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Items: 1 to 50 of 68

1.

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.

Winterbottom EF, Moroishi Y, Halchenko Y, Armstrong DA, Beach PJ, Nguyen QP, Capobianco AJ, Ayad NG, Marsit CJ, Li Z, Karagas MR, Robbins DJ.

Environ Health. 2019 Feb 28;18(1):18. doi: 10.1186/s12940-019-0455-9.

2.

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.

Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ.

Clin Cancer Res. 2019 Feb 15;25(4):1379-1388. doi: 10.1158/1078-0432.CCR-18-1319. Epub 2018 Nov 28.

PMID:
30487124
3.

Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma.

Lohse I, Al-Ali H, Volmar CH, D Alvarez Trotta A, Brothers SP, Capobianco AJ, Wahlestedt C.

PLoS One. 2018 Sep 13;13(9):e0203173. doi: 10.1371/journal.pone.0203173. eCollection 2018.

4.

Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.

Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ.

Oncogene. 2017 Nov 9;36(45):6306-6314. doi: 10.1038/onc.2017.232. Epub 2017 Jul 17.

5.

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ.

Sci Signal. 2017 Jun 27;10(485). pii: eaak9916. doi: 10.1126/scisignal.aak9916.

6.

Acetylation of Mastermind-like 1 by p300 Drives the Recruitment of NACK to Initiate Notch-Dependent Transcription.

Jin K, Zhou W, Han X, Wang Z, Li B, Jeffries S, Tao W, Robbins DJ, Capobianco AJ.

Cancer Res. 2017 Aug 15;77(16):4228-4237. doi: 10.1158/0008-5472.CAN-16-3156. Epub 2017 Jun 16.

7.

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression.

Winterbottom EF, Koestler DC, Fei DL, Wika E, Capobianco AJ, Marsit CJ, Karagas MR, Robbins DJ.

Environ Health. 2017 Jun 14;16(1):59. doi: 10.1186/s12940-017-0267-8.

8.

Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex.

Han X, Ranganathan P, Tzimas C, Weaver KL, Jin K, Astudillo L, Zhou W, Zhu X, Li B, Robbins DJ, Capobianco AJ.

Mol Cancer Res. 2017 Sep;15(9):1173-1183. doi: 10.1158/1541-7786.MCR-17-0241. Epub 2017 Jun 5.

9.

p16 loss rescues functional decline of Brca1-deficient mammary stem cells.

Scott A, Bai F, Chan HL, Liu S, Slingerland JM, Robbins DJ, Capobianco AJ, Pei XH.

Cell Cycle. 2017 Apr 18;16(8):759-764. doi: 10.1080/15384101.2017.1295185. Epub 2017 Feb 22.

10.

p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.

Scott A, Bai F, Chan HL, Liu S, Ma J, Slingerland JM, Robbins DJ, Capobianco AJ, Pei XH.

Oncotarget. 2016 Dec 20;7(51):84496-84507. doi: 10.18632/oncotarget.13015.

11.

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.

Liu S, Chan HL, Bai F, Ma J, Scott A, Robbins DJ, Capobianco AJ, Zhu P, Pei XH.

Oncotarget. 2016 Sep 27;7(39):64007-64020. doi: 10.18632/oncotarget.11746.

12.

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.

Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E.

Cell Rep. 2016 May 31;15(9):1920-9. doi: 10.1016/j.celrep.2016.04.070. Epub 2016 May 19.

13.

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD Jr, Capobianco AJ.

Cancer Res. 2016 Jun 15;76(12):3593-603. doi: 10.1158/0008-5472.CAN-16-0061. Epub 2016 Apr 13.

14.

Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner.

Li B, Giambelli C, Tang B, Winterbottom E, Long J, Jin K, Wang Z, Fei DL, Nguyen DM, Athar M, Wang B, Subbarayan PR, Wang L, Rai P, Ardalan B, Capobianco AJ, Robbins DJ.

Mol Pharmacol. 2016 Feb;89(2):226-32. doi: 10.1124/mol.115.100867. Epub 2015 Nov 16.

15.

Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion.

Shao H, Kong R, Ferrari ML, Radtke F, Capobianco AJ, Liu ZJ.

PLoS One. 2015 Nov 12;10(11):e0142815. doi: 10.1371/journal.pone.0142815. eCollection 2015.

16.

The Notch signaling pathway in esophageal adenocarcinoma.

Wang Z, Chen J, Capobianco AJ.

Cell Mol Biol (Noisy-le-grand). 2015 Oct 30;61(6):24-32. Review.

PMID:
26518893
17.

GLI3 Links Environmental Arsenic Exposure and Human Fetal Growth.

Winterbottom EF, Fei DL, Koestler DC, Giambelli C, Wika E, Capobianco AJ, Lee E, Marsit CJ, Karagas MR, Robbins DJ.

EBioMedicine. 2015 May 1;2(6):536-43. doi: 10.1016/j.ebiom.2015.04.019. eCollection 2015 Jun.

18.

Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL.

Pelullo M, Quaranta R, Talora C, Checquolo S, Cialfi S, Felli MP, te Kronnie G, Borga C, Besharat ZM, Palermo R, Di Marcotullio L, Capobianco AJ, Gulino A, Screpanti I, Bellavia D.

Neoplasia. 2014 Dec;16(12):1007-17. doi: 10.1016/j.neo.2014.10.004.

19.

Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.

Allen BK, Stathias V, Maloof ME, Vidovic D, Winterbottom EF, Capobianco AJ, Clarke J, Schurer S, Robbins DJ, Ayad NG.

J Cell Biochem. 2015 Mar;116(3):351-63. doi: 10.1002/jcb.24990. Review.

PMID:
25290986
20.

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development.

Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou CM, Livingstone AS, Robbins DJ, Capobianco AJ, Pei XH.

Cancer Res. 2014 Nov 1;74(21):6161-72. doi: 10.1158/0008-5472.CAN-14-1119. Epub 2014 Sep 19.

21.

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma.

Wang Z, Da Silva TG, Jin K, Han X, Ranganathan P, Zhu X, Sanchez-Mejias A, Bai F, Li B, Fei DL, Weaver K, Carpio RV, Moscowitz AE, Koshenkov VP, Sanchez L, Sparling L, Pei XH, Franceschi D, Ribeiro A, Robbins DJ, Livingstone AS, Capobianco AJ.

Cancer Res. 2014 Nov 1;74(21):6364-74. doi: 10.1158/0008-5472.CAN-14-2051. Epub 2014 Aug 27.

22.

NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

Weaver KL, Alves-Guerra MC, Jin K, Wang Z, Han X, Ranganathan P, Zhu X, DaSilva T, Liu W, Ratti F, Demarest RM, Tzimas C, Rice M, Vasquez-Del Carpio R, Dahmane N, Robbins DJ, Capobianco AJ.

Cancer Res. 2014 Sep 1;74(17):4741-51. doi: 10.1158/0008-5472.CAN-14-1547. Epub 2014 Jul 18.

23.

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

Li B, Flaveny CA, Giambelli C, Fei DL, Han L, Hang BI, Bai F, Pei XH, Nose V, Burlingame O, Capobianco AJ, Orton D, Lee E, Robbins DJ.

PLoS One. 2014 Jul 8;9(7):e101969. doi: 10.1371/journal.pone.0101969. eCollection 2014.

24.

Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ.

Cancer Res. 2014 Sep 1;74(17):4811-21. doi: 10.1158/0008-5472.CAN-14-0317. Epub 2014 Jul 3.

25.

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses.

Azzam DJ, Zhao D, Sun J, Minn AJ, Ranganathan P, Drews-Elger K, Han X, Picon-Ruiz M, Gilbert CA, Wander SA, Capobianco AJ, El-Ashry D, Slingerland JM.

EMBO Mol Med. 2013 Oct;5(10):1502-22. doi: 10.1002/emmm.201302558. Epub 2013 Aug 27.

26.

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.

Licciulli S, Avila JL, Hanlon L, Troutman S, Cesaroni M, Kota S, Keith B, Simon MC, Puré E, Radtke F, Capobianco AJ, Kissil JL.

Cancer Res. 2013 Oct 1;73(19):5974-84. doi: 10.1158/0008-5472.CAN-13-1384. Epub 2013 Aug 13.

27.

Retraction: Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

Negorev DG, Vladimirova OV, Kossenkov AV, Demarest RM, Showe MK, Rauscher FJ 3rd, Showe LC, Nikonova EV, Capobianco AJ.

Cancer Res. 2013 Aug 1;73(15):4960-1. doi: 10.1158/0008-5472.CAN-13-1715. No abstract available.

28.

Hedgehog signaling regulates bladder cancer growth and tumorigenicity.

Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, Bejarano P, Capobianco AJ, Robbins DJ.

Cancer Res. 2012 Sep 1;72(17):4449-58. Epub 2012 Jul 19.

29.

The hedgehog processing pathway is required for NSCLC growth and survival.

Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, Lam WL, Dmitrovsky E, Capobianco AJ, Robbins DJ.

Oncogene. 2013 May 2;32(18):2335-45. doi: 10.1038/onc.2012.243. Epub 2012 Jun 25.

30.

Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity.

Ranganathan P, Vasquez-Del Carpio R, Kaplan FM, Wang H, Gupta A, VanWye JD, Capobianco AJ.

J Biol Chem. 2011 Aug 19;286(33):28844-57. doi: 10.1074/jbc.M111.243600. Epub 2011 Jun 17.

31.

Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.

Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ.

Cancer Res. 2011 Jul 1;71(13):4454-63. doi: 10.1158/0008-5472.CAN-10-2313. Epub 2011 May 12.

32.

Notch signalling in solid tumours: a little bit of everything but not all the time.

Ranganathan P, Weaver KL, Capobianco AJ.

