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Pharmacological antagonism of the incretin system protects against diet-induced obesity.

Svendsen B, Capozzi ME, Nui J, Hannou SA, Finan B, Naylor J, Ravn P, D'Alessio DA, Campbell JE.

Mol Metab. 2020 Feb;32:44-55. doi: 10.1016/j.molmet.2019.11.018. Epub 2019 Dec 3.


The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.

Capozzi ME, Coch RW, Koech J, Astapova II, Wait JB, Encisco SE, Douros JD, El K, Finan B, Sloop KW, Herman MA, D'Alessio DA, Campbell JE.

Diabetes. 2020 Jan 31. pii: db191216. doi: 10.2337/db19-1216. [Epub ahead of print]


Prognostic and Predictive Role of CXC Chemokine Receptor 4 in Metastatic Colorectal Cancer Patients.

Ottaiano A, Scala S, Normanno N, Botti G, Tatangelo F, Di Mauro A, Capozzi M, Facchini S, Tafuto S, Nasti G.

Appl Immunohistochem Mol Morphol. 2020 Jan 23. doi: 10.1097/PAI.0000000000000828. [Epub ahead of print]


The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis.

Capozzi ME, Savage SR, McCollum GW, Hammer SS, Ramos CJ, Yang R, Bretz CA, Penn JS.

Exp Eye Res. 2020 Jan;190:107885. doi: 10.1016/j.exer.2019.107885. Epub 2019 Nov 20.


Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of immunologically-selected advanced colorectal cancer patients: the CIFRA study protocol.

Ottaiano A, Scala S, Normanno N, Napolitano M, Capozzi M, Rachiglio AM, Roma C, Trotta AM, D'Alterio C, Portella L, Romano C, Cassata A, Casaretti R, Silvestro L, Nappi A, Tafuto S, Avallone A, De Stefano A, Tamburini M, Picone C, Petrillo A, Izzo F, Palaia R, Albino V, Amore A, Belli A, Pace U, Di Marzo M, Chiodini P, Botti G, De Feo G, Delrio P, Nasti G.

BMC Cancer. 2019 Sep 9;19(1):899. doi: 10.1186/s12885-019-6109-z.


1,5-Diaminonaphtalene is a Highly Performing Electron-Transfer Secondary-Reaction Matrix for Laser Desorption Ionization Mass Spectrometry of Indolenine-Based Croconaines.

Calvano CD, Capozzi MAM, Punzi A, Farinola GM, Cataldi TRI, Palmisano F.

ACS Omega. 2018 Dec 19;3(12):17821-17827. doi: 10.1021/acsomega.8b02575. eCollection 2018 Dec 31.


Folfiri-Aflibercept vs. Folfiri-Bevacizumab as Second Line Treatment of RAS Mutated Metastatic Colorectal Cancer in Real Practice.

Ottaiano A, Capozzi M, Tafuto S, De Stefano A, De Divitiis C, Romano C, Avallone A, Nasti G.

Front Oncol. 2019 Aug 13;9:766. doi: 10.3389/fonc.2019.00766. eCollection 2019.


Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms.

von Arx C, Capozzi M, López-Jiménez E, Ottaiano A, Tatangelo F, Di Mauro A, Nasti G, Tornesello ML, Tafuto S.

J Clin Med. 2019 Aug 22;8(9). pii: E1277. doi: 10.3390/jcm8091277. Review.


Safety and Activity of Metronomic Temozolomide in Second-Line Treatment of Advanced Neuroendocrine Neoplasms.

Tafuto S, von Arx C, Capozzi M, Tatangelo F, Mura M, Modica R, Barretta ML, Di Sarno A, Tornesello ML, Colao A, Ottaiano A.

J Clin Med. 2019 Aug 15;8(8). pii: E1224. doi: 10.3390/jcm8081224.


Glucagon lowers glycemia when β-cells are active.

Capozzi ME, Wait JB, Koech J, Gordon AN, Coch RW, Svendsen B, Finan B, D'Alessio DA, Campbell JE.

JCI Insight. 2019 Jul 23;5. pii: 129954. doi: 10.1172/jci.insight.129954.


Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes.

Finan B, Capozzi ME, Campbell JE.

Diabetes. 2019 Jun 9. pii: dbi190004. doi: 10.2337/dbi19-0004. [Epub ahead of print]


Lenvatinib, a molecule with versatile application: from preclinical evidence to future development in anti-cancer treatment.

