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To Be or Not To Be a Testis.

Capel B.

Reproduction. 2019 Jul 1. pii: REP-19-0151.R1. doi: 10.1530/REP-19-0151. [Epub ahead of print] Review.


The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.

Ruthig VA, Friedersdorf MB, Garness JA, Munger SC, Bunce C, Keene JD, Capel B.

Development. 2019 Jul 25;146(19). pii: dev175950. doi: 10.1242/dev.175950.


CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.

Garcia-Moreno SA, Lin YT, Futtner CR, Salamone IM, Capel B, Maatouk DM.

PLoS Genet. 2019 May 22;15(5):e1007895. doi: 10.1371/journal.pgen.1007895. eCollection 2019 May.



Capel B.

Curr Top Dev Biol. 2019;134:xiii-xvii. doi: 10.1016/S0070-2153(19)30050-X. No abstract available.


Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.

McKey J, Bunce C, Batchvarov IS, Ornitz DM, Capel B.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5570-5575. doi: 10.1073/pnas.1814930116. Epub 2019 Feb 28.


Sex reversal.

Weber C, Capel B.

Curr Biol. 2018 Nov 5;28(21):R1234-R1236. doi: 10.1016/j.cub.2018.09.043.


The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species.

Ge C, Ye J, Weber C, Sun W, Zhang H, Zhou Y, Cai C, Qian G, Capel B.

Science. 2018 May 11;360(6389):645-648. doi: 10.1126/science.aap8328.


Epigenetic regulation of male fate commitment from an initially bipotential system.

Garcia-Moreno SA, Plebanek MP, Capel B.

Mol Cell Endocrinol. 2018 Jun 15;468:19-30. doi: 10.1016/j.mce.2018.01.009. Epub 2018 Feb 2. Review.


Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer.

Pierpont TM, Lyndaker AM, Anderson CM, Jin Q, Moore ES, Roden JL, Braxton A, Bagepalli L, Kataria N, Hu HZ, Garness J, Cook MS, Capel B, Schlafer DH, Southard T, Weiss RS.

Cell Rep. 2017 Nov 14;21(7):1896-1909. doi: 10.1016/j.celrep.2017.10.078.


Vertebrate sex determination: evolutionary plasticity of a fundamental switch.

Capel B.

Nat Rev Genet. 2017 Nov;18(11):675-689. doi: 10.1038/nrg.2017.60. Epub 2017 Aug 14. Review.


Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination.

Ge C, Ye J, Zhang H, Zhang Y, Sun W, Sang Y, Capel B, Qian G.

Development. 2017 Jun 15;144(12):2222-2233. doi: 10.1242/dev.152033. Epub 2017 May 15.


Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.

Lin YT, Barske L, DeFalco T, Capel B.

Development. 2017 May 1;144(9):1607-1618. doi: 10.1242/dev.149203. Epub 2017 Mar 30.


Genome-wide identification of regulatory elements in Sertoli cells.

Maatouk DM, Natarajan A, Shibata Y, Song L, Crawford GE, Ohler U, Capel B.

Development. 2017 Feb 15;144(4):720-730. doi: 10.1242/dev.142554. Epub 2017 Jan 13.


A grafted ovarian fragment rescues host fertility after chemotherapy.

Batchvarov IS, Taylor RW, Bustamante-Marín X, Czerwinski M, Johnson ES, Kornbluth S, Capel B.

Mol Hum Reprod. 2016 Dec;22(12):842-851. Epub 2016 Oct 3.


A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans.

Czerwinski M, Natarajan A, Barske L, Looger LL, Capel B.

Dev Biol. 2016 Dec 1;420(1):166-177. doi: 10.1016/j.ydbio.2016.09.018. Epub 2016 Sep 23.


Cycling in the Cell Fate Landscape.

Bunce C, Capel B.

Curr Top Dev Biol. 2016;116:153-65. doi: 10.1016/bs.ctdb.2015.10.001. Epub 2016 Jan 21. Review.


Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.

DeFalco T, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B.

Cell Rep. 2015 Aug 18;12(7):1107-19. doi: 10.1016/j.celrep.2015.07.015. Epub 2015 Aug 6.


Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.

Bustamante-Marin XM, Cook MS, Gooding J, Newgard C, Capel B.

Biol Reprod. 2015 Sep;93(3):78. doi: 10.1095/biolreprod.115.128850. Epub 2015 Jul 29.


Cell fate commitment during mammalian sex determination.

Lin YT, Capel B.

Curr Opin Genet Dev. 2015 Jun;32:144-52. doi: 10.1016/j.gde.2015.03.003. Epub 2015 Apr 1. Review.


Ovarian epithelium regeneration by Lgr5(+) cells.

Capel B.

Nat Cell Biol. 2014 Aug;16(8):743-4. doi: 10.1038/ncb3020.


Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis.

DeFalco T, Bhattacharya I, Williams AV, Sams DM, Capel B.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93. doi: 10.1073/pnas.1400057111. Epub 2014 May 27.


Development. The minimalist Y.

Capel B.

Science. 2014 Jan 3;343(6166):32-3. doi: 10.1126/science.1248486. No abstract available.


Predetermination of sexual fate in a turtle with temperature-dependent sex determination.

Mork L, Czerwinski M, Capel B.

Dev Biol. 2014 Feb 1;386(1):264-71. doi: 10.1016/j.ydbio.2013.11.026. Epub 2013 Dec 4.


Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.

Maatouk DM, Mork L, Chassot AA, Chaboissier MC, Capel B.

