelli G, Conte R, Martelli AM.

Br J Haematol. 2005 Jun;129(5):677-86.

PMID:
15916691
42.

Severe intrauterine growth restriction and trisomy 15 confined placental mosaicism: a case report and review of literature.

Redaelli S, Sala E, Roncaglia N, Colombo C, Crosti F, Villa N, Tagliabue P, Cappellini A, Dalprà L.

Prenat Diagn. 2005 Feb;25(2):140-7. Review.

PMID:
15712378
43.

Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation.

Cappellini A, Tazzari PL, Mantovani I, Billi AM, Tassi C, Ricci F, Conte R, Martelli AM.

Apoptosis. 2005 Jan;10(1):141-52.

PMID:
15711930
44.

Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in the resistance to therapeutic treatments of human leukemias.

Martelli AM, Tabellini G, Bortul R, Tazzari PL, Cappellini A, Billi AM, Cocco L.

Histol Histopathol. 2005 Jan;20(1):239-52. doi: 10.14670/HH-20.239. Review.

PMID:
15578442
45.

Nuclear diacylglycerol kinase-theta is activated in response to nerve growth factor stimulation of PC12 cells.

Tabellini G, Billi AM, Falà F, Cappellini A, Evagelisti C, Manzoli L, Cocco L, Martelli AM.

Cell Signal. 2004 Nov;16(11):1263-71.

PMID:
15337525
46.

Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry.

Tazzari PL, Cappellini A, Grafone T, Mantovani I, Ricci F, Billi AM, Ottaviani E, Conte R, Martinelli G, Martelli AM.

Br J Haematol. 2004 Sep;126(5):675-81.

PMID:
15327518
47.

Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells.

Tabellini G, Cappellini A, Tazzari PL, Falà F, Billi AM, Manzoli L, Cocco L, Martelli AM.

J Cell Physiol. 2005 Feb;202(2):623-34.

PMID:
15316930
48.

Metabolism and signaling activities of nuclear lipids.

Martelli AM, Falà F, Faenza I, Billi AM, Cappellini A, Manzoli L, Cocco L.

Cell Mol Life Sci. 2004 May;61(10):1143-56. Review.

PMID:
15141300
49.

Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes.

Martelli AM, Cappellini A, Tazzari PL, Billi AM, Tassi C, Ricci F, Falà F, Conte R.

Haematologica. 2004 Apr;89(4):471-9.

50.

L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species.

Noris M, Todeschini M, Cassis P, Pasta F, Cappellini A, Bonazzola S, Macconi D, Maucci R, Porrati F, Benigni A, Picciolo C, Remuzzi G.

Hypertension. 2004 Mar;43(3):614-22. Epub 2004 Jan 26.

PMID:
14744923

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