Capozzi M, De Divitiis C, Ottaiano A, von Arx C, Scala S, Tatangelo F, Delrio P, Tafuto S.

Cancer Manag Res. 2019 May 1;11:3847-3860. doi: 10.2147/CMAR.S188316. eCollection 2019. Review.


β Cell tone is defined by proglucagon peptides through cAMP signaling.

Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE.

JCI Insight. 2019 Mar 7;4(5). pii: 126742. doi: 10.1172/jci.insight.126742. eCollection 2019 Mar 7.


Structural insights into methyl- or methoxy-substituted 1-(α-aminobenzyl)-2-naphthol structures: the role of C-H...π interactions.

Capozzi MAM, Terraneo G, Cardellicchio C.

Acta Crystallogr C Struct Chem. 2019 Feb 1;75(Pt 2):189-195. doi: 10.1107/S2053229619001050. Epub 2019 Jan 29.


Integration of stereotactic radiotherapy in the treatment of metastatic colorectal cancer patients: a real practice study with long-term outcome and prognostic factors.

Ottaiano A, Scotti V, De Divitiis C, Capozzi M, Romano C, Cassata A, Casaretti R, Silvestro L, Nappi A, Vicario V, De Stefano A, Tafuto S, Berretta M, Nasti G, Avallone A.

Oncotarget. 2018 Oct 16;9(81):35251-35265. doi: 10.18632/oncotarget.25834. eCollection 2018 Oct 16.


Synthesis and Computational Study of Semicroconaines and Nonsymmetric Croconaines.

Capozzi MAM, Punzi A, Babudri F, Musio R, Farinola GM.

J Org Chem. 2018 Dec 7;83(23):14396-14405. doi: 10.1021/acs.joc.8b01930. Epub 2018 Nov 26.


Funds Reimbursement of High-Cost Drugs in Gastrointestinal Oncology: An Italian Real Practice 1 Year Experience at the National Cancer Institute of Naples.

Capozzi M, De Divitiis C, Ottaiano A, Teresa T, Capuozzo M, Maiolino P, Botti G, Tafuto S, Avallone A; Abdominal Oncology Group.

Front Public Health. 2018 Oct 12;6:291. doi: 10.3389/fpubh.2018.00291. eCollection 2018.


Solvent-Free Pd-Catalyzed Heteroaryl-Aryl Coupling via C-H Bond Activation for the Synthesis of Extended Heteroaromatic Conjugated Molecules.

Punzi A, Capozzi MAM, Di Noja S, Ragni R, Zappimbulso N, Farinola GM.

J Org Chem. 2018 Aug 17;83(16):9312-9321. doi: 10.1021/acs.joc.8b01284. Epub 2018 Aug 3.


Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes.

Capozzi ME, DiMarchi RD, Tschöp MH, Finan B, Campbell JE.

Endocr Rev. 2018 Oct 1;39(5):719-738. doi: 10.1210/er.2018-00117. Review.


First Biologic Drug in the Treatment of RAS Wild-Type Metastatic Colorectal Cancer: Anti-EGFR or Bevacizumab? Results From a Meta-Analysis.

Ottaiano A, De Stefano A, Capozzi M, Nappi A, De Divitiis C, Romano C, Silvestro L, Cassata A, Casaretti R, Tafuto S, Caraglia M, Berretta M, Nasti G, Avallone A.

Front Pharmacol. 2018 May 3;9:441. doi: 10.3389/fphar.2018.00441. eCollection 2018. Review.


Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.

Douros JD, Lewis AG, Smith EP, Niu J, Capozzi M, Wittmann A, Campbell J, Tong J, Wagner C, Mahbod P, Seeley R, D'Alessio DA.

Diabetes. 2018 Aug;67(8):1504-1511. doi: 10.2337/db18-0081. Epub 2018 May 14.


Palmitic Acid Induces Müller Cell Inflammation that is Potentiated by Co-treatment with Glucose.

Capozzi ME, Giblin MJ, Penn JS.

Sci Rep. 2018 Apr 3;8(1):5459. doi: 10.1038/s41598-018-23601-1.


Biotherapies in Solid Tumors: Are Negative Results Still of Low Priority for Publication?

Ottaiano A, Cassata A, Capozzi M, De Divitiis C, De Stefano A, Avallone A.

