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Items: 1 to 50 of 148

1.

Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16.

Jiao WH, Salim AA, Khalil ZG, Dewapriya P, Lin HW, Butler MS, Capon RJ.

J Nat Prod. 2019 Oct 18. doi: 10.1021/acs.jnatprod.9b00760. [Epub ahead of print]

PMID:
31625738
2.

A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.

Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, Du YP, Canals M, Sessions RB, Kelly E, Capon RJ, Alewood PF, Christie MJ.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201908662. doi: 10.1073/pnas.1908662116. [Epub ahead of print]

3.

Chrysosporazines A-E: P-Glycoprotein Inhibitory Piperazines from an Australian Marine Fish Gastrointestinal Tract-Derived Fungus, Chrysosporium sp. CMB-F214.

Elbanna AH, Khalil ZG, Bernhardt PV, Capon RJ.

Org Lett. 2019 Oct 4;21(19):8097-8100. doi: 10.1021/acs.orglett.9b03094. Epub 2019 Sep 23.

PMID:
31544463
4.

Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea.

Jiao WH, Li J, Wang D, Zhang MM, Liu LY, Sun F, Li JY, Capon RJ, Lin HW.

J Nat Prod. 2019 Sep 27;82(9):2586-2593. doi: 10.1021/acs.jnatprod.9b00471. Epub 2019 Sep 18.

PMID:
31532203
5.

Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus.

Azuar A, Zhao L, Hei TT, Nevagi RJ, Bartlett S, Hussein WM, Khalil ZG, Capon RJ, Toth I, Skwarczynski M.

ACS Med Chem Lett. 2019 Jul 24;10(9):1253-1259. doi: 10.1021/acsmedchemlett.9b00239. eCollection 2019 Sep 12.

PMID:
31531193
6.

Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi.

Elbanna AH, Khalil ZG, Bernhardt PV, Capon RJ.

Mar Drugs. 2019 Aug 16;17(8). pii: E475. doi: 10.3390/md17080475.

7.

Predator-induced changes in the chemical defence of a vertebrate.

Hettyey A, Üveges B, Móricz ÁM, Drahos L, Capon RJ, Van Buskirk J, Tóth Z, Bókony V.

J Anim Ecol. 2019 Aug 13. doi: 10.1111/1365-2656.13083. [Epub ahead of print]

PMID:
31408536
8.

Acylpeptide hydrolase is a novel regulator of KRAS plasma membrane localization and function.

Tan L, Cho KJ, Kattan WE, Garrido CM, Zhou Y, Neupane P, Capon RJ, Hancock JF.

J Cell Sci. 2019 Jul 31;132(15). pii: jcs232132. doi: 10.1242/jcs.232132.

PMID:
31266814
9.

Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system.

Nevagi RJ, Dai W, Khalil ZG, Hussein WM, Capon RJ, Skwarczynski M, Toth I.

Eur J Med Chem. 2019 Oct 1;179:100-108. doi: 10.1016/j.ejmech.2019.06.047. Epub 2019 Jun 18.

PMID:
31247372
10.

Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system.

Nevagi RJ, Dai W, Khalil ZG, Hussein WM, Capon RJ, Skwarczynski M, Toth I.

Bioorg Med Chem. 2019 Jul 15;27(14):3082-3088. doi: 10.1016/j.bmc.2019.05.033. Epub 2019 May 22.

PMID:
31176567
11.

Antioxidant activity and cellular uptake of the hydroxamate-based fungal iron chelators pyridoxatin, desferriastechrome and desferricoprogen.

da Silva GS, Shang Z, Kalansuriya P, Capon RJ, Espósito BP.

Biometals. 2019 Aug;32(4):707-715. doi: 10.1007/s10534-019-00202-7. Epub 2019 Jun 1.

PMID:
31152280
12.

Extracting value: mechanistic insights into the formation of natural product artifacts - case studies in marine natural products.

Capon RJ.

Nat Prod Rep. 2019 May 2. doi: 10.1039/c9np00013e. [Epub ahead of print] Review.

PMID:
31046051
13.