Dev Biol. 2013 Nov 15;383(2):295-306. doi: 10.1016/j.ydbio.2013.08.026. Epub 2013 Sep 11.


Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.

Munger SC, Natarajan A, Looger LL, Ohler U, Capel B.

PLoS Genet. 2013;9(7):e1003630. doi: 10.1371/journal.pgen.1003630. Epub 2013 Jul 11.


Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis.

Cool J, DeFalco T, Capel B.

Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec;1(6):847-59. doi: 10.1002/wdev.62. Epub 2012 Apr 26. Review.


Testicular teratomas: an intersection of pluripotency, differentiation and cancer biology.

Bustamante-Marín X, Garness JA, Capel B.

Int J Dev Biol. 2013;57(2-4):201-10. doi: 10.1387/ijdb.130136bc. Review.


The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.

Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AP, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK.

Genome Biol. 2013 Mar 28;14(3):R28. doi: 10.1186/gb-2013-14-3-r28.


Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.

Defalco T, Saraswathula A, Briot A, Iruela-Arispe ML, Capel B.

Biol Reprod. 2013 Apr 11;88(4):91. doi: 10.1095/biolreprod.112.106138. Print 2013 Apr.


Conserved action of β-catenin during female fate determination in the red-eared slider turtle.

Mork L, Capel B.

Evol Dev. 2013 Mar-Apr;15(2):96-106. doi: 10.1111/ede.12020.


Forward to the special issue on sex determination.

Capel B, Tanaka M.

Dev Dyn. 2013 Apr;242(4):303-6. doi: 10.1002/dvdy.23937. Epub 2013 Mar 6. No abstract available.


Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence.

Garcia TX, DeFalco T, Capel B, Hofmann MC.

Dev Biol. 2013 May 1;377(1):188-201. doi: 10.1016/j.ydbio.2013.01.031. Epub 2013 Feb 4.


Germ cells are not required to establish the female pathway in mouse fetal gonads.

Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B.

PLoS One. 2012;7(10):e47238. doi: 10.1371/journal.pone.0047238. Epub 2012 Oct 16.


Testis development requires the repression of Wnt4 by Fgf signaling.

Jameson SA, Lin YT, Capel B.

Dev Biol. 2012 Oct 1;370(1):24-32. doi: 10.1016/j.ydbio.2012.06.009. Epub 2012 Jun 15.


Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination.

Munger SC, Capel B.

Wiley Interdiscip Rev Syst Biol Med. 2012 Jul-Aug;4(4):401-12. doi: 10.1002/wsbm.1172. Epub 2012 May 17.


Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.

Jameson SA, Natarajan A, Cool J, DeFalco T, Maatouk DM, Mork L, Munger SC, Capel B.

PLoS Genet. 2012;8(3):e1002575. doi: 10.1371/journal.pgen.1002575. Epub 2012 Mar 15.


Mouse germ cell clusters form by aggregation as well as clonal divisions.

Mork L, Tang H, Batchvarov I, Capel B.

Mech Dev. 2012 Jan-Feb;128(11-12):591-6. doi: 10.1016/j.mod.2011.12.005. Epub 2012 Jan 5.


Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.

Mork L, Maatouk DM, McMahon JA, Guo JJ, Zhang P, McMahon AP, Capel B.

Biol Reprod. 2012 Feb 14;86(2):37. doi: 10.1095/biolreprod.111.095208. Print 2012 Feb.


Two distinct origins for Leydig cell progenitors in the fetal testis.

DeFalco T, Takahashi S, Capel B.

Dev Biol. 2011 Apr 1;352(1):14-26. doi: 10.1016/j.ydbio.2011.01.011. Epub 2011 Jan 19.


Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.

Cool J, DeFalco TJ, Capel B.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):167-72. doi: 10.1073/pnas.1010299108. Epub 2010 Dec 20.


Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background.

Cook MS, Munger SC, Nadeau JH, Capel B.

Development. 2011 Jan;138(1):23-32. doi: 10.1242/dev.057000. Epub 2010 Nov 29.


Unmasking a role for sex chromosomes in gene silencing.

Maatouk DM, Capel B.

Genome Biol. 2010;11(9):134. doi: 10.1186/gb-2010-11-9-134. Epub 2010 Sep 27.


Oestrogen shuts the door on SOX9.

Mork L, Capel B.

BMC Biol. 2010 Aug 31;8:110. doi: 10.1186/1741-7007-8-110.


Sex determination: An avian sexual revolution.

Barske LA, Capel B.

Nature. 2010 Mar 11;464(7286):171-2. doi: 10.1038/464171a. No abstract available.


Estrogen represses SOX9 during sex determination in the red-eared slider turtle Trachemys scripta.

Barske LA, Capel B.

Dev Biol. 2010 May 1;341(1):305-14. doi: 10.1016/j.ydbio.2010.02.010. Epub 2010 Feb 12.


Shifting gears and putting on the brakes: Female germ cells transition into meiosis.

Cook MS, Capel B.

Cell Cycle. 2010 Feb 1;9(3):447-8. Epub 2010 Feb 1. No abstract available.


The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22323-8. doi: 10.1073/pnas.0905431106. Epub 2009 Dec 10.


Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.

Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B.

Genes Dev. 2009 Nov 1;23(21):2521-36. doi: 10.1101/gad.1835809.


Gonad morphogenesis in vertebrates: divergent means to a convergent end.

DeFalco T, Capel B.

Annu Rev Cell Dev Biol. 2009;25:457-82. doi: 10.1146/annurev.cellbio.042308.13350. Review.

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