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Holding open the door reveals a new view of polycystin channel function.

Caplan MJ.

EMBO Rep. 2019 Nov 5;20(11):e49156. doi: 10.15252/embr.201949156. Epub 2019 Sep 26.


Everything You Always Wanted to Know about β3-AR * (* But Were Afraid to Ask).

Schena G, Caplan MJ.

Cells. 2019 Apr 16;8(4). pii: E357. doi: 10.3390/cells8040357. Review.


The Polycystin Complex Reveals Its Complexity.

Padovano V, Caplan MJ.

Biochemistry. 2018 Dec 26;57(51):6917-6918. doi: 10.1021/acs.biochem.8b01205. Epub 2018 Dec 12. No abstract available.


Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ.

Merrick D, Mistry K, Wu J, Gresko N, Baggs JE, Hogenesch JB, Sun Z, Caplan MJ.

Hum Mol Genet. 2019 Jan 1;28(1):16-30. doi: 10.1093/hmg/ddy322.


Newly synthesized polycystin-1 takes different trafficking pathways to the apical and ciliary membranes.

Gilder AL, Chapin HC, Padovano V, Hueschen CL, Rajendran V, Caplan MJ.

Traffic. 2018 Dec;19(12):933-945. doi: 10.1111/tra.12612. Epub 2018 Sep 24.


Metabolism and mitochondria in polycystic kidney disease research and therapy.

Padovano V, Podrini C, Boletta A, Caplan MJ.

Nat Rev Nephrol. 2018 Nov;14(11):678-687. doi: 10.1038/s41581-018-0051-1. Review.


Implications of AMPK in the Formation of Epithelial Tight Junctions.

Rowart P, Wu J, Caplan MJ, Jouret F.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2040. doi: 10.3390/ijms19072040. Review.


The secretory pathway at 50: a golden anniversary for some momentous grains of silver.

Matlin KS, Caplan MJ.

Mol Biol Cell. 2017 Jan 15;28(2):229-232. doi: 10.1091/mbc.E16-07-0508.


The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function.

Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ.

Mol Biol Cell. 2017 Jan 15;28(2):261-269. doi: 10.1091/mbc.E16-08-0597. Epub 2016 Nov 23.


Newly synthesized and recycling pools of the apical protein gp135 do not occupy the same compartments.

Stoops EH, Hull M, Caplan MJ.

Traffic. 2016 Dec;17(12):1272-1285. doi: 10.1111/tra.12449. Epub 2016 Nov 1.


A Practical Forensic Approach to Fatal Pediatric Endocrinopathies.

Caplan MJ.

Acad Forensic Pathol. 2016 Jun;6(2):258-270. doi: 10.23907/2016.027. Epub 2016 Jun 1. Review.


Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy.

Siefert AL, Caplan MJ, Fahmy TM.

Biomaterials. 2016 Aug;97:85-96. doi: 10.1016/j.biomaterials.2016.03.039. Epub 2016 Apr 1.


Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy.

Srivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA.

J Allergy Clin Immunol. 2016 Aug;138(2):536-543.e4. doi: 10.1016/j.jaci.2016.01.047. Epub 2016 Apr 26.


The tail of polycystin-1 pays the kidney a complement.

Caplan MJ.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1180-1. doi: 10.1152/ajprenal.00141.2016. Epub 2016 Mar 23. No abstract available.


2016 Robert W. Berliner Award for Excellence in Renal Physiology.

Caplan MJ.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F803-F804. doi: 10.1152/ajprenal.00128.2016. Epub 2016 Mar 9. No abstract available.


The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135.

Stoops EH, Hull M, Olesen C, Mistry K, Harder JL, Rivera-Molina F, Toomre D, Caplan MJ.

J Cell Biol. 2015 Oct 26;211(2):287-94. doi: 10.1083/jcb.201502045.


Dual pulse-chase microscopy reveals early divergence in the biosynthetic trafficking of the Na,K-ATPase and E-cadherin.

Farr GA, Hull M, Stoops EH, Bateson R, Caplan MJ.

Mol Biol Cell. 2015 Dec 1;26(24):4401-11. doi: 10.1091/mbc.E14-09-1385. Epub 2015 Sep 30.


Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability.