Solvolysis Artifacts: Leucettazoles as Cryptic Macrocyclic Alkaloid Dimers from a Southern Australian Marine Sponge, Leucetta sp.

Prasad P, Salim AA, Khushi S, Khalil ZG, Quezada M, Capon RJ.

Mar Drugs. 2019 Feb 9;17(2). pii: E106. doi: 10.3390/md17020106.

14.

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance.

Atif M, Smith JJ, Estrada-Mondragon A, Xiao X, Salim AA, Capon RJ, Lynch JW, Keramidas A.

PLoS Pathog. 2019 Jan 29;15(1):e1007570. doi: 10.1371/journal.ppat.1007570. eCollection 2019 Jan.

15.

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis.

Khalil ZG, Hill TA, De Leon Rodriguez LM, Lohman RJ, Hoang HN, Reiling N, Hillemann D, Brimble MA, Fairlie DP, Blumenthal A, Capon RJ.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01773-18. doi: 10.1128/AAC.01773-18. Print 2019 Mar.

16.

Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16.

Jiao WH, Dewapriya P, Mohamed O, Khalil ZG, Salim AA, Lin HW, Capon RJ.

J Nat Prod. 2019 Jan 25;82(1):87-95. doi: 10.1021/acs.jnatprod.8b00746. Epub 2018 Dec 31.

PMID:
30596497
17.

Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers.

Wang D, Neupane P, Ragnarsson L, Capon RJ, Lewis RJ.

Mar Drugs. 2018 Nov 28;16(12). pii: E475. doi: 10.3390/md16120475.

18.

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):248-249. doi: 10.1039/c8np90041h. Epub 2018 Nov 23.

19.

Cacolides: Sesterterpene Butenolides from a Southern Australian Marine Sponge, Cacospongia sp.

Khushi S, Nahar L, Salim AA, Capon RJ.

Mar Drugs. 2018 Nov 20;16(11). pii: E456. doi: 10.3390/md16110456.

20.

Bromocatechol conjugates from a Chinese marine red alga, Symphyocladia latiuscula.

Xu X, Yang H, Khalil ZG, Yin L, Xiao X, Salim AA, Song F, Capon RJ.

Phytochemistry. 2019 Feb;158:20-25. doi: 10.1016/j.phytochem.2018.10.026. Epub 2018 Nov 15.

PMID:
30447546
21.

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus.

Nevagi RJ, Khalil ZG, Hussein WM, Powell J, Batzloff MR, Capon RJ, Good MF, Skwarczynski M, Toth I.

Acta Biomater. 2018 Oct 15;80:278-287. doi: 10.1016/j.actbio.2018.09.037. Epub 2018 Sep 25.

PMID:
30266637
22.

Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp.

Dewapriya P, Khalil ZG, Prasad P, Salim AA, Cruz-Morales P, Marcellin E, Capon RJ.

Front Chem. 2018 Sep 4;6:394. doi: 10.3389/fchem.2018.00394. eCollection 2018.

23.

Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences.

Khalil ZG, Cruz-Morales P, Licona-Cassani C, Marcellin E, Capon RJ.

ISME J. 2019 Jan;13(1):147-158. doi: 10.1038/s41396-018-0265-z. Epub 2018 Aug 16.

PMID:
30116041
24.

Cytotoxic Spiroepoxide Lactone and Its Putative Biosynthetic Precursor from Goniobranchus Splendidus.

Forster LC, Pierens GK, White AM, Cheney KL, Dewapriya P, Capon RJ, Garson MJ.

ACS Omega. 2017 Jun 30;2(6):2672-2677. doi: 10.1021/acsomega.7b00641. Epub 2017 Jun 15.

25.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):35-107. doi: 10.1039/c7np00064b. Epub 2018 Jul 13. Review. Erratum in: Nat Prod Rep. 2018 Nov 23;:.

26.

An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth.

Tan L, Cho KJ, Neupane P, Capon RJ, Hancock JF.

J Biol Chem. 2018 Aug 31;293(35):13696-13706. doi: 10.1074/jbc.RA118.003907. Epub 2018 Jul 3.

27.

Trichodermides A-E: New Peptaibols Isolated from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16.

