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Items: 1 to 50 of 101

1.

Iron and Zinc in the Embryo and Endosperm of Rice (Oryza sativa L.) Seeds in Contrasting 2'-Deoxymugineic Acid/Nicotianamine Scenarios.

Díaz-Benito P, Banakar R, Rodríguez-Menéndez S, Capell T, Pereiro R, Christou P, Abadía J, Fernández B, Álvarez-Fernández A.

Front Plant Sci. 2018 Aug 21;9:1190. doi: 10.3389/fpls.2018.01190. eCollection 2018.

2.

CRISPR/Cas9-induced monoallelic mutations in the cytosolic AGPase large subunit gene APL2 induce the ectopic expression of APL2 and the corresponding small subunit gene APS2b in rice leaves.

Pérez L, Soto E, Villorbina G, Bassie L, Medina V, Muñoz P, Capell T, Zhu C, Christou P, Farré G.

Transgenic Res. 2018 Aug 11. doi: 10.1007/s11248-018-0089-7. [Epub ahead of print]

PMID:
30099722
3.

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm.

Vamvaka E, Farré G, Molinos-Albert LM, Evans A, Canela-Xandri A, Twyman RM, Carrillo J, Ordóñez RA, Shattock RJ, O'Keefe BR, Clotet B, Blanco J, Khush GS, Christou P, Capell T.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7854-E7862. doi: 10.1073/pnas.1806022115. Epub 2018 Jul 30.

4.

Carotenoids moderate the effectiveness of a Bt gene against the European corn borer, Ostrinia nubilalis.

Zanga D, Sanahuja G, Eizaguirre M, Albajes R, Christou P, Capell T, Fraser P, Gerrisch C, López C.

PLoS One. 2018 Jul 10;13(7):e0199317. doi: 10.1371/journal.pone.0199317. eCollection 2018.

5.

The Silencing of Carotenoid β-Hydroxylases by RNA Interference in Different Maize Genetic Backgrounds Increases the β-Carotene Content of the Endosperm.

Berman J, Zorrilla-López U, Sandmann G, Capell T, Christou P, Zhu C.

Int J Mol Sci. 2017 Nov 24;18(12). pii: E2515. doi: 10.3390/ijms18122515.

6.

Phytosiderophores determine thresholds for iron and zinc accumulation in biofortified rice endosperm while inhibiting the accumulation of cadmium.

Banakar R, Alvarez Fernandez A, Díaz-Benito P, Abadia J, Capell T, Christou P.

J Exp Bot. 2017 Oct 13;68(17):4983-4995. doi: 10.1093/jxb/erx304.

7.

Provitamin A carotenoids from an engineered high-carotenoid maize are bioavailable and zeaxanthin does not compromise β-carotene absorption in poultry.

Díaz-Gómez J, Moreno JA, Angulo E, Sandmann G, Zhu C, Capell T, Nogareda C.

Transgenic Res. 2017 Oct;26(5):591-601. doi: 10.1007/s11248-017-0029-y. Epub 2017 Jun 23.

PMID:
28646243
8.

The Arabidopsis ORANGE (AtOR) gene promotes carotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools.

Berman J, Zorrilla-López U, Medina V, Farré G, Sandmann G, Capell T, Christou P, Zhu C.

Plant Cell Rep. 2017 Jun;36(6):933-945. doi: 10.1007/s00299-017-2126-z. Epub 2017 Mar 17.

PMID:
28314904
9.

Biofortification of crops with nutrients: factors affecting utilization and storage.

Díaz-Gómez J, Twyman RM, Zhu C, Farré G, Serrano JC, Portero-Otin M, Muñoz P, Sandmann G, Capell T, Christou P.

Curr Opin Biotechnol. 2017 Apr;44:115-123. doi: 10.1016/j.copbio.2016.12.002. Epub 2017 Jan 6. Review.

PMID:
28068552
10.

A carotenogenic mini-pathway introduced into white corn does not affect development or agronomic performance.

Zanga D, Capell T, Slafer GA, Christou P, Savin R.

Sci Rep. 2016 Dec 6;6:38288. doi: 10.1038/srep38288.

11.

The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage.

Moreno JA, Díaz-Gómez J, Nogareda C, Angulo E, Sandmann G, Portero-Otin M, Serrano JC, Twyman RM, Capell T, Zhu C, Christou P.

Sci Rep. 2016 Oct 14;6:35346. doi: 10.1038/srep35346.

12.

Characteristics of Genome Editing Mutations in Cereal Crops.

Zhu C, Bortesi L, Baysal C, Twyman RM, Fischer R, Capell T, Schillberg S, Christou P.