Pedrozo Z, Criollo A, Battiprolu PK, Morales CR, Contreras-Ferrat A, Fernández C, Jiang N, Luo X, Caplan MJ, Somlo S, Rothermel BA, Gillette TG, Lavandero S, Hill JA.

Circulation. 2015 Jun 16;131(24):2131-42. doi: 10.1161/CIRCULATIONAHA.114.013537. Epub 2015 Apr 17.


Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia.

Alves DS, Thulin G, Loffing J, Kashgarian M, Caplan MJ.

J Am Soc Nephrol. 2015 Nov;26(11):2765-76. doi: 10.1681/ASN.2013101040. Epub 2015 Mar 18.


Developmental lung malformations in children: recent advances in imaging techniques, classification system, and imaging findings.

Thacker PG, Schooler GR, Caplan MJ, Lee EY.

J Thorac Imaging. 2015 Jan;30(1):29-43; quiz 44-5. doi: 10.1097/RTI.0000000000000125. Review.


Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice.

Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, Ueno Y, Tsukita S, Asano S.

Hepatology. 2015 May;61(5):1660-71. doi: 10.1002/hep.27565. Epub 2015 Mar 23.


Chemical and Physical Sensors in the Regulation of Renal Function.

Pluznick JL, Caplan MJ.

Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1626-35. doi: 10.2215/CJN.00730114. Epub 2014 Oct 3. Review.


SNAP-tag to monitor trafficking of membrane proteins in polarized epithelial cells.

Stoops EH, Farr GA, Hull M, Caplan MJ.

Methods Mol Biol. 2014;1174:171-82. doi: 10.1007/978-1-4939-0944-5_11.


Trafficking to the apical and basolateral membranes in polarized epithelial cells.

Stoops EH, Caplan MJ.

J Am Soc Nephrol. 2014 Jul;25(7):1375-86. doi: 10.1681/ASN.2013080883. Epub 2014 Mar 20. Review.


A growing lesion on the cheek.

Rawl JW, Caplan MJ, Lentsch EJ.

JAMA Otolaryngol Head Neck Surg. 2014 Apr;140(4):383-4. doi: 10.1001/jamaoto.2013.6770. No abstract available.


Sex differences in cerebral blood flow following chorioamnionitis in healthy term infants.

Koch FR, Wagner CL, Jenkins DD, Caplan MJ, Perkel JK, Rollins LG, Katikaneni LD, Mulvihill DM.

J Perinatol. 2014 Mar;34(3):197-202. doi: 10.1038/jp.2013.179. Epub 2014 Jan 23.


Activation of the Ca²+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane.

Jouret F, Wu J, Hull M, Rajendran V, Mayr B, Schöfl C, Geibel J, Caplan MJ.

J Cell Sci. 2013 Nov 15;126(Pt 22):5132-42. doi: 10.1242/jcs.127555. Epub 2013 Sep 6.


Polycystin-1 cleavage and the regulation of transcriptional pathways.

Merrick D, Bertuccio CA, Chapin HC, Lal M, Chauvet V, Caplan MJ.

Pediatr Nephrol. 2014 Apr;29(4):505-11. doi: 10.1007/s00467-013-2548-y. Epub 2013 Jul 4. Review.


Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity.

Bryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, Redegeld F, Blokhuis BR, Wojcikowski J, Daniel AW, Groot Kormelink T, Askenase PW.

J Allergy Clin Immunol. 2013 Jul;132(1):170-81. doi: 10.1016/j.jaci.2013.04.048. Epub 2013 May 31.


An inversin convergence. Focus on "Inversin modulates the cortical actin network during mitosis".

Caplan MJ.

Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C22-3. doi: 10.1152/ajpcell.00126.2013. Epub 2013 May 15. No abstract available.


Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8.

Wells EK, Yarborough O 3rd, Lifton RP, Cantley LG, Caplan MJ.

Am J Physiol Cell Physiol. 2013 May 15;304(10):C966-75. doi: 10.1152/ajpcell.00261.2012. Epub 2013 Mar 13.


A rapidly expanding orbital lesion.

Magrath GN, Cheeseman EW, Eiseman AS, Caplan MJ.