Nat Rev Cancer. 2011 May;11(5):338-51. doi: 10.1038/nrc3035. Epub 2011 Apr 14. Review.

PMID:
21508972
33.

Assembly of a Notch transcriptional activation complex requires multimerization.

Vasquez-Del Carpio R, Kaplan FM, Weaver KL, VanWye JD, Alves-Guerra MC, Robbins DJ, Capobianco AJ.

Mol Cell Biol. 2011 Apr;31(7):1396-408. doi: 10.1128/MCB.00360-10. Epub 2011 Jan 18.

34.

Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia.

Demarest RM, Dahmane N, Capobianco AJ.

Blood. 2011 Mar 10;117(10):2901-9. doi: 10.1182/blood-2010-05-286351. Epub 2011 Jan 7. Erratum in: Blood. 2011 Jun 16;117(24):6739.

35.

Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

Negorev DG, Vladimirova OV, Kossenkov AV, Nikonova EV, Demarest RM, Capobianco AJ, Showe MK, Rauscher FJ 3rd, Showe LC, Maul GG.

Cancer Res. 2010 Dec 1;70(23):9991-10001. doi: 10.1158/0008-5472.CAN-10-1483. Epub 2010 Nov 30. Retraction in: Negorev DG, Vladimirova OV, Kossenkov AV, Demarest RM, Showe MK, Rauscher FJ 3rd, Showe LC, Nikonova EV, Capobianco AJ. Cancer Res. 2013 Aug 1;73(15):4960-1.

36.

Epimorphic regeneration in mice is p53-independent.

Arthur LM, Demarest RM, Clark L, Gourevitch D, Bedelbaeva K, Anderson R, Snyder A, Capobianco AJ, Lieberman P, Feigenbaum L, Heber-Katz E.

Cell Cycle. 2010 Sep 15;9(18):3667-73. Epub 2010 Sep 21.

37.

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.

Hanlon L, Avila JL, Demarest RM, Troutman S, Allen M, Ratti F, Rustgi AK, Stanger BZ, Radtke F, Adsay V, Long F, Capobianco AJ, Kissil JL.

Cancer Res. 2010 Jun 1;70(11):4280-6. doi: 10.1158/0008-5472.CAN-09-4645. Epub 2010 May 18.

38.

Active Notch1 confers a transformed phenotype to primary human melanocytes.

Pinnix CC, Lee JT, Liu ZJ, McDaid R, Balint K, Beverly LJ, Brafford PA, Xiao M, Himes B, Zabierowski SE, Yashiro-Ohtani Y, Nathanson KL, Bengston A, Pollock PM, Weeraratna AT, Nickoloff BJ, Pear WS, Capobianco AJ, Herlyn M.

Cancer Res. 2009 Jul 1;69(13):5312-20. doi: 10.1158/0008-5472.CAN-08-3767. Epub 2009 Jun 23.

39.

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.

Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA.

Blood. 2009 Feb 19;113(8):1689-98. doi: 10.1182/blood-2008-03-147967. Epub 2008 Nov 10.

40.

It's T-ALL about Notch.

Demarest RM, Ratti F, Capobianco AJ.

Oncogene. 2008 Sep 1;27(38):5082-91. doi: 10.1038/onc.2008.222. Review.

PMID:
18758476
41.
42.

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T.

Cancer Res. 2007 Sep 1;67(17):8089-94.

43.

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.

Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ, Kelliher MA.

Mol Cell Biol. 2006 Nov;26(21):8022-31. Epub 2006 Sep 5.

44.

Expression of JAGGED1 in T-lymphocytes results in thymic involution by inducing apoptosis of thymic stromal epithelial cells.

Beverly LJ, Ascano JM, Capobianco AJ.

Genes Immun. 2006 Sep;7(6):476-86. Epub 2006 Jun 22.

PMID:
16791277
45.

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1.

Liu ZJ, Xiao M, Balint K, Soma A, Pinnix CC, Capobianco AJ, Velazquez OC, Herlyn M.

FASEB J. 2006 May;20(7):1009-11. Epub 2006 Mar 29.

PMID:
16571776
46.

Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.

Balint K, Xiao M, Pinnix CC, Soma A, Veres I, Juhasz I, Brown EJ, Capobianco AJ, Herlyn M, Liu ZJ.

J Clin Invest. 2005 Nov;115(11):3166-76. Epub 2005 Oct 20.

47.

Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.

Zhang XY, DeSalle LM, Patel JH, Capobianco AJ, Yu D, Thomas-Tikhonenko A, McMahon SB.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13968-73. Epub 2005 Sep 19.

48.

Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression.

Beverly LJ, Felsher DW, Capobianco AJ.

Cancer Res. 2005 Aug 15;65(16):7159-68.

49.

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.

Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9884-9. Epub 2005 Jun 30. Erratum in: Proc Natl Acad Sci U S A. 2006 May 9;103(19):7530.

50.

Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost.

Beverly LJ, Capobianco AJ.

Trends Mol Med. 2004 Dec;10(12):591-8. Review.

PMID:
15567329

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