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Analysis and Characterization of Immune Cells and Their Activation Status by Whole-Cell MALDI-TOF Mass Spectrometry.

Ouedraogo R, Textoris J, Gorvel L, Daumas A, Capo C, Mege JL.

Methods Mol Biol. 2019;2024:339-351. doi: 10.1007/978-1-4939-9597-4_23.


Succinic semialdehyde dehydrogenase deficiency: The combination of a novel ALDH5A1 gene mutation and a missense SNP strongly affects SSADH enzyme activity and stability.

Menduti G, Biamino E, Vittorini R, Vesco S, Puccinelli MP, Porta F, Capo C, Leo S, Ciminelli BM, Iacovelli F, Spada M, Falconi M, Malaspina P, Rossi L.

Mol Genet Metab. 2018 Jul;124(3):210-215. doi: 10.1016/j.ymgme.2018.05.006. Epub 2018 Jun 2.


Oleuropein shows copper complexing properties and noxious effect on cultured SH-SY5Y neuroblastoma cells depending on cell copper content.

Capo CR, Pedersen JZ, Falconi M, Rossi L.

J Trace Elem Med Biol. 2017 Dec;44:225-232. doi: 10.1016/j.jtemb.2017.08.002. Epub 2017 Aug 5.


SSADH deficiency in an Italian family: a novel ALDH5A1 gene mutation affecting the succinic semialdehyde substrate binding site.

Leo S, Capo C, Ciminelli BM, Iacovelli F, Menduti G, Funghini S, Donati MA, Falconi M, Rossi L, Malaspina P.

Metab Brain Dis. 2017 Oct;32(5):1383-1388. doi: 10.1007/s11011-017-0058-5. Epub 2017 Jun 29.


Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload.

Arciello M, Longo A, Viscomi C, Capo C, Angeloni A, Rossi L, Balsano C.

Biometals. 2015 Dec;28(6):1017-29. doi: 10.1007/s10534-015-9886-0. Epub 2015 Oct 5.


Imbalance of circulating monocyte subsets and PD-1 dysregulation in Q fever endocarditis: the role of IL-10 in PD-1 modulation.

Ka MB, Gondois-Rey F, Capo C, Textoris J, Million M, Raoult D, Olive D, Mege JL.

PLoS One. 2014 Sep 11;9(9):e107533. doi: 10.1371/journal.pone.0107533. eCollection 2014.


Acute vocal fold hemorrhage after phonosurgery.

Portnoy JE, Capo C, Sataloff RT.

Ear Nose Throat J. 2014 Jul;93(7):E33. No abstract available.


Intracellular bacteria interfere with dendritic cell functions: role of the type I interferon pathway.

Gorvel L, Textoris J, Banchereau R, Ben Amara A, Tantibhedhyangkul W, von Bargen K, Ka MB, Capo C, Ghigo E, Gorvel JP, Mege JL.

PLoS One. 2014 Jun 10;9(6):e99420. doi: 10.1371/journal.pone.0099420. eCollection 2014.


Persistence of Coxiella burnetii, the agent of Q fever, in murine adipose tissue.

Bechah Y, Verneau J, Ben Amara A, Barry AO, Lépolard C, Achard V, Panicot-Dubois L, Textoris J, Capo C, Ghigo E, Mege JL.

PLoS One. 2014 May 16;9(5):e97503. doi: 10.1371/journal.pone.0097503. eCollection 2014.


Whole-cell MALDI-TOF mass spectrometry is an accurate and rapid method to analyze different modes of macrophage activation.

Ouedraogo R, Daumas A, Capo C, Mege JL, Textoris J.

J Vis Exp. 2013 Dec 26;(82):50926. doi: 10.3791/50926.


Early sex-specific modulation of the molecular clock in trauma.

Mehraj V, Wiramus S, Capo C, Leone M, Mege JL, Textoris J.

J Trauma Acute Care Surg. 2014 Jan;76(1):241-4. doi: 10.1097/TA.0b013e3182a90014.


Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells.

De Benedetto ML, Capo CR, Ferri A, Valle C, Polimanti R, Carrì MT, Rossi L.

Biochim Biophys Acta. 2014 Jan;1840(1):255-61. doi: 10.1016/j.bbagen.2013.09.008. Epub 2013 Sep 13.


Whole-cell MALDI-TOF mass spectrometry: a tool for immune cell analysis and characterization.

Ouedraogo R, Textoris J, Daumas A, Capo C, Mege JL.

Methods Mol Biol. 2013;1061:197-209. doi: 10.1007/978-1-62703-589-7_12.


Monocyte responses in the context of Q fever: from a static polarized model to a kinetic model of activation.

Mehraj V, Textoris J, Ben Amara A, Ghigo E, Raoult D, Capo C, Mege JL.

J Infect Dis. 2013 Sep;208(6):942-51. doi: 10.1093/infdis/jit266. Epub 2013 Jun 24.


Impaired stimulation of p38α-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes.

Barry AO, Boucherit N, Mottola G, Vadovic P, Trouplin V, Soubeyran P, Capo C, Bonatti S, Nebreda A, Toman R, Lemichez E, Mege JL, Ghigo E.

Cell Host Microbe. 2012 Dec 13;12(6):751-63. doi: 10.1016/j.chom.2012.10.015.


Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages.

Tantibhedhyangkul W, Ben Amara A, Textoris J, Gorvel L, Ghigo E, Capo C, Mege JL.

Microb Pathog. 2013 Feb;55:55-63. doi: 10.1016/j.micpath.2012.10.001. Epub 2012 Oct 23.


Overexpression of the Per2 gene in male patients with acute Q fever.

Mehraj V, Textoris J, Capo C, Raoult D, Leone M, Mege JL.

J Infect Dis. 2012 Dec 1;206(11):1768-70. doi: 10.1093/infdis/jis600. Epub 2012 Sep 14.


Whole-cell MALDI-TOF MS: a new tool to assess the multifaceted activation of macrophages.

Ouedraogo R, Daumas A, Ghigo E, Capo C, Mege JL, Textoris J.

J Proteomics. 2012 Oct 22;75(18):5523-32. doi: 10.1016/j.jprot.2012.07.046. Epub 2012 Aug 8.


Role of innate and adaptive immunity in the control of Q fever.

Capo C, Mege JL.

Adv Exp Med Biol. 2012;984:273-86. doi: 10.1007/978-94-007-4315-1_14. Review.


Defective monocyte dynamics in Q fever granuloma deficiency.

Delaby A, Gorvel L, Espinosa L, Lépolard C, Raoult D, Ghigo E, Capo C, Mege JL.

J Infect Dis. 2012 Apr 1;205(7):1086-94. doi: 10.1093/infdis/jis013. Epub 2012 Feb 20.


The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis.

Thuny F, Textoris J, Amara AB, Filali AE, Capo C, Habib G, Raoult D, Mege JL.

PLoS One. 2012;7(2):e31490. doi: 10.1371/journal.pone.0031490. Epub 2012 Feb 3.


Foxp3(+)CD4(+)CD25(+) regulatory T cells are increased in patients with Coxiella burnetii endocarditis.

Layez C, Brunet C, Lépolard C, Ghigo E, Capo C, Raoult D, Mege JL.

FEMS Immunol Med Microbiol. 2012 Feb;64(1):137-9. doi: 10.1111/j.1574-695X.2011.00902.x. Epub 2011 Dec 22.


Effects of Coxiella burnetii on MAPKinases phosphorylation.

Boucherit N, Barry AO, Mottola G, Trouplin V, Capo C, Mege JL, Ghigo E.

FEMS Immunol Med Microbiol. 2012 Feb;64(1):101-3. doi: 10.1111/j.1574-695X.2011.00852.x. Epub 2011 Aug 30.


The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever.