J Pediatr. 2013 Jul;163(1):294-5.e1-2. doi: 10.1016/j.jpeds.2013.01.038. Epub 2013 Feb 28. No abstract available.


Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.

Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4410-5. doi: 10.1073/pnas.1215927110. Epub 2013 Feb 11.


VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis.

Takiar V, Mistry K, Carmosino M, Schaeren-Wiemers N, Caplan MJ.

Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C862-71. doi: 10.1152/ajpcell.00338.2011. Epub 2012 Aug 15.


Novel sensory signaling systems in the kidney.

Pluznick JL, Caplan MJ.

Curr Opin Nephrol Hypertens. 2012 Jul;21(4):404-9. doi: 10.1097/MNH.0b013e328354a6bd. Review.


Protein phosphatase 2A interacts with the Na,K-ATPase and modulates its trafficking by inhibition of its association with arrestin.

Kimura T, Han W, Pagel P, Nairn AC, Caplan MJ.

PLoS One. 2011;6(12):e29269. doi: 10.1371/journal.pone.0029269. Epub 2011 Dec 29.


The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism.

Merrick D, Chapin H, Baggs JE, Yu Z, Somlo S, Sun Z, Hogenesch JB, Caplan MJ.

Dev Cell. 2012 Jan 17;22(1):197-210. doi: 10.1016/j.devcel.2011.10.028. Epub 2011 Dec 15.


Disseminated neuroendocrine carcinoma in a pediatric patient: a rare case and diagnostic challenge.

Post GR, Lewis JA, Hudspeth MP, Caplan MJ, Lazarchick J.

J Pediatr Hematol Oncol. 2012 Apr;34(3):200-3. doi: 10.1097/MPH.0b013e3182288235.


Macrophages promote cyst growth in polycystic kidney disease.

Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG.

J Am Soc Nephrol. 2011 Oct;22(10):1809-14. doi: 10.1681/ASN.2011010084. Epub 2011 Sep 15.


Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

Seo-Mayer PW, Thulin G, Zhang L, Alves DS, Ardito T, Kashgarian M, Caplan MJ.

Am J Physiol Renal Physiol. 2011 Dec;301(6):F1346-57. doi: 10.1152/ajprenal.00420.2010. Epub 2011 Aug 17.


Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.

Choi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84. doi: 10.1073/pnas.1016214108. Epub 2011 Jun 13.


Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium.

Pluznick JL, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ.

PLoS One. 2011;6(5):e19694. doi: 10.1371/journal.pone.0019694. Epub 2011 May 13.


AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.

Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ.

J Biol Chem. 2011 May 13;286(19):16879-90. doi: 10.1074/jbc.M110.186932. Epub 2011 Mar 7.


Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.

Takiar V, Nishio S, Seo-Mayer P, King JD Jr, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2462-7. doi: 10.1073/pnas.1011498108. Epub 2011 Jan 24.


Polycystic kidney disease: pathogenesis and potential therapies.

Takiar V, Caplan MJ.

Biochim Biophys Acta. 2011 Oct;1812(10):1337-43. doi: 10.1016/j.bbadis.2010.11.014. Epub 2010 Dec 10. Review.


The cell biology of polycystic kidney disease.

Chapin HC, Caplan MJ.

J Cell Biol. 2010 Nov 15;191(4):701-10. doi: 10.1083/jcb.201006173. Review.


Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.

Chapin HC, Rajendran V, Caplan MJ.

Mol Biol Cell. 2010 Dec;21(24):4338-48. doi: 10.1091/mbc.E10-05-0407. Epub 2010 Oct 27.


AS160 associates with the Na+,K+-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression.

Alves DS, Farr GA, Seo-Mayer P, Caplan MJ.

Mol Biol Cell. 2010 Dec;21(24):4400-8. doi: 10.1091/mbc.E10-06-0507. Epub 2010 Oct 13.


MAL/VIP17, a new player in the regulation of NKCC2 in the kidney.

Carmosino M, Rizzo F, Procino G, Basco D, Valenti G, Forbush B, Schaeren-Wiemers N, Caplan MJ, Svelto M.

Mol Biol Cell. 2010 Nov 15;21(22):3985-97. doi: 10.1091/mbc.E10-05-0456. Epub 2010 Sep 22.

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