Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 222

1.

HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.

Patel N, Wang J, Shiozawa K, Jones KB, Zhang Y, Prokop JW, Davenport GG, Nihira NT, Hao Z, Wong D, Brandsmeier L, Meadows SK, Sampaio AV, Werff RV, Endo M, Capecchi MR, McNagny KM, Mak TW, Nielsen TO, Underhill TM, Myers RM, Kondo T, Su L.

iScience. 2019 Mar 29;13:43-54. doi: 10.1016/j.isci.2019.02.008. Epub 2019 Feb 15.

2.

Correction: Two distinct ontogenies confer heterogeneity to mouse brain microglia (doi: 10.1242/dev.152306).

De S, Van Deren D, Peden E, Hockin M, Boulet A, Titen S, Capecchi MR.

Development. 2019 Feb 7;146(3). pii: dev175901. doi: 10.1242/dev.175901. No abstract available.

3.

Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning.

Yu D, Wang J, Zou H, Feng T, Chen L, Li J, Qi X, Li Z, Duan X, Xu C, Zhang L, Long X, Lan J, Chen C, Wang C, Xu X, Ren J, Zhao Y, Hu X, Lian Z, Men H, Pan D, Li N, Capecchi MR, Du X, Zhao Y, Wu S.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11071-E11080. doi: 10.1073/pnas.1814514115. Epub 2018 Oct 31.

4.

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.

Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW.

Cancer Cell. 2018 Aug 13;34(2):346-348. doi: 10.1016/j.ccell.2018.07.006. No abstract available.

5.

Two distinct ontogenies confer heterogeneity to mouse brain microglia.

De S, Van Deren D, Peden E, Hockin M, Boulet A, Titen S, Capecchi MR.

Development. 2018 Jul 4;145(13). pii: dev152306. doi: 10.1242/dev.152306. Erratum in: Development. 2019 Feb 7;146(3):.

6.

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.

Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW.

Cancer Cell. 2018 Mar 12;33(3):527-541.e8. doi: 10.1016/j.ccell.2018.01.018. Epub 2018 Mar 1. Erratum in: Cancer Cell. 2018 Aug 13;34(2):346-348.

7.

Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells.

Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB.

J Clin Invest. 2018 Jan 2;128(1):207-218. doi: 10.1172/JCI94955. Epub 2017 Nov 20.

8.

Corticostriatal circuit defects in Hoxb8 mutant mice.

Nagarajan N, Jones BW, West PJ, Marc RE, Capecchi MR.

Mol Psychiatry. 2017 Nov 28. doi: 10.1038/mp.2017.251. [Epub ahead of print]

PMID:
29180671
9.

ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.

Langer EM, Kendsersky ND, Daniel CJ, Kuziel GM, Pelz C, Murphy KM, Capecchi MR, Sears RC.

Oncogene. 2018 Feb 22;37(8):1005-1019. doi: 10.1038/onc.2017.356. Epub 2017 Oct 30.

10.

Corticostriatal circuit defects in Hoxb8 mutant mice.

Nagarajan N, Jones BW, West PJ, Marc RE, Capecchi MR.

Mol Psychiatry. 2018 Sep;23(9):1868-1877. doi: 10.1038/mp.2017.180. Epub 2017 Sep 26. Erratum in: Mol Psychiatry. 2017 Nov 28;:.

11.

The Influential Role of BCL2 Family Members in Synovial Sarcomagenesis.

Barrott JJ, Zhu JF, Smith-Fry K, Susko AM, Nollner D, Burrell LD, Pozner A, Capecchi MR, Yap JT, Cannon-Albright LA, Deng X, Jones KB.

Mol Cancer Res. 2017 Dec;15(12):1733-1740. doi: 10.1158/1541-7786.MCR-17-0315. Epub 2017 Aug 29.

12.

Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins.

Ruff JS, Saffarini RB, Ramoz LL, Morrison LC, Baker S, Laverty SM, Tvrdik P, Capecchi MR, Potts WK.

PLoS One. 2017 Apr 5;12(4):e0174975. doi: 10.1371/journal.pone.0174975. eCollection 2017.

13.

Derivation of Transgene-Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells.

Li S, Lan H, Men H, Wu Y, Li N, Capecchi MR, Bryda EC, Wu S.

Stem Cells Transl Med. 2017 Feb;6(2):340-351. doi: 10.5966/sctm.2015-0390. Epub 2016 Sep 13.

14.

piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice.