Trends Plant Sci. 2017 Jan;22(1):38-52. doi: 10.1016/j.tplants.2016.08.009. Epub 2016 Sep 17. Review.

PMID:
27645899
13.

The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport.

Banakar R, Alvarez Fernández Á, Abadía J, Capell T, Christou P.

Plant Biotechnol J. 2017 Apr;15(4):423-432. doi: 10.1111/pbi.12637. Epub 2016 Oct 10.

14.

Patterns of CRISPR/Cas9 activity in plants, animals and microbes.

Bortesi L, Zhu C, Zischewski J, Perez L, Bassié L, Nadi R, Forni G, Lade SB, Soto E, Jin X, Medina V, Villorbina G, Muñoz P, Farré G, Fischer R, Twyman RM, Capell T, Christou P, Schillberg S.

Plant Biotechnol J. 2016 Dec;14(12):2203-2216. doi: 10.1111/pbi.12634. Epub 2016 Oct 11. Review.

15.

Red Anthocyanins and Yellow Carotenoids Form the Color of Orange-Flower Gentian (Gentiana lutea L. var. aurantiaca).

Berman J, Sheng Y, Gómez Gómez L, Veiga T, Ni X, Farré G, Capell T, Guitián J, Guitián P, Sandmann G, Christou P, Zhu C.

PLoS One. 2016 Sep 2;11(9):e0162410. doi: 10.1371/journal.pone.0162410. eCollection 2016.

16.

Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity.

Bai C, Berman J, Farre G, Capell T, Sandmann G, Christou P, Zhu C.

Transgenic Res. 2017 Feb;26(1):13-23. doi: 10.1007/s11248-016-9977-x. Epub 2016 Aug 27.

PMID:
27567632
17.

Engineered maize as a source of astaxanthin: processing and application as fish feed.

Breitenbach J, Nogueira M, Farré G, Zhu C, Capell T, Christou P, Fleck G, Focken U, Fraser PD, Sandmann G.

Transgenic Res. 2016 Dec;25(6):785-793. Epub 2016 Aug 12.

PMID:
27520497
18.

Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling.

Comas J, Benfeitas R, Vilaprinyo E, Sorribas A, Solsona F, Farré G, Berman J, Zorrilla U, Capell T, Sandmann G, Zhu C, Christou P, Alves R.

Plant J. 2016 Sep;87(5):455-71. doi: 10.1111/tpj.13210. Epub 2016 Jul 18.

19.

Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro.

Vamvaka E, Evans A, Ramessar K, Krumpe LR, Shattock RJ, O'Keefe BR, Christou P, Capell T.

Plant Cell Rep. 2016 Jun;35(6):1309-19. doi: 10.1007/s00299-016-1963-5. Epub 2016 Mar 23.

PMID:
27007716
20.

Metabolic engineering of astaxanthin biosynthesis in maize endosperm and characterization of a prototype high oil hybrid.

Farré G, Perez-Fons L, Decourcelle M, Breitenbach J, Hem S, Zhu C, Capell T, Christou P, Fraser PD, Sandmann G.

Transgenic Res. 2016 Aug;25(4):477-89. doi: 10.1007/s11248-016-9943-7. Epub 2016 Mar 1.

PMID:
26931320
21.

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

Vamvaka E, Arcalis E, Ramessar K, Evans A, O'Keefe BR, Shattock RJ, Medina V, Stöger E, Christou P, Capell T.

Plant Biotechnol J. 2016 Jun;14(6):1427-37. doi: 10.1111/pbi.12507. Epub 2016 Jan 23.

22.

Freedom-to-operate analysis of a transgenic multivitamin corn variety.

Zanga D, Capell T, Zhu C, Christou P, Thangaraj H.

Plant Biotechnol J. 2016 May;14(5):1225-40. doi: 10.1111/pbi.12488. Epub 2015 Oct 15.

23.

The carotenoid cleavage dioxygenase CCD2 catalysing the synthesis of crocetin in spring crocuses and saffron is a plastidial enzyme.

Ahrazem O, Rubio-Moraga A, Berman J, Capell T, Christou P, Zhu C, Gómez-Gómez L.

New Phytol. 2016 Jan;209(2):650-63. doi: 10.1111/nph.13609. Epub 2015 Sep 17.

24.

Cloning and Functional Characterization of the Maize (Zea mays L.) Carotenoid Epsilon Hydroxylase Gene.

Chang S, Berman J, Sheng Y, Wang Y, Capell T, Shi L, Ni X, Sandmann G, Christou P, Zhu C.