Mehraj V, Boucherit N, Ben Amara A, Capo C, Bonatti S, Mege JL, Mottola G, Ghigo E.

FEMS Immunol Med Microbiol. 2012 Feb;64(1):98-100. doi: 10.1111/j.1574-695X.2011.00860.x.


Orientia tsutsugamushi stimulates an original gene expression program in monocytes: relationship with gene expression in patients with scrub typhus.

Tantibhedhyangkul W, Prachason T, Waywa D, El Filali A, Ghigo E, Thongnoppakhun W, Raoult D, Suputtamongkol Y, Capo C, Limwongse C, Mege JL.

PLoS Negl Trop Dis. 2011 May;5(5):e1028. doi: 10.1371/journal.pntd.0001028. Epub 2011 May 17.


Tropheryma whipplei, the Whipple's disease bacillus, induces macrophage apoptosis through the extrinsic pathway.

Gorvel L, Al Moussawi K, Ghigo E, Capo C, Mege JL, Desnues B.

Cell Death Dis. 2010 Apr 8;1:e34. doi: 10.1038/cddis.2010.11.


Macrophage polarization and bacterial infections.

Mège JL, Mehraj V, Capo C.

Curr Opin Infect Dis. 2011 Jun;24(3):230-4. doi: 10.1097/QCO.0b013e328344b73e. Review.


Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response.

Ben Amara A, Ghigo E, Le Priol Y, Lépolard C, Salcedo SP, Lemichez E, Bretelle F, Capo C, Mege JL.

PLoS One. 2010 Dec 14;5(12):e15315. doi: 10.1371/journal.pone.0015315.


Copper depletion increases the mitochondrial-associated SOD1 in neuronal cells.

Arciello M, Capo CR, D'Annibale S, Cozzolino M, Ferri A, Carrì MT, Rossi L.

Biometals. 2011 Apr;24(2):269-78. doi: 10.1007/s10534-010-9392-3. Epub 2010 Dec 8.


Global analysis of circulating immune cells by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

Ouedraogo R, Flaudrops C, Ben Amara A, Capo C, Raoult D, Mege JL.

PLoS One. 2010 Oct 27;5(10):e13691. doi: 10.1371/journal.pone.0013691.


IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation.

Ghigo E, Barry AO, Pretat L, Al Moussawi K, Desnues B, Capo C, Kornfeld H, Mege JL.

PLoS One. 2010 Oct 21;5(10):e13561. doi: 10.1371/journal.pone.0013561.


Sex-related differences in gene expression following Coxiella burnetii infection in mice: potential role of circadian rhythm.

Textoris J, Ban LH, Capo C, Raoult D, Leone M, Mege JL.

PLoS One. 2010 Aug 13;5(8):e12190. doi: 10.1371/journal.pone.0012190.


3D reconstruction of granulomas from transmitted light images implemented for long-time microscope applications.

Delaby A, Espinosa L, Lépolard C, Capo C, Mège JL.

J Immunol Methods. 2010 Aug 31;360(1-2):10-9. doi: 10.1016/j.jim.2010.06.008. Epub 2010 Jun 16. Review.


[Is macrophage polarization the Gordian knot of bacterial infections?].

Mege JL, Capo C.

Med Sci (Paris). 2010 Jan;26(1):83-8. doi: 10.1051/medsci/201026183. Review. French.


The transcriptional programme of human heart valves reveals the natural history of infective endocarditis.

Benoit M, Thuny F, Le Priol Y, Lepidi H, Bastonero S, Casalta JP, Collart F, Capo C, Raoult D, Mege JL.

PLoS One. 2010 Jan 28;5(1):e8939. doi: 10.1371/journal.pone.0008939.


Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model.

Bechah Y, Paddock CD, Capo C, Mege JL, Raoult D.

PLoS One. 2010 Jan 1;5(1):e8547. doi: 10.1371/journal.pone.0008547.


Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide.

Arciello M, Capo CR, Cozzolino M, Ferri A, Nencini M, Carrì MT, Rossi L.

J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.