Xu C, Qi X, Du X, Zou H, Gao F, Feng T, Lu H, Li S, An X, Zhang L, Wu Y, Liu Y, Li N, Capecchi MR, Wu S.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):722-727. doi: 10.1073/pnas.1615735114. Epub 2017 Jan 6.

15.

Modeling synovial sarcoma metastasis in the mouse: PI3'-lipid signaling and inflammation.

Barrott JJ, Kafchinski LA, Jin H, Potter JW, Kannan SD, Kennedy R, Mosbruger T, Wang WL, Tsai JW, Araujo DM, Liu T, Capecchi MR, Lazar AJ, Jones KB.

J Exp Med. 2016 Dec 12;213(13):2989-3005. Epub 2016 Nov 9.

16.

Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming.

Zhang X, Wei X, Wu Y, Wang Y, Tan C, Hu X, Li N, Capecchi MR, Wu S.

Protein Cell. 2017 Feb;8(2):134-139. doi: 10.1007/s13238-016-0332-z. No abstract available.

17.

Efficient generation of selection-gene-free rat knockout models by homologous recombination in ES cells.

Lan H, Li S, Guo Z, Men H, Wu Y, Li N, Bryda EC, Capecchi MR, Wu S.

FEBS Lett. 2016 Oct;590(19):3416-3424. doi: 10.1002/1873-3468.12388. Epub 2016 Sep 18.

18.

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.

Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR.

Oncogene. 2016 Sep 22;35(38):5021-32. doi: 10.1038/onc.2016.38. Epub 2016 Mar 7.

19.

ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

Capecchi MR, Pozner A.

Nat Commun. 2015 Nov 19;6:8763. doi: 10.1038/ncomms9763.

20.

Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice.

Prigge JR, Hoyt TR, Dobrinen E, Capecchi MR, Schmidt EE, Meissner N.

J Immunol. 2015 Dec 1;195(11):5347-57. doi: 10.4049/jimmunol.1501553. Epub 2015 Oct 30.

21.

Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling.

Carroll LS, Capecchi MR.

Development. 2015 Dec 1;142(23):4056-67. doi: 10.1242/dev.128298. Epub 2015 Oct 12.

22.

β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition.

Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones KB.

Oncotarget. 2015 Sep 8;6(26):22758-66.

23.

Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse.

Pozner A, Xu B, Palumbos S, Gee JM, Tvrdik P, Capecchi MR.

Front Mol Neurosci. 2015 May 8;8:12. doi: 10.3389/fnmol.2015.00012. eCollection 2015.

24.

Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation.

Gee JM, Gibbons MB, Taheri M, Palumbos S, Morris SC, Smeal RM, Flynn KF, Economo MN, Cizek CG, Capecchi MR, Tvrdik P, Wilcox KS, White JA.

Front Mol Neurosci. 2015 Apr 15;8:10. doi: 10.3389/fnmol.2015.00010. eCollection 2015.

25.

Response: Contributions of the Myf5-independent lineage to myogenesis.

Haldar M, Karan G, Watanabe S, Guenther S, Braun T, Capecchi MR.

Dev Cell. 2014 Dec 8;31(5):539-41. doi: 10.1016/j.devcel.2014.11.010.

26.

Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment.

Goodwin ML, Jin H, Straessler K, Smith-Fry K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB.

Cancer Cell. 2014 Dec 8;26(6):851-862. doi: 10.1016/j.ccell.2014.10.003. Epub 2014 Nov 26.

27.

The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.

Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB.

Oncogene. 2015 Aug 6;34(32):4278-84. doi: 10.1038/onc.2014.354. Epub 2014 Oct 27.

28.

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS.

Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26.

PMID:
25344740
29.

Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.

Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, Morris SC, Talbot A, Palumbos S, Ichida JM, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA, Tvrdik P.

Neuron. 2014 Sep 3;83(5):1058-72. doi: 10.1016/j.neuron.2014.07.024. Epub 2014 Aug 21.

30.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C.

Genes Dev. 2014 Jul 15;28(14):1578-91. doi: 10.1101/gad.238733.114.

31.

Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells.

Wu S, Wu Y, Zhang X, Capecchi MR.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10678-83. doi: 10.1073/pnas.1409933111. Epub 2014 Jul 7.

32.

Fine-tuning of iPSC derivation by an inducible reprogramming system at the protein level.

Sui D, Sun Z, Xu C, Wu Y, Capecchi MR, Wu S, Li N.