PLoS One. 2015 Jun 1;10(6):e0128758. doi: 10.1371/journal.pone.0128758. eCollection 2015.

25.

Bottlenecks in carotenoid biosynthesis and accumulation in rice endosperm are influenced by the precursor-product balance.

Bai C, Capell T, Berman J, Medina V, Sandmann G, Christou P, Zhu C.

Plant Biotechnol J. 2016 Jan;14(1):195-205. doi: 10.1111/pbi.12373. Epub 2015 Apr 7.

26.

Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis.

Nogareda C, Moreno JA, Angulo E, Sandmann G, Portero M, Capell T, Zhu C, Christou P.

Plant Biotechnol J. 2016 Jan;14(1):160-8. doi: 10.1111/pbi.12369. Epub 2015 Apr 2.

27.

Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12.

Vamvaka E, Twyman RM, Murad AM, Melnik S, Teh AY, Arcalis E, Altmann F, Stoger E, Rech E, Ma JK, Christou P, Capell T.

Plant Biotechnol J. 2016 Jan;14(1):97-108. doi: 10.1111/pbi.12360. Epub 2015 Apr 7.

28.

Combined transcript, proteome, and metabolite analysis of transgenic maize seeds engineered for enhanced carotenoid synthesis reveals pleotropic effects in core metabolism.

Decourcelle M, Perez-Fons L, Baulande S, Steiger S, Couvelard L, Hem S, Zhu C, Capell T, Christou P, Fraser P, Sandmann G.

J Exp Bot. 2015 Jun;66(11):3141-50. doi: 10.1093/jxb/erv120. Epub 2015 Mar 20.

29.

Knowledge-driven approaches for engineering complex metabolic pathways in plants.

Farré G, Twyman RM, Christou P, Capell T, Zhu C.

Curr Opin Biotechnol. 2015 Apr;32:54-60. doi: 10.1016/j.copbio.2014.11.004. Epub 2014 Nov 25. Review.

PMID:
25448233
30.

Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks.

Sabalza M, Christou P, Capell T.

Biotechnol Lett. 2014 Dec;36(12):2367-79. doi: 10.1007/s10529-014-1621-3. Epub 2014 Jul 22. Review.

PMID:
25048244
31.

Can plant biotechnology help break the HIV-malaria link?

Vamvaka E, Twyman RM, Christou P, Capell T.

Biotechnol Adv. 2014 May-Jun;32(3):575-82. doi: 10.1016/j.biotechadv.2014.02.004. Epub 2014 Mar 6. Review.

PMID:
24607600
32.

Engineering complex metabolic pathways in plants.

Farré G, Blancquaert D, Capell T, Van Der Straeten D, Christou P, Zhu C.

Annu Rev Plant Biol. 2014;65:187-223. doi: 10.1146/annurev-arplant-050213-035825. Epub 2014 Feb 26. Review.

PMID:
24579989
33.

Strategic patent analysis in plant biotechnology: terpenoid indole alkaloid metabolic engineering as a case study.

Miralpeix B, Sabalza M, Twyman RM, Capell T, Christou P.

Plant Biotechnol J. 2014 Feb;12(2):117-34. doi: 10.1111/pbi.12134. Review.

34.

A novel carotenoid, 4-keto-α-carotene, as an unexpected by-product during genetic engineering of carotenogenesis in rice callus.

Breitenbach J, Bai C, Rivera SM, Canela R, Capell T, Christou P, Zhu C, Sandmann G.

Phytochemistry. 2014 Feb;98:85-91. doi: 10.1016/j.phytochem.2013.12.008. Epub 2014 Jan 3.

PMID:
24393458
35.

An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation.

Bai C, Rivera SM, Medina V, Alves R, Vilaprinyo E, Sorribas A, Canela R, Capell T, Sandmann G, Christou P, Zhu C.

Plant J. 2014 Feb;77(3):464-75. doi: 10.1111/tpj.12384. Epub 2014 Jan 8.

36.

Cloning and functional analysis of the promoters that upregulate carotenogenic gene expression during flower development in Gentiana lutea.

Zhu C, Yang Q, Ni X, Bai C, Sheng Y, Shi L, Capell T, Sandmann G, Christou P.

Physiol Plant. 2014 Apr;150(4):493-504. doi: 10.1111/ppl.12129. Epub 2013 Dec 27.

PMID:
24256196
37.

Engineering metabolic pathways in plants by multigene transformation.

Zorrilla-López U, Masip G, Arjó G, Bai C, Banakar R, Bassie L, Berman J, Farré G, Miralpeix B, Pérez-Massot E, Sabalza M, Sanahuja G, Vamvaka E, Twyman RM, Christou P, Zhu C, Capell T.