Jiao WH, Khalil Z, Dewapriya P, Salim AA, Lin HW, Capon RJ.

J Nat Prod. 2018 Apr 27;81(4):976-984. doi: 10.1021/acs.jnatprod.7b01072. Epub 2018 Mar 12.

PMID:
29528227
28.

Prolinimines: N-Amino-l-Pro-methyl Ester (Hydrazine) Schiff Bases from a Fish Gastrointestinal Tract-Derived Fungus, Trichoderma sp. CMB-F563.

Mohamed OG, Khalil ZG, Capon RJ.

Org Lett. 2018 Jan 19;20(2):377-380. doi: 10.1021/acs.orglett.7b03666. Epub 2018 Jan 9.

PMID:
29314856
29.

Diverse Cone-Snail Species Harbor Closely Related Streptomyces Species with Conserved Chemical and Genetic Profiles, Including Polycyclic Tetramic Acid Macrolactams.

Quezada M, Licona-Cassani C, Cruz-Morales P, Salim AA, Marcellin E, Capon RJ, Barona-Gómez F.

Front Microbiol. 2017 Nov 24;8:2305. doi: 10.3389/fmicb.2017.02305. eCollection 2017.

30.

Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula.

Xu X, Yang H, Khalil ZG, Yin L, Xiao X, Neupane P, Bernhardt PV, Salim AA, Song F, Capon RJ.

Mar Drugs. 2017 Dec 1;15(12). pii: E374. doi: 10.3390/md15120374.

31.

Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494.

Khalil ZG, Salim AA, Vuong D, Crombie A, Lacey E, Blumenthal A, Capon RJ.

J Antibiot (Tokyo). 2017 Dec;70(12):1097-1103. doi: 10.1038/ja.2017.119. Epub 2017 Oct 25.

PMID:
29066791
32.

Pursuing sesterterpene lactams in Australian Irciniidae sponges.

Prasad P, Zhang A, Salim AA, Capon RJ.

Fitoterapia. 2018 Apr;126:83-89. doi: 10.1016/j.fitote.2017.09.003. Epub 2017 Sep 6.

PMID:
28888966
33.

Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity.

Shang Z, Raju R, Salim AA, Khalil ZG, Capon RJ.

J Org Chem. 2017 Sep 15;82(18):9704-9709. doi: 10.1021/acs.joc.7b01793. Epub 2017 Aug 31.

PMID:
28831797
34.

Microbiome-Mediated Biotransformation of Cane Toad Bufagenins.

Kamalakkannan V, Salim AA, Capon RJ.

J Nat Prod. 2017 Jul 28;80(7):2012-2017. doi: 10.1021/acs.jnatprod.7b00134. Epub 2017 Jul 10.

PMID:
28691813
35.

Chaunopyran A: Co-Cultivation of Marine Mollusk-Derived Fungi Activates a Rare Class of 2-Alkenyl-Tetrahydropyran.

Shang Z, Salim AA, Capon RJ.

J Nat Prod. 2017 Apr 28;80(4):1167-1172. doi: 10.1021/acs.jnatprod.7b00144. Epub 2017 Apr 6.

36.

Talarolide A, a Cyclic Heptapeptide Hydroxamate from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. (CMB-TU011).

Dewapriya P, Prasad P, Damodar R, Salim AA, Capon RJ.

Org Lett. 2017 Apr 21;19(8):2046-2049. doi: 10.1021/acs.orglett.7b00638. Epub 2017 Apr 6.

37.

Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillus sp. (CMB-W031).

Quezada M, Shang Z, Kalansuriya P, Salim AA, Lacey E, Capon RJ.

J Nat Prod. 2017 Apr 28;80(4):1192-1195. doi: 10.1021/acs.jnatprod.6b01062. Epub 2017 Feb 24.

PMID:
28234476
38.

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

Fontaine F, Overman J, Moustaqil M, Mamidyala S, Salim A, Narasimhan K, Prokoph N, Robertson AAB, Lua L, Alexandrov K, Koopman P, Capon RJ, Sierecki E, Gambin Y, Jauch R, Cooper MA, Zuegg J, Francois M.