Front Oncol. 2018 Mar 14;8:62. doi: 10.3389/fonc.2018.00062. eCollection 2018.


Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ.

Cell Metab. 2018 Feb 6;27(2):450-460.e6. doi: 10.1016/j.cmet.2017.11.003. Epub 2017 Dec 21.


Natural killer cells activity in a metastatic colorectal cancer patient with complete and long lasting response to therapy.

Ottaiano A, Napolitano M, Capozzi M, Tafuto S, Avallone A, Scala S.

World J Clin Cases. 2017 Nov 16;5(11):390-396. doi: 10.12998/wjcc.v5.i11.390.


Stereochemical analysis of β-keto sulfoxides by circular dichroism.

Górecki M, Capozzi MAM, Albano G, Cardellicchio C, Di Bari L, Pescitelli G.

Chirality. 2018 Jan;30(1):29-42. doi: 10.1002/chir.22773. Epub 2017 Nov 4.


Pd-Catalyzed Thiophene-Aryl Coupling Reaction via C-H Bond Activation in Deep Eutectic Solvents.

Punzi A, Coppi DI, Matera S, Capozzi MAM, Operamolla A, Ragni R, Babudri F, Farinola GM.

Org Lett. 2017 Sep 15;19(18):4754-4757. doi: 10.1021/acs.orglett.7b02114. Epub 2017 Sep 6.


Nab-Paclitaxel and Gemcitabine in Advanced Pancreatic Cancer: The One-year Experience of the National Cancer Institute of Naples.

Ottaiano A, Capozzi M, DE Divitiis C, VON Arx C, DI Girolamo E, Nasti G, Cavalcanti E, Tatangelo F, Romano G, Avallone A, Tafuto S.

Anticancer Res. 2017 Apr;37(4):1975-1978.


The rice LysM receptor-like kinase OsCERK1 is required for the perception of short-chain chitin oligomers in arbuscular mycorrhizal signaling.

Carotenuto G, Chabaud M, Miyata K, Capozzi M, Takeda N, Kaku H, Shibuya N, Nakagawa T, Barker DG, Genre A.

New Phytol. 2017 Jun;214(4):1440-1446. doi: 10.1111/nph.14539. Epub 2017 Mar 29.


Obesity and Cancer: Biological Links and Treatment Implications.

Ottaiano A, De Divitiis C, Capozzi M, Avallone A, Pisano C, Pignata S, Tafuto S.

Curr Cancer Drug Targets. 2018;18(3):231-238. doi: 10.2174/1568009617666170330125619. Review.


Gemcitabine mono-therapy versus gemcitabine plus targeted therapy in advanced pancreatic cancer: a meta-analysis of randomized phase III trials.

Ottaiano A, Capozzi M, De Divitiis C, De Stefano A, Botti G, Avallone A, Tafuto S.

Acta Oncol. 2017 Mar;56(3):377-383. doi: 10.1080/0284186X.2017.1288922. Epub 2017 Feb 17. Review. Erratum in: Acta Oncol. 2017 Mar;56(3):499.


Linoleic Acid is a Diabetes-relevant Stimulator of Retinal Inflammation in Human Retinal Muller Cells and Microvascular Endothelial Cells.

Capozzi ME, McCollum GW, Cousins DB, Penn JS.

J Diabetes Metab. 2016 Dec;7(12). pii: 718. doi: 10.4172/2155-6156.1000718. Epub 2016 Nov 30.


Epoxygenated Fatty Acids Inhibit Retinal Vascular Inflammation.

Capozzi ME, Hammer SS, McCollum GW, Penn JS.

Sci Rep. 2016 Dec 14;6:39211. doi: 10.1038/srep39211.


Collection of umbilical cord blood for banking: collection rate and factors influencing collection.

Valle V, Screnci M, Murgi E, Capozzi M, Girelli G.

Blood Transfus. 2017 Oct;15(6):587-588. doi: 10.2450/2016.0262-16. Epub 2016 Nov 7. No abstract available.


Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors.

Capozzi M, VON Arx C, DE Divitiis C, Ottaiano A, Tatangelo F, Romano GM, Tafuto S; (On behalf of ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples, Italy).

Anticancer Res. 2016 Oct;36(10):5025-5030. Review.


In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy.

Uddin MI, Evans SM, Craft JR, Capozzi ME, McCollum GW, Yang R, Marnett LJ, Uddin MJ, Jayagopal A, Penn JS.