Int J Dev Biol. 2013;57(6-8):565-76. doi: 10.1387/ijdb.130162pc. Review.

38.

A question of balance: achieving appropriate nutrient levels in biofortified staple crops.

Sanahuja G, Farré G, Berman J, Zorrilla-López U, Twyman RM, Capell T, Christou P, Zhu C.

Nutr Res Rev. 2013 Dec;26(2):235-45. doi: 10.1017/S0954422413000176. Epub 2013 Oct 18. Review.

PMID:
24134863
39.

Efficient recovery of recombinant proteins from cereal endosperm is affected by interaction with endogenous storage proteins.

Peters J, Sabalza M, Ramessar K, Christou P, Capell T, Stöger E, Arcalís E.

Biotechnol J. 2013 Oct;8(10):1203-12. doi: 10.1002/biot.201300068. Epub 2013 Sep 17.

PMID:
23960004
40.

Ascorbic acid synthesis and metabolism in maize are subject to complex and genotype-dependent feedback regulation during endosperm development.

Sanahuja G, Farré G, Bassie L, Zhu C, Christou P, Capell T.

Biotechnol J. 2013 Oct;8(10):1221-30. doi: 10.1002/biot.201300064. Epub 2013 Jul 11.

PMID:
23744785
41.

Paradoxical EU agricultural policies on genetically engineered crops.

Masip G, Sabalza M, Pérez-Massot E, Banakar R, Cebrian D, Twyman RM, Capell T, Albajes R, Christou P.

Trends Plant Sci. 2013 Jun;18(6):312-24. doi: 10.1016/j.tplants.2013.03.004. Epub 2013 Apr 25. Review.

PMID:
23623240
42.

Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering.

Farré G, Maiam Rivera S, Alves R, Vilaprinyo E, Sorribas A, Canela R, Naqvi S, Sandmann G, Capell T, Zhu C, Christou P.

Plant J. 2013 Aug;75(3):441-55. doi: 10.1111/tpj.12214. Epub 2013 May 30.

43.

Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats.

Arjó G, Portero M, Piñol C, Viñas J, Matias-Guiu X, Capell T, Bartholomaeus A, Parrott W, Christou P.

Transgenic Res. 2013 Apr;22(2):255-67. doi: 10.1007/s11248-013-9692-9. Epub 2013 Feb 22.

PMID:
23430588
44.

Can the world afford to ignore biotechnology solutions that address food insecurity?

Berman J, Zhu C, Pérez-Massot E, Arjó G, Zorrilla-López U, Masip G, Banakar R, Sanahuja G, Farré G, Miralpeix B, Bai C, Vamvaka E, Sabalza M, Twyman RM, Bassié L, Capell T, Christou P.

Plant Mol Biol. 2013 Sep;83(1-2):5-19. doi: 10.1007/s11103-013-0027-2. Epub 2013 Feb 21.

PMID:
23430566
45.

Seeds as a production system for molecular pharming applications: status and prospects.

Sabalza M, Vamvaka E, Christou P, Capell T.

Curr Pharm Des. 2013;19(31):5543-52. Review.

PMID:
23394568
46.

Plant cells as pharmaceutical factories.

Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Miralpeix B, Capell T, Christou P, Oksman-Caldentey KM.

Curr Pharm Des. 2013;19(31):5640-60. Review.

PMID:
23394561
47.

Metabolic engineering of plant secondary products: which way forward?

Miralpeix B, Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Oksman-Caldentey KM, Capell T, Christou P.

Curr Pharm Des. 2013;19(31):5622-39. Review.

PMID:
23394556
48.

Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies.

Zhu C, Sanahuja G, Yuan D, Farré G, Arjó G, Berman J, Zorrilla-López U, Banakar R, Bai C, Pérez-Massot E, Bassie L, Capell T, Christou P.

Plant Biotechnol J. 2013 Feb;11(2):129-41. doi: 10.1111/j.1467-7652.2012.00740.x. Epub 2012 Sep 13. Review.

49.

Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds.

Sabalza M, Madeira L, van Dolleweerd C, Ma JK, Capell T, Christou P.

Plant Mol Biol. 2012 Nov;80(4-5):477-88. doi: 10.1007/s11103-012-9962-6. Epub 2012 Sep 11.

PMID:
22965278
50.

Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity.

Arjó G, Capell T, Matias-Guiu X, Zhu C, Christou P, Piñol C.

Plant Biotechnol J. 2012 Dec;10(9):1026-34. doi: 10.1111/j.1467-7652.2012.00730.x. Epub 2012 Aug 29.

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