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Items: 26


The Unexpected Noncatalytic Roles of Histone Modifiers in Development and Disease.

Aubert Y, Egolf S, Capell BC.

Trends Genet. 2019 Jul 10. pii: S0168-9525(19)30123-4. doi: 10.1016/j.tig.2019.06.004. [Epub ahead of print] Review.


Paget's Diseases: United by Epidermis and Epigenetics.

Capell BC.

J Invest Dermatol. 2019 Apr;139(4):753-754. doi: 10.1016/j.jid.2018.10.001.


KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis.

Lin-Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson CL, Sen P, Saffie R, Busino L, Garcia BA, Berger SL, Capell BC.

Genes Dev. 2018 Jan 15;32(2):181-193. doi: 10.1101/gad.306241.117. Epub 2018 Feb 12.


Histone modifiers: Dynamic regulators of the cutaneous transcriptome.

Ghosh K, O'Neil K, Capell BC.

J Dermatol Sci. 2018 Mar;89(3):226-232. doi: 10.1016/j.jdermsci.2017.12.006. Epub 2017 Dec 18. Review.


BAP1: case report and insight into a novel tumor suppressor.

Ghosh K, Modi B, James WD, Capell BC.

BMC Dermatol. 2017 Nov 22;17(1):13. doi: 10.1186/s12895-017-0065-6.


Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.

Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.


Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas.

Miller CJ, Shin TM, Sobanko JF, Sharkey JM, Grunyk JW, Elenitsas R, Chu EY, Capell BC, Ming ME, Etzkorn JR.

J Am Acad Dermatol. 2017 Aug;77(2):333-340.e1. doi: 10.1016/j.jaad.2017.03.025.


The Senescence-Associated Secretory Phenotype: Critical Effector in Skin CancerĀ and Aging.

Ghosh K, Capell BC.

J Invest Dermatol. 2016 Nov;136(11):2133-2139. doi: 10.1016/j.jid.2016.06.621. Epub 2016 Aug 17. Review.


MLL1 is essential for the senescence-associated secretory phenotype.

Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL.

Genes Dev. 2016 Feb 1;30(3):321-36. doi: 10.1101/gad.271882.115.


Autophagy mediates degradation of nuclear lamina.

Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL.

Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548. Epub 2015 Oct 28.


CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.

McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW.

Cancer Discov. 2015 Oct;5(10):1072-85. doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16.


Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape.

Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V, Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD, Berger SL.

Genes Dev. 2013 Aug 15;27(16):1787-99. doi: 10.1101/gad.223834.113. Epub 2013 Aug 9.


Genome-wide epigenetics.

Capell BC, Berger SL.

J Invest Dermatol. 2013 Jun;133(6):e9. doi: 10.1038/jid.2013.173. Review. No abstract available.


Human longevity and common variations in the LMNA gene: a meta-analysis.

Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS.

Aging Cell. 2012 Jun;11(3):475-81. doi: 10.1111/j.1474-9726.2012.00808.x. Epub 2012 Mar 27.


Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect.

Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4997-5002. doi: 10.1073/pnas.1019532108. Epub 2011 Mar 7.


Rapidly fatal pulmonary fibrosis in a patient with psoriatic arthritis treated with adalimumab.

Cohen JV, Capell BC, Kinniry PA, Epstein AL.

J Rheumatol. 2011 Feb;38(2):398-9. doi: 10.3899/jrheum.100641. No abstract available.


From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging.

Capell BC, Tlougan BE, Orlow SJ.

J Invest Dermatol. 2009 Oct;129(10):2340-50. doi: 10.1038/jid.2009.103. Epub 2009 Apr 23. Review.


A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.

Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Avallone H, Kolodgie FD, Virmani R, Nabel EG, Collins FS.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15902-7. doi: 10.1073/pnas.0807840105. Epub 2008 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13143.


Diabetes increases p53-mediated apoptosis following ischemia.

Jazayeri L, Callaghan MJ, Grogan RH, Hamou CD, Thanik V, Ingraham CR, Capell BC, Pelo CR, Gurtner GC.

Plast Reconstr Surg. 2008 Apr;121(4):1135-43. doi: 10.1097/01.prs.0000302499.18738.c2.


Mechanisms of cardiovascular disease in accelerated aging syndromes.

Capell BC, Collins FS, Nabel EG.

Circ Res. 2007 Jul 6;101(1):13-26. Review.


A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.

Cao K, Capell BC, Erdos MR, Djabali K, Collins FS.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4949-54. Epub 2007 Mar 14.


Human laminopathies: nuclei gone genetically awry.

Capell BC, Collins FS.

Nat Rev Genet. 2006 Dec;7(12):940-52. Review.


Successful management of orbital cellulitis and temporary visual loss after blepharoplasty.

Chiu ES, Capell BC, Press R, Aston SJ, Jelks EB, Jelks GW.

Plast Reconstr Surg. 2006 Sep;118(3):67e-72e. Review. No abstract available. Erratum in: Plast Reconstr Surg. 2006 Sep 15;118(4):109e. Plast Reconstr Surg. 2007 Apr 1;119(4):95e. Capel, Brian [corrected to Capell, Brian C].


Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome.

Varga R, Eriksson M, Erdos MR, Olive M, Harten I, Kolodgie F, Capell BC, Cheng J, Faddah D, Perkins S, Avallone H, San H, Qu X, Ganesh S, Gordon LB, Virmani R, Wight TN, Nabel EG, Collins FS.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3250-5. Epub 2006 Feb 21.


Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12879-84. Epub 2005 Aug 29.

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