Role of the cytoplasmic pattern recognition receptor Nod2 in Coxiella burnetii infection.

Benoit M, Bechah Y, Capo C, Murray PJ, Mege JL, Desnues B.

Clin Microbiol Infect. 2009 Dec;15 Suppl 2:154-5. doi: 10.1111/j.1469-0691.2008.02270.x. Epub 2009 Jun 22. No abstract available.


Intracellular life of Coxiella burnetii in macrophages.

Ghigo E, Pretat L, Desnues B, Capo C, Raoult D, Mege JL.

Ann N Y Acad Sci. 2009 May;1166:55-66. doi: 10.1111/j.1749-6632.2009.04515.x. Review.


Rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through alphavbeta3 integrin engagement.

Bechah Y, Capo C, Grau G, Raoult D, Mege JL.

Clin Microbiol Infect. 2009 Dec;15 Suppl 2:249-50. doi: 10.1111/j.1469-0691.2008.02675.x. Epub 2009 Apr 30. No abstract available.


Intracellular trafficking of the Coxiella burnetii lipopolysaccharide.

Pretat L, Toman R, Vadovic P, Capo C, Mege JL, Ghigo E.

Clin Microbiol Infect. 2009 Dec;15 Suppl 2:185-7. doi: 10.1111/j.1469-0691.2008.02219.x. Epub 2009 Mar 26. No abstract available.


New microbicidal functions of tracheal glands: defective anti-infectious response to Pseudomonas aeruginosa in cystic fibrosis.

Bastonero S, Le Priol Y, Armand M, Bernard CS, Reynaud-Gaubert M, Olive D, Parzy D, de Bentzmann S, Capo C, Mege JL.

PLoS One. 2009;4(4):e5357. doi: 10.1371/journal.pone.0005357. Epub 2009 Apr 28.


Epidemic typhus.

Bechah Y, Capo C, Mege JL, Raoult D.

Lancet Infect Dis. 2008 Jul;8(7):417-26. doi: 10.1016/S1473-3099(08)70150-6. Review.


Ameobal pathogen mimivirus infects macrophages through phagocytosis.

Ghigo E, Kartenbeck J, Lien P, Pelkmans L, Capo C, Mege JL, Raoult D.

PLoS Pathog. 2008 Jun 13;4(6):e1000087. doi: 10.1371/journal.ppat.1000087.


The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis.

Benoit M, Ghigo E, Capo C, Raoult D, Mege JL.

PLoS Pathog. 2008 May 16;4(5):e1000066. doi: 10.1371/journal.ppat.1000066.


Benefits from dietary polyphenols for brain aging and Alzheimer's disease.

Rossi L, Mazzitelli S, Arciello M, Capo CR, Rotilio G.

Neurochem Res. 2008 Dec;33(12):2390-400. doi: 10.1007/s11064-008-9696-7. Epub 2008 Apr 16. Review.


Rickettsial diseases: from Rickettsia-arthropod relationships to pathophysiology and animal models.

Bechah Y, Capo C, Mege JL, Raoult D.

Future Microbiol. 2008 Apr;3(2):223-36. doi: 10.2217/17460913.3.2.223. Review.


Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor.

Mokart D, Kipnis E, Guerre-Berthelot P, Vey N, Capo C, Sannini A, Brun JP, Blache JL, Mege JL, Blaise D, Guery BP.

Crit Care. 2008;12(1):R17. doi: 10.1186/cc6791. Epub 2008 Feb 18.


Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis.

Meghari S, Bechah Y, Capo C, Lepidi H, Raoult D, Murray PJ, Mege JL.

PLoS Pathog. 2008 Feb 8;4(2):e23. doi: 10.1371/journal.ppat.0040023.


Infection of endothelial cells with virulent Rickettsia prowazekii increases the transmigration of leukocytes.

Bechah Y, Capo C, Raoult D, Mege JL.

J Infect Dis. 2008 Jan 1;197(1):142-7. doi: 10.1086/523649.


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