Sci Rep. 2016 Aug 5;6:31011. doi: 10.1038/srep31011.


Diabetes and Body Mass Index Are Associated with Neuropathy and Prognosis in Colon Cancer Patients Treated with Capecitabine and Oxaliplatin Adjuvant Chemotherapy.

Ottaiano A, Nappi A, Tafuto S, Nasti G, De Divitiis C, Romano C, Cassata A, Casaretti R, Silvestro L, Avallone A, Capuozzo M, Capozzi M, Maiolino P, Quagliariello V, Scala S, Iaffaioli VR.

Oncology. 2016;90(1):36-42. doi: 10.1159/000442527. Epub 2016 Jan 6.


Real life thromboprophylaxis in orthopedic surgery in Italy. Results of the GIOTTO study.

Randelli F, Cimminiello C, Capozzi M, Bosco M, Cerulli G; GIOTTO Investigators.

Thromb Res. 2016 Jan;137:103-107. doi: 10.1016/j.thromres.2015.11.007. Epub 2015 Nov 11.


NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.

Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS.

Sci Rep. 2015 Nov 3;5:14963. doi: 10.1038/srep14963.


Isolated reconstruction of the medial patellofemoral ligament with autologous quadriceps tendon.

Vavalle G, Capozzi M.

J Orthop Traumatol. 2016 Jun;17(2):155-62. doi: 10.1007/s10195-015-0375-6. Epub 2015 Sep 19.


Everolimus and pancreatic neuroendocrine tumors (PNETs): Activity, resistance and how to overcome it.

Capozzi M, Caterina I, De Divitiis C, von Arx C, Maiolino P, Tatangelo F, Cavalcanti E, Di Girolamo E, Iaffaioli RV, Scala S, Tafuto S; ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy).

Int J Surg. 2015 Sep;21 Suppl 1:S89-94. doi: 10.1016/j.ijsu.2015.06.064. Epub 2015 Jun 27. Review.


Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ.

Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS.

Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):8232-40. doi: 10.1167/iovs.14-14217.


Stacked naphthyls and weak hydrogen-bond interactions govern the conformational behavior of P-resolved cyclic phosphonamides: a combined experimental and computational study.

Capozzi MA, Capitelli F, Bottoni A, Calvaresi M, Cardellicchio C.

J Org Chem. 2014 Nov 21;79(22):11101-9. doi: 10.1021/jo502094g. Epub 2014 Nov 7.


Molecular probes for imaging of hypoxia in the retina.

Evans SM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A.

Bioconjug Chem. 2014 Nov 19;25(11):2030-7. doi: 10.1021/bc500400z. Epub 2014 Oct 9.


The role of cytochrome P450 epoxygenases in retinal angiogenesis.

Capozzi ME, McCollum GW, Penn JS.

Invest Ophthalmol Vis Sci. 2014 Jun 10;55(7):4253-60. doi: 10.1167/iovs.14-14216.


Mitigation of oxygen-induced retinopathy in α2β1 integrin-deficient mice.

Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM.

Invest Ophthalmol Vis Sci. 2014 Jun 10;55(7):4338-47. doi: 10.1167/iovs.14-14061.


Bioactivity of a family of chiral nonracemic aminobenzylnaphthols towards Candida albicans.

Capozzi MA, Cardellicchio C, Magaletti A, Bevilacqua A, Perricone M, Corbo MR.

Molecules. 2014 Apr 23;19(4):5219-30. doi: 10.3390/molecules19045219.


Circadian perinatal photoperiod has enduring effects on retinal dopamine and visual function.

Jackson CR, Capozzi M, Dai H, McMahon DG.

J Neurosci. 2014 Mar 26;34(13):4627-33. doi: 10.1523/JNEUROSCI.4887-13.2014.


Strong intermolecular exciton couplings in solid-state circular dichroism of aryl benzyl sulfoxides.

Padula D, Di Pietro S, Capozzi MA, Cardellicchio C, Pescitelli G.

Chirality. 2014 Sep;26(9):462-70. doi: 10.1002/chir.22270. Epub 2013 Dec 11.


Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types.

Watkins WM, McCollum GW, Savage SR, Capozzi ME, Penn JS, Morrison DG.

Exp Eye Res. 2013 Nov;116:240-6. doi: 10.1016/j.exer.2013.09.014. Epub 2013 Sep 26.

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