Stem Cell Reports. 2014 May 8;2(5):721-33. doi: 10.1016/j.stemcr.2014.03.013. eCollection 2014 May 6.

33.

Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1.

Kurokawa S, Eriksson S, Rose KL, Wu S, Motley AK, Hill S, Winfrey VP, McDonald WH, Capecchi MR, Atkins JF, Arnér ES, Hill KE, Burk RF.

Free Radic Biol Med. 2014 Apr;69:67-76. doi: 10.1016/j.freeradbiomed.2014.01.010. Epub 2014 Jan 14.

34.

Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei.

Prigge JR, Wiley JA, Talago EA, Young EM, Johns LL, Kundert JA, Sonsteng KM, Halford WP, Capecchi MR, Schmidt EE.

Mamm Genome. 2013 Sep 11. [Epub ahead of print]

35.

Targeting the Wnt pathway in synovial sarcoma models.

Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE.

Cancer Discov. 2013 Nov;3(11):1286-301. doi: 10.1158/2159-8290.CD-13-0138. Epub 2013 Aug 6.

36.

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification.

Iverson SV, Eriksson S, Xu J, Prigge JR, Talago EA, Meade TA, Meade ES, Capecchi MR, Arnér ES, Schmidt EE.

Free Radic Biol Med. 2013 Oct;63:369-80. doi: 10.1016/j.freeradbiomed.2013.05.028. Epub 2013 Jun 3.

37.

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.

Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD.

Nat Cell Biol. 2013 Jul;15(7):846-52. doi: 10.1038/ncb2766. Epub 2013 Jun 2.

38.

Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage.

Gahring LC, Enioutina EY, Myers EJ, Spangrude GJ, Efimova OV, Kelley TW, Tvrdik P, Capecchi MR, Rogers SW.

PLoS One. 2013;8(3):e57481. doi: 10.1371/journal.pone.0057481. Epub 2013 Mar 1.

39.

Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.

Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR.

Cancer Cell. 2013 Feb 11;23(2):215-27. doi: 10.1016/j.ccr.2012.12.019.

40.

Toward an understanding of the short bone phenotype associated with multiple osteochondromas.

Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi MR.

J Orthop Res. 2013 Apr;31(4):651-7. doi: 10.1002/jor.22280. Epub 2012 Nov 28.

41.

Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis.

Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF.

J Biol Chem. 2012 Nov 23;287(48):40414-24. doi: 10.1074/jbc.M112.421404. Epub 2012 Oct 4.

42.

Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo.

Boulet AM, Capecchi MR.

Dev Biol. 2012 Nov 15;371(2):235-45. doi: 10.1016/j.ydbio.2012.08.017. Epub 2012 Aug 30.

43.

SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas.

Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR.

Oncogene. 2013 May 2;32(18):2365-71, 2375.e1-5. doi: 10.1038/onc.2012.247. Epub 2012 Jul 16.

44.

Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase.

Suo L, Lu H, Ying G, Capecchi MR, Wu Q.

J Mol Cell Biol. 2012 Dec;4(6):362-76. doi: 10.1093/jmcb/mjs034. Epub 2012 Jun 21.

PMID:
22730554
45.

Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure.

Rogers SW, Tvrdik P, Capecchi MR, Gahring LC.

Am J Med Genet A. 2012 May;158A(5):1135-44. doi: 10.1002/ajmg.a.35372. Epub 2012 Mar 30.

46.

Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.

Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO.

Cancer Cell. 2012 Mar 20;21(3):333-47. doi: 10.1016/j.ccr.2012.01.010.

47.

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.

Prigge JR, Eriksson S, Iverson SV, Meade TA, Capecchi MR, Arnér ES, Schmidt EE.

Free Radic Biol Med. 2012 Feb 15;52(4):803-10. doi: 10.1016/j.freeradbiomed.2011.11.025. Epub 2011 Dec 8.

48.

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations.

Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):466-71. doi: 10.1073/pnas.1118857109. Epub 2011 Dec 21.

49.

Cardiovascular defects in a mouse model of HOXA1 syndrome.

Makki N, Capecchi MR.

Hum Mol Genet. 2012 Jan 1;21(1):26-31. doi: 10.1093/hmg/ddr434. Epub 2011 Sep 22.

50.

Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.

Makki N, Capecchi MR.

Dev Biol. 2011 Sep 15;357(2):295-304. doi: 10.1016/j.ydbio.2011.06.042. Epub 2011 Jul 18.

Supplemental Content

Loading ...
Support Center