Cell Chem Biol. 2017 Mar 16;24(3):346-359. doi: 10.1016/j.chembiol.2017.01.003. Epub 2017 Feb 2.

39.

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AA, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M.

Elife. 2017 Jan 31;6. pii: e21221. doi: 10.7554/eLife.21221.

40.

Talarazines A-E: Noncytotoxic Iron(III) Chelators from an Australian Mud Dauber Wasp-Associated Fungus, Talaromyces sp. (CMB-W045).

Kalansuriya P, Quezada M, Espósito BP, Capon RJ.

J Nat Prod. 2017 Mar 24;80(3):609-615. doi: 10.1021/acs.jnatprod.6b00889. Epub 2017 Jan 6.

PMID:
28058837
41.

Spongian-16-one Diterpenes and Their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi.

Forster LC, Winters AE, Cheney KL, Dewapriya P, Capon RJ, Garson MJ.

J Nat Prod. 2017 Mar 24;80(3):670-675. doi: 10.1021/acs.jnatprod.6b00936. Epub 2016 Dec 29.

PMID:
28032760
42.

Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery.

Marasini N, Giddam AK, Khalil ZG, Hussein WM, Capon RJ, Batzloff MR, Good MF, Toth I, Skwarczynski M.

Nanomedicine (Lond). 2016 Dec;11(24):3223-3235. Epub 2016 Nov 10.

PMID:
27830630
43.

Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus.

Marasini N, Khalil ZG, Giddam AK, Ghaffar KA, Hussein WM, Capon RJ, Batzloff MR, Good MF, Skwarczynski M, Toth I.

Int J Pharm. 2016 Nov 20;513(1-2):410-420. doi: 10.1016/j.ijpharm.2016.09.057. Epub 2016 Sep 20.

PMID:
27659862
44.

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.

Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF.

Mol Cell Biol. 2016 Nov 28;36(24):3086-3099. Print 2016 Dec 15.

45.

Linear and branched polyacrylates as a delivery platform for peptide-based vaccines.

Chandrudu S, Bartlett S, Khalil ZG, Jia Z, Hussein WM, Capon RJ, Batzloff MR, Good MF, Monteiro MJ, Skwarczynski M, Toth I.

Ther Deliv. 2016 Sep;7(9):601-9. doi: 10.4155/tde-2016-0037.

PMID:
27582233
46.

Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions.

Shang Z, Khalil Z, Li L, Salim AA, Quezada M, Kalansuriya P, Capon RJ.

Org Lett. 2016 Sep 2;18(17):4340-3. doi: 10.1021/acs.orglett.6b02099. Epub 2016 Aug 18.

PMID:
27537356
47.

Fungal Biotransformation of Tetracycline Antibiotics.

Shang Z, Salim AA, Khalil Z, Bernhardt PV, Capon RJ.

J Org Chem. 2016 Aug 5;81(15):6186-94. doi: 10.1021/acs.joc.6b01272. Epub 2016 Jul 25.

48.

Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C.

Booth TJ, Alt S, Capon RJ, Wilkinson B.

Chem Commun (Camb). 2016 May 11;52(38):6383-6. doi: 10.1039/c6cc01930g. Epub 2016 Apr 19.

PMID:
27091090
49.

Variation in Chemical Defense Among Natural Populations of Common Toad, Bufo bufo, Tadpoles: the Role of Environmental Factors.

Bókony V, Móricz ÁM, Tóth Z, Gál Z, Kurali A, Mikó Z, Pásztor K, Szederkényi M, Tóth Z, Ujszegi J, Üveges B, Krüzselyi D, Capon RJ, Hoi H, Hettyey A.

J Chem Ecol. 2016 Apr;42(4):329-38. doi: 10.1007/s10886-016-0690-2. Epub 2016 Apr 8.

PMID:
27059330
50.

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains.

Azmi F, Elliott AG, Khalil ZG, Hussein WM, Kavanagh A, Huang JX, Quezada M, Blaskovich MA, Capon RJ, Cooper MA, Skwarczynski M, Toth I.

Nanomedicine (Lond). 2015 Nov;10(22):3359-71.

PMID:
